Inaliti ye-Filgrastim

-Delile

• Ngaphambi kokusebenzisa imikhiqizo yomjovo we-filgrastim,
• Imikhiqizo yomjovo we-Filgrastim ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo we-Filgrastim, umjovo we-filgrastim-aafi, umjovo we-filgrastim-sndz, kanye nomjovo we-tbo-filgrastim yimithi ye-biologic (imithi eyenziwe ngezinto eziphilayo). Umjovo we-Biosimilar filgrastim-aafi, umjovo we-filgrastim-sndz, nomjovo we-tbo-filgrastim ufana kakhulu nomjovo we-filgrastim futhi usebenza ngendlela efanayo nomjovo we-filgrastim emzimbeni. Ngakho-ke, igama elithi imikhiqizo yomjovo we-filgrastim lizosetshenziselwa ukumela le mithi kule ngxoxo.

Imikhiqizo yomjovo we-Filgrastim (i-Granix, i-Neupogen, i-Nivestym, i-Zarxio) isetshenziselwa ukunciphisa amathuba okutheleleka kubantu abanomdlavuza ongelona i-myeloid (umdlavuza ongabandakanyi umnkantsha) futhi abathola imishanguzo ye-chemotherapy enganciphisa inani lama-neutrophils ( uhlobo lwengqamuzana legazi oludingekayo ukulwa nezifo). Imikhiqizo yomjovo we-Filgrastim (Neupogen, Nivestym, Zarxio) nayo isetshenziselwa ukusiza ukukhulisa inani lamaseli amhlophe egazi, nokunciphisa ubude besikhathi nomkhuhlane kubantu abane-acute myeloid leukemia (AML; uhlobo lomdlavuza wamaseli amhlophe egazi) abathola ukwelashwa ngemithi yokwelashwa ngamakhemikhali.Imikhiqizo yomjovo we-Filgrastim (i-Neupogen, i-Nivestym, i-Zarxio) iyasetshenziswa nakubantu abafakelwa umnkantsha wethambo, kubantu abane-neutropenia engapheli (isimo lapho kunenombolo ephansi yama-neutrophils egazini), nokulungisa igazi i-leukapheresis (ukwelashwa lapho kukhishwa khona amangqamuzana athile egazi emzimbeni. Umjovo we-Filgrastim (Neupogen) nawo usetshenziselwa ukwandisa amathuba okusinda kubantu abachayeke emithanjeni eyingozi yemisebe, engadala ukusongela okukhulu nokubeka impilo engcupheni I-Filgrastim isekilasini lemithi ebizwa ngokuthi yizici ezivuselela ikholoni.Isebenza ngokusiza umzimba ukuthi wenze ama-neutrophil amaningi.

Imikhiqizo yomjovo we-Filgrastim iza njengesisombululo (uketshezi) ezitsheni kanye nemijovo ekhethiwe yokujova ngaphansi kwesikhumba noma emthanjeni. Imvamisa inikezwa kanye ngosuku, kepha imikhiqizo yomjovo we-filgrastim (Neupogen, Nivestym, Zarxio) inganikezwa kabili ngosuku lapho isetshenziselwa ukwelapha i-neutropenia engapheli. Ubude bokwelashwa kwakho buya ngesimo onaso nokuthi umzimba wakho uphendula kahle kanjani emithini.

Uma usebenzisa imikhiqizo yomjovo we-filgrastim ukunciphisa ubungozi bokutheleleka, ukunciphisa isikhathi ngomkhuhlane, noma ukwandisa inani lamaseli amhlophe egazi ngesikhathi se-chemotherapy, uzothola umthamo wakho wokuqala womuthi okungenani amahora angama-24 ngemuva kokuthola umthamo chemotherapy, futhi uzoqhubeka nokuthola umuthi nsuku zonke kuze kube amasonto ama-2 noma kuze kubalwe amaseli egazi lakho abuyele kokujwayelekile. Uma usebenzisa umkhiqizo womjovo we-filgrastim ukunciphisa ingozi yokutheleleka ngesikhathi sokufakelwa komnkantsha wethambo, uzothola umuthi okungenani amahora angama-24 ngemuva kokuthola i-chemotherapy futhi okungenani amahora angama-24 ngemuva kokufakwa komnkantsha. Uma usebenzisa imikhiqizo yomjovo we-filgrastim ukulungiselela igazi lakho leukapheresis, uzothola umthamo wakho wokuqala okungenani ezinsukwini ezine ngaphambi kwe-leukapheresis yokuqala futhi uzoqhubeka nokuthola umuthi kuze kufike i-leukapheresis yokugcina. Uma usebenzisa imikhiqizo yomjovo we-filgrastim ukwelapha i-neutropenia engapheli, ungahle udinge ukusebenzisa umuthi isikhathi eside. Uma usebenzisa umjovo we-filgrastim ngoba uvezwe emisebeni eyingozi, udokotela wakho uzokuqapha ngokucophelela futhi nobude bokwelashwa kwakho kuzoya ngokuthi umzimba wakho uphendula kanjani emithini. Ungayeki ukusebenzisa imikhiqizo yomjovo we-filgrastim ngaphandle kokukhuluma nodokotela wakho.

