IGlecaprevir nePibrentasvir

-Delile

• Ngaphambi kokuthatha i-glecaprevir ne-pibrentasvir,
• I-Glecaprevir ne-pibrentasvir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• I-Glecaprevir ne-pibrentasvir kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-glecaprevir ne-pibrentasvir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngenhlanganisela ye-glecaprevir ne-pibrentasvir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, fonela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu, ukuhlanza, indle ephaphathekile, ubuhlungu ohlangothini olungaphezulu kwesokudla sendawo yesisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-glecaprevir ne-pibrentasvir.

Khuluma nodokotela wakho ngezingozi zokuthatha i-glecaprevir ne-pibrentasvir.

Inhlanganisela ye-glecaprevir ne-pibrentasvir isetshenziselwa ukwelapha izinhlobo ezithile zezifo ezingalapheki (zesikhathi eside) zesifo sokusha kwesibindi kohlobo C (ukuvuvukala kwesibindi okubangelwa igciwane) kubantu abadala nezingane ezineminyaka engu-12 nangaphezulu ezinesisindo okungenani esingamaphawundi angama-99 (45 amakhilogremu). Ibuye isetshenziselwe ukwelapha izinhlobo ezithile zokutheleleka okungapheli kwe-hepatitis C kubantu abadala nasezinganeni ezineminyaka engu-12 ubudala nangaphezulu ezinesisindo okungenani esingamakhilogremu angama-99 (45 kilograms) asebethole omunye umuthi wokwelapha ukutheleleka kwabo nge-hepatitis C. IGlecaprevir isekilasini lemithi ebizwa nge-HCV NS3 / 4A protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. IPibrentasvir isekilasini lemithi ebizwa nge-HCV NS5A inhibitors. Isebenza ngokumisa igciwane elibangela ukuthi i-hepatitis C isabalale emzimbeni.

Inhlanganisela ye-glecaprevir ne-pibrentasvir iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla kanye nsuku zonke amasonto ayi-8 kuya kwayi-16. Thatha i-glecaprevir ne-pibrentasvir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-glecaprevir ne-pibrentasvir njengoba nje kuyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Qhubeka uthathe i-glecaprevir ne-pibrentasvir noma ngabe uzizwa uphilile. Ubude bokwelashwa kwakho buxhomeke esimeni sakho, uma uke wayiphuza imishanguzo ethile ye-HCV, ukuthi uphendula kahle kangakanani emithini, nokuthi ngabe unemiphumela emibi yini. Ungayeki ukuthatha i-glecaprevir ne-pibrentasvir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-glecaprevir ne-pibrentasvir,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-glecaprevir, pibrentasvir, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-glecaprevir kanye ne-pibrentasvir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-atazanavir (Reyataz, e-Evotaz) noma i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, e-Rifater). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-glecaprevir ne-pibrentasvir uma uthatha owodwa wale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), imithi yokwehlisa i-cholesterol (ama-statins) anjenge-atorvastatin (Lipitor, eCaduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastol ICrestor), kanye ne-simvastatin (iZocor, eSimcor, eVytorin); i-cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); i-digoxin (i-Lanoxin); izindlela zokuvimbela inzalo ze-ethinyl estradiol ezinjengalezi ezithile (‘amaphilisi okulawula ukuzalwa’), amabala, izindandatho zesitho sangasese sowesifazane, neminye imikhiqizo ye-ethinyl estradiol; izindlela ezithile zokwelapha ezibuyisela ama-hormone (HRT); nemithi ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) okubandakanya i-darunavir (Prezista, e-Prezcobix), i-efavirenz (i-Sustiva, e-Atripla), i-lopinavir (e-Kaletra), noma i-ritonavir (i-Norvir, e-Kaletra); kanye ne-phenytoin (iDilantin, Phenytek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma unanoma yiluphi uhlobo lwesifo sesibindi ngaphandle kwe-hepatitis C. Udokotela wakho angakutshela ukuthi ungathathi i-glecaprevir ne-pibrentasvir.
• Tshela udokotela wakho uma ngabe uke waba negciwane lesandulela ngculaza noma i-HIV noma ngabe uke waba nesibindi noma ukufakelwa izinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-glecaprevir ne-pibrentasvir, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma ngabe kungamahora ayi-18 noma ngaphansi ngemuva kokuphuthelwa umthamo we-glecaprevir ne-pibrentasvir, thatha umthamo owulahlekile ngokudla ngokushesha nje lapho usakukhumbula. Kodwa-ke, uma kungaphezu kwamahora we-18 kusukela ngesikhathi obekufanele uthathe umthamo wakho, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Glecaprevir ne-pibrentasvir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukukhathala
• ubuthakathaka
• isicanucanu
• isifo sohudo
• ukulunywa

I-Glecaprevir ne-pibrentasvir kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

• ubuthongo
• ukudideka
• ukuvuvukala kwendawo yesisu
• ukuhlanza igazi noma okokusebenza okubukeka njengezizathu zekhofi
• indle emnyama, emnyama, noma enegazi

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Mavyret^®