I-Tezacaftor ne-Ivacaftor
-Delile
- Ngaphambi kokuthatha i-tezacaftor ne-ivacaftor,
- I-Tezacaftor ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
- Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-tezacaftor ne-ivacaftor bese ushayela udokotela wakho ngokushesha:
Inhlanganisela ye-tezacaftor ne-ivacaftor isetshenziswa kanye ne-ivacaftor ukwelapha izinhlobo ezithile ze-cystic fibrosis (isifo esizalwa naso esidala izinkinga ngokuphefumula, ukugaya ukudla nokuzala) kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu. I-Tezacaftor ne-ivacaftor kufanele zisetshenziswe kuphela kubantu abanokwakheka okuthile kofuzo. Udokotela wakho angalawula ukuhlolwa kwegazi ukusiza ukunquma ukuthi le mithi ikulungele yini. UTezacaftor usesigabeni semithi ebizwa ngokuthi i-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor isekilasini lemithi ebizwa nge-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Yomibili le mithi isebenza ngokwenza ngcono ukusebenza kweprotheni emzimbeni ukwehlisa ukwakheka komfinyela obukhulu emaphashini futhi kuthuthukise ezinye izimpawu ze-cystic fibrosis.
Inhlanganisela ye-tezacaftor ne-ivacaftor ne-ivacaftor iza njengamaphilisi okuphuza ngomlomo. Lo muthi uza ngephakeji elinamasonto amane emithi. Umthamo ngamunye wansuku zonke unezinhlobo ezahlukene zamathebulethi: ithebhulethi eyodwa inhlanganisela ye-tezacaftor ne-ivacaftor kanti elinye ithebhulethi yi-ivacaftor. Thatha i-tezacaftor ne-ivacaftor (ithebhulethi ephuzi eyi-1) njalo ekuseni ngokudla okunamafutha kanye ne-ivacaftor (ithebhulethi eli-1 eliluhlaza okwesibhakabhaka) njalo kusihlwa ngokudla okunamafutha, ukwahlukana ngamahora ayi-12. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha le mithi ngendlela eqondiswe ngayo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.
Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.
Thatha inhlanganisela ye-tezacaftor ne-ivacaftor ne-ivacaftor ngokudla okunamafutha okufana namaqanda, ibhotela, amantongomane, ibhotela lamantongomane, i-pizza yoshizi, nemikhiqizo yobisi lonke (njengobisi lonke, ushizi ne-yogurt). Khuluma nodokotela wakho mayelana nokunye ukudla okunamafutha ongakudla nale mithi.
Inhlanganisela ye-tezacaftor ne-ivacaftor kanye ne-ivacaftor isebenza ukulawula i-cystic fibrosis, kepha ayiyelaphi. Qhubeka nokuphuza le mithi noma ngabe uzizwa uphilile. Ungayeki ukuthatha le mithi ngaphandle kokukhuluma nodokotela wakho.
Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.
Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.
Ngaphambi kokuthatha i-tezacaftor ne-ivacaftor,
- Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-tezacaftor, i-ivacaftor, noma imuphi omunye umuthi, noma iziphi izithako ezise-tezacaftor kanye ne-ivacaftor kanye namaphilisi e-ivacaftor. Buza usokhemisi wakho ukuthola uhlu lwezithako.
- Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qinisekisa ukusho noma yikuphi kokulandelayo: ama-antibiotic athile afana ne-clarithromycin (i-Biaxin, e-PrevPac), i-erythromycin (i-E.E.S., i-E-Mycin, i-Ery-Tab, i-Erythrocin), ne-telithromycin (i-Ketek); ezinye izinto zokuvikela ezifana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole, i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); everolimus (Afinitor, Zortress); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); i-sirolimus (i-Rapamune); noma i-tacrolimus (i-Astagraf, Prograf). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-tezacaftor ne-ivacaftor, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
- utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-wort yaseSt.John ngenkathi uthatha inhlanganisela ye-tezacaftor ne-ivacaftor kanye ne-ivacaftor.
- tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi.
- utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha inhlanganisela ye-tezacaftor ne-ivacaftor kanye ne-ivacaftor, shayela udokotela wakho.
- kufanele wazi ukuthi le mithi ingakwenza ukozele. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi le mithi ikuthinta kanjani.
Ungadli i-grapefruit noma amawolintshi aseSeville noma uphuze ijusi lamagilebhisi ngenkathi uthatha le mithi.
Uma ukhumbula umthamo ongabanjwanga wethebhulethi kungakapheli amahora angu-6 ngesikhathi obehlelelwe ukuwuthatha, thatha umthamo ongabanjwanga ngaso leso sikhathi ngokudla okuqukethe amafutha. Kodwa-ke, uma kudlule amahora angaphezu kwayi-6 kusukela ngesikhathi esihleliwe sokuthatha noma iyiphi ithebhulethi, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.
I-Tezacaftor ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
- ikhanda
- ukuminyana kwamakhala
- isiyezi
Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-tezacaftor ne-ivacaftor bese ushayela udokotela wakho ngokushesha:
- ukuphuzi kwesikhumba noma kwamehlo
- ukulahlekelwa isifiso sokudla
- isicanucanu
- ukuhlanza
- indle ephaphathekile
- ubuhlungu besisu
- umchamo omnyama
I-Tezacaftor ne-ivacaftor kungadala i-cataract (ukufiphazwa kwelensi yeso okungadala izinkinga zokubona) ezinganeni nasebusheni. Izingane nentsha ethatha i-tezacaftor ne-ivacaftor kufanele babonane nodokotela wamehlo ngaphambi nangesikhathi belashwa. Khuluma nodokotela wengane yakho ngezingozi zokunikeza ingane yakho i-tezacaftor ne-ivacaftor.
I-Tezacaftor ne-ivacaftor kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.
Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).
Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).
Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org
Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.
Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.
Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwamehlo (kwezingane nentsha) kanye nokuhlolwa okuthile kwelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-tezacaftor ne-ivacaftor.
Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.
Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.
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