I-Itraconazole

-Delile

• Ngaphambi kokuthatha i-itraconazole,
• I-Itraconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, yeka ukuthatha i-itraconazole bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Itraconazole ingadala ukwehluleka kwenhliziyo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele emzimbeni). Tshela udokotela wakho uma ngabe uke waba nokuhluleka kwenhliziyo. Udokotela wakho angakutshela ukuthi ungayithathi i-itraconazole. Tshela nodokotela wakho uma uke wahlaselwa yinhliziyo noma wake wahlaselwa; ukushaya kwenhliziyo okungajwayelekile; noma yiluphi olunye uhlobo lwenhliziyo, amaphaphu, isibindi noma isifo sezinso. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-itraconazole bese ushayela udokotela wakho ngokushesha: ukuphefumula; ukukhwehlela uphlegm omhlophe noma obomvana; ubuthakathaka; ukukhathala ngokweqile; ukushaya kwenhliziyo okusheshayo; ukuvuvukala kwezinyawo, amaqakala, noma imilenze; ukuvuka ebusuku; nokuzuza kwesisindo okungazelelwe.

Ungathathi i-cisapride (Propulsid) (ayitholakali e-US), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), eplerenone (Inspra), imithi yohlobo lwe-ergot efana ne-dihydroergotamine (DHE, Migranal), ergotamine ( I-Ergomar, eCafergot, eMigergot), imethylergometrine (Methergine); felodipine (Plendil), irinotecan (Camptosar), ivabradine (Corlanor), levomethadyl acetate (Orlaam) (ayitholakali e-US), lovastatin (Altoprev, e-Advicor), lurasidone (Latuda), methadone (Dolophine, Methadose), midazolam kuthathwe ngomlomo), nisoldipine (Sular), pimozide (Orap), quinidine (eNuedexta), ranolazine (Ranexa), simvastatin (Zocor, eSimcor, eVytorin), ticagrelor (Brilinta), nase-triazolam (Halcion) ngenkathi ithatha i-itraconazole futhi amasonto ama-2 ngemuva kwalokho. Tshela udokotela wakho uma unesifo sezinso noma sesibindi futhi uthatha noma imuphi umuthi olandelayo: i-colchicine (Colcrys, Mitigare), fesoterodine (Toviaz), solifenacin (Vesicare), noma i-telithromycin (Ketek). Ukuthatha le mithi nge-itraconazole kungadala izinkinga ezinkulu zenhliziyo kufaka phakathi i-QT prolongation (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe).

Khuluma nodokotela wakho ngezingozi zokuthatha i-itraconazole.

Ama-capsule e-Itraconazole asetshenziselwa ukwelapha izifo ezikhunta emaphashini ezingasabalala emzimbeni wonke. Ama-capsules e-Itraconazole nawo asetshenziselwa ukwelapha ukutheleleka kwamafungal ezinzwaneni. Amaphilisi nama-capsule e-Itraconazole namaphilisi asetshenziselwa ukwelapha izifo zokukhunta zezinzwani. Isixazululo somlomo se-Itraconazole (uketshezi) sisetshenziselwa ukwelapha ukutheleleka ngemvubelo emlonyeni nasemphinjeni noma emcingeni (ishubhu elihlanganisa umphimbo nesisu). I-Itraconazole isekilasini lama-antifungal abizwa ngama-triazoles. Isebenza ngokunciphisa ukukhula kwesikhunta okubangela ukutheleleka.