Imikhiqizo ye-Filgrastiminjection ingakunikezwa ngumhlengikazi noma omunye umhlinzeki wezokunakekelwa kwezempilo, noma ungatshelwa ukuthi ujove umuthi ngaphansi kwesikhumba ekhaya. Uma wena noma umnakekeli uzobe ujova imikhiqizo yomjovo we-filgrastim ekhaya, umhlinzeki wezokunakekelwa kwezempilo uzokukhombisa wena noma umnakekeli wakho ukuthi ungawujova kanjani umuthi. Qiniseka ukuthi uyaziqonda lezi zinkomba. Buza umhlinzeki wakho wezokunakekelwa kwezempilo uma unemibuzo. Sebenzisa imikhiqizo yomjovo we-filgrastim njengoba iqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Ungaxukuzi izitsha noma amasirinji aqukethe isisombululo se-filgrastim. Njalo bheka imikhiqizo yomjovo we-filgrastim ngaphambi kokujova. Ungayisebenzisi uma usuku lokuphelelwa yisikhathi seludlulile, noma uma isisombululo se-filgrastim sinezinhlayiya noma sibukeka sinamagwebu, siguqubele, noma sikhanyayo.

Sebenzisa isipetu noma isitsha esisodwa kanye kuphela. Noma ngabe kusekhona isixazululo esisele kumjovo noma i-vial, ungasisebenzisi futhi. Lahla izinaliti, imijovo, nezitsha ezisemgodini ongamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Udokotela wakho angakuqala ngomthamo ophansi wemikhiqizo yomjovo we-filgrastim futhi akhuphule kancane umthamo wakho. Udokotela wakho futhi anganciphisa umthamo wakho, kuya ngokuthi umzimba wakho usabela kanjani emithini.

Uma usebenzisa imikhiqizo yomjovo we-filgrastim ukwelapha i-neutropenia engapheli, kufanele wazi ukuthi lo muthi uzolawula isimo sakho kepha ngeke uselaphe. Qhubeka nokusebenzisa imikhiqizo yomjovo we-filgrastim noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa imikhiqizo yomjovo we-filgrastim ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Imikhiqizo yomjovo we-Filgrastim kwesinye isikhathi isetshenziselwa ukwelapha izinhlobo ezithile ze-myelodysplastic syndrome (iqembu lezimo lapho umnkantsha ukhiqiza khona amangqamuzana egazi angafakwanga kahle futhi angavezi amaseli egazi anempilo anele) kanye ne-aplastic anemia (isimo lapho umnkantsha ayenzi amaseli wegazi anele). Imikhiqizo yomjovo we-Filgrastim kwesinye isikhathi isetshenziselwa ukunciphisa amathuba okutheleleka kubantu abanegciwane lesandulela ngculazi (i-HIV) noma abantu abathatha imishanguzo ethile eyehlisa inani lama-neutrophils. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa imikhiqizo yomjovo we-filgrastim,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-filgrastim, i-pegfilgrastim (i-Neulasta), noma imiphi eminye imishanguzo noma ezinye izithako zemikhiqizo yomjovo we-filgrastim. Phinda utshele udokotela wakho uma wena noma umuntu ozojova imikhiqizo yomjovo we-filgrastim (Neupogen, Zarxio) ayizwani ne-latex.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uphathwa ngemithi yokwelashwa ngemisebe futhi uma uke waba nesifo esingalapheki se-myeloid leukemia (isifo esiqhubeka kancane lapho kwenziwa khona amangqamuzana amhlophe egazi amaningi emnkantsheni), noma i-myelodysplasia (izinkinga ezinamaseli omnkantsha) lokho kungakhula kube i-leukemia).
• Tshela udokotela wakho uma unesifo se-sickle cell (isifo segazi esingadala izingqinamba ezibuhlungu, inani eliphansi lamaseli abomvu egazi, ukutheleleka, nokulimala ezithweni zangaphakathi). Uma unesifo se-sickle cell, ungahle ube nenkinga ngesikhathi sokwelashwa kwakho ngemikhiqizo yomjovo we-filgrastim. Phuza uketshezi oluningi ngesikhathi sokwelashwa kwakho ngemikhiqizo yomjovo we-filgrastim bese ushayela udokotela wakho ngokushesha uma unenkinga yeseli yesikela ngesikhathi sokwelashwa kwakho.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa imikhiqizo yomjovo we-filgrastim shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa imikhiqizo yomjovo we-filgrastim.
• kufanele wazi ukuthi imikhiqizo yomjovo we-filgrastim inciphisa ubungozi bokutheleleka, kepha ayikuvimbeli konke ukutheleleka okungakhula ngesikhathi noma ngemuva kwe-chemotherapy. Shayela udokotela wakho uma uba nezimpawu zokutheleleka ezifana nomkhuhlane; Ukugodola; ukuqubuka; Umphimbo obuhlungu; isifo sohudo; noma ububomvu, ukuvuvukala, noma ubuhlungu obuzungeze ukusika noma ubuhlungu.
• uma uthola isisombululo se-filgrastim esikhunjeni sakho, geza indawo ngensipho namanzi. Uma isixazululo se-filgrastim singena esweni lakho, gcoba iso lakho kahle ngamanzi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uzobe ujova umkhiqizo womjovo we-filgrastim ekhaya, khuluma nodokotela wakho ngalokho okufanele ukwenze uma ukhohlwa ukujova umuthi ngesikhathi esifanele.

