I-Neratinib

-Delile

• Ngaphambi kokuthatha i-neratinib,
• I-Neratinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Neratinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza webele owamukela i-hormone (umdlavuza webele oncike kumahomoni afana ne-estrogen ukukhula) kubantu abadala ngemuva kokwelashwa nge-trastuzumab (Herceptin) neminye imishanguzo. I-Neratinib isetshenziswa kanye ne-capecitabine (i-Xeloda) ukwelapha uhlobo oluthile lomdlavuza webele we-hormone receptor-positive noma umdlavuza webele osabalele kwezinye izingxenye zomzimba ngemuva kokwelashwa okungenani ngeminye imithi emibili. INeratinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

INeratinib iza njengethebhulethi ezothathwa ngomlomo. Lapho i-neratinib ithathwa yodwa ukwelapha umdlavuza webele, imvamisa iphuzwa kanye kanye ngosuku unyaka ngamunye. Lapho i-neratinib ithathwa nge-capecitabine ukwelapha umdlavuza webele ophakeme noma umdlavuza webele osakazekele kwezinye izingxenye zomzimba, kuvame ukuthathwa kanye ngosuku ngokudla ngezinsuku 1 kuya ku-21 zomjikelezo wezinsuku ezingama-21 kuze kube yilapho isimo sakho siba sibi imiphumela emibi kakhulu. Thatha i-neratinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-neratinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho anganciphisa umthamo wakho noma ayeke okwesikhashana noma unomphela ukwelashwa kwakho kwe-neratinib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-neratinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-neratinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-neratinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-neratinib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-neratinib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qinisekisa ukusho noma yikuphi kokulandelayo: ama-antibiotic athile afaka i-ciprofloxacin (Cipro), i-clarithromycin (i-Biaxin, e-Prevpac), i-erythromycin (i-E.E.S., i-E-Mycin, i-Erythrocin), ne-troleandomycin (ayisatholakali e-U.S.); ama-antifungal athile afaka i-clotrimazole (i-Mycelex), i-fluconazole (i-Diflucan), i-itraconazole (i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-aprepitant (Hlela); i-bosentan (iTracleer); ezinye izivimbeli zesiteshi se-calcium kufaka phakathi i-diltiazem (Cardizem, Tiazac, abanye) ne-verapamil (Calan, Verelan, others); i-cobicistat (iTybost); i-conivaptan (iVaprisol); i-crizotinib (i-Xalkori); i-cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); i-digoxin (i-Lanoxin); i-dronedarone (iMultaq); enzalutamide (Xtandi); i-fexofenadine (Allegra); i-fluvoxamine (i-Luvox); idelalisib (iZydelig); imatinib (Gleevec); imithi ethile ye-hepatitis C ehlanganisa i-boceprevir (ayisatholakali e-U.S., Victrelis), i-dasabuvir (e-Viekira Pak), i-ombitasvir (e-Technivie, e-Viekira XR), ne-paritaprevir (e-Technivie, e-Viekira XR); imishanguzo ethile yegciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efaka i-efavirenz (Sustiva, e-Atripla), elvitegravir (eGenvoya, eStribild), etravirine (Intelence), indinavir (Crixivan), lopinavir (eKaletra), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra), i-saquinavir (i-Invirase), ne-tipranavir (i-Aptivus); i-mitotane (iLysodren); i-modafinil (i-Provigil); nefazodone; ama-proton pump inhibitors afana ne-esomeprazole (Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (i-Protonix), ne-rabeprazole (i-AcipHex); i-rifampin (iRifadin, iRimactane, eRifater); nemithi ethile yokuquleka okubandakanya i-carbamazepine (Carbatrol, Epitol, Tegretol) kanye ne phenytoin (Dilantin, Phenytek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-neratinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-antacid, yithathe okungenani amahora amathathu ngaphambi noma amahora amathathu ngemuva kokuthatha i-neratinib.
• uma uthatha i-neratinib nemithi yokugaya ukudla, isilungulela, noma izilonda (i-H₂ blocker) njenge-cimetidine, i-famotidine (i-Pepcid, e-Duexis), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), thatha i-neratinib okungenani amahora amabili ngaphambi noma okungenani amahora ayi-10 ngemuva kokuthatha i-H₂ vimba.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Akufanele ukhulelwe ngenkathi uthatha i-neratinib. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ne-neratinib futhi okungenani inyanga eyodwa ngemuva kokuthatha umthamo wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-neratinib futhi niqhubeke izinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-neratinib, shayela udokotela wakho ngokushesha. I-Neratinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthatha i-neratinib futhi kuze kube inyanga engu-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-neratinib ivame ukudala isifo sohudo, esingaba nzima. Udokotela wakho mhlawumbe uzokutshela ukuthi uthathe i-loperamide (Imodium AD), umuthi olwa nohudo, ukuvimbela ukomisa (ukulahleka kwamanzi amaningi emzimbeni wakho) ezinsukwini zokuqala ezingama-56 zokwelashwa kwakho nge-neratinib. Ngemuva kwezinsuku ezingama-56 zokwelashwa, udokotela wakho uzolungisa umthamo wakho we-loperamide ukuze ube nokuhamba kwamathumbu okungu-1 kuya ku-2 nsuku zonke ngenkathi uthatha i-neratinib. Udokotela wakho futhi angakutshela ukuthi uphuze iziphuzo eziningi, wenze izinguquko ekudleni kwakho, noma uthathe eminye imithi yokulawula isifo sohudo. Shayela udokotela wakho ngokushesha uma unesifo sohudo esibi (ngaphezu kokuhamba kwamathumbu amabili ngosuku olungu-1 noma uhudo olungapheli) noma isifo sohudo kanye nobuthakathaka, isiyezi, noma umkhuhlane ngenkathi uthatha i-neratinib. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo zokoma: ukoma ngokweqile, umlomo owomile kanye / noma isikhumba, ukuncipha kokuchama, noma ukushaya kwenhliziyo okusheshayo.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Neratinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ubuhlungu besisu
• isilungulela
• ukuqunjelwa
• izilonda zomlomo
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukuphuma kwamakhala
• izinkinga zezipikili noma izinguquko
• ukuphazamiseka kwemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• amehlo aphuzi nesikhumba
• umchamo omnyama
• ubuhlungu noma ukungaphatheki kahle endaweni engaphezulu yesisu
• ukukhathala
• isicanucanu
• ukuhlanza
• ukuqubuka
• umkhuhlane, ubunzima bokuchama, ubuhlungu lapho uchama, nezinye izimpawu zokutheleleka

I-Neratinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isifo sohudo
• isicanucanu
• ukuhlanza
• ubuhlungu besisu

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-neratinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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