Umlobi: Roger Morrison
Usuku Lokudalwa: 17 Usepthemba 2021
Ukuvuselela Usuku: 1 Ujulayi 2024
Anonim
Aubagio (Teriflunomide) Trial Information
Ividiyo: Aubagio (Teriflunomide) Trial Information

-Delile

Kuyini i-Aubagio?

I-Aubagio ngumuthi kadokotela ogama lomuthi. Isetshenziselwa ukwelapha amafomu abuyela emuva e-multiple sclerosis (MS) kubantu abadala. I-MS yisifo lapho amasosha akho omzimba ehlasela khona isimiso sakho sezinzwa esiyinhloko.

I-Aubagio iqukethe izidakamizwa teriflunomide, eyi-pyrimidine synthesis inhibitor. Izidakamizwa kuleli klasi zisiza ukuvimbela amaseli omzimba ekuphindaphindaneni ngokushesha. Lesi senzo sisiza ukunciphisa ukuvuvukala (ukuvuvukala).

I-Aubagio iza njengethebhulethi oyigwinyayo. Isidakamizwa sitholakala ngamandla amabili: 7 mg no-14 mg.

I-Aubagio yaqhathaniswa ne-placebo (akukho ukwelashwa) ezivivinyweni ezine zokwelashwa. Abantu abathathe i-Aubagio babene:

  • ukubuyela emuva okumbalwa (ama-flare-ups)
  • ukuqhubeka kancane kokukhubazeka (ukukhubazeka kwabo ngokomzimba akuzange kubhebhetheke ngokushesha okukhulu)
  • ingozi ephansi yezilonda ezintsha (izicubu ezibomvu) ebuchosheni

Ngemininingwane ethile kusuka kulezi zifundo, bheka isigaba "se-Aubagio uses".

I-Aubagio ejwayelekile

I-Aubagio okwamanje itholakala kuphela njengomuthi wegama lomkhiqizo.


I-Aubagio iqukethe isithako esisebenzayo se-teriflunomide. Ku-2018, i-Food and Drug Administration (i-FDA) ivume uhlobo olujwayelekile lwe-teriflunomide, kodwa ayikatholakali okwamanje.

Imiphumela emibi ye-Aubagio

I-Aubagio ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha i-Aubagio. Lolu hlu alufaki yonke imiphumela emibi engaba khona.

Ngeminye imininingwane ngemiphumela engemihle ye-Aubagio, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu wokuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi ekhathazayo.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Aubagio ingafaka:

  • ikhanda
  • i-alopecia (ukuncipha kwezinwele noma ukulahleka kwezinwele)
  • kwehle amazinga e-phosphate
  • amazinga anciphile wamaseli amhlophe egazi
  • isicanucanu
  • isifo sohudo
  • amazinga akhuphukile ama-enzyme wesibindi (kungaba uphawu lokulimala kwesibindi)
  • ukwanda komfutho wegazi
  • ukuba ndikindiki noma ukuncinza ezandleni noma ezinyaweni
  • ubuhlungu obuhlangene

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.


