INaltrexone neBupropion

-Delile

• Ngaphambi kokuthatha inhlanganisela ye-naltrexone ne-bupropion,
• Ukuhlanganiswa kwe-naltrexone ne-bupropion kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOKUQAPHA, yeka ukuthatha inhlanganisela ye-naltrexone ne-bupropion bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Lo muthi uqukethe i-bupropion, isithako esifanayo esisebenzayo njengemithi ethile elwa nokudangala (Wellbutrin, Aplenzin) kanye nomuthi osetshenziselwa ukusiza abantu bayeke ukubhema (iZyban). Inani elincane lezingane, intsha, nabantu abadala abasebasha (abangafika eminyakeni engama-24 ubudala) abathathe imishanguzo yokulwa nengcindezi ('mood elevators') efana ne-bupropion phakathi nezifundo zomtholampilo baba ukuzibulala (becabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo ). Izingane, intsha, kanye nabantu abadala abasebancane abathatha imishanguzo yokulwisana nokucindezelwa ukwelapha ukudangala noma ezinye izifo zengqondo bangase babe sethubeni lokuzibulala kunezingane, intsha kanye nabantu abadala abangawasebenzisi ama-anti-depressants ukwelapha lezi zimo. Inhlanganisela ye-naltrexone ne-bupropion ayivunyelwe ukusetshenziswa ezinganeni ezingaphansi kweminyaka engu-18.

Kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile lapho uthatha inhlanganisela ye-naltrexone ne-bupropion noma ngabe ungumuntu omdala ongaphezu kweminyaka engama-24 ubudala. Ungase uzibulale, ikakhulukazi ekuqaleni kokwelashwa kwakho futhi nganoma yisiphi isikhathi lapho umthamo wakho wanda noma wehla. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukucindezeleka okusha noma okuya kuba kubi; ukucabanga ngokuzilimaza noma ukuzibulala, noma ukuhlela noma ukuzama ukwenza kanjalo; ukukhathazeka ngokweqile; ukuyaluza; ukukhathazeka noma ukwethuka; ubunzima bokulala noma ukulala; ulaka, intukuthelo, noma ukuziphatha okunodlame; ukucasuka; ukwenza ngaphandle kokucabanga; ukungahlaliseki okukhulu; imicabango engajwayelekile noma imizwa; ukuzwa ukuthi abantu bayaphikisana nawe; ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho); ukuzizwa udidekile; injabulo evuthayo engavamile; noma olunye ushintsho olungazelelwe noma olungajwayelekile ekuziphatheni. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Umhlinzeki wakho wezokunakekelwa kwempilo uzofuna ukukubona kaningi ngenkathi uthatha inhlanganisela ye-naltrexone ne-bupropion, ikakhulukazi ekuqaleni kokwelashwa kwakho. Qiniseka ukuthi ugcina wonke ama-aphoyintimenti wokuvakashelwa ehhovisi nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngenhlanganisela ye-naltrexone ne-bupropion futhi njalo lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha inhlanganisela ye-naltrexone ne-bupropion.

Inhlanganisela ye-naltrexone ne-bupropion isetshenziswa kanye nokuncipha kokudla kwekhalori nohlelo lokuzivocavoca ukusiza abantu abadala abakhuluphele, noma abakhuluphele ngokweqile futhi abanezinkinga zezokwelapha ezihlobene nesisindo, ukwehlisa isisindo bese begcina ekubuyiseni leso sisindo. INaltrexone isekilasini lemithi ebizwa ngama-opiate antagonists. I-Bupropion isesigabeni semithi ebizwa ngama-antidepressants. Le mithi isebenza ngokubambisana ezindaweni ezimbili zobuchopho, isikhungo sendlala nohlelo lokuvuza, ukunciphisa isifiso sokudla nokusiza ukulawula izifiso.

