Umlobi: Joan Hall
Usuku Lokudalwa: 1 Ufebhuwari 2021
Ukuvuselela Usuku: 19 Unovemba 2024
Anonim
Acyclovir - Mechanism of Action, Indications, and Side Effects
Ividiyo: Acyclovir - Mechanism of Action, Indications, and Side Effects

-Delile

I-Acyclovir isetshenziselwa ukunciphisa ubuhlungu futhi isheshise ukuphulukiswa kwezilonda noma amabhamuza kubantu abane-varicella (inkukhu), i-herpes zoster (ama-shingles; ukuqubuka okungenzeka kubantu abake baba nenkukhu ngaphambili), futhi okokuqala noma ukuphinda ukuqubuka kwe-herpes yesitho sangasese (ukutheleleka ngegciwane le-herpes elibanga ukubuna kwezilonda ezizungeze izitho zangasese kanye ne-rectum ngezikhathi ezithile). I-Acyclovir nayo kwesinye isikhathi isetshenziselwa ukuvimbela ukuqubuka kwe-herpes yesitho sangasese kubantu abanegciwane. I-Acyclovir isekilasini lemithi elwa namagciwane ebizwa nge-synthetic nucleoside analogues. Isebenza ngokumisa ukusabalala kwegciwane le-herpes emzimbeni. I-Acyclovir ngeke yelaphe i-herpes yezitho zangasese futhi kungenzeka ingavimbi ukusakazeka kwe-herpes yezitho zobulili kwabanye abantu.

I-Acyclovir iza njengethebhulethi, i-capsule, nokumiswa (uketshezi) okuzothathwa ngomlomo. Kubuye futhi njengethebhulethi ye-buccal ekhishwe ukubambezeleka ukufaka ku-gum engenhla yomlomo. Amathebulethi, amaphilisi, nokumiswa kuvame ukuthathwa noma ngaphandle kokudla izikhathi ezimbili kuya kwezihlanu ngosuku izinsuku ezinhlanu kuya kweziyi-10, ukuqala ngokushesha okukhulu ngemuva kokuqala kwezimpawu zakho. Lapho i-acyclovir isetshenziselwa ukuvimbela ukuqubuka kwe-herpes yesitho sangasese, kuvame ukuthathwa izikhathi ezimbili kuya kwezihlanu ngosuku izinyanga ezifika kwezili-12. Ithebhulethi ye-buccal ekhishwe ukubambezeleka ivame ukufakwa ngomunwe owomile njengomthamo wesikhathi esisodwa kungakapheli ihora elingu-1 ngemuva kokulunywa, ububomvu, ukuvutha noma ukushoshozela kwezimpawu ezibandayo zokuqala kodwa ngaphambi kokuvela kwesifo esibandayo. Thatha noma usebenzise i-acyclovir cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha noma usebenzise i-acyclovir njengoba nje iyalelwe. Ungayithathi noma uyisebenzise ngaphezulu noma ngaphansi kwayo noma uyithathe kaningi noma isikhathi eside kunokuyalelwa ngudokotela wakho.


Musa ukuhlafuna, ukuchoboza, ukuncela, noma ukugwinya amaphilisi e-buccal abambezelekile. Phuza iziphuzo eziningi, uma unomlomo owomile ngenkathi usebenzisa amaphilisi we-buccal abambezelekile.

Ukuze usebenzise i-buccal acyclovir, landela lezi zinyathelo:

  1. Thola indawo engxenyeni engenhla ngenhla kwamazinyo akho angakwesokunxele nangakwesokudla (amazinyo angakwesobunxele nangakwesokudla kwamazinyo akho amabili angaphambili).
  2. Ngezandla ezomile, susa ithebhulethi eyodwa ebambezelekile yokukhipha esitsheni.
  3. Sebenzisa ngobumnene ithebhulethi endaweni yezinsini ephezulu njengoba izongena kushungamu lakho ngaphezu kwelinye lamazinyo akho e-incisor ohlangothini lomlomo wakho nesifo esibandayo. Ungayifaki ngaphakathi kwendebe noma esihlathini.
  4. Bamba ithebhulethi endaweni yayo imizuzwana engama-30.
  5. Uma ithebhulethi inganamatheli kunsini yakho noma uma inamathela esihlathini sakho noma ngaphakathi kwendebe yakho, ibeke kabusha ukuze inamathele kunsamu yakho. Shiya ithebhulethi isendaweni ize inyibilike.
  6. Ungaphazamisi ukubekwa kwethebhulethi. Hlola ukubona ukuthi ithebhulethi isekhona yini ngemuva kokudla, ukuphuza, noma ukugeza umlomo wakho.

Uma ngabe ithebhulethi ye-buccal ekhishwe ukubambezeleka ivela phakathi kwamahora angu-6 okuqala wokufaka isicelo, faka ithebhulethi efanayo Uma namanje ngeke unamathele ke ukusebenzisa ithebhulethi entsha. Uma ngengozi ugwinya ithebhulethi kungakapheli amahora wokuqala ayisithupha wokufaka isicelo, phuza ingilazi yamanzi bese ubeka ithebhulethi entsha kusinamu sakho. Uma ithebhulethi iwa noma igwinywa amahora angama-6 noma ngaphezulu ngemuva kokufakwa kwesicelo, ungasebenzisi ithebhulethi entsha kuze kube yisikhathi sakho esijwayelekile.


Gwema okulandelayo ngenkathi usebenzisa i-acyclovir buccal tablet ephuzile ukukhishwa:

  • Musa ukuhlafuna ushingamu, uthinte noma ucindezele ithebhulethi ye-buccal ngemuva kokuthi isetshenzisiwe.
  • Ungagqoki amazinyo okufakelwa aphezulu.
  • Musa ukuxubha amazinyo aze ancibilike. Uma amazinyo akho edinga ukuhlanzwa ngenkathi ithebhulethi isendaweni, hlambulula umlomo ngobumnene.

