Selinexor

-Delile

• Ngaphambi kokuthatha i-selinexor,
• I-Selinexor ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Selinexor isetshenziswa kanye ne-dexamethasone ukwelapha i-myeloma eminingi (uhlobo lomdlavuza womnkantsha wamathambo) obuyile noma ongaphendulanga kokunye okungenani ukwelashwa okungu-4. I-Selinexor isetshenziswa futhi ne-bortezomib ne-dexamethasone ukwelapha i-myeloma eminingi ezigulini ezake zelashwa okungenani ngomunye umuthi. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-B-cell lymphoma enkulu (i-DLBCL; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kubantu abadala abanomdlavuza obuyile noma ongaphenduli kokunye ukwelashwa okungenani okubili. USelinexor usekilasini lemithi ebizwa nge-selective inhibitors yokuthunyelwa kwenyukliya ngaphandle (SINE). Isebenza ngokubulala amangqamuzana omdlavuza.

I-Selinexor iza njenge-tablet ezothathwa ngomlomo noma ngaphandle kokudla. Ukusetshenziswa kuhlanganiswe ne-dexamethasone ekwelapheni i-myeloma eminingi noma ekwelapheni i-DLBCL, i-selinexor ivame ukuthathwa ngezinsuku 1 no-3 zeviki ngalinye. Ukusetshenziswa kuhlanganiswe ne-bortezomib ne-dexamethasone ekwelapheni i-myeloma eminingi, i-selinexor ivame ukuthathwa kanye ngesonto. Thatha i-selinexor cishe ngesikhathi esifanayo sosuku nsuku zonke oyithatha. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-selinexor njengoba nje kuyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya amaphilisi wonke ngamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokudla i-selinexor, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angakutshela ukuthi uthathe imithi yokuvimbela isicanucanu nokuhlanza ngaphambi nangesikhathi sokwelashwa kwakho nge-selinexor.

Udokotela wakho angadinga ukumisa noma aphazamise ukwelashwa kwakho noma anciphise umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-selinexor.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-selinexor,

• Tshela udokotela wakho kanye nosokhemisi uma une-alejixor, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-selinexor. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nokutheleleka noma usanda kuba nayo, uma unezinkinga zokopha noma unenkinga yamehlo (ukugcwala kwe-lens yeso).
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa okungekuhle ngaphambi kokuba uqale ukuthatha i-selinexor. Uma ungowesifazane, akufanele ukhulelwe ngenkathi uthatha i-selinexor futhi kuze kube yiviki elilodwa ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi niqhubeke nokusebenzisa ukubeletha isonto elilodwa ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-selinexor, shayela udokotela wakho ngokushesha. I-Selinexor ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-selinexor kanye neviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane.
• kufanele wazi ukuthi i-selinexor ingakwenza ukozele noma ibangele isiyezi noma ukuquleka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Udokotela wakho futhi mhlawumbe uzoncoma ukuthi uphuze uketshezi olwanele futhi udle amakhalori anele ngesikhathi sokwelashwa kwakho.

Uma uphuthelwa umthamo, weqa lowo umthamo uthathe imishanguzo yakho ngosuku nesikhathi sakho esihleliwe esijwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Selinexor ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukuncipha komzimba
• ukulahlekelwa isifiso sokudla
• ukukhathala ngokweqile
• ubunzima bokulala noma ukulala
• ikhanda
• izinguquko zokunambitheka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukopha okulula noma ukulimaza
• ukukhathala, isikhumba esiphaphathekile, noma ukuphefumula okuncane
• umkhuhlane, ukukhwehlela, ukubanda, noma ezinye izimpawu zokutheleleka
• ukubona izinto noma ukuzwa amazwi engekho
• ukudideka
• ukufiphala noma ukubona kabili
• ukwanda kokuzwela ekukhanyeni nasekukhanyeni

I-Selinexor ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoqapha isisindo somzimba wakho futhi a-ode izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-selinexor.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Xpovio^®