I-Aldesleukin

-Delile

• Ngaphambi kokuthola i-aldesleukin,
• I-Aldesleukin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo we-Aldesleukin kufanele unikezwe esibhedlela noma esikhungweni sezokwelapha ngaphansi kweso lodokotela onolwazi lokunikeza imishanguzo yokwelashwa ngamakhemikhali yomdlavuza.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi kuphephile yini ukuthola umjovo we-aldesleukin nokuhlola impendulo yomzimba wakho kumjovo we-aldesleukin.

I-Aldesleukin ingadala ukusabela okunzima nokusongela impilo okubizwa nge-capillary leak syndrome (isimo esidala ukuthi umzimba ugcine uketshezi oluningi, umfutho ophansi wegazi, kanye namazinga aphansi eprotheni [albumin] egazini) okungadala ukulimala emzimbeni wakho. inhliziyo, amaphaphu, izinso, kanye nomgudu wamathumbu. ICapillary leak syndrome ingenzeka ngokushesha ngemuva kokunikezwa i-aldesleukin. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi; ukukhuluphala; ukuphelelwa umoya; ukuquleka; isiyezi noma ikhanda elikhanyayo; ukudideka; ezinegazi noma ezimnyama, ezilindile, indle enamathelayo; ubuhlungu besifuba; ukushaya kwenhliziyo okusheshayo noma okungajwayelekile.

I-Aldesleukin ingadala ukwehla kwenani lamaseli amhlophe egazi. Ukwehla kwenani lamaseli amhlophe egazi emzimbeni wakho kungandisa ubungozi bokuthi uzoba nokutheleleka okungathi sína. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: umkhuhlane, amakhaza, umphimbo obuhlungu, ukukhwehlela, ukuchama kaningi noma okubuhlungu, noma ezinye izimpawu zokutheleleka.

I-Aldesleukin ingathinta uhlelo lwezinzwa futhi ingadala ikhoma. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukulala ngokweqile noma ukukhathala.

I-Aldesleukin isetshenziselwa ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala ezinso) oluye lwasakazekela kwezinye izingxenye zomzimba wakho. I-Aldesleukin ibuye isetshenziselwe ukwelapha i-melanoma (uhlobo lomdlavuza wesikhumba) oluye lwasakazekela kwezinye izingxenye zomzimba wakho. I-Aldesleukin isekilasini lezidakamizwa ezaziwa ngokuthi ama-cytokines. Yinguqulo eyenziwe ngumuntu yeprotheyini eyenzeka ngokwemvelo evuselela umzimba ukuthi ikhiqize amanye amakhemikhali akhulisa amandla omzimba okulwa nomdlavuza.

I-Aldesleukin iza njengempuphu ezohlanganiswa noketshezi oluzofakwa ngaphakathi emthanjeni (emthanjeni) ngaphezu kwemizuzu engu-15 ngudokotela noma umhlengikazi esibhedlela. Imvamisa ijovwa njalo ngamahora ayisishiyagalombili izinsuku ezi-5 zilandelana (imijovo eyi-14 isiyonke). Lo mjikelezo ungaphindwa ngemuva kwezinsuku eziyi-9. Ubude bokwelashwa buxhomeke ekutheni umzimba wakho uphendula kanjani ekwelashweni.

Udokotela wakho kungadingeka ukuthi akubambezele noma ayeke unomphela ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Uzobe uqapha ngokucophelela ngesikhathi sokwelashwa kwakho ne-aldesleukin. Kubalulekile ukuthi utshele udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ne-aldesleukin.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola i-aldesleukin,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-aldesleukin, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-aldesleukin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-beta blocker anjenge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), nepropranolol (Inderal); imishanguzo ethile ye-cancer chemotherapy efana ne-asparaginase (Elspar), cisplatin (Platinol), dacarbazine (DTIC-dome), doxorubicin (Doxil), interferon-alfa (Pegasys, PEG-Intron), methotrexate (Rheumatrex, Trexall), ne-tolokadex ( ); imithi yomfutho wegazi ophakeme; imithi yokuhlanza nokuhlanza; izidakamizwa kanye neminye imithi yezinhlungu; isidambisi, amaphilisi okulala, nezidakamizwa ezithomalalisayo; i-steroids efana ne-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (i-Medrol) ne-prednisone (i-Deltasone); nama-steroid okhilimu, ama-lotion, noma amafutha okugcoba afana ne-hydrocortisone (Cortizone, Westcort). Phinda utshele udokotela wakho kanye nosokhemisi ngayo yonke imithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe ikhona yini imishanguzo yakho engakhuphula ubungozi bokuthi uzoba nokulimala kwezinso noma kwesibindi ngenkathi welashwa nge-aldesleukin.
• Tshela udokotela wakho uma uke wahlaselwa yisifo sokuwa, ukopha emathunjini (GI) okudinga ukwelashwa, noma enye i-GI, inhliziyo, uhlelo lwezinzwa, noma izinkinga zezinso ngemuva kokuthola i-aldesleukin noma uma uke wafakelwa isitho somzimba isitho emzimbeni). Udokotela wakho angahle angafuni ukuthi uthole i-aldesleukin.
• Tshela udokotela wakho ukuthi uke wahlaselwa yini noma wake wahlaselwa yini, isifo sikaCrohn, i-scleroderma (isifo esithinta izicubu ezisekela isikhumba nezitho zangaphakathi), isifo se-thyroid, isifo samathambo, isifo sikashukela, i-myasthenia gravis (isifo esinciphisa imisipha), noma i-cholecystitis (ukuvuvukala kwenyongo okubanga ubuhlungu obukhulu).
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola i-aldesleukin, shayela udokotela wakho. Akufanele uncelise ibele ngenkathi uthola i-aldesleukin.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Aldesleukin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukulahlekelwa isifiso sokudla
• izilonda emlonyeni nasemphinjeni
• ukukhathala
• ubuthakathaka
• isiyezi
• umuzwa ojwayelekile wokungaphili
• ubuhlungu noma ububomvu lapho kunikezwe khona umjovo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• isithuthwane
• ubuhlungu besifuba
• ukukhathazeka ngokweqile
• isasasa elingajwayelekile noma ukuyaluza
• ukucindezeleka okusha noma okuya kuba kubi
• ukubona izinto noma ukuzwa amazwi angekho (hallucinating)
• izinguquko kumbono wakho noma enkulumweni
• ukulahleka kokuxhumanisa
• ukunciphisa ukuqapha
• ukulimaza noma ukopha okungavamile
• ukulala ngokweqile noma ukukhathala
• ukuphefumula kanzima
• isifuba
• ubuhlungu besisu
• ukuphuzi kwesikhumba noma kwamehlo
• ukuncipha kokuchama
• ukuqubuka
• isifuba
• ukulunywa
• ukuphefumula kanzima noma ukugwinya

I-Aldesleukin ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isithuthwane
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ikhoma
• ukuncipha kokuchama
• ukuvuvukala kobuso, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukukhathala okungajwayelekile noma ubuthakathaka
• ubuhlungu besisu
• uhlanza olunegazi noma olubukeka njengezizathu zekhofi
• igazi esitokisini
• indle emnyama neyokulinda

Uma une-x-ray, tshela udokotela ukuthi uthola ukwelashwa kwe-aldesleukin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Proleukin^®

• I-Interleukin-2