I-Hydroxyurea

-Delile

• Ngaphambi kokuthatha i-hydroxyurea,
• I-Hydroxyurea ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Hydroxyurea ingadala ukwehla okukhulu kwenani lamaseli egazi emnkantsheni wakho wethambo. Lokhu kungandisa ubungozi bokuthi uzoba nokutheleleka okungathi sína noma ukopha. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: imfiva, ukugodola, ukukhathala ngokweqile noma ubuthakathaka, ukuqaqamba komzimba, umphimbo obuhlungu, ukuphelelwa umoya, ukukhwehlela okuqhubekayo nokuminyana, noma ezinye izimpawu zokutheleleka; ukopha okungavamile noma ukulimaza; ezinegazi noma ezimnyama, izitulo zokulinda; noma ukugabha igazi noma okokusundu okufana nezindawo zekhofi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile njalo ukuze ahlole impendulo yomzimba wakho ku-hydroxyurea futhi abone ukuthi isibalo segazi lakho sehlile yini. Udokotela wakho angadinga ukushintsha umthamo wakho noma akutshele ukuthi uyeke ukuthatha i-hydroxyurea isikhathi esithile ukuvumela ukubalwa kwegazi lakho kubuyele kokujwayelekile uma kwehle kakhulu.

I-Hydroxyurea ingakhuphula ubungozi bokuthi uzoba namanye umdlavuza, kufaka phakathi umdlavuza wesikhumba. Hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikrini selanga. Khuluma nodokotela wakho ngezingozi zokuthatha i-hydroxyurea.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-hydroxyurea futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

I-Hydroxyurea (i-Hydrea) isetshenziswa yodwa noma ngeminye imishanguzo noma ngemishanguzo yokwelapha ngemisebe ukwelapha uhlobo oluthile lwe-leukemia engapheli (i-CML; uhlobo lomdlavuza wamangqamuzana amhlophe egazi) nezinhlobo ezithile zomdlavuza wekhanda nentamo (kufaka phakathi umdlavuza womlomo , isihlathi, ulimi, umphimbo, amalaka, nama-sinus). I-Hydroxyurea (i-Droxia, iSiklos) isetshenziselwa ukunciphisa imvamisa yezinkinga ezibuhlungu futhi yehlise isidingo sokumpontshelwa igazi kubantu abadala nezingane ezineminyaka engu-2 nangaphezulu nge-sickle cell anemia (isifo segazi esizuzwe njengefa lapho amangqamuzana abomvu egazi abunjwe ngokungajwayelekile [ebunjiwe njengelikela] futhi ayikwazi ukuletha umoya-mpilo owenele kuzo zonke izingxenye zomzimba). I-Hydroxyurea isekilasini lemithi ebizwa ngama-antimetabolites. I-Hydroxyurea iphatha umdlavuza ngokunciphisa noma ngokumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho. I-Hydroxyurea iphatha i-sickle cell anemia ngokusiza ukuvimbela ukwakheka kwamangqamuzana egazi abomvu amile okwe-sickle.

I-Hydroxyurea iza njenge-capsule kanye ne-tablet ezothathwa ngomlomo. Kuvame ukuthathwa kanye ngosuku ngengilazi yamanzi. Lapho i-hydroxyurea isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza, ingathathwa kanye ngosuku lwesithathu. Thatha i-hydroxyurea ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-hydroxyurea njengoba nje iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho noma alungise umthamo wakho we-hydroxyurea ngokuya ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi ongayithola. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-hydroxyurea ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho mhlawumbe uzokutshela ukuthi uthathe omunye umuthi, i-folic acid (uvithamini), ukwehlisa eminye imiphumela emibi yalo muthi. Thatha le mithi ngendlela eqondiswe ngayo.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Amaphilisi e-hydroxyurea 1,000-mg (Siklos) athola amaphuzu ukuze ahlukaniswe kalula abe amahafu noma amakota ukuze ahlinzeke ngemithamo emincane. Ungaphuli amaphilisi e-hydroxyurea 100-mg abe izingxenye ezincane. Udokotela wakho uzokutshela ukuthi ungawaphula kanjani amaphilisi nokuthi mangaki amaphilisi noma izingxenye zethebhulethi okufanele uzithathe.

Uma ungakwazi ukugwinya amaphilisi e-hydroxyurea noma izingxenye (zam) zamathebulethi, ungahlakaza umthamo wakho emanzini. Faka umthamo wakho kusipuni bese ufaka amanzi amancane. Linda cishe umzuzu owodwa ukuvumela ama-tablet (s) ukuthi ancibilike, bese ugwinya ingxube ngaso leso sikhathi.

