I-Tolvaptan (isifo sezinso)

-Delile

• Ngaphambi kokuthatha i-tolvaptan (Jynarque),
• I-Tolvaptan (Jynarque) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Tolvaptan (Jynarque) ingadala ukulimala kwesibindi, kwesinye isikhathi kube kubi ngokwanele ukudinga ukufakelwa kwesibindi noma ukubangela ukufa. Tshela udokotela wakho uma uke waba nezinkinga zesibindi, noma i-hepatitis. Udokotela wakho angakutshela ukuthi ungathathi i-tolvaptan (Jynarque). Udokotela wakho uzo-oda ukuhlolwa kwe-laboratory njalo ngaphambi nangesikhathi sokwelashwa kwakho ukubona ukuthi i-tolvaptan (Jynarque) iyasithinta yini isibindi sakho. Udokotela wakho angakutshela ukuthi akufanele uthole le mithi uma izivivinyo zibonisa ukuthi unenkinga yesibindi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isicanucanu, ukuhlanza, ukukhathala ngokweqile, ukopha okungavamile noma ukulimaza, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engakwesokudla esiswini, ukuphuka kwesikhumba noma kwamehlo , umchamo onombala omnyama, ukuqubuka, ukulunywa, noma izimpawu ezifana nomkhuhlane.

Ngenxa yezingozi zalo muthi, i-tolvaptan (Jynarque) itholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Uhlelo olubizwa ngeJynarque Risk Evaluation and Mitigation Strategies (REMS) lubekiwe ukunciphisa ubungozi bokuthatha i-tolvaptan (Jynarque). Udokotela wakho kanye nosokhemisi wakho kumele babhaliswe nohlelo lweJynarque REMS. Buza udokotela wakho ukuthola eminye imininingwane ngalolu hlelo nokuthi uzoyithola kanjani imithi yakho. Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-tolvaptan (Jynarque).

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-tolvaptan (Jynarque) futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngengozi yokuthatha i-tolvaptan (Jynarque).

I-Tolvaptan (Jynarque) isetshenziselwa ukubambezela ukwanda kokusebenza kwezinso ezigulini ezithile ezine-autosomal dominant polycystic kidney disease (ADPKD; uhlobo oluthile lwesifo sezinso esizuzwe njengefa). I-Tolvaptan (Jynarque) isekilasini lemithi ebizwa nge-vasopressin V₂ abaphikisi be-receptor. Isebenza ngokwandisa inani lamanzi akhishwe emzimbeni njengomchamo futhi kunciphisa ukukhula kwama-cysts ezinso. Ukususa uketshezi emzimbeni nokunciphisa ukukhula kwama-cysts kusiza ukunciphisa ukubhebhetheka kokusebenza kwezinso.

I-Tolvaptan iyatholakala njengethebhulethi (iSamsca) ukwelapha amazinga egazi aphansi e-sodium kubantu abanesifo senhliziyo noma ezinye izimo ezithile. Le monograph inika kuphela imininingwane ngamaphilisi e-tolvaptan (Jynarque) ukwehlisa ukwanda kokusebenza kwezinso ezigulini ezine-ADPKD. Uma usebenzisa lo muthi ukwelapha amazinga aphansi e-sodium egazini, funda i-monograph enesihloko esithi tolvaptan (low sodium sodium).

I-Tolvaptan (Jynarque) iza njengethebhulethi ezothathwa ngomlomo. Imvamisa iphuzwa kabili ngosuku, ithebhulethi eyodwa ekuseni kanye nethebhulethi elilodwa emahoreni ayi-8 kamuva, noma ngaphandle kokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tolvaptan (Jynarque) njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-tolvaptan (Jynarque) futhi akhuphule kancane umthamo wakho.

Udokotela wakho angadinga ukwehlisa umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Kubalulekile ukuthi utshele udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tolvaptan (Jynarque),

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-tolvaptan (Jynarque, Samsca), noma imuphi omunye umuthi, noma iziphi izithako ezikumathebulethi e-tolvaptan. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha ama-antifungal athile afana ne-ketoconazole (Nizoral) noma i-itraconazole (Sporanox); i-clarithromycin (i-Biaxin); noma imishanguzo ethile ye-HIV efana ne-indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), noma saquinavir (Invirase); i-conivaptan (iVaprisol); noma nefazodone. Udokotela wakho angakutshela ukuthi ungathathi i-tolvaptan (Jynarque) uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: atorvastatin (Lipitor, eCaduet), bosentan (Tracleer), desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin), fluconazole (Diflucan); furosemide (Lasix), glyburide (Diabeta, Glynase), lovastatin (Altoprev), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), nateglinide (Starlix), pravastatin (Pravachol), repaglinide (Prandin), rifampin (Rifadin, Rifadin, Rifadin) ), i-rosuvastatin (i-Crestor), ne-simvastatin (iZocor, eVytorin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-tolvaptan (Jynarque), ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma unanoma yiziphi zalezi zimo ezishiwo esigabeni SESixwayiso ESIBALULEKILE, uma ngabe uke waba nezinga eliphakeme le-sodium egazini lakho, uma unenkinga yokuchama noma ungakwazi ukuchama, uma uke wahlanza kakhulu noma uhudo noma ucabange ukuthi kungenzeka uphelelwe amanzi emzimbeni, noma uma ungakwazi ukubona ukuthi womile. Udokotela wakho angakutshela ukuthi ungathathi i-tolvaptan (Jynarque).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-tolvaptan (Jynarque), shayela udokotela wakho. Akufanele uncelise ibele ngenkathi uthatha i-tolvaptan (Jynarque).

Uzodinga ukuphuza amanzi anele ngenkathi uthatha i-tolvaptan (Jynarque) ukuze ungomi noma uphelelwe amanzi emzimbeni.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Tolvaptan (Jynarque) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukoma
• umlomo owomile
• ukuchama kaningi, ngokweqile
• isilungulela
• ukuncipha kokudla

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• isifo sohudo
• ukungakwazi ukuphuza ngokwejwayelekile
• isiyezi
• ukuquleka
• ukuncipha kokuchama
• ubuthakathaka
• ukozela
• ukudideka
• ukuncipha komzimba
• ukushaya kwenhliziyo okusheshayo noma okushaya ngamandla
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• isifuba

I-Tolvaptan (Jynarque) ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukuchama ngokweqile
• ukoma ngokweqile
• isiyezi
• ukuquleka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-tolvaptan (Jynarque).

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Jynarque^®