Imiphumela emibi kakhulu

Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

  • Ukusabela okweqile. Izimpawu zingafaka:
    • ukuvuvukala ebusweni noma ezandleni zakho
    • ukulunywa noma isifuba
    • ukuvuvukala noma ukuncinza emlonyeni noma emphinjeni
    • ukuqina kwesifuba
    • inkinga yokuphefumula
  • Ukulimala kwesibindi, kufaka phakathi ukwehluleka kwesibindi. Izimpawu zezinkinga zesibindi zingafaka:
    • isicanucanu
    • ukuhlanza
    • ubuhlungu esiswini sakho
    • ukulahlekelwa isifiso sokudla
    • ukukhathala
    • umchamo omnyama
    • ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho
  • Amazinga aphansi amangqamuzana amhlophe egazi. Izimpawu zingafaka:
    • imfiva
    • ukukhathala
    • Ubuhlungu bomzimba
    • Ukugodola
    • isicanucanu
    • ukuhlanza
  • Ukusabela kwesikhumba okunzima. Izimpawu zingafaka:
    • I-Stevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emphinjeni, emehlweni noma ezithweni zangasese)
    • ukulinyazwa noma ukopha okungachazeki
    • ukuvuvukala
    • isikhumba esinamabala noma esikhwezayo
    • izilonda emlonyeni wakho, emehlweni, ekhaleni, noma emphinjeni
  • Umfutho wegazi ophezulu. Izimpawu zingafaka:
    • ikhanda
    • ukukhathala noma ukudideka
    • umbono uyashintsha
    • ukushaya kwenhliziyo okungajwayelekile
  • Izinkinga zokuphefumula, kufaka phakathi isifo samaphaphu esiphakathi. Izimpawu zingafaka:
    • ukuphelelwa umoya
    • ukukhwehlela ngomkhuhlane noma ngaphandle kwawo

Imininingwane yomphumela oseceleni

Ungazibuza ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi, noma ukuthi imiphumela ethile engemihle ihlobene nawo yini. Nayi imininingwane ngeminye imiphumela engemihle lo muthi ongadala noma ongabanga ngayo.


Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba nokungezwani komzimba ngemuva kokuthatha i-Aubagio. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okubi kakhulu zingabandakanya:

  • i-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo)
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula
  • isikhumba esibomvu noma esikhanyayo

Shayela udokotela wakho khona manjalo uma une-reaction engathí sina ye-Aubagio. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Izinkinga zesikhumba / ukuqubuka

I-Aubagio ingadala ukusabela okukhulu kwesikhumba. Lokhu kufaka phakathi iStevens-Johnson syndrome, esiphuthumayo kwezokwelapha. Kubangela izilonda ezibuhlungu emlonyeni wakho, emphinjeni, emehlweni noma esithweni sangasese.

Kwabikwa ukuthi umuntu oyedwa owathatha i-Aubagio waba ne-epidermal necrolysis (TEN) enobuthi, eyabulala. I-TEN yisifo i-Stevens-Johnson syndrome esithinta umzimba wakho ngaphezu kuka-30%. Kuqala njengokuqubuka okubuhlungu okunezimpawu ezifana nomkhuhlane, bese kuvela amabhamuza.

Uma isikhumba sakho siyaxebuka noma sibe bomvu, sivuvuke, noma sibe namabhamuza, tshela udokotela wakho khona manjalo. Uma une-Stevens-Johnson syndrome noma i-TEN, kungadingeka ukuthi ulaliswe esibhedlela.

Ukulimala kwesibindi

Ekuvivinyweni kwemitholampilo, cishe abantu abangu-6% abathathe i-Aubagio babenezinga eliphezulu lama-enzyme wesibindi. Cishe i-4% yabantu ababene-placebo (ingekho imishanguzo) babenyuse amazinga e-enzyme yesibindi.

I-Aubagio ingakhuphula amazinga ama-enzyme wesibindi, okungaba uphawu lwezinkinga ezinkulu zesibindi. Tshela udokotela wakho uma unanoma iyiphi yalezi zimpawu:

  • isicanucanu
  • ukuhlanza
  • ubuhlungu esiswini sakho
  • ukulahlekelwa isifiso sokudla
  • ukukhathala
  • umchamo omnyama
  • ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho

Ngaphambi kokuba uqale ukuthatha i-Aubagio, udokotela wakho uzokunika ukuhlolwa kwegazi ukuze uhlole ukusebenza kwesibindi sakho. Bazokunika nokuhlolwa kwanyanga zonke ngenkathi uthatha i-Aubagio ukubona ukuthi isibindi sakho sisebenza kanjani.