Kufanele ugqoke amagilavu ​​wenjoloba noma we-latex lapho uphatha amaphilisi noma amaphilisi ukuze isikhumba sakho singathintani nemithi. Geza izandla zakho ngensipho namanzi ngaphambi nangemva kokuthinta ibhodlela noma umuthi. Uma i-hydroxyurea ingena emehlweni akho, masisha amehlo akho ngamanzi okungenani imizuzu eyi-15. Uma i-powder evela ku-capsule noma ithebhulethi ichitheka, isule ngokushesha ngethawula elimanzi elilahlwayo. Bese ubeka ithawula esitsheni esivaliwe, njengesikhwama sepulasitiki, bese ulilahla emgqonyeni kadoti ongafinyeleleki ezinganeni nasezifuyweni. Hlanza indawo yokuchitheka usebenzisa isisombululo sokuhlanza kulandelwe ngamanzi ahlanzekile.

I-Hydroxyurea kwesinye isikhathi isetshenziselwa ukwelapha i-polycythemia vera (isifo segazi lapho umzimba wakho wenza amangqamuzana egazi abomvu amaningi kakhulu). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-hydroxyurea,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-hydroxyurea, noma imiphi eminye imithi, noma iziphi izithako ezingasebenzi kuma-capsule we-hydroxyurea noma amaphilisi. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo ethile ye-HIV (igciwane lengculazi) njenge-didanosine (i-Videx) ne-stavudine (i-Zerit) ne-interferon (i-Actimmune, i-Avonex, i-Betaseron, i-Infergen, i-Intron A, neminye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unegciwane lengculazi (i-HIV), une-immunodeficiency syndrome (i-AIDS), amazinga aphezulu e-uric acid egazini lakho, noma izilonda zomlenze; uma welashwa noma wake waphathwa ngemisebe, i-cancer chemotherapy, noma i-hemodialysis; noma uma uke waba nesifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele ukhulelwe noma uncelise ngenkathi uthatha i-hydroxyurea. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuba uqale ukwelashwa nge-hydroxyurea. Uma ungowesifazane, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngenkathi uthatha i-hydroxyurea futhi okungenani izinyanga eziyisithupha ngemuva kokuyeka ukwelashwa kwakho. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha okusebenzayo ngenkathi nithatha i-hydroxyurea futhi okungenani izinyanga eziyisithupha (Siklos) noma okungenani unyaka owodwa (iDroxia, Hydrea) ngemuva kokumisa ukwelashwa kwakho. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi nangemva kokwelashwa kwakho nokuthi kufanele uqhubeke nokusebenzisa isikhathi esingakanani. Uma ukhulelwa ngenkathi uthatha i-hydroxyurea, shayela udokotela wakho ngokushesha. I-Hydroxyurea ingalimaza umbungu.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-hydroxyurea.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Hydroxyurea ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukulahlekelwa isifiso sokudla
• ukuzuza kwesisindo
• izilonda emlonyeni nasemphinjeni
• ukuqunjelwa
• ukuqubuka
• isikhumba esiphaphathekile
• isiyezi
• ikhanda
• ukulahleka kwezinwele
• izinguquko esikhunjeni nasezipikili

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okusheshayo
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala baye emuva
• amanxeba emlenzeni noma izilonda
• ubuhlungu, ukulunywa, ububomvu, ukuvuvukala, noma amabhamuza esikhunjeni
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni noma ezinyaweni
• umkhuhlane, ukukhwehlela, ukuphelelwa umoya, nezinye izinkinga zokuphefumula

I-Hydroxyurea ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivaliwe ngokuqinile, futhi lapho izingane nezilwane ezifuywayo zingafinyeleli khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Amaphilisi we-1,000-mg ephukile kufanele agcinwe esitsheni futhi kufanele asetshenziswe ezinyangeni ezintathu.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• izilonda emlonyeni nasemphinjeni
• ubuhlungu, ubomvu, ukuvuvukala, nokukala ezandleni nasezinyaweni
• ukufiphaza kwesikhumba

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-hydroxyurea.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho.Abantu abangathathi i-hydroxyurea kufanele bagweme ukuthinta umuthi noma ibhodlela eliqukethe umuthi.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Droxia^®
• I-Hydrea^®
• Siklos^®

• I-Hydroxycarbamide