Inaliti yeRanitidine

-Delile

• Umjovo we-Ranitidine usetshenziswa kubantu abalaliswe esibhedlela ukwelapha izimo ezithile lapho isisu sikhiqiza i-asidi eningi kakhulu noma ukwelapha izilonda (izilonda kulolwelwesi lwesisu noma amathumbu) ezingazange zelashwe ngempumelelo ngeminye imithi. Umjovo weRanitidine nawo usetshenziswa okwesikhashana kubantu abangakwazi ukuthatha imishanguzo yomlomo
• Ngaphambi kokuthola umjovo we-ranitidine,
• Umjovo weRanitidine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

[Kuthunyelwe 04/01/2020]

ISIQEPHU: I-FDA imemezele ukuthi icela abakhiqizi ukuthi bahoxise yonke imishanguzo kadokotela kanye ne-over-the-counter (OTC) ranitidine emakethe ngokushesha.

Lesi yisinyathelo sakamuva kuphenyo oluqhubekayo lomuthi ongcolisayo owaziwa nge-N-Nitrosodimethylamine (NDMA) emithini ye-ranitidine (eyaziwa kakhulu ngegama lomkhiqizo iZantac). I-NDMA iyi-carcinogen yabantu (into engadala umdlavuza). I-FDA inqume ukuthi ukungcola kweminye imikhiqizo ye-ranitidine kuyanda ngokuhamba kwesikhathi futhi uma kugcinwa emazingeni aphezulu okushisa ekamelweni kungaholela ekuvezweni kwabathengi emazingeni angamukeleki kulokhu kungcola. Njengomphumela walesi sicelo esisheshayo sokuhoxiswa kwemakethe, imikhiqizo ye-ranitidine ngeke itholakale ngemiyalo emisha noma ekhona noma ukusetshenziswa kwe-OTC e-U.S.

ISENDLALELO: I-Ranitidine iyi-blockamine ye-histamine-2, eyehlisa inani le-asidi edalwe isisu. I-ranitidine kadokotela ivunyelwe izinkomba eziningi, kufaka phakathi ukwelashwa nokuvimbelwa kwezilonda zesisu namathumbu kanye nokwelashwa kwesifo se-reflux se-gastroesophageal.

Ukuncoma:

• Abathengi: I-FDA iphinde yeluleke abathengi abathatha i-OTC ranitidine ukuthi bayeke ukuphuza noma imaphi amaphilisi noma uketshezi abanalo njengamanje, balahle ngendlela efanele bangathengi ngaphezulu; kulabo abafisa ukuqhubeka belapha isimo sabo, kufanele bacabangele ukusebenzisa eminye imikhiqizo evunyelwe ye-OTC.
• Iziguli: Iziguli ezithatha i-ranitidine kadokotela kufanele zikhulume nochwepheshe wazo wezokunakekelwa kwempilo mayelana nezinye izindlela zokwelashwa ngaphambi kokumisa umuthi, ngoba kunemithi eminingi evunyelwe ukusetshenziswa okufanayo noma okufanayo ne-ranitidine engenazo izingozi ezifanayo ezivela ku-NDMA. Kuze kube manje, ukuhlolwa kwe-FDA akutholanga i-NDMA ku-famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) noma omeprazole (Prilosec).
• Abathengi neziguli:Ngenxa yobhadane lwamanje lwe-COVID-19, i-FDA incoma iziguli nabathengi ukuthi bangayithathi imishanguzo yabo endaweni yokubuyisa izidakamizwa kodwa balandele izinyathelo ezinconyiwe ze-FDA, ezitholakala ku: https://bit.ly/3dOccPG, okubandakanya izindlela ukulahla ngokuphepha le mithi ekhaya.

Ukuthola eminye imininingwane vakashela iwebhusayithi ye-FDA ku: http://www.fda.gov/Safety/MedWatch/SafetyInformation naku-http: //www.fda.gov/Drugs/DrugSafety.

Umjovo we-Ranitidine usetshenziswa kubantu abalaliswe esibhedlela ukwelapha izimo ezithile lapho isisu sikhiqiza i-asidi eningi kakhulu noma ukwelapha izilonda (izilonda kulolwelwesi lwesisu noma amathumbu) ezingazange zelashwe ngempumelelo ngeminye imithi. Umjovo weRanitidine nawo usetshenziswa okwesikhashana kubantu abangakwazi ukuthatha imishanguzo yomlomo

• ukwelapha izilonda,
• ukuvimbela izilonda ekubuyeni ngemuva kokuphulukiswa,
• ukwelapha isifo se-reflux se-gastroesophageal (i-GERD, isimo lapho ukuhlehlela emuva kwe-asidi esiswini kubangela ukushaya kwenhliziyo nokulimala komphimbo [ithubhu phakathi komphimbo nesisu],
• nokwelapha izimo lapho isisu sikhiqiza i-asidi eningi kakhulu, njenge-Zollinger-Ellison syndrome (izicubu ezisemanyikwe kanye namathumbu amancane okuholele ekukhiqizeni ukwanda kwesisu esiswini).

Umjovo weRanitidine usesigabeni semithi ebizwa nge-H₂ abavimba. Isebenza ngokunciphisa inani le-asidi eyenziwe esiswini.

Umjovo weRanitidine uza njengesisombululo (uketshezi) ukuhlanganiswa nolunye uketshezi bese ufakwa ngomjovo (emthanjeni) ngaphezu kwemizuzu engu-5 kuye kwengu-20. I-Ranitidine nayo ingajovwa emsipheni. Imvamisa inikezwa njalo emahoreni ayisithupha kuye kwayi-8, kodwa futhi inganikezwa njengokumnika okuqhubekayo ngaphezu kwamahora angama-24.

Ungathola umjovo we-ranitidine esibhedlela noma ungahlinzeka imithi ekhaya. Uma uzothola umjovo we-ranitidine ekhaya, umhlinzeki wakho wezokunakekelwa kwezempilo uzokukhombisa ukuthi uwusebenzisa kanjani umuthi. Qiniseka ukuthi uyaziqonda lezi zinkomba, bese ubuza umhlinzeki wakho wezokunakekelwa kwezempilo uma unemibuzo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ranitidine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ranitidine, i-famotidine, i-cimetidine, i-nizatidine (i-Axid), noma imiphi eminye imithi, noma iziphi izithako zomjovo we-ranitidine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants ('ama-blood thinner') afana ne-warfarin (Coumadin), atazanavir (Reyataz, e-Evotaz), delavirdine (Rescriptor), gefitinib (Iressa), glipizide (Glucotrol), ketoconazole (Nizoral) , midazolam (ngomlomo), i-procainamide, ne-triazolam (i-Halcion). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba ne-porphyria (isifo segazi esizuzwe njengefa esingadala izinkinga zesikhumba noma sezinzwa), noma isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-ranitidine, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weRanitidine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu, ukushisa, noma ukulunywa endaweni lapho kwajova khona umuthi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okuhamba kancane
• isifuba
• ukulunywa
• ukuqubuka
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• isisu esibuhlungu
• ukukhathala ngokweqile
• ukopha okungajwayelekile noma ukulinyazwa
• ukungabi namandla
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• izimpawu ezinjengomkhuhlane

Umjovo weRanitidine ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-ranitidine.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho nabasebenzi belebhuthi ukuthi usebenzisa umjovo we-ranitidine.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zantac^®