Buza Uchwepheshe: UDkt Amesh Adalja Ngezindlela Ezintsha Zokwelapha I-Hepatitis C

-Delile

• Iyini i-Hepatitis C, futhi yehluka kanjani kwezinye izinhlobo ze-Hepatitis?
• Yiziphi Izifundo Ezijwayelekile Zokwelapha?
• Yiziphi Izinhlobo Zokwelapha Ezintsha Ezizuzayo, Futhi Zibonakala Ziphumelela Kangakanani?
• Ngabe Lezi Zindlela Zokwelapha Ezintsha Ziqhathaniswa Kanjani Nezokwelapha Okujwayelekile?
• Iziguli Kufanele Zenze Kanjani Izinqumo Zazo Zokwelapha?

Sixoxisane noDkt Amesh Adalja, uchwepheshe wezifo ezithathelwanayo e-University of Pittsburgh Medical Center, mayelana nokuhlangenwe nakho kwakhe ngokwelapha isifo sokusha kwesibindi kohlobo C (HCV). Uchwepheshe kulo mkhakha, uDkt. Adalja unikeza ukubuka konke nge-HCV, ukwelashwa okujwayelekile, kanye nokwelashwa okusha okuthokozisayo okungaguqula umdlalo weziguli ze-hepatitis C yonke indawo.

Iyini i-Hepatitis C, futhi yehluka kanjani kwezinye izinhlobo ze-Hepatitis?

I-Hepatitis C wuhlobo lwesifo sokusha kwesibindi kohlobo lwegciwane esihlukile kwezinye izinhlobo zesifo sokusha kwesibindi kohlobo lwegciwane lesandulela ngculaza ngoba sinokuthambekela ekubeni yisifo esingelapheki futhi singaholela esibindini sokuqina kwesibindi, umdlavuza wesibindi, nakwezinye izinkinga zesistimu. Ithelela cishe e-US futhi futhi iyimbangela ehamba phambili yesidingo sokufakelwa kwesibindi. Isakazeka ngokuchayeka kwegazi njengokumpontshelwa igazi (ngaphambi kokuhlolwa), ukusetshenziswa kwezidakamizwa zomjovo futhi kuyaqabukela ngokuxhumana ngokocansi. I-Hepatitis A ayinaso isimo esingalapheki, iyagwenyelwa umuthi wokugoma, isatshalaliswa umzila womlomo womlomo, futhi ayiholeli esibindini sesibindi kanye / noma umdlavuza. I-Hepatitis B, nayo ethwalwa ngegazi futhi ekwaziyo ukudala isifo sokuqina kwesibindi nomdlavuza, umuthi wokugoma uyavikeleka futhi usakazeka kalula ngokuxhumana ngokocansi nokusuka komama uye ezinganeni zabo ngesikhathi sokukhulelwa nokuzalwa. I-Hepatitis E ifana kakhulu nesifo sokusha kwesibindi kohlobo A kodwa, ezimweni ezingandile, ingaba yisifo esingelapheki, futhi ibuye ibe nezinga eliphezulu lokufa kwabesifazane abakhulelwe.

Yiziphi Izifundo Ezijwayelekile Zokwelapha?

Izifundo zokwelashwa kwesifo sokusha kwesibindi kohlobo C zincike ngokuphelele ekutheni hlobo luni lwe-hepatitis C umuntu alugcinayo. Kunezakhi zofuzo eziyisithupha zesifo sokusha kwesibindi kohlobo C kanti ezinye kulula ukuzelapha kunezinye. Ngokuvamile, ukwelashwa kwesifo sokusha kwesibindi kohlobo C kubandakanya inhlanganisela yemithi emibili kuya kwemithathu, imvamisa kufaka phakathi i-interferon, enikezwa okungenani amasonto ayi-12.

Yiziphi Izinhlobo Zokwelapha Ezintsha Ezizuzayo, Futhi Zibonakala Ziphumelela Kangakanani?

Ukwelashwa okusha okuthokozisa kakhulu i-sofavbuvir yemithi elwa namagciwane, ekhonjiswe ukuthi ayisebenzi nje kuphela, kepha futhi inamandla okunciphisa kakhulu izifundo zokwelashwa ezisuka emikhakheni emide kakhulu ngaphambi kokwethulwa kwayo.

I-Sofosbuvir isebenza ngokuvimbela i-enzyme yegciwane i-RNA polymerase. Le yindlela igciwane elikwazi ngayo ukuzenzela amakhophi. Ekuvivinyweni komtholampilo lo muthi, uhlanganisiwe, wakhonjiswa ukuthi usebenza kahle kakhulu ekucindezeleni igciwane ngokushesha nangokuqina, uvumela ukufinyezwa okuphawulekayo kwemithi yokwelashwa. Yize ezinye izidakamizwa zikhombe le enzyme, ukwakheka kwalesi sidakamizwa ukuthi kuguqulwe ngokushesha nangendlela efanelekile kube yimo esebenzayo emzimbeni, kuvumela ukuvinjelwa okunamandla kwe-enzyme. USofosbuvir wayekhona

Futhi, kwezinye izimo, inhlanganisela yezidakamizwa engafaki i-interferon-esabekayo ngephrofayili yayo engathandeki ye-side-profile nayo ingasetshenziswa. [Yize isebenza ngempumelelo, i-interferon aziwa kakhulu ngokubangela ukucindezeleka nezimpawu ezifana nomkhuhlane. ISofosbuvir kwakuyisidakamizwa sokuqala esivunyelwe i-FDA ukuthi sisetshenziswe ngaphandle kokubambisana kwe-interferon kwezinye izimo.]

Ngabe Lezi Zindlela Zokwelapha Ezintsha Ziqhathaniswa Kanjani Nezokwelapha Okujwayelekile?

Inzuzo, njengoba ngishilo ngenhla, ukuthi ama-regimens amasha amafushane, ayabekezeleleka futhi asebenza kahle. Okubi ukuthi izidakamizwa ezintsha zibiza kakhulu. Kodwa-ke, uma umuntu ebheka umongo ophelele, ofaka izindleko zokwenziwa kwezidakamizwa ezitholakele, ngenxa yekhono lokuvimbela izinkinga ezibucayi kakhulu nezibizayo zokutheleleka nge-hepatitis C, le mithi emisha iyisengezo esamukelekile kakhulu ku-arsenal.

Iziguli Kufanele Zenze Kanjani Izinqumo Zazo Zokwelapha?

Ngingancoma ukuthi iziguli zithathe izinqumo zokwelashwa ngokubambisana nodokotela wazo ngemuva kwengxoxo yesimo samanje sokutheleleka kwazo, isimo samanje sesibindi sabo, kanye nokukwazi kwabo ukunamathela emithini.