Imikhiqizo yomjovo we-Filgrastim ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukuvuvukala, ukulinyazwa, ukulunywa noma isigaxa endaweni lapho kwajova khona umuthi
• ithambo, ilunga, iqolo, ingalo, umlenze, umlomo, umphimbo, noma ubuhlungu bemisipha
• ikhanda
• ukuqubuka
• ukuqunjelwa
• isifo sohudo
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ubunzima bokulala noma ukulala
• ukuncipha komuzwa wokuthinta
• ukulahleka kwezinwele
• ukuphuma kwamakhala
• ukukhathala, ukungabi namandla
• ngizizwa ngingaphilile
• isiyezi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ubuhlungu engxenyeni engenhla yesobunxele yesisu noma ichopho lehlombe lesobunxele
• umkhuhlane, ukuphefumula okuncane, ukukhathazeka ngokuphefumula, ukuphefumula okusheshayo
• inkinga yokuphefumula, ukukhwehlela igazi
• umkhuhlane, ubuhlungu besisu, iqolo, ukuzizwa ungaphilile
• ukuvuvukala kwendawo yesisu noma okunye ukuvuvukala, ukuncipha kokuchama, ukuphefumula kanzima, isiyezi, ukukhathala
• ukuqubuka, isifuba, ukulunywa, ukuvuvukala kobuso, amehlo, noma umlomo, ukuqhuma, ukuphefumula okuncane
• ukopha okungavamile noma ukulimaza, ukumakwa okunsomi ngaphansi kwesikhumba, isikhumba esibomvu
• ukuncipha kokuchama, umchamo omnyama noma onegazi, ukuvuvukala kobuso noma amaqakala
• ukuchama okubuhlungu, okuphuthumayo, noma okuvamile

Abanye abantu abasebenzise imikhiqizo yomjovo we-filgrastim ukwelapha i-neutropenia engapheli enesifo somdlavuza we-leukemia (umdlavuza oqala emnkantsheni wethambo) noma ushintsho kumaseli omnkantsha wamathambo akhombisa ukuthi i-leukemia ingahle ikhule ngokuzayo. Abantu abane-neutropenia elukhuni engapheli bangaba ne-leukemia noma bengayisebenzisi i-filgrastim. Akukho lwazi olwanele ukusho ukuthi imikhiqizo yomjovo we-filgrastim yandisa amathuba okuthi abantu abane-neutropenia elukhuni engalapheki bayoba ne-leukemia. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi.

Imikhiqizo yomjovo we-Filgrastim ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina imikhiqizo yomjovo we-filgrastim esiqandisini. Uma ngephutha umisa i-filgrastim (i-Neupogen, i-Nivestym, i-Zarxio), ungayivumela ukuthi incibilike esiqandisini. Kodwa-ke, uma ufaka umjovo ofanayo noma isitsha se-filgrastim okwesibili, kufanele usilahle leso sirinji noma isitsha. I-Filgrastim (i-Neupogen, i-Nivestym, i-Zarxio) ingagcinwa ekamelweni lokushisa kuze kube ngamahora angama-24 kepha kufanele igcinwe kude nelanga eliqondile. IFilgrastim (iGranix) ingagcinwa efrijini kuze kufike emahoreni angama-24, noma ingagcinwa ekamelweni lokushisa kuze kube yizinsuku ezi-5 kodwa kufanele ivikelwe ekukhanyeni.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumikhiqizo yomjovo we-filgrastim.

Ngaphambi kokwenza ucwaningo lwamathambo, tshela udokotela wakho nochwepheshe ukuthi usebenzisa imikhiqizo yomjovo we-filgrastim. Imikhiqizo yomjovo we-Filgrastim ingathinta imiphumela yalolu hlobo lokutadisha.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Granix^® (tbo-filgrastim)
• I-Neupogen^® (filgrastim)
• Nivestym^® (i-filgrastim-aafi)
• Zarxio^® (filgrastim-sndz)

• Isici Esikhuthaza I-Granulocyte Colony
• I-G-CSF
• I-Methionyl Human G-CSF ephindayo