Inhlanganisela ye-naltrexone ne-bupropion iza njengethebhulethi enwetshiwe (esebenza isikhathi eside) ezothathwa ngomlomo. Kuvame ukuthathwa kabili ngosuku. Ungathathi lo muthi ngesidlo esinamafutha amaningi. Thatha i-naltrexone ne-bupropion ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-naltrexone ne-bupropion njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi akhululiwe; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi wenhlanganisela ye-naltrexone ne-bupropion futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa ngesonto, amasonto ama-4. Ngemuva kwamasonto ayi-16 ekwelashwa, udokotela wakho uzohlola ukuthi ulahlekelwe isisindo esingakanani. Uma ungalahlekanga isisindo esithile, udokotela wakho angakutshela ukuthi uyeke ukuthatha inhlanganisela ye-naltrexone ne-bupropion ngoba akunakwenzeka ukuthi uzozuza ngokuqhubeka nokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha inhlanganisela ye-naltrexone ne-bupropion,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-naltrexone, bupropion, noma imuphi omunye umuthi, noma yiziphi izithako ezikumaphilisi e-naltrexone nakuma-bupropion. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-monoamine oxidase (MAO) inhibitor efana ne-isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Zelapar), ne-tranylcypromine (iParnate) ) noma uma uyekile ukuthatha i-MAO inhibitor ezinsukwini eziyi-14 ezedlule. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi inhlanganisela ye-naltrexone ne-bupropion. Uma uyeka ukuthatha inhlanganisela ye-naltrexone ne-bupropion, udokotela wakho uzokutshela ukuthi kufanele ulinde okungenani izinsuku eziyi-14 ngaphambi kokuqala ukuthatha i-MAO inhibitor.
• Tshela udokotela wakho uma uthatha noma yimiphi imishanguzo ye-opioid noma izidakamizwa zasemgwaqweni ezibandakanya i-heroin, imithi yezinhlungu kadokotela, i-tramadol (i-Ultram, i-Ultracet), imishanguzo yokuncika kuma-opioid njenge-buprenorphine (i-Buprenex, i-Butrans, i-Sublocade) noma i-methadone (i-Dolophine, i-Methadose), nokunye imithi yohudo, ukukhwehlela, noma ukubanda. Tshela nodokotela wakho uma ngabe uphuze noma iyiphi yale mithi okungenani ezinsukwini eziyi-7 kuya kwezingu-10 ezedlule. Buza udokotela wakho ukuthi awuqiniseki ukuthi umuthi owuthathile uyi-opioid. Udokotela wakho uzokutshela ukuthi ungathathi inhlanganisela ye-naltrexone ne-bupropion uma uthathe noma usebenzise ama-opioid okungenani ezinsukwini eziyi-7 kuya kwezingu-10 ezedlule.
• ungathathi noma imiphi imishanguzo ye-opioid noma usebenzise izidakamizwa zomgwaqo opioid ngesikhathi sokwelashwa kwakho ngenhlanganisela ye-naltrexone ne-bupropion. INaltrexone ivimba imiphumela yemithi yama-opioid nezidakamizwa zasemgwaqweni ze-opioid. Ungahle ungazizwa imiphumela yalezi zinto uma uzithatha noma uzisebenzisa ngamanani aphansi noma ajwayelekile. Uma uthatha noma usebenzisa imithamo ephezulu yemithi ye-opioid noma izidakamizwa ngesikhathi sokwelashwa kwakho ngenhlanganisela ye-naltrexone ne-bupropion, kungadala ukulimala okukhulu, ikhoma noma ukufa.
• kufanele wazi ukuthi uma uthathe imishanguzo ye-opioid ngaphambi kokwelapha kwakho ngenhlanganisela ye-naltrexone ne-bupropion, ungahle uzwele kakhulu kwimiphumela yemithi ye-opioid lapho umthamo wakho olandelayo wenhlanganisela ye-naltrexone ne-bupropion kufanele, uma uphuthelwa umthamo yenhlanganisela ye-naltrexone ne-bupropion, ngemuva kokuqeda ukwelashwa kwakho, noma uma uthola ukukhishwa emzimbeni. Uma usebenzisa ama-opioid ngamanani owasebenzise ngaphambi kokwelapha kwakho ngokuhlanganiswa kwe-naltrexone ne-bupropion, kungaholela ekudluleni ngokweqile nasekufeni. Ngemuva kokuqeda ukwelashwa kwakho, tshela noma yimuphi udokotela ongakunika imishanguzo owake welashwa ngenhlanganisela ye-naltrexone ne-bupropion. Kubalulekile ukuthi utshele umndeni wakho noma umnakekeli ngalokhu kukhuphuka kokuzwela kuma-opioid kanye nengozi yokweqisa. Wena noma umnakekeli wakho kufanele uthole usizo oluphuthumayo lwezokwelapha ngokushesha uma uba nezimpawu ezilandelayo: ukukhathazeka ukuphefumula, ukuphefumula kancane, ukozela, ukuzizwa uphela amandla, isiyezi, noma ukudideka.
