Inaliti ye-Brodalumab

-Delile

• Ngaphambi kokusebenzisa umjovo we-brodalumab,
• Umjovo weBrodalumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESixwayiso noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:

Abanye abantu abasebenzisa umjovo we-brodalumab babe nemicabango yokuzibulala nokuziphatha (becabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo). Akwaziwa ukuthi umjovo we-brodalumab ubangela imicabango yokuzibulala nokuziphatha. Tshela udokotela wakho kanye nosokhemisi uma unomlando wokucindezeleka noma imicabango yokuzibulala. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukucindezeleka okusha noma okuya kuba kubi noma ukukhathazeka; imicabango yokuzibulala, ukufa, noma ukuzilimaza wena, noma ukuhlela noma ukuzama ukwenza kanjalo; izinguquko ekuziphatheni kwakho noma emoyeni; noma ukwenza ngemicabango eyingozi. Umhlinzeki wakho wezokunakekelwa kwezempilo uzokunikeza iKhadi Lesikhwama Sesiguli esinohlu lwezimpawu. Uma kwenzeka noma yiziphi zalezi zimpawu, kufanele uthole usizo lwezokwelapha ngokushesha. Phatha ikhadi njalo ngezikhathi zokwelashwa kwakho ngomjovo we-brodalumab, bese ulikhombisa kubo bonke abahlinzeki bakho bezempilo.

Ngenxa yengozi yemicabango yokuzibulala nokuziphatha ngalo muthi, umjovo we-brodalumab utholakala kuphela ngohlelo olukhethekile olubizwa nge-Siliq REMS^®. Wena, udokotela wakho, kanye nosokhemisi wakho kumele nibhalise kulolu hlelo ngaphambi kokuthola umjovo we-brodalumab. Bonke abantu abanikezwe umjovo we-brodalumab kumele bathole incwadi kadokotela evela kudokotela obhaliswe ne-Siliq REMS^® futhi ugcwaliswe ngudokotela ekhemisi elibhaliswe ne-Siliq REMS^® ukuze uthole lo muthi. Buza udokotela wakho ukuthola eminye imininingwane ngalolu hlelo nokuthi uzoyithola kanjani imithi yakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-brodalumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-brodalumab.

Umjovo we-Brodalumab usetshenziselwa ukwelapha i-plaque psoriasis (isifo sesikhumba lapho kuvela khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) kubantu abane-psoriasis enzima kakhulu ukuthi ingalashwa ngemithi yezinhlayiya yodwa futhi abangazange belashwe ngempumelelo eminye imithi. Umjovo we-Brodalumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokuvimba ukusebenza kwento ethile yemvelo emzimbeni edala izimpawu ze-psoriasis.

Umjovo we-Brodalumab uza njengoketshezi esirinji esivele ifakwa ukuze ujovwe ngomgogodla (ngaphansi kwesikhumba). Kuvamise ukujova kanye ngesonto emithamo yokuqala emi-3 bese kuthi kanye njalo emavikini ama-2. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-brodalumab njengoba uqondisiwe. Ungayifaki ngaphezulu noma ngaphansi kwayo noma uyijoje kaningi kunokuyalelwa ngudokotela wakho.

Ungakwazi ukujova umjovo we-brodalumab noma ube nomngane noma isihlobo esenza imijovo. Ngaphambi kokusebenzisa umjovo we-brodalumab okokuqala ngqa, funda ngokucophelela imiyalelo yomkhiqizi. Buza udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozobe ejova umuthi ukuthi ungawujova kanjani.

Sebenzisa isirinji ngayinye oyikhethile kanye kuphela bese ujova sonke isisombululo esirinji. Lahla imijovo nezibaya ezisetshenzisiwe esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Uma usebenzisa isirinji efakiwe efrijiwe, beka isirinji endaweni eyisicaba ngaphandle kokukhipha ikepisi lenaliti bese uyivumela ukuba ifudumale ekamelweni lokushisa cishe imizuzu engama-30 ngaphambi kokuyisebenzisa. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwubeke emanzini ashisayo, noma ngenye indlela. Ungabeki isirinji oyikhethile emuva esiqandisini ngemuva kokufinyelela ekamelweni lokushisa.

Unganyakazisi umuthi.

Njalo bheka isisombululo se-brodalumab ngaphambi kokusijova. Umuthi kufanele ucace futhi ungabi nombala ophuzi kancane. Ungasebenzisi isirinji uma umuthi unamafu, ukhaliphile, noma uqukethe ama-flakes noma izinhlayiya.

Ungasebenzisi isirinji uma iwele endaweni eqinile. Ingxenye yesirinji ingahle yephulwe noma ungaboni ikhefu.

