Ukujova kweLeuprolide

-Delile

• Ngaphambi kokuthola umjovo we-leuprolide,
• Umjovo weLeuprolide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo weLeuprolide (Eligard, Lupron Depot) usetshenziselwa ukwelapha izimpawu ezihambisana nomdlavuza we-Prostate. Umjovo weLeuprolide (Lupron Depot-PED, Fensolvi) usetshenziswa ezinganeni ezineminyaka engu-2 noma ngaphezulu ukwelapha ukuthomba okuphakathi (i-CPP; isimo esibangela amantombazane [imvamisa angaphansi kweminyaka eyi-8 ubudala] nabafana [imvamisa engaphansi kweminyaka engu-9 yobudala] ukungena ebusheni ngokushesha okukhulu, okuholela ekukhuleni kwamathambo okujwayelekile nokuthuthuka kwezici zobulili). Umjovo weLeuprolide (Lupron Depot) usetshenziswa wedwa noma ngomunye umuthi (norethindrone) ukwelapha i-endometriosis (isimo lapho uhlobo lwethishu eligudla isibeletho [isibeletho] lukhula kwezinye izindawo zomzimba futhi lubangele ubuhlungu, ukuya esikhathini okunzima noma okungajwayelekile [izikhathi], nezinye izimpawu). Umjovo weLeuprolide (Lupron Depot) uyasetshenziswa neminye imithi yokwelapha i-anemia (inani eliphansi kunelijwayelekile lamaseli abomvu egazi) elibangelwa yi-uterine fibroids (ukukhula okungenaso umdlavuza esibelethweni). Umjovo weLeuprolide usesigabeni semithi ebizwa nge-gonadotropin-release hormone (GnRH) agonists. Isebenza ngokunciphisa inani lamahomoni athile emzimbeni.

Umjovo weLeuprolide uza njengokumiswa okuthatha isikhathi eside (i-Lupron) okujovwa ngemisipha (emsipheni) ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo futhi kuvame ukunikezwa kanye ngenyanga (iLupron Depot, Lupron Depot-PED) noma njalo Izinyanga ezi-3, 4, noma ezi-6 (Inyanga ye-Lupron Depot-3, inyanga ye-Lupron Depot-PED-3, inyanga ye-Lupron Depot-4, iLupron Depot-Inyanga eyi-6). Umjovo weLeuprolide nawo uza njengokumiswa okuthatha isikhathi eside (i-Eligard) okujovwa ngomgogodla (ngaphansi kwesikhumba) ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo futhi kuvame ukunikezwa njalo ezinyangeni ezi-1, 3, 4, noma ezi-6. Umjovo weLeuprolide nawo uza njengokumiswa okuthatha isikhathi eside (Fensolvi) okujovwa ngomgogodla (ngaphansi kwesikhumba) ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo futhi uvame ukunikezwa njalo ezinyangeni eziyisithupha. Udokotela wakho uzokutshela ukuthi ukwelashwa kwakho ngomjovo we-leuprolide kuzohlala isikhathi esingakanani. Uma isetshenziswa ezinganeni ezinokuthomba ngaphambi kwesikhathi, umjovo we-leuprolide (i-Lupron Depot-PED, inyanga ye-Lupron Depot-PED-3, i-Fensolvi) kungenzeka imiswe ngudokotela wengane yakho ngaphambi kweminyaka engu-11 yamantombazane neminyaka engu-12 kubafana.

Uma uthola ukumiswa kwe-leuprolide okusebenza isikhathi eside (i-Eligard) njengomjovo ongaphansi, ungahle ubone ibump encane endaweni lapho umjovo wanikezwa khona lapho uqala ukuthola umuthi. Leli bump kufanele ekugcineni lihambe.

I-Leuprolide ingadala ukwanda kwamahomoni athile emasontweni ambalwa okuqala ngemuva komjovo. Udokotela wakho uzokuqapha ngokucophelela nganoma yiziphi izimpawu ezintsha noma eziba nzima ngalesi sikhathi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-leuprolide,

