Inaliti ye-Topotecan

-Delile

• Ngaphambi kokuthola umjovo we-topotecan,
• I-Topotecan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo we-Topotecan kufanele unikezwe kuphela esibhedlela noma emtholampilo ngaphansi kweso lodokotela onolwazi ekusetshenzisweni kwemithi yokwelapha ngamakhemikhali yomdlavuza.

Umjovo we-Topotecan ungadala ukwehla kwenani lamaseli amhlophe egazi (uhlobo lweseli legazi oludingekayo ukulwa nokutheleleka). Lokhu kwandisa ubungozi bokuthi uzoba nesifo esibi noma esisongela impilo. Umjovo we-Topotecan nawo ungadala i-thrombocytopenia (inani elingaphansi kwenani elijwayelekile lama-platelet) elingakhuphula ubungozi bezinkinga zokopha ezinkulu noma ezisongela ukuphila. Udokotela wakho uzo-oda izivivinyo zaselebhu njalo ngaphambi nangesikhathi sokwelashwa kwakho ukuze abheke ukuthi umzimba wakho unamaseli amhlophe egazi anele noma amaplatelets. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukugodola, ukukhwehlela, ukulimaza noma ukopha okungavamile, ukushisa ukuchama, noma ezinye izimpawu zokutheleleka.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-topotecan.

Umjovo we-Topotecan usetshenziselwa ukwelapha umdlavuza we-ovari (umdlavuza oqala ezithweni zokuzala zabesifazane lapho kwakhiwa khona amaqanda) nomdlavuza omncane wamaphaphu wamangqamuzana (uhlobo lomdlavuza oqala emaphashini) osakazekile futhi awuzange uthuthuke ngemuva kokwelashwa ngeminye imithi . Iphinde isetshenziswe kanye neminye imishanguzo yokwelapha umdlavuza womlomo wesibeletho (umdlavuza oqala ekuvulekeni kwesibeletho [isibeletho]) ongakathuthuki noma obuyile ngemuva kokunye ukwelashwa. I-Topotecan isekilasini lemithi ebizwa nge-topoisomerase type I inhibitors. Isebenza ngokubulala amangqamuzana omdlavuza.

ITototecan iza njengoketshezi okufanele lunikezwe ngemithambo yegazi (emthanjeni) ngaphezu kwemizuzu engama-30 ngudokotela noma umhlengikazi esibhedlela noma emtholampilo. Lapho umjovo we-topotecan usetshenziselwa ukwelapha umdlavuza we-ovari noma wamaphaphu, uvame ukunikezwa kanye ngosuku izinsuku ezinhlanu zilandelana njalo ezinsukwini ezingama-21. Lapho umjovo we-topotecan usetshenziselwa ukwelapha umdlavuza womlomo wesibeletho, uvame ukunikezwa kanye ngosuku izinsuku ezintathu zilandelana njalo ezinsukwini ezingama-21. Mhlawumbe uzothola okungenani imijikelezo engu-4 yokwelashwa ngoba kungathatha isikhathi esithile ukusho ukuthi isimo sakho siphendulile yini kulowo muthi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-topotecan,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji kumjovo we-topotecan, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-topotecan. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthola umjovo we-topotecan. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthola umjovo we-topotecan, shayela udokotela wakho ngokushesha. Umjovo we-Topotecan ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthola umjovo we-topotecan.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-topotecan.
• kufanele wazi ukuthi umjovo we-topotecan ungakwenza uzizwe ukhathele kakhulu noma ubuthakathaka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Shayela udokotela wakho ngokushesha uma ungakwazi ukugcina i-aphoyintimenti ukuze uthole umthamo womjovo we-topotecan.

I-Topotecan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukulahlekelwa isifiso sokudla
• isisu noma iqolo
• izilonda zomlomo
• ikhanda
• ukuncipha noma ukulahleka kwezinwele
• ububomvu noma ukulinyazwa endaweni lapho kwajova khona umuthi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukukhathala ngokweqile
• ubuthakathaka
• isikhumba esiphaphathekile
• ukuphelelwa umoya
• ubuhlungu besifuba
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ukuba ndikindiki, ukuhayiza, noma ukuzwa ukushisa ezandleni noma ezinyaweni
• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi

I-Topotecan ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela.Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Hycamtin^®