I-Itraconazole iza njenge-capsule, ithebhulethi, nesisombululo (uketshezi) ukuthatha ngomlomo. Uma uthatha i-itraconazole ukwelapha izifo zokukhunta emaphashini, ama-capsule avame ukuthathwa phakathi noma ngemuva kokudla okugcwele kanye noma kabili ngosuku okungenani izinyanga ezintathu. Kodwa-ke, uma uthatha i-itraconazole ukwelapha ukutheleleka okungathi sína emaphashini, ama-capsule angathathwa ngokudla kathathu ngosuku ezinsukwini ezintathu zokuqala zokwelashwa bese uthathwa kanye noma kabili ngosuku ngokudla okungenani 3 izinyanga. Uma uthatha i-itraconazole ukwelapha izifo zokukhunta zezinzwani (kufaka phakathi noma ngaphandle kokutheleleka ngozipho), ama-capsule noma amaphilisi kuvame ukuthathwa kanye ngosuku ngokudla okugcwele amasonto ayi-12. Uma uthatha i-itraconazole ukwelapha ukutheleleka kwefungal yezinzipho kuphela, ama-capsules ngokuvamile athathwa kabili ngosuku ngokudla okugcwele isonto elilodwa, eqe amaviki ama-3, bese ethathwa kabili ngosuku ngokudla isonto lonke. Isixazululo somlomo se-Itraconazole ngokuvamile sithathwa esiswini esingenalutho kanye noma kabili ngosuku amasonto ayi-1 kuye kwayi-4 noma kwesinye isikhathi isikhathi eside. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-itraconazole njengoba nje uqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi e-itraconazole; ungazivuli, uzihlafune noma uzichoboze.

Udokotela wakho angakutshela ukuthi uthathe amaphilisi e-itraconazole ngesiphuzo esithambile se-cola uma unezimo ezithile zezokwelapha noma usebenzisa noma imiphi yale mithi elandelayo: i-cimetidine; i-famotidine (i-Pepcid); i-nizatidine (i-Axid); ama-proton-pump inhibitors afana ne-esomeprazole (Nexium, eVimovo), i-lansoprazole (Prevacid, e-Prevpac), i-omeprazole (Prilosec, e-Zegerid), i-pantoprazole (i-Protonix), i-rabeprazole (i-AcipHex), noma i-ranitidine (i-Zantac). Landela lezi zinkomba ngokucophelela.

Ukuthatha isisombululo somlomo se-itraconazole sokutheleleka komlomo noma komphimbo, swish 10 milliliters (cishe amathisipuni ama-2) wesisombululo esisemlonyeni wakho imizuzwana eminingana bese ugwinya. Phinda uma kunesidingo ukuthatha wonke umthamo wakho.

Amaphilisi e-Itraconazole nesisombululo somlomo kufakwa emzimbeni ngezindlela ezahlukahlukene futhi kusebenza ukwelapha izimo ezihlukile. Ungafaki amaphilisi endaweni ketshezi noma uketshezi esikhundleni samaphilisi. Qiniseka ukuthi usokhemisi wakho ukukunikeza umkhiqizo we-itraconazole onikezwe ngudokotela wakho.

Uma uthatha i-itraconazole ukwelapha ukutheleleka kwe-nail, izinzipho zakho kungenzeka zingabukeki ziphilile kuze kukhule izinzipho ezintsha. Kungathatha izinyanga ezi-6 ukukhula ngozipho omusha futhi kufika ezinyangeni eziyi-12 ukukhulisa uzipho olusha, ngakho-ke akufanele ulindele ukubona ukuthuthuka phakathi nokwelashwa kwakho noma izinyanga ezimbalwa ngemuva kwalokho. Qhubeka uthathe i-itraconazole noma ngabe ungaboni ngcono.

Qhubeka uthathe i-itraconazole kuze kube yilapho udokotela wakho ekutshela ukuthi uyeke noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-itraconazole ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-itraconazole maduzane, ukutheleleka kwakho kungabuya emuva kwesikhashana.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

