ISofosbuvir neVelpatasvir

-Delile

• Ngaphambi kokuthatha i-sofosbuvir ne-velpatasvir,
• I-Sofosbuvir ne-velpatasvir zingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi), kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-sofosbuvir ne-velpatasvir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngokuhlanganiswa kwe-sofosbuvir ne-velpatasvir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-sofosbuvir ne-velpatasvir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha inhlanganisela ye-sofosbuvir ne-velpatasvir.

Inhlanganisela ye-sofosbuvir ne-velpatasvir isetshenziswa yodwa noma i-ribavirin (i-Copegus, i-Rebetol, i-Ribasphere) ukwelapha i-hepatitis C engapheli (ukutheleleka okuqhubekayo kwegciwane okulimaza isibindi) kubantu abadala nezingane ezineminyaka engu-6 ubudala nangaphezulu noma ezinesisindo okungenani esingu-37 amakhilogremu angu-17 I-Sofosbuvir isekilasini lemithi elwa namagciwane ebizwa nge-nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. IVelpatasvir isekilasini lemithi elwa namagciwane ebizwa nge-HCV NS5A replication complex inhibitors. Inhlanganisela yesofosbuvir ne-velpatasvir isebenza ngokumisa igciwane elibanga ukusabalala kwesifo sokusha kwesibindi kohlobo C emzimbeni.

Inhlanganisela yesofosbuvir ne-velpatasvir iza njengethebhulethi ezothathwa ngomlomo. Kuthathwa ngokujwayelekile noma ngaphandle kokudla kanye ngosuku amasonto ayi-12. Thatha i-sofosbuvir ne-velpatasvir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sofosbuvir ne-velpatasvir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Qhubeka uthathe i-sofosbuvir ne-velpatasvir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-sofosbuvir ne-velpatasvir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sofosbuvir ne-velpatasvir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sofosbuvir, i-velpatasvir, noma imuphi omunye umuthi, noma iziphi izithako kumathebulethi e-sofosbuvir ne-velpatasvir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma ongayinikiwe, amavithamini, izithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); i-atorvastatin (Lipitor, eCaduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-digoxin (i-Lanoxin); i-efavirenz (iSustiva, e-Atripla); oxcarbazepine (Oxtellar, Trileptal); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ama-proton-pump inhibitors afana ne-dexlansoprazole (Dexilant), esomeprazole (Nexium, eVimovo), i-lansoprazole (Prevacid, e-Prevpac), i-omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), ne-rabeprazole (AcipHex): i-rifabin) i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, i-Rifater); i-rifapentine (Priftin); i-rosuvastatin (iCrestor); i-tenofovir DF (Viread, e-Atripla, Complera, Stribild, Truvada, nabanye); i-tipranavir (Aptivus) lapho ithathwa nge-ritonavir (Norvir); i-topotecan (iHycamtin); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-sofosbuvir ne-velpatasvir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha ama-antacids, thatha amahora amane ngaphambi noma amahora amane ngemuva kwe-sofosbuvir ne-velpatasvir.
• Tshela udokotela wakho uma uthatha umuthi wokugaya ukudla, isilungulela, noma izilonda (H₂ blockers) njenge-cimetidine, i-ranitidine (i-Zantac), i-famotidine (i-Pepcid, e-Duexis), noma i-nizatidine. Udokotela wakho angakutshela ukuthi uthathe lo muthi amahora ayi-12 ngaphambi noma amahora ayi-12 ngemuva kwe-sofosbuvir ne-velpatasvir, noma ngasikhathi sinye lapho uthatha i-sofosbuvir ne-velpatasvir.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma une-human immunodeficiency virus (HIV), noma uke waba nanoma yiluphi uhlobo lwenkinga yesibindi ngaphandle kwe-hepatitis C.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-sofosbuvir ne-velpatasvir, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sofosbuvir ne-velpatasvir zingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqubuka
• ukungabi namandla
• ukuzwa ukucasuka
• ngizizwa ngicindezelekile

I-Sofosbuvir ne-velpatasvir zingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Epclusa^®