Ukulahleka kwezinwele

Omunye wemiphumela emibi kakhulu ye-Aubagio yi-alopecia (ukuncipha kwezinwele noma ukulahleka kwezinwele).

Ekuhlolweni kwemitholampilo, cishe abantu abayi-13% abathathe i-Aubagio babene-alopecia. Iningi labantu linezimpawu ze-alopecia zingakapheli izinyanga ezintathu zithathiwe. I-Alopecia yahlala ngaphansi kwezinyanga eziyisithupha ngokwesilinganiso. Lo mphumela ohlangothini ubungowesikhashana, futhi amacala amaningi athuthukile njengoba abantu beqhubeka nokuthatha i-Aubagio.

Uma uthatha i-Aubagio futhi ukhathazekile ngokulahleka kwezinwele, khuluma nodokotela wakho.

Uhudo

Uhudo kungumphumela ojwayelekile we-Aubagio.

Ezivivinyweni zokwelashwa, cishe abantu abangu-14% abathathe i-Aubagio babenehudo. Lokhu kwaqhathaniswa nabantu abangu-8% ababene-placebo (ingekho imishanguzo). Izimo eziningi zohudo bezimaphakathi ukuya kokulingene futhi zihambe zodwa.

Ukwelapha isifo sohudo, phuza amanzi amaningi noma izixazululo ze-electrolyte ukusiza umzimba wakho ukuthi ubuyisele uketshezi olulahlekile. Uma isifo sohudo sithatha izinsuku ezimbalwa, shayela udokotela wakho. Bangaphakamisa izindlela zokunciphisa izimpawu zakho.

PML (hhayi umphumela ohlangothini)

I-leukoencephalopathy ye-multifocal eqhubekayo (PML) ayiwona umphumela we-Aubagio. I-PLM yisifo esihlasela isimiso sakho sezinzwa esiyinhloko.

Embikweni wecala, umuntu oyedwa uthuthukise i-PML ngemuva kokushintshela ku-Aubagio esuka ku-natalizumab, umuthi osetshenziselwa ukwelapha i-multiple sclerosis (MS). I-natalizumab yezidakamizwa inesixwayiso esibhokisi esivela ku-Food and Drug Administration (FDA) maqondana nengozi eyandayo yokuthuthukisa i-PML. Isexwayiso esibhakeleni yisixwayiso esibi kakhulu esivela ku-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Akunakwenzeka ukuthi i-Aubagio ibangele ukuthi umuntu athuthukise i-PML. Kungenzeka ukuthi i-natalizumab ibangele lokho.

Uma ushintshela ku-Aubagio ngemuva kokuthatha i-natalizumab, udokotela wakho uzokuhlolela i-PML.

Ukukhathala (hhayi umphumela ohlangothini)

Ukukhathala (ukungabi namandla) akuyona imiphumela ejwayelekile ye-Aubagio. Kodwa-ke, ukukhathala kuyisifo esivamile se-multiple sclerosis (MS). Ukukhathala nakho kungaba uphawu lokulimala kwesibindi.

Uma ukhathazekile ngokukhathala ngenkathi uthatha i-Aubagio, khuluma nodokotela wakho. Bangakwazi ukuhlola izimbangela ezingaba khona futhi basikisele izindlela zokuthuthukisa amandla akho.

Ukwehla kwesisindo noma ukuzuza kwesisindo (hhayi umphumela ohlangothini)

Ukwehla kwesisindo nokuzuza kwesisindo kwakungeyona imiphumela emibi ye-Aubagio ezifundweni zokwelashwa. Ngeke wehle noma uthole isisindo ngenkathi uthatha i-Aubagio.

Kodwa-ke, esinye sezimpawu ezivame kakhulu ze-multiple sclerosis (MS) ukukhathala (ukungabi namandla). Lapho izinga lakho lamandla liphansi, ungahle ungasebenzi kangako. Lokhu kungaholela ekutheni ukhuluphale. Uma futhi unengcindezelo, ungahle uthande ukudla kakhulu noma okuncane kakhulu, okungaholela ekutholeni isisindo noma ekwehliseni isisindo.