I-Itraconazole kwesinye isikhathi isetshenziselwa ukwelapha ezinye izinhlobo zezifo zokukhunta kanye nokuvikela ukutheleleka kwezifo kubantu abanegciwane lesandulela ngculaza (i-HIV) noma abathola i-immunodeficiency syndrome (i-AIDS). Khuluma nodokotela wakho ngezingozi ezingenzeka zokusebenzisa lesi sidakamizwa ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-itraconazole,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-itraconazole; eminye imishanguzo efana ne-fluconazole (Diflucan), i-ketoconazole (i-Nizoral), noma i-voriconazole (i-Vfend); noma imuphi omunye umuthi, noma iziphi izithako kwimikhiqizo ye-itraconazole. Uma uthatha isisombululo somlomo se-itraconazole, tshela udokotela wakho uma uneguliswa nemithi ye-saccharin noma ye-sulfa. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela kanye nosokhemisi wakho uma uphuza le mithi elandelayo noma uyiphuze emavikini amabili edlule ngaphambi kokuqala ukwelashwa nge-itraconazole: carbamazepine (Epitol, Tegretol, Teril, others); i-efavirenz (iSustiva, e-Atripla); i-isoniazid (iLaniazid, eRifamate, eRifater); i-rifabutin (i-Mycobutin); i-rifampicin; i-nevirapine (i-Viramune); i-phenobarbital; kanye ne-phenytoin (iDilantin, Phenytek).
• Tshela udokotela wakho noma usokhemisi uma uthatha le mithi elandelayo: i-aliskiren (Tekturna, e-Amturnide, Tekamlo, ne-Tekturna HCT), i-apixaban (i-Eliquis), i-axitinib (i-Inlyta), i-colchicine (i-Colcrys, i-Mitigare), i-dabrafemob (Taflinar), i-darifenacin (Enablex), dasatinib (Sprycel), everolimus (Afinitor, Zortress), ibrutinib (Imbruvica), nilotinib (Tasigna), rivaroxaban powder (Xarelto), salmeterol (Serevent), sildenafil (kuphela uphawu lweRevatio olusetshenziselwa isifo samaphaphu), i-simepreo ), sunitinib (Sutent), tamsulosin (Flomax, eJalyn), temsirolimus (Torisel), trabectedin (Yondelis), kanye ne-vardenafil (Staxyn, Levitra). Udokotela wakho angakutshela ukuthi ungayithathi le mithi ngesikhathi ukwelashwa kwakho futhi namasonto ama-2 ngemuva kokwelashwa kwakho nge-itraconazole.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo kanye nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nanoma yikuphi okulandelayo: imithi elwa namagciwane efana ne-ciprofloxacin (Cipro), i-clarithromycin (i-Biaxin, e-PrevPac), i-erythromycin (i-EES Ery-Tab, abanye), ne-telithromycin (Ketek) ; i-anticoagulant (’’ igazi elinciphileyo ’’) njenge-warfarin (Coumadin, Jantoven); i-alprazolam (Xanax); i-aprepitant (Hlela); i-aripiprazole (Abilify); i-atorvastatin (Lipitor, eCaduet, eLiptruzet); i-bortezomib (iVelcade); i-bosentan (iTracleer); i-budesonide (i-Entocort EC, i-Pulmicort, i-Uceris); i-buprenorphine (iBuprenex, iButrans, eBunavail; abanye); buspirone; i-ciclesonide (i-Alvesco, i-Omnaris, i-Zetonna); i-cilostazol (i-Pletal); i-cinacalcet (i-Sensipar); i-cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); i-dexamethasone; diazepam (Valium); i-digoxin (i-Lanoxin); i-docetaxel (i-Docefrez, i-Taxotere); i-eletriptan (i-Relpax); i-erlotinib (iTarceva); fentanyl (Actiq, Duragesic, Fentora, Subsys, abanye); i-fesoterodine (Toviaz); i-fluticasone (i-Flovent, e-Advair); gefitinib (Iressa); i-haloperidol (iHaldol); Ama-HIV protease inhibitors afaka i-indinavir (Crixivan), darunavir (Prezista) ethathwe nge-ritonavir, fosamprenavir (Lexiva) ethathwe nge-ritonavir, ne-saquinavir (i-Invirase); imatinib (Gleevac); ixabepilone (Ixempra Kit); i-lapatinib (iTykerb); i-maraviroc (i-Selzentry); i-meloxicam (i-Mobic); i-methylprednisolone (iMedrol); i-nadolol (Corgard, eCorzide); i-oxybutynin (Ditropan XL, Oxytrol); i-oxycodone (i-Oxaydo, i-Oxycontin, ePercodan; abanye); i-ponatinib (Iclusig); i-praziquantel (i-Biltricide); i-quetiapine (iSeroquel); i-ramelteon (iRozerem); i-repaglinide (Prandin, ePrandimet); i-riociguat (i-Adempas); i-risperidone (i-Risperdal); i-saxagliptin (iKombiglyze XR, i-Onglyza); i-sirolimus (i-Rapamune); i-solifenacin (i-Vesicare); i-tacrolimus (i-Astagraf, Prograf); i-tadalafil (i-Adcirca, i-Cialis); i-tolterodine (i-Detrol); i-vardenafil (i-Levitra, iStaxyn); i-verapamil (i-Calan, i-Covera, i-Verelan PM, eTarka), i-vinblastine, i-vincristine (i-Marqibo Kit), ne-vinorelbine (i-Navelbine). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-itraconazole, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulezi zinhlu.
• uma uthatha i-antacid, thatha ihora eli-1 ngaphambi noma ngemuva kwamahora ama-2 uthathe i-itraconazole.
• Tshela udokotela wakho uma ngabe uke waba nezimo okukhulunywe ngazo esigabeni ESIBALULEKILE SEXWAYISO ,, i-cystic fibrosis (isifo esizalwa naso esidala izinkinga ngokuphefumula, ukugaya ukudla, nokuzala kabusha), noma yisiphi isimo esinciphisa inani le-asidi esiswini sakho noma i-HIV.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele uthathe i-itraconazole ukwelapha ukhunta lwe-nail uma ukhulelwe noma ungakhulelwa. Ungaqala ukuthatha i-itraconazole ukwelapha ukhunta lwe-nail kuphela ngosuku lwesibili noma lwesithathu esikhathini sakho sokuya esikhathini lapho uqiniseka ukuthi awukhulelwe. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezimbili ngemuva kwalokho. Uma ukhulelwa ngenkathi uthatha i-itraconazole ukwelapha noma isiphi isimo, shayela udokotela wakho.
• kufanele wazi ukuthi i-itraconazole ingakwenza ube nesiyezi noma ikubangele ukufiphala noma umbono ophindwe kabili. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Khuluma nodokotela wakho ngokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Itraconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• igesi noma ukuqunjelwa
• isilungulela
• ukunambitheka okungathandeki
• izinsini ezibuhlungu noma ezophayo
• ikhanda
• isiyezi
• ukujuluka
• ubuhlungu bemisipha noma ubuthakathaka
• ubuhlungu obuhlangene
• kwehle isifiso sobulili noma ikhono
• uvalo
• ukudana
• ukuphuma kwamakhala nezinye izimpawu ezibandayo
• imfiva
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukungaboni kahle noma ukubona kabili
• kukhala ezindlebeni
• ukwehluleka ukulawula ukuchama noma ukuchama ngaphezu kokujwayelekile