Ungajova umjovo we-brodalumab noma yikuphi emathangeni akho (umlenze ongaphezulu), izingalo ezingaphezulu, noma isisu ngaphandle kwenkaba yakho nendawo engamasentimitha ama-5 ukuyizungeza. Ukwehlisa amathuba okuba buhlungu noma okubomvu, sebenzisa isiza esihlukile ngomjovo ngamunye. Musa ukujova endaweni lapho isikhumba sithambile, silinyaziwe, sibomvu, siqinile, sijiyile, sinesikhumba, sithinteka yi-psoriasis, noma lapho unezibazi noma izimpawu zokwelula.

Umhlinzeki wakho wezokunakekelwa kwempilo angakutshela ukuthi uyeke ukusebenzisa umjovo we-brodalumab uma i-psoriasis yakho ingathuthuki kungakapheli amasonto ayi-12 kuya kwayi-16 yokwelashwa. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-brodalumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-brodalumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-brodalumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-cyclosporine (Gengraf, Neoral, Sandimmune) ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana nomjovo we-brodalumab, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma unesifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya ukudla edala ubuhlungu, isifo sohudo, ukuncipha komzimba nomkhuhlane). Udokotela wakho uzokutshela ukuthi ungasebenzisi umjovo we-brodalumab.
• tshela udokotela wakho uma ngabe uke waba nesimo esithile sezempilo noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-brodalumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-brodalumab.
• thintana nodokotela wakho ukuze ubone uma ngabe udinga ukuthola noma yimiphi imigomo. Kubalulekile ukuthi yonke imishanguzo yokugoma ilungele iminyaka yakho ngaphambi kokuqala ukwelashwa ngomjovo we-brodalumab. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.
• kufanele wazi ukuthi umjovo we-brodalumab unganciphisa ikhono lakho lokulwa nokutheleleka kusuka kubhaktheriya, amagciwane, nesikhunta futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína noma okusongela ukuphila. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma une noma ucabanga ukuthi ungahle ube nolunye uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njenge-herpes noma izilonda ezibandayo), kanye nezifo ezingapheli ezingapheli. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelashwa kwakho ngomjovo we-brodalumab, shayela udokotela wakho ngokushesha: umkhuhlane, ukujuluka, noma ukubanda; ubuhlungu bemisipha; ukukhwehlela; ukuphelelwa umoya; umphimbo obuhlungu noma ubunzima bokugwinya; isikhumba esifudumele, esibomvu, noma esibuhlungu noma izilonda emzimbeni wakho; isifo sohudo; ubuhlungu besisu; ukuchama kaningi, okuphuthumayo noma okubuhlungu; noma ezinye izimpawu zokutheleleka.
• kufanele wazi ukuthi ukusebenzisa umjovo we-brodalumab kwandisa ubungozi bokuthi uzoba nesifo sofuba (i-TB; ukutheleleka okuyingozi kwamaphaphu), ikakhulukazi uma usuvele ungenwe yi-TB kodwa ungenazo izimpawu zesifo. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma ngabe uhlala ezweni lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Udokotela wakho uzokuhlolela i-TB ngaphambi kokuqala ukwelashwa ngomjovo we-brodalumab futhi angakwelapha i-TB uma unomlando we-TB noma une-TB esebenzayo. Uma unalezi zimpawu ezilandelayo ze-TB noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukukhwehlela igazi noma amafinyila, ubuthakathaka noma ukukhathala, ukuncipha komzimba, ukulahlekelwa isifiso sokudla, ukugodola, umkhuhlane, noma ukujuluka ebusuku.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Sebenzisa umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Umjovo weBrodalumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu obuhlangene noma besisipha
• isicanucanu
• ubuhlungu, ububomvu, ukulimaza, ukopha, noma ukulunywa endaweni lapho kwajova khona umuthi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESixwayiso noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:

• isifo sohudo esibuhlungu
• indle enegazi
• ukunyakaza kwamathumbu ngokuzumayo noma okungalawuleki
• ubuhlungu besisu noma ukuqunjelwa
• ukuqunjelwa
• ukuncipha komzimba

Umjovo weBrodalumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina imijovo ekhethiwe ye-brodalumab esiqandisini, kodwa ungayiqandisi. Gcina imijovo emabhokisini abo okuqala ukuvikela ekukhanyeni. Uma kunesidingo, imijovo ekhethiwe ingagcinwa ekamelweni lokushisa kuze kube yizinsuku eziyi-14. Lahla imijovo ngemuva kwezinsuku eziyi-14 ekamelweni lokushisa. Ungafaki imijovo egcotshiwe egcinwe ekamelweni lokushisa emuva esiqandisini.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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