• ungathathi umkhiqizo ongaphezu kowodwa oqukethe i-bupropion ngasikhathi, kufaka phakathi ama-anti-depressants noma imikhiqizo yokuyeka ukubhema. Ungathola i-bupropion eningi kakhulu bese uhlangabezana nemiphumela emibi kakhulu.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amantadine (Osmolex ER), amitriptyline, amoxapine, carbamazepine (Carbatrol, Tegretol), citalopram (Celexa), clopidogrel (Plavix), desipramine (Norpramin), dexamethasone, digoxin (Lanoxin), Silenor), efavirenz (Sustiva, e-Atripla), escitalopram (Lexapro), flecainide (Tambocor), fluoxetine (Prozac), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), insulini noma imishanguzo yomlomo yesifo sikashukela, i-levodopa eSinemet, eStalevo), lopinavir (eKaletra), methylprednisolone (Medrol), metoprolol (Lopressor, Toprol XL), nortriptyline (Pamelor), paroxetine (Paxil), phenobarbital, phenytoin (Dilantin), prednisone, propafenone , protriptyline (Vivactil), risperidone (Risperdal), ritonavir (Norvir, eKaletra), sertraline (Zoloft), theophylline (Theo-24, Theochron), thioridazine, ticlopidine, trimipramine (Surmontil), venlafaxine (Effexor) imithi yokulahlekelwa. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-naltrexone ne-bupropion, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waquleka noma wake wahlaselwa yisifo sokuwa, i-anorexia nervosa (isifo sokudla), noma i-bulimia (ukuphazamiseka kwemikhuba yokudla), futhi uma unengcindezi ephezulu yegazi engalawulwa. Phinda utshele udokotela wakho uma uphuza utshwala obuningi kodwa ulindele ukuyeka ukuphuza ngokungazelelwe, uphuza imishanguzo yokuthambisa, i-hypnotics, i-benzodiazepines, noma imishanguzo yokulwa nokubanjwa kodwa ulindele ukuyeka ngokuzumayo, noma uma ukuhoxiswa kwe-opioid. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi inhlanganisela ye-naltrexone ne-bupropion.
• Tshela udokotela wakho uma wena noma omunye emndenini wakho uke wacabanga noma wazama ukuzibulala noma uke waba nesifo sokuphazamiseka kwengqondo okuguquguqukayo (imizwa eguquka isuke ekucindezelekeni iye ekuthokozeni okungavamile), i-mania (ijabule, ijabule ngokweqile), ukucindezeleka, i-schizophrenia (ingqondo ukugula okubangela ukucabanga okuphazamisekile noma okungajwayelekile, ukuphelelwa yintshisekelo empilweni, nemizwelo enamandla noma engafanele), noma ezinye izifo zengqondo; uma umdala kuneminyaka engama-65; uma ubhema noma ulindele ukuyeka ukubhema; futhi uma uke walimala ekhanda noma wahlaselwa yikhanda, isifo senhliziyo, isifo sohlangothi, isimila noma ukutheleleka kobuchopho noma umgogodla, isifo sikashukela, ushukela ophansi wegazi, amazinga aphansi e-sodium egazini, noma isifo senhliziyo, sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha inhlanganisela ye-naltrexone ne-bupropion, shayela udokotela wakho ngokushesha.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha inhlanganisela ye-naltrexone ne-bupropion.
• buza udokotela wakho ngokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha inhlanganisela ye-naltrexone ne-bupropion. Utshwala bungenza imiphumela emibi evela ku-naltrexone ne-bupropion ibe yimbi kakhulu.
• kufanele wazi ukuthi ukuhlanganiswa kwe-naltrexone ne-bupropion kungadala umfutho wegazi ophakeme nokushaya kwenhliziyo okusheshayo. Udokotela wakho angahlola umfutho wegazi nokushaya kwenhliziyo ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uthatha lo muthi.
• kufanele wazi ukuthi ukuhlanganiswa kwe-naltrexone ne-bupropion kungadala i-angle-closure glaucoma (isimo lapho uketshezi luvinjwe khona ngokuzumayo futhi lungakwazi ukuphuma esweni kubangele ukwanda okusheshayo, okunzima kwengcindezi yamehlo okungaholela ekulahlekelweni kombono) . Khuluma nodokotela wakho ngokuhlolwa iso ngaphambi kokuba uqale ukusebenzisa le mithi ukubona ukuthi usengozini yalesi simo. Uma unezinhlungu zamehlo, ushintsho kumbono, noma ukuvuvukala noma ukubomvu ngaphakathi noma ezungeze iso, shayela udokotela wakho noma uthole ukwelashwa okuphuthumayo ngokushesha.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Ukuhlanganiswa kwe-naltrexone ne-bupropion kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• umlomo owomile
• ushintsho kumqondo wakho wokunambitha
• ikhanda
• isiyezi
• ukukhathala
• ukuqhuma
• ukuzamazama okungalawuleki kwengxenye yomzimba
• ukujuluka okweqile
• kukhala ezindlebeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOKUQAPHA, yeka ukuthatha inhlanganisela ye-naltrexone ne-bupropion bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isithuthwane
• ukuqubuka noma amabhamuza
• ukulunywa
• isifuba
• izindlala ezivuvukele
• izilonda ezibuhlungu emlonyeni wakho noma eduze kwamehlo akho
• ukuphelelwa umoya
• ukuvuvukala kwezindebe noma ulimi
• ubuhlungu besifuba
• imfiva
• ubuhlungu besisu
• umchamo omnyama
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu bemisipha noma bamalunga

Ukuhlanganiswa kwe-naltrexone ne-bupropion kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese)

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukudlikiza
• ukubona izinto noma ukuzwa amazwi engekho
• ukulahlekelwa ukwazi
• ukushaya kwenhliziyo okusheshayo noma okushaya ngamandla

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha inhlanganisela ye-naltrexone ne-bupropion.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Phikisa^®