Inaliti yeLixisenatide

-Delile

• Ngaphambi kokuthatha umjovo we-lixisenatide,
• Umjovo weLixisenatide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha umjovo we-lixisenatide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo weLixisenatide usetshenziswa kanye nokudla nokuzivocavoca ukwelapha uhlobo lwesifo sikashukela sohlobo 2 (isimo lapho umzimba ungasebenzisi i-insulin ngokujwayelekile ngakho-ke awukwazi ukulawula inani likashukela egazini). Umjovo weLixisenatide awusetshenziswanga ukwelapha uhlobo lwesifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi i-insulin ngakho-ke awukwazi ukulawula inani likashukela egazini). ILixisenatide ayisetshenziswanga esikhundleni se-insulin ukwelapha abantu abanesifo sikashukela abadinga i-insulin. Umjovo weLixisenatide usesigabeni semithi ebizwa nge-incretin mimetics. Isebenza ngokuvuselela amanyikwe ukukhipha i-insulin lapho amazinga kashukela egazi ephezulu. I-insulin isiza ukuhambisa ushukela egazini uye kwezinye izicubu zomzimba lapho usetshenziselwa khona amandla. Umjovo weLixisenatide nawo ubambezela ukuphuma kwesisu futhi ubangele ukwehla kwesifiso sokudla.

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukusebenzisa imithi, ukwenza izinguquko endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela futhi kuthuthukise impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-lixisenatide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Umjovo weLixisenatide uza njengepeni lomthamo eligcwalisiwe ukujova ngomgogodla (ngaphansi kwesikhumba). Imvamisa ijovwa kanye ngosuku, kungakapheli ihora elilodwa (imizuzu engama-60) ngaphambi kokudla kokuqala kosuku. Sebenzisa umjovo we-lixisenatide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-lixisenatide njengoba uqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-lixisenatide abese ekhulisa umthamo wakho ngemuva kwezinsuku eziyi-14.

Umjovo weLixisenatide ulawula isifo sikashukela kepha awuselaphi. Qhubeka nokusebenzisa umjovo we-lixisenatide noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-lixisenatide ngaphandle kokukhuluma nodokotela wakho.

Uzodinga ukuthenga izinaliti ngokwehlukana. Buza udokotela wakho noma usokhemisi ukuthi iziphi izinhlobo zezinaliti ozodinga ukujova umuthi wakho. Qiniseka ukuthi ufunda futhi uqonde imiyalo yomkhiqizi yokujova i-lixisenatide. Futhi qiniseka ukuthi uyazi ukuthi ungasetha kanjani ipeni elisha futhi nini. Uma ungaboni noma ungaboni kahle ungasebenzisi leli peni ngaphandle kosizo. Cela udokotela wakho noma usokhemisi ukuthi akubonise ukuthi uyisebenzisa kanjani ipeni. Landela izinkomba ngokucophelela.

Njalo bheka isisombululo se-lixisenatide ngaphambi kokusijova. Kufanele icace, ingenambala, futhi ingabi nezinhlayiya. Ungasebenzisi i-lixisenatide uma inombala, inamafu, ijiyile, noma iqukethe izinhlayiya eziqinile, noma uma usuku lokuphelelwa isikhathi esibayeni seludlulile.

Umjovo weLixisenatide ungalawulwa ethangeni (umlenze ongaphezulu), isisu (indawo yesisu), noma ingalo ephezulu. Sebenzisa isiza esihlukile ngomjovo ngamunye. Vumela ipeni ukuthi lifudumale ekamelweni lokushisa ngaphambi kokulisebenzisa uma ligcinwe esiqandisini.