Nyakazisa ukumiswa kahle ngaphambi kokusebenzisa ngakunye ukuxuba umuthi ngokulinganayo.

Izimpawu zakho kufanele zithuthuke ngesikhathi sokwelashwa kwakho nge-acyclovir. Shayela udokotela wakho uma izimpawu zakho zingathuthuki noma uma ziba zimbi kakhulu.

Thatha noma usebenzise i-acyclovir uze uqede incwadi kadokotela, noma ngabe uzizwa ungcono. Uma uyeka ukuthatha i-acyclovir maduzane noma weqe imithamo, ukutheleleka kwakho kungenzeka kungalashwa ngokuphelele noma kungaba nzima ukwelapha. Ithebhulethi ye-buccal ekhishwe ukubambezeleka isetshenziswa njengomthamo wesikhathi esisodwa.

I-Acyclovir kwesinye isikhathi isetshenziselwa ukwelapha i-eczema herpeticum (ukutheleleka kwesikhumba okubangelwa igciwane le-herpes) ukwelapha nokuvimbela ukutheleleka kwe-herpes esikhunjeni, emehlweni, ekhaleni nasemlonyeni ezigulini ezinegciwane lesandulela-ngculazi (i-HIV), nokwelapha uboya bomlomo i-leukoplakia (isimo esidala amabala amhlophe noma anombala ompunga olimini noma ngaphakathi kwesihlathi).


Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-acyclovir,

  • Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-acyclovir, i-valacyclovir (i-Valtrex), noma imiphi eminye imithi, amaprotheni obisi, noma iziphi izithako emikhiqizweni ye-acyclovir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-amphotericin B (i-Fungizone); ama-antibiotic e-aminoglycoside afana ne-amikacin (Amikin), i-gentamicin (i-Garamycin), i-kanamycin (i-Kantrex), i-neomycin (i-Nes-RX, i-Neo-Fradin), i-paramomycin (i-Humatin), i-streptomycin, ne-tobramycin (i-Tobi, i-Nebcin); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala ezifana ne-ibuprofen (Advil, Motrin), ne-naproxen (Aleve, Naprosyn); i-cyclosporine (Gengraf, Neoral, Sandimmune); imithi yokwelapha i-HIV noma i-AIDS njenge-zidovudine (Retrovir, AZT); ipentamidine (NebuPent); ama-probenecid (i-Benemid); i-sulfonamides efana ne-sulfamethoxazole ne-trimethoprim (Bactrim); itacrolimus (Prograf); kanye ne-vancomycin. Eminye imishanguzo eminingi ingaxhumana ne-acyclovir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
  • utshele udokotela wakho ukuthi kungenzeka yini ukuthi uphelelwe amanzi emzimbeni ngenxa yokugula noma umsebenzi osanda kuwenza, noma uma uke waba nezinkinga kumasosha akho omzimba; ukutheleleka ngegciwane lesandulela ngculaza (i-HIV); wathola i-immunodeficiency syndrome (i-AIDS); noma isifo sezinso.
  • utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-acyclovir, shayela udokotela wakho.
  • uma uthatha i-acyclovir ukwelapha i-herpes yezitho zangasese, kufanele wazi ukuthi i-herpes yezitho zobulili ingasakazeka ngokuxhumana ngocansi noma ngabe awunamabhamuza noma ezinye izimpawu futhi mhlawumbe noma ngabe uthatha i-acyclovir. Khuluma nodokotela wakho ngezindlela zokunqanda ukusabalala kwe-herpes yezitho zangasese nokuthi ngabe abalingani bakho kufanele bakuthole yini ukwelashwa.

Phuza uketshezi oluningi ngenkathi uthatha noma usebenzisa i-acyclovir.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha noma imiphi imithamo esele yalolo suku ngezikhathi ezihlukaniswe ngokulingana. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Acyclovir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • isisu esibuhlungu
  • ukuhlanza
  • isifo sohudo
  • isiyezi
  • ukukhathala
  • ukuyaluza
  • ubuhlungu, ikakhulukazi emajoyintini
  • ukulahleka kwezinwele
  • izinguquko embonweni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:

  • isifuba
  • ukuqubuka noma amabhamuza
  • ukulunywa
  • ukuphefumula kanzima noma ukugwinya
  • ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
  • ukushaqeka
  • ukushaya kwenhliziyo okusheshayo
  • ubuthakathaka
  • isikhumba esiphaphathekile
  • ubunzima bokulala
  • umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
  • ukulimaza noma ukopha okungavamile
  • igazi emchameni
  • ubuhlungu besisu noma amajaqamba
  • uhudo olunegazi
  • ukuncipha kokuchama
  • ikhanda
  • ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
  • ukudideka
  • isimilo esinolaka
  • kunzima ukukhuluma
  • ukuba ndikindiki, ukushiswa, noma ukuncinza ezingalweni noma emilenzeni
  • ukungakwazi okwesikhashana ukuhambisa izingxenye zomzimba wakho
  • ukuzamazama kwengxenye yomzimba wakho ongeke ukwazi ukuyilawula
  • isithuthwane
  • ukulahlekelwa ukwazi

I-Acyclovir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha noma usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

  • ukuyaluza
  • isithuthwane
  • ukukhathala ngokweqile
  • ukulahlekelwa ukwazi
  • ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
  • ukuncipha kokuchama

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yakho ku-acyclovir.

Ungavumeli noma ngubani omunye athathe noma asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

  • Sitavig®
  • Zovirax® Amaphilisi
  • Zovirax® Amathebulethi
  • I-Acycloguanosine
  • ACV
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