Uma ukhathazekile ngoshintsho kusisindo sakho, khuluma nodokotela wakho. Bangaphakamisa amathiphu wokudla awusizo noma bancome isazi sokudla ukuze baqiniseke ukuthi uthola umsoco ofanele.

Umdlavuza (hhayi umphumela ohlangothini)

Ukuthatha imithi ethinta amasosha akho omzimba, njenge-Aubagio, kungakhuphula ingozi yokuba nomdlavuza. Kodwa-ke, izivivinyo zomtholampilo ze-Aubagio azange zibike ukwanda kwenani labantu ababa nomdlavuza.

Uma ukhathazekile ngokuhlaselwa umdlavuza, khuluma nodokotela wakho.

Ukucindezeleka (hhayi umphumela ohlangothini)

Ukudangala akuwona umphumela ohlangothini lwe-Aubagio. Noma kunjalo, ukucindezeleka kuyisifo esivamile se-MS.

Uma unezimpawu zokucindezeleka, yazisa udokotela wakho. Izidakamizwa eziningana zokulwa nokudangala ziyatholakala ezingasiza ekunciphiseni izimpawu zakho.

Izindleko ze-Aubagio

Njengayo yonke imithi, izindleko ze-Aubagio zingahluka.

Inani langempela ozolikhokha lizoxhomeka kumshwalense wakho, indawo okuyo nasekhemisi oyisebenzisayo.

Usizo lwezezimali

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Aubagio, usizo luyatholakala. IGenzyme Corporation, umenzi we-Aubagio, unikela ngohlelo lwe-Aubagio Co-Pay. Ngeminye imininingwane nokuthola ukuthi uyakufanelekela yini ukwesekwa, shayela ku-855-676-6326 noma uvakashele iwebhusayithi yohlelo.

I-Aubagio isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana ne-Aubagio ukwelapha izimo ezithile.

I-Aubagio ye-MS

I-Aubagio ivunyelwe yi-FDA ukwelapha abantu abadala abanezinhlobo eziphindayo ze-multiple sclerosis (MS). I-MS yisifo esingelapheki (sesikhathi eside) esibangela ukuthi amasosha omzimba wakho ahlasele i-myelin (ungqimba lwangaphandle) emithanjeni esemehlweni akho, ebuchosheni nasemgogodleni. Lokhu kudala izicubu ezibomvu, ezenza kube nzima ebuchosheni bakho ukuthumela amasiginali kwezinye izingxenye zomzimba wakho.

Esivivinyweni somtholampilo, abantu abangaphezu kuka-1 000 ababene-MS ebuyela emuva (ama-flare-ups) bathatha i-Aubagio noma i-placebo (akukho ukwelashwa). Eqenjini le-Aubagio, ama-57% abo ahlala engabuyeli emuva ngenkathi ethatha umuthi. Lokhu kwaqhathaniswa ne-46% yeqembu le-placebo. Abantu abathathe i-Aubagio baphinde babuyela emuva okuncane ngama-31% kunabantu abathathe i-placebo.

Isivivinyo esifanayo somtholampilo sikhombisile ukuthi, uma kuqhathaniswa neqembu le-placebo, abantu abathathe i-Aubagio babene:

  • ukubuyela emuva okukodwa njalo eminyakeni eyisithupha ngenkathi uthatha umuthi
  • ukuqhubeka kancane kokukhubazeka (ukukhubazeka kwabo ngokomzimba akuzange kubhebhetheke ngokushesha okukhulu)
  • izilonda ezintsha ezimbalwa (izicubu ezibomvu) ebuchosheni

Ezinye izifundo zihlolisise ukuthi i-Aubagio isebenza kanjani:

  • Kokunye ukuhlolwa kwasemtholampilo, cishe abantu abangama-72% abathathe i-Aubagio bahlala bengenakho ukubuyela emuva ngesikhathi kufundwa. Lokhu kwaqhathaniswa nabantu abangama-62% abathatha i-placebo.
  • Izifundo ezimbili zokwelashwa zabheka abantu abane-MS ebuyela emuva. Kokunye ukuhlola, labo abathathe i-Aubagio babebuyela emuva okumbalwa ngama-31% kunabantu abathathe i-placebo. Kokunye ukufunda, lelo nani lalingama-36%.
  • Ezivivinyweni zokwelashwa, okungenani ama-80% abantu abathathe i-Aubagio babengenayo inqubekela phambili ekukhubazekeni kwabo. Lokhu kusho ukuthi ukukhubazeka kwabo ngokomzimba akuzange kubhebhetheke ngokushesha okukhulu. Kwabaningi balaba bantu, lo mphumela uthathe iminyaka engu-7.5.

Kwesinye isifundo somtholampilo, abantu bathathe i-Aubagio kuma-14-mg noma ama-7-mg doses. Abaphenyi bathole ukuthi uma kuqhathaniswa nabantu abathathe i-placebo:

  • Ama-80% abantu abaseqenjini ledosi le-14-mg babenezilonda ezintsha ezimbalwa
  • Ama-57% abantu abaseqenjini ledosi le-7-mg babenezilonda ezintsha ezimbalwa

I-Aubagio notshwala

Akukho ukuxhumana okwaziwayo phakathi kwe-Aubagio notshwala. Kodwa-ke, ukuphuza utshwala ngenkathi uthatha i-Aubagio kungakhuphula ubungozi bakho bemiphumela emibi, efana nale:

  • isicanucanu
  • isifo sohudo
  • ikhanda

Ukuphuza kakhulu utshwala ngenkathi uthatha i-Aubagio kungakhuphula nobungozi bokulimala kwesibindi.

Uma uthatha i-Aubagio, khuluma nodokotela wakho mayelana nokuthi kuphephile yini ukuphuza utshwala.

Ukusebenzisana kwe-Aubagio

I-Aubagio ingaxhumana neminye imithi eminingana. Ingabuye ihlanganyele nezithako ezithile nokudla.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kungakhuphula inani lemiphumela emibi noma kubenze babe nzima kakhulu.

I-Aubagio neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana ne-Aubagio. Lolu hlu alunazo zonke izidakamizwa ezingasebenzisana ne-Aubagio.

Ngaphambi kokuthatha i-Aubagio, khuluma nodokotela wakho nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Umuthi wokugomela i-Aubagio nomkhuhlane

Kuphephile ukuthola umkhuhlane ngenkathi uthatha i-Aubagio. Umuthi wokugomela umkhuhlane awusebenzi, okusho ukuthi wenziwe ngegciwane elibulewe.

Umuthi wokugoma ophilayo ngakolunye uhlangothi, yilowo oqukethe uhlobo olubuthakathaka lwegciwane. Uma unamasosha omzimba abuthakathaka, uvamise ukwelulekwa ngokumelene nokuthola imigomo ebukhoma. Lokhu kungenxa yokuthi ezikhathini ezingavamile kakhulu, imithi yokugoma ephilayo ingashintsha ibuyele kugciwane elinamandla agcwele elibanga isifo. Uma lokhu kwenzeka, abantu abanamasosha omzimba abuthakathaka bangaba nengozi enkulu kakhulu yokuthuthukisa isifo umgomo ohlose ukusivikela.

Uma uthatha i-Aubagio, akufanele uthole imigomo ebukhoma. I-Aubagio ingawenza buthakathaka amasosha akho omzimba, ngakho-ke ukuthola umuthi wokugoma bukhoma kungakubeka engcupheni yokugula lo mgomo okufanele ukuvikele kuwo.