Ungalokothi usebenzise izinaliti futhi ungalokothi wabelane ngezinaliti noma izibaya. Susa njalo inaliti ngemuva nje kokujova umthamo wakho. Phonsa izinaliti esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esimelana nokubhoboza.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha umjovo we-lixisenatide,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-lixisenatide, exenatide (Bydureon, Byetta), liraglutide (Saxenda, Victoza), noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-lixisenatide. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyiphuzayo ngomlomo ngoba i-lixisenatide ingashintsha indlela umzimba wakho oyithatha ngayo le mithi. Uma uthatha imishanguzo yobuhlungu efana ne-acetaminophen (Tylenol), noma ama-antibiotics, yithathe okungenani ihora elilodwa ngaphambi komjovo we-lixisenatide. Uma uthatha izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo) uwaphuze okungenani ihora elilodwa ngaphambili, noma amahora ayi-11 ngemuva kokujova i-lixisenatide. Futhi, qiniseka ukusho noma imiphi yale mithi elandelayo: i-chlorpropamide (i-Diabinese), i-digoxin (i-Lanoxin), i-glimepiride (i-Amaryl, e-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-DiaBeta, i-Glynase, e-Glucovance), i-insulin, i-tolazamide, ne tolbutamide. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, noma uma uke waba nezinkinga ezinzima zesisu, kufaka phakathi i-gastroparesis (ukuhamba kancane kokudla kusuka esiswini kuya emathunjini amancane), noma izinkinga ukugaya ukudla; i-pancreatitis (ukuvuvukala kwamanyikwe); ama-gallstones (amadiphozi aqinile akha ku-gallbladder); noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha umjovo we-lixisenatide, shayela udokotela wakho.
• buza udokotela wakho ukuthi wenzeni uma kunoshintsho olukhulu ekudleni kwakho, ekuzivocavoca umzimba, noma esisindweni; noma uma ugula, uba nesifo noma umkhuhlane, ube nengcindezi engajwayelekile, noma ulimale. Lezi zinguquko nezimo zingathinta ushukela wegazi lakho nenani lomjovo we-lixisenatide ongawudinga.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo.

Jova umthamo ophuthelwe kungakapheli ihora eli-1 (imizuzu engama-60) ngaphambi kokudla kwakho okulandelayo. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

Umjovo weLixisenatide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukugaya ukudla
• ukuqunjelwa
• ikhanda
• ubuhlungu, ukulunywa, noma ububomvu endaweni yomjovo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha umjovo we-lixisenatide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu obuqhubekayo obuqala ngaphezulu kwesobunxele noma maphakathi nesisu kepha bungasabalala buye emhlane, ngokuhlanza noma ngaphandle kokuhlanza
• isifuba
• ukuqubuka
• ukulunywa
• ukushaya kwenhliziyo
• ukuquleka noma uzizwe unesiyezi
• ukuvuvukala kwamehlo, ubuso, umlomo, ulimi, umphimbo, izinyawo, amaqakala noma imilenze engezansi
• ubunzima bokugwinya noma ukuphefumula
• ukushaqeka
• ukuncipha ukuchama,
• umlomo owomile kakhulu noma isikhumba noma ukoma ngokweqile

Umjovo weLixisenatide ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Kugcine kude nokukhanya, ukushisa, uthuli nokungcola. Gcina izibaya ze-lixisenatide ezingasetshenzisiwe esiqandisini (36 ° F kuye ku-46 ° F [2 ° C kuye ku-8 ° C]). Lapho nje ipeni le-lixisenatide selisetshenzisiwe, ligcine ekamelweni lokushisa (ngaphansi kuka-86 ° F [30 ° C]) lifake nophawu lwalo. Ungafrizi. Ungasebenzisi i-lixisenatide uma iqandisiwe. Lahla izibaya ze-lixisenatide esitsheni esingamelana nokubhoboza ngemuva kwezinsuku eziyi-14 kusukela isetshenziswe okokuqala, noma ngabe kukhona isixazululo esisele esibayeni.

Lapho usohambweni, qiniseka ukuthi ugcina izibaya ze-lixisenatide zomile. Izibaya ezingasetshenziswanga kufanele zifakwe esiqandisini noma zigcinwe lapho kubanda khona phakathi kuka-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Amapeni asetshenziswayo angagcinwa ekamelweni lokushisa kuze kufike ku-86 ° F [30 ° C] (hhayi egumbini lamagilavu ​​wemoto noma kwenye indawo eshisayo).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ubuhlungu besisu noma ukuqunjelwa
• ukugaya ukudla
• ukuqunjelwa

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Ushukela wegazi kanye ne-hemoglobin ye-glycosylated (HbA1c) kufanele ihlolwe njalo ukuthola impendulo yakho kumjovo we-lixisenatide. Udokotela wakho uzokutshela ukuthi ungayihlola kanjani impendulo yakho kulo muthi ngokulinganisa amazinga egazi lakho noma umchamo ekhaya. Landela le miyalo ngokucophelela.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Adlyxin^®
• Soliqua^® (njengomkhiqizo ohlanganisiwe oqukethe i-Insulin Glargine neLixisenatide)