Pexidartinib

-Delile

• Ngaphambi kokuthatha i-pexidartinib,
• I-Pexidartinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Pexidartinib ingadala ukulimala kwesibindi okungathi sína noma okusongela impilo. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Tshela udokotela wakho kanye nosokhemisi ngemithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe imiphi imithi yakho ingakhuphula ubungozi bokuthi uzoba nokulimala kwesibindi ngesikhathi ukwelashwa kwakho nge-pexidartinib. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukulahlekelwa isifiso sokudla, ukuncipha komzimba, isicanucanu, ukuhlanza, ukopha okungavamile noma ukulimaza, ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama ophuzi noma onsundu, izihlalo eziphaphathekile , noma ubuhlungu engxenyeni engaphezulu kwesokudla yesisu. Udokotela wakho kungadingeka anciphise umthamo wakho we-pexidartinib noma unqande unomphela noma okwesikhashana ukwelashwa kwakho.

Uhlelo olubizwa ngeTuralio Risk Evaluation and Mitigation Strategy (REMS) lubekiwe ukuphatha ubungozi balo muthi. Uzokwazi ukuthola i-pexidartinib kuphela uma wena nodokotela onquma ukuthi umuthi wakho ubhalisiwe uhlelo. Ungathola kuphela umuthi ekhemisi elibamba iqhaza ohlelweni. Buza udokotela wakho uma unemibuzo mayelana nokuhlanganyela kulolu hlelo noma ukuthi ungayithola kanjani imithi yakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile yini kuwe ukuthatha i-pexidartinib nokuhlola impendulo yomzimba wakho emithini.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-pexidartinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-pexidartinib.

I-Pexidartinib isetshenziselwa ukwelapha izicubu zeseli ezinkulu ze-tenosynovial (TGCT; izicubu ngaphakathi noma ezungeze ilunga elingadala ubuhlungu, ukuvuvukala, futhi linciphise ukunyakaza) kubantu abadala abangalashwa ngokuhlinzwa. I-Pexidartinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo samaprotheni angajwayelekile angasiza isimila ukuncipha.

I-Pexidartinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku ngesisu esingenalutho okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla noma okulula. Thatha i-pexidartinib cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-pexidartinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli, uzihlafune noma uzichoboze.

Uma uhlanza ngemuva kokuthatha i-pexidartinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-pexidartinib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-pexidartinib, noma imiphi eminye imishanguzo, noma yiziphi izithako kuma-capsules we-pexidartinib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clarithromycin (i-Biaxin, e-Prevpac); ezinye izinto zokuvikela ezifana ne-itraconazole (i-Onmel, i-Sporanox) noma i-ketoconazole; enzalutamide (Xtandi); imishanguzo ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kanye i-saquinavir (i-Invirase); i-modafinil (i-Provigil); nefazodone; i-pioglitazone (Actos, eDuetact, e-Oseni); ama-probenecid (i-Probalan); ama-proton-pump inhibitors afana ne-esomeprazole (Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (i-Protonix), ne-rabeprazole (i-AcipHex); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin); imithi ethile yokuquleka efana ne-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, ne-phenytoin (iDilantin, Phenytek); noma i-oral steroids efana ne-dexamethasone, methylprednisolone (Medrol), ne-prednisone. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-pexidartinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma uthatha ama-antacids aqukethe i-magnesium noma i-aluminium (Maalox, Mylanta, Tums, others), thatha i-antacid 2 hours ngaphambi noma okungenani amahora amabili ngemuva kokuthatha i-pexidartinib.
• uma uthatha umuthi we-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid, e-Duexis), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), thatha okungenani amahora ayi-10 ngaphambi noma okungenani okungu-2 amahora ngemuva kokuthatha i-pexidartinib.
• utshele udokotela wakho kanye nosokhemisi ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSort John's wort. Akufanele uthathe i-wort yaseSt.John ngesikhathi sokwelashwa kwakho nge-pexidartinib.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nenyanga eyodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-pexidartinib kanye neviki elilodwa ngemuva kwesilinganiso sakho sokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. I-Pexidartinib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-pexidartinib, shayela udokotela wakho ngokushesha. I-Pexidartinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-pexidartinib kanye neviki elilodwa ngemuva komthamo wakho wokugcina.

Ungadli inani elikhulu lamagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Pexidartinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• izinguquko zombala wezinwele
• izinguquko ekunambithekeni
• ukukhathala
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• ukulunywa
• ukuvuvukala kwezandla, izinyawo, imilenze noma amaqakala
• ubuhlungu ezingalweni noma emilenzeni
• ukuvuvukala ngaphakathi noma nxazonke zeso

I-Pexidartinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungayikhiphi i-desiccant (iphakethe elincane elifakwe nemithi yokumunca umswakama) ebhodleleni, uma kuhlinzekiwe.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Turalio^®