Inaliti ye-Ocrelizumab

-Delile

• Umjovo we-Ocrelizumab usetshenziselwa ukwelapha abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi:
• Ngaphambi kokuthola umjovo we-ocrelizumab,
• I-Ocrelizumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Ocrelizumab usetshenziselwa ukwelapha abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi:

• amafomu okuthuthuka (izimpawu ziya ngokuya ziba zimbi ngokuhamba kwesikhathi) ze-MS,
• i-syndrome ehlukanisiwe nomtholampilo (i-CIS; iziqephu zezimpawu zemizwa ezihlala okungenani amahora angama-24),
• amafomu wokubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile), noma
• amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi).

I-Ocrelizumab ekilasini lemithi ebizwa ngama-antibody monoclonal. Isebenza ngokumisa amaseli athile amasosha omzimba ekulimaleni.

Umjovo we-Ocrelizumab uza njengesisombululo (uketshezi) esizofakwa ngaphakathi (emthanjeni) ngudokotela noma unesi. Imvamisa inikezwa kanye njalo emavikini ama-2 emithamo emibili yokuqala (ngeviki 0 nangeviki 2), bese kuthi ukumnika kunikezwe kanye ezinyangeni eziyisithupha.

Umjovo we-Ocrelizumab ungadala ukusabela okungathi sína ngesikhathi sokumnika kuze kufike osukwini ngemuva kokuthola ukumnika. Unganikezwa eminye imithi yokwelapha noma yokusiza ukuvimbela ukusabela ku-ocrelizumab. Udokotela noma umhlengikazi uzokubuka eduze ngenkathi ethola ukumnika futhi okungenani ihora elilodwa ngemuva kwalokho ukuhlinzeka ngemithi uma kunemiphumela ethile emibi emithini. Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo, uma uhlangabezana nemiphumela ethile emibi. Tshela udokotela wakho noma umhlengikazi uma uhlangabezana nanoma ikuphi kokulandelayo phakathi noma ngaphakathi kwamahora angama-24 ngemuva kokumnika: ukuqubuka; ukulunywa; isifuba; ububomvu endaweni yokujova; ubunzima bokuphefumula noma ukugwinya; ukukhwehlela; ukushaya; ukuqubuka; ukuzizwa ngiphelile; ukucasuka komphimbo; ubuhlungu bomlomo noma bomphimbo; ukuphelelwa umoya; ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, noma izindebe; ukuqhuma; imfiva; ukukhathala; ukukhathala; ikhanda; isiyezi; isicanucanu; noma ukushaya kwenhliziyo okugijimayo. Shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha uma uhlangabezana nanoma yiziphi zalezi zimpawu ngemuva kokuphuma ehhovisi likadokotela noma esikhungweni sezokwelapha.

I-Ocrelizumab ingasiza ekulawuleni izimpawu ze-multiple sclerosis kepha ayizelaphi.Udokotela wakho uzokubuka ngokucophelela ukuze abone ukuthi i-ocrelizumab ikusebenzela kanjani. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-ocrelizumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ocrelizumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ocrelizumab, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-ocrelizumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukukhuluma ngemithi ecindezela amasosha akho omzimba njengokulandelayo: ama-corticosteroids afaka i-dexamethasone, i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-daclizumab (iZinbryta); i-fingolimod (Gilenya); mitoxantrone; natalizumab (iTysabri); i-tacrolimus (i-Astagraf, Prograf); noma i-teriflunomide (Aubagio). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba ne-hepatitis B (HBV; igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi noma umdlavuza wesibindi). Udokotela wakho mhlawumbe uzokutshela ukuthi ungatholi i-ocrelizumab.
• Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka ngaphambi kokuqala ukwelashwa kwakho ngomjovo we-ocrelizumab.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ne-ocrelizumab nezinyanga eziyisithupha ngemuva komthamo wokugcina. Uma ukhulelwa ngenkathi uthola i-ocrelizumab, shayela udokotela wakho. Uma uthola umjovo we-ocrelizumab ngesikhathi sokukhulelwa kwakho, qiniseka ukuthi ukhuluma nodokotela wengane yakho ngalokhu ngemuva kokuzalwa kwengane yakho. Ingane yakho ingadinga ukubambezeleka ukuthola imigomo ethile.
• utshele udokotela wakho uma ngabe uke wagonywa kamuva nje noma uhlelelwe ukuthola noma yimiphi imigomo. Ungadinga ukuthola izinhlobo ezithile zemigomo okungenani amasonto ama-4 ngaphambili kanti ezinye okungenani amasonto ama-2 ngaphambi kokuqala ukwelashwa ngomjovo we-ocrelizumab. Ungabi nayo imigomo ngaphandle kokukhuluma nodokotela wakho ngesikhathi sokwelashwa kwakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola i-ocrelizumab, shayela udokotela wakho ngokushesha okukhulu ukuze ubeke kabusha i-aphoyintimenti yakho.

I-Ocrelizumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuvuvukala noma ubuhlungu ezandleni, ezingalweni, emilenzeni, noma ezinyaweni
• isifo sohudo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukubanda, ukukhwehlela okungapheli, noma ezinye izimpawu zokutheleleka
• izilonda zomlomo
• ama-shingles (ukuqhuma okungenzeka kubantu abaye baba nenkukhu esikhathini esidlule)
• izilonda ezizungeze izitho zangasese noma i-rectum
• ukutheleleka kwesikhumba
• ubuthakathaka ohlangothini olulodwa lomzimba; ubulukhuni bezingalo nemilenze; izinguquko zombono; izinguquko ekucabangeni, kwimemori, nasekujwayeleni; ukudideka; noma izinguquko zobuntu

I-Ocrelizumab ingakhuphula ubungozi bakho bomdlavuza othile, kufaka phakathi umdlavuza webele. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

I-Ocrelizumab ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-ocrelizumab.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-ocrelizumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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