Uma unemibuzo mayelana nokuthola imigomo ngenkathi uthatha i-Aubagio, khuluma nodokotela wakho.

I-Aubagio ne-leflunomide

I-Arava (leflunomide) yisidakamizwa esisetshenziselwa ukwelapha i-rheumatoid arthritis (RA). Ukuthatha i-Aubagio nge-leflunomide kungakhuphula inani le-Aubagio emzimbeni wakho. Lokhu kungalimaza isibindi sakho. Ungathathi i-Aubagio ne-leflunomide ndawonye.

Uma uthatha i-Arava futhi udinga ukuthatha i-Aubagio, khuluma nodokotela wakho. Bangaphakamisa umuthi ohlukile we-RA.

I-Aubagio ne-warfarin

Ukuthatha i-Aubagio nge-warfarin kungenza i-warfarin ingasebenzi kahle (ingasebenzi kahle nasemzimbeni wakho). Ngenxa yalokhu, igazi lakho kungenzeka likwazi ukujiya.

Uma uthatha i-warfarin, khuluma nodokotela wakho. Bazohlola igazi lakho ngaphambi nangesikhathi sokwelashwa kwakho nge-Aubagio.

I-Aubagio kanye ne-immunosuppressants

Imithi ethile, njengezidakamizwa zomdlavuza, ingenza buthaka amasosha akho omzimba. Babizwa ngama-immunosuppressants. I-Aubagio inganciphisa amasosha akho omzimba, futhi. Uma uthatha umuthi womdlavuza kanye ne-Aubagio, amasosha akho omzimba kungenzeka angabi namandla ngokwanele ukulwa namagciwane. Lokhu kungandisa ubungozi bokutheleleka.

Izibonelo zale mithi zifaka:

  • bendamustine (Bendeka, Treanda, Belrapzo)
  • i-cladribine (i-Mavenclad)
  • i-erlotinib (Tarceva)

Uma uthatha umuthi womdlavuza noma omunye umuthi ocindezela amasosha akho omzimba, khuluma nodokotela wakho. Bangacabanga ukushintsha uhlelo lwakho lokwelashwa.

Izindlela zokuvimbela inzalo ze-Aubagio nezomlomo

Izindlela zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo) yimithi esiza ukuvimbela ukukhulelwa. Ukuthatha i-Aubagio ngamaphilisi athile wokulawula inzalo kungakhuphula amazinga omzimba wakho wamahomoni kumaphilisi okulawula ukuzalwa. Lokhu kungadala ukungalingani emazingeni akho e-hormone.

Izibonelo zale mithi zifaka:

  • i-ethinyl estradiol
  • i-levonorgestrel (Hlela B Isinyathelo esisodwa, iMirena, i-Skyla)
  • i-ethinyl estradiol / levonogestrel (eLutera, eVienva)

Uma uthatha amaphilisi okulawula ukubeletha, khuluma nodokotela wakho. Bangancoma uhlobo olungeke lusabele ngokuqinile nge-Aubagio.

Imithi yokwehlisa i-Aubagio ne-cholesterol

Ukuthatha i-Aubagio ngemithi ethile yokwehlisa i-cholesterol kungakhuphula amazinga ale mithi emzimbeni wakho. Lokhu kungadala imiphumela emibi eyengeziwe evela emithini ye-cholesterol.

Izibonelo zale mithi zifaka:

  • i-atorvastatin (Lipitor)
  • i-pravastatin (Pravachol)
  • i-simvastatin (Zocor, FloLipid)
  • rosuvastatin

Uma uthatha umuthi ukwehlisa i-cholesterol yakho, khuluma nodokotela wakho. Kungenzeka ukuthi bahlole isilinganiso sakho somuthi ngamunye futhi baqinisekise ukuthi kuphephile ukuhlangana ndawonye.

