Ukuhlolwa kwe-Antineutrophil Cytoplasmic Antibodies (ANCA)

-Delile

• Kuyini ukuhlolwa kwe-antineutrophil cytoplasmic antibodies (ANCA)?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kwe-ANCA?
• Kwenzekani ngesikhathi sokuhlolwa kwe-ANCA?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-ANCA?
• Izinkomba

Kuyini ukuhlolwa kwe-antineutrophil cytoplasmic antibodies (ANCA)?

Lokhu kuhlolwa kubheka ama-antineutrophil cytoplasmic antibodies (ANCA) egazini lakho. Ama-antibody amaprotheni enziwa amasosha akho omzimba ukulwa nezinto zangaphandle njengamagciwane namagciwane. Kepha ama-ANCAs ahlasela amaseli aphilile aziwa ngama-neutrophil (uhlobo lweseli elimhlophe) ngephutha. Lokhu kungaholela ekuphazamisekeni okwaziwa njenge-autoimmune vasculitis. I-autoimmune vasculitis ibangela ukuvuvukala nokuvuvukala kwemithambo yegazi.

Imithambo yegazi ithwala igazi lisuke enhliziyweni yakho liye ezingalweni zakho, ezicutshini, nakwezinye izinhlelo, bese libuya futhi. Izinhlobo zemithambo yegazi zifaka imithambo yegazi, imithambo, nama-capillaries. Ukuvuvukala emithanjeni yegazi kungadala izinkinga ezinkulu zempilo. Izinkinga ziyahlukahluka kuye ngokuthi imiphi imithambo yegazi nezinhlelo zomzimba ezithintekayo.

Kunezinhlobo ezimbili eziyinhloko ze-ANCA. Ngamunye uhlose amaprotheni athile ngaphakathi kwamangqamuzana amhlophe egazi:

• i-pANCA, ehlose iprotheni ebizwa nge-MPO (myeloperoxidase)
• I-cANCA, ehlose iphrotheni ebizwa nge-PR3 (proteinase 3)

Ukuhlola kungakhombisa ukuthi unalo yini uhlobo noma zombili izinhlobo zama-antibody. Lokhu kungasiza umhlinzeki wakho wezokunakekelwa kwempilo ukuthi abone futhi aphathe ukuphazamiseka kwakho.

Amanye amagama: Amasosha omzimba we-ANCA, i-cANCA pANCA, amasosha omzimba we-cytoplasmic neutrophil, serum, anticytoplasmic autoantibodies

Kusetshenziselwa ini?

Ukuhlolwa kwe-ANCA kuvame ukusetshenziselwa ukuthola ukuthi unalo yini uhlobo lwe-vasculitis elizimele. Kunezinhlobo ezahlukahlukene zalesi sifo. Zonke zidala ukuvuvukala nokuvuvukala kwemithambo yegazi, kepha uhlobo ngalunye luthinta imithambo yegazi ehlukene nezitho zomzimba. Izinhlobo ze-vasculitis ezizimele zifaka:

• IGranulomatosis ene-polyangiitis (GPA), ngaphambili sasibizwa ngesifo sika-Wegener. Imvamisa kuthinta amaphaphu, izinso nezinsimbi.
• I-Microscopic polyangiitis (MPA). Lesi sifo singathinta izitho eziningana emzimbeni, kufaka phakathi amaphaphu, izinso, uhlelo lwezinzwa, nesikhumba.
• I-granulomatosis ye-eosinophilic ene-polyangiitis (EGPA), phambilini ebibizwa ngeChurg-Strauss syndrome. Lesi sifo sivame ukuthinta isikhumba namaphaphu. Imvamisa kubangela isifuba somoya.
• I-Polyarteritis nodosa (PAN). Lesi sifo sivame ukuthinta inhliziyo, izinso, isikhumba, nesistimu yezinzwa emaphakathi.

Ukuhlolwa kwe-ANCA kungasetshenziswa futhi ukuqapha ukwelashwa kwalezi zinkinga.

Kungani ngidinga ukuhlolwa kwe-ANCA?

Umhlinzeki wakho wezokunakekelwa kwempilo anga-oda ukuhlolwa kwe-ANCA uma unezimpawu ze-autoimmune vasculitis. Izimpawu zifaka:

• Imfiva
• Ukukhathala
• Ukwehla kwesisindo
• Ubuhlungu bemisipha kanye / noma obuhlangene

Izimpawu zakho zingathinta futhi isitho esisodwa noma ngaphezulu emzimbeni wakho. Izitho ezithinteka ngokujwayelekile nezimpawu ezizibangelayo zifaka:

• Amehlo
  • Ububomvu
  • Ukubona okufiphele
  • Ukulahleka kombono
• Izindlebe
  • Ukukhala ezindlebeni (tinnitus)
  • Ukulahlekelwa ukuzwa
• Izono
  • Ubuhlungu besono
  • Iphunga eligijimayo
  • Kuphuma igazi ekhaleni
• Isikhumba
  • AmaRash
  • Izilonda noma izilonda, uhlobo lwesilonda esijulile esephuzayo ukuphola futhi / noma esilokhu sibuya
• Amaphaphu
  • Khwehlela
  • Ukuphefumula kanzima
  • Ubuhlungu besifuba
• Izinso
  • Igazi emchameni
  • Umchamo wegwebu, obangelwa amaprotheni emchameni
• Uhlelo lwezinzwa
  • Ukuba ndikindiki nokushosheka ezingxenyeni ezihlukene zomzimba

Kwenzekani ngesikhathi sokuhlolwa kwe-ANCA?

Uchwepheshe wezempilo uzothatha isampula yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Awudingi amalungiselelo akhethekile wokuhlolwa kwe-ANCA.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Isho ukuthini imiphumela?

Uma imiphumela yakho ibingeyinhle, kusho ukuthi izimpawu zakho kungenzeka azibangelwa yi-autoimmune vasculitis.

Uma imiphumela yakho ibimihle, kungasho ukuthi une-vasculitis ezenzakalelayo. Ingakhombisa nokuthi ngabe ama-cANCA noma ama-pANCA atholakele. Lokhu kungasiza ekunqumeni ukuthi yiluphi uhlobo lwe-vasculitis onalo.

Akunandaba ukuthi yiluphi uhlobo lwama-antibodies atholakele, ungadinga ukuhlolwa okwengeziwe, okwaziwa njenge-biopsy, ukuqinisekisa ukuxilongwa. I-biopsy inqubo esusa isampula elincane lezicubu noma amaseli wokuhlola. Umhlinzeki wakho wezokunakekelwa kwempilo naye anga-oda ukuhlolwa okwengeziwe ukukala inani le-ANCA egazini lakho.

Uma okwamanje welashelwa i-autoimmune vasculitis, imiphumela yakho ingakhombisa ukuthi ukwelashwa kwakho kuyasebenza yini.

Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi ngokuhlolwa kwe-ANCA?

Uma imiphumela yakho ye-ANCA ikhombisa ukuthi une-vasculitis ezenzakalelayo, kunezindlela zokwelapha nokuphatha lesi simo. Ukwelashwa kungabandakanya umuthi, izindlela zokwelapha ezisusa ama-ANCA okwesikhashana egazini lakho, kanye / noma ukuhlinzwa.

Izinkomba

1. I-Allina Health [Inthanethi]. IMinneapolis: Impilo ka-Allina; Isilinganiso se-C-ANCA; [kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://account.allinahealth.org/library/content/49/150100
2. I-Allina Health [Inthanethi]. IMinneapolis: Impilo ka-Allina; Ukukalwa kwe-P-ANCA; [kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://account.allinahealth.org/library/content/49/150470
3. Umtholampilo waseCleveland [Inthanethi]. I-Cleveland (OH): Umtholampilo waseCleveland; c2019. Izilonda Zemilenze Nezinyawo; [kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2019. Ama-antibody e-ANCA / MPO / PR3; [kubuyekezwe 2019 Ephreli 29; kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2019. Isidumbu; [kubuyekezwe 2017 Jul 10; kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/glossary/biopsy
6. Ukuhlolwa Kwelebhu Ku-inthanethi [i-Intanethi]. IWashington DC: I-American Association for Clinical Chemistry; c2001–2019. I-Vasculitis; [kubuyekezwe i-2017 Sep 8; kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-2]. Kutholakala kusuka: https://labtestsonline.org/conditions/vasculitis
7. UMansi IA, Opran A, uRosner F. ANCA-Isikebhe Esincane Esihlotshaniswa Ne-Vessel Vasculitis. Ngingudokotela We-Fam [Inthanethi]. 2002 Ephreli 15 [icashunwe ngo-2019 Meyi 3]; 65 (8): 1615-1621. Kutholakala kusuka: https://www.aafp.org/afp/2002/0415/p1615.html
8. IMayo Clinic Laboratories [i-Intanethi]. IMayo Foundation for Medical Education and Research; c1995–2019. I-ID Yokuhlola: I-ANCA: AmaCytoplasmic Neutrophil Antibodies, iSerum: Clinical and Interpretive; [kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-4]. Kutholakala kusuka: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. I-National Heart, Lung, ne-Blood Institute [i-Intanethi]. I-Bethesda (MD): UMnyango Wezempilo kanye Nezinsizakalo Zabantu e-U.S. Ukuhlolwa Kwegazi; [kucashunwe ngo-2019 Meyi 3]; [cishe izikrini ezi-3]. Kutholakala kusuka: https://www.nhlbi.nih.gov/health-topics/blood-tests
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Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.