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, yeka ukuthatha i-itraconazole bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukukhathala ngokweqile
• ukulahlekelwa isifiso sokudla
• isicanucanu
• ubuhlungu besisu
• ukuhlanza
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo omnyama
• indle ephaphathekile
• imizwa yokuba ndikindiki, ukuhayiza, ukubhoboza, ukushisa, noma ukukhasa esikhunjeni
• ukulahlekelwa ukuzwa
• ukwanda kokuzwela ekukhanyeni
• ukuphazamiseka kwesikhumba okunzima
• ukulahlekelwa ukuzwa
• ukuqubuka
• isifuba
• ukulunywa
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, amaqakala noma imilenze engezansi
• ukushaqeka
• ukuphefumula kanzima noma ukugwinya

Esinye sezithako kusisombululo somlomo se-itraconazole sidale umdlavuza kwezinye izinhlobo zezilwane zaselebhu. Akwaziwa ukuthi abantu abathatha isisombululo i-itraconazole basengozini enkulu yokuba nomdlavuza. Khuluma nodokotela wakho ngezingozi zokuthatha isisombululo se-itraconazole.

I-Itraconazole ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokushisa okweqile, ukukhanya nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yakho ku-itraconazole.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho. Uma usenezimpawu zokutheleleka ngemuva kokuqeda i-itraconazole, shayela udokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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