• Tshela udokotela kanye nosokhemisi wakho uma une-allergies ku-leuprolide, goserelin (Zoladex), histrelin (Supprelin LA, Vantas), nafarelin (Synarel), triptorelin (Triptodur, Trelstar), noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-leuprolide. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone), i-disopyramide (i-Norpace), i-procainamide (i-Procanbid), i-quinidine, ne-sotalol (i-Betapace, i-Betapace AF, i-Sorine); i-buproprion (i-Aplenzin, i-Forfivo, i-Wellbutrin, ku-Contrave); imithi yokuquleka; i-steroids yomlomo efana ne-dexamethasone (Hemady), i-methylprednisolone (Medrol), ne-prednisone (i-Rayos); ne-serotonin reuptake inhibitors (SSRIs) ekhethiwe efana ne-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, e-Symbyax), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil) ne-sertraline (i-Zoloft). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-leuprolide, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma unegazi elingajwayelekile langasese. Udokotela wakho angakutshela ukuthi ungasebenzisi umjovo we-leuprolide.
• utshele udokotela wakho uma wena noma omunye emndenini wakho enesifo sokukhumuzeka kwamathambo (isimo lapho amathambo mancane futhi kungenzeka aphuke khona); uma unomlando wokuphuza utshwala noma ukusebenzisa imikhiqizo kagwayi isikhathi eside; noma uma uke waba nokudangala, ukuquleka, izimila ebuchosheni, umdlavuza osakaze emgogodleni (umgogodla), isifo sikashukela, ukuvinjelwa komchamo (ukuvinjelwa okubangela ubunzima bokuchama), igazi emchameni wakho, isikhathi se-QT eside (okungajwayelekile inkinga yenhliziyo engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), isifo se-cerebrovascular (ukuvimba noma ukwenza buthaka imithambo yegazi ebuchosheni noma eholele ebuchosheni), isifo senhliziyo, noma izinga eliphansi le-potassium, calcium, noma i-magnesium igazi lakho.
• kufanele wazi ukuthi i-leuprolide akufanele isetshenziswe kwabesifazane abakhulelwe, abangakhulelwa, noma abancelisayo. Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma ukuncelisa. Udokotela wakho angenza isivivinyo sokukhulelwa ukuze aqiniseke ukuthi awukhulelwe lapho uqala ukuthola umjovo we-leuprolide. Uzodinga ukusebenzisa indlela ethembekile yokulawula ukubeletha engeyona eye-hormone ukuvimbela ukukhulelwa ngenkathi uthola umjovo we-leuprolide. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokubeletha ezikulungele, bese uqhubeka nokusebenzisa ukubeletha yize kungafanele ukuthi ube nesikhathi sokuya esikhathini njalo lapho welashwa. Uma ucabanga ukuthi ukhulelwe ngenkathi uthola umjovo we-leuprolide, shayela udokotela wakho ngokushesha. Umjovo weLeuprolide ungalimaza umbungu.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola umjovo we-leuprolide, kufanele ushayele umhlinzeki wakho wezokunakekelwa kwezempilo khona manjalo ukusetha kabusha isikhathi sakho.

Umjovo weLeuprolide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ukushisa okushisayo (ukuqhuma okungazelelwe kokushisa komzimba okuncane noma okukhulu), ukujuluka, noma ukuqina
• ubumnene besifuba, ubuhlungu, noma ushintsho kusayizi webele kwabesilisa nabesifazane
• ukukhishwa kwesitho sangasese sowesifazane, ukoma, noma ukulunywa kwabesifazane
• ukubona (ukuphuma kwegazi lesitho sangasese sowesifazane okukhanyayo) noma ukuya esikhathini (izikhathi)
• ukwehla ngosayizi wamasende
• ukuncipha kwekhono lezocansi noma isifiso
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ubuhlungu, ukushisa, noma ukuncinza ezandleni noma ezinyaweni
• ubuhlungu, ukushiswa, ukulinyazwa, ubomvu, noma ukuqina endaweni lapho kunikezwe khona umjovo
• shintsha ngesisindo
• ubuhlungu bemisipha noma bamalunga
• ukuphuma kwamakhala, ukukhwehlela, umphimbo obuhlungu, noma izimpawu ezifana nomkhuhlane
• imfiva
• ubuhlungu besisu
• ukuqunjelwa
• ikhanda
• induna
• ukudana
• ayikwazi ukulawula imizwelo nokushintsha kwemizwelo njalo
• uvalo
• umuzwa ojwayelekile wokungakhululeki noma wokungakhululeki
• ubunzima ngememori

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukulunywa, ukuqubuka noma isifuba
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu ezingalweni, emuva, esifubeni, entanyeni, noma emhlathini
• inkulumo ehamba kancane noma enzima
• isiyezi noma ukuquleka
• ubuthakathaka, ukuba ndikindiki, noma ukungakwazi ukuhambisa ingalo noma umlenze
• ubuhlungu bamathambo
• ukuchama okubuhlungu, okuvamile, noma okunzima
• igazi emchameni
• ukoma ngokweqile
• ubuthakathaka
• umlomo owomile
• isicanucanu
• ukuhlanza
• umoya onuka izithelo
• kwehle ukwazi
• ikhanda elingalindelekile
• ukungaboni kahle
• umbono uyashintsha
• ubunzima bokuhambisa amehlo
• amajwabu amehlo alengayo
• ukudideka
• isithuthwane

Umjovo weLeuprolide ungadala ukwehla kobuningi bamathambo akho okungakhuphula amathuba amathambo aphukile. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi nokuthi uthole ukuthi yini ongayenza ukunciphisa lezi zingozi.

Ezinganeni ezithola umjovo we-leuprolide (i-Lupron Depot-PED, i-Fensolvi) yokuthomba ngaphambi kwesikhathi, izimpawu ezintsha noma eziya ziba zimbi zokukhula kocansi kungenzeka emasontweni ambalwa okuqala okwelashwa. Emantombazaneni athola umjovo we-leuprolide (i-Lupron Depot-PED) yokuthomba ngaphambi kwesikhathi, ukuqala kokuya esikhathini noma ukubona (ukuphuma kwegazi lesitho sangasese sowesifazane okukhanyayo) kungenzeka ezinyangeni ezimbili zokuqala zokwelashwa. Uma ukuphuma kwegazi kuqhubeka ngaphezu kwenyanga yesibili, shayela udokotela wakho.

Umjovo weLeuprolide ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu futhi athathe izilinganiso ezithile ukuhlola impendulo yomzimba wakho kumjovo we-leuprolide. Ushukela wakho wegazi kanye ne-hemoglobin eglycosylated (HbA1c) nayo ingahlolwa njalo.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-leuprolide.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Eligard^®
• I-Fensolvi^®
• ILupron^®
• ILupron Depot^®
• ILupron Depot-PED^®
• Iphakethe leLupaneta^® (njengomkhiqizo ohlanganisiwe oqukethe iLeurprolide, Norethindrone)

• I-Leuprorelin Acetate