I-Aubagio nezinye izidakamizwa

I-Aubagio ingaxhumana nemithi eminingi ehlukene. Futhi eminye yale mithi ingathinta ukuthi i-Aubagio isebenza kanjani. Lokhu kungenxa yokuthi umzimba wakho uhlanganisa i-Aubagio nezinye izidakamizwa eziningi ngendlela efanayo. Lapho imithi idilizwa ndawonye, ​​kwesinye isikhathi ingahlangana.

I-Aubagio ingadala ukuthi umzimba wakho wephule ezinye izidakamizwa ngokushesha noma kancane. Lokhu kungakhuphula noma kwehle amazinga alezo zidakamizwa emzimbeni wakho. Uma inyusa amazinga, ingakhuphula ubungozi bemiphumela emibi. Uma yehlisa amazinga, umuthi kungenzeka ungasebenzi futhi.

Izibonelo zale mithi zifaka:

  • amodiquine
  • asunaprevir
  • I-Bacillus Calmette-Guerin (BCG)
  • i-elagolix (Orilissa)
  • grvoprevir
  • i-natalizumab (Tysabri)
  • i-pazopanib (Votrient)
  • i-pimecrolimus (Elidel)
  • i-revefenacin (Yupelri)
  • I-tacrolimus yama-topical
  • I-topotecan (Hycamtin)
  • uswazi

Uma uthatha noma iyiphi yale mithi, khuluma nodokotela wakho. Bazobheka amazinga ale mithi emzimbeni wakho ngenkathi uthatha i-Aubagio.

Isilinganiso se-Aubagio

Umthamo we-Aubagio odokotela wakho abeka wona uzoncika ezicini ezithile. Lokhu kungafaka:

  • uhlobo nobukhali besimo osithathayo i-Aubagio
  • iminyaka yakho
  • ifomu le-Aubagio olithathayo
  • ezinye izimo zezokwelapha ongahle ube nazo

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi. Ngemuva kwalokho bazoyilungisa ngokuhamba kwesikhathi ukufinyelela kumthamo olungele wena. Ekugcineni bazonquma isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

I-Aubagio iza njengethebhulethi oyigwinyayo. Itholakala ngamandla amabili: 7 mg no-14 mg.

Isilinganiso sezinhlobo zokubuyela emuva ze-MS

Udokotela wakho angakuqala ku-7 mg, kanye ngosuku. Uma lo mthamo wokuqala ungakusebenzeli, bangakhuphula umthamo ube ngu-14 mg, kanye ngosuku.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa umthamo, thatha umthamo wakho ongabanjwanga ngokushesha nje lapho ukhumbula. Uma ususondele esikhathini somthamo wakho olandelayo, weqa umthamo ongabanjwanga bese ubuyela esikhathini sakho esijwayelekile. Ungathathi imithamo emibili ngasikhathi sinye noma eminye imithamo eyengeziwe.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Aubagio yenzelwe ukuthi isetshenziswe njengokwelashwa kwesikhathi eside kwezindlela zokubuyela emuva ze-multiple sclerosis.Uma wena nodokotela wakho nibona ukuthi i-Aubagio iphephile futhi iyasebenza kuwe, kungenzeka uyithathe isikhathi eside. Qiniseka ukuthi uphuza imishanguzo njengoba udokotela ekutshela.

Ezinye izindlela eziya e-Aubagio

Ezinye izidakamizwa ziyatholakala ezingelapha izinhlobo ezibuyayo ze-multiple sclerosis (MS). Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela kune-Aubagio, khuluma nodokotela wakho ukuze ufunde kabanzi ngeminye imithi engakusebenzela kahle.

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha amafomu abuyayo we-MS afaka:

  • ama-beta interferon (Rebif, Avonex)
  • ocrelizumab (Ocrevus)
  • i-dimethyl fumarate (iTecfidera)
  • i-glatiramer acetate (iCopaxone)
  • i-fingolimod (Gilenya)
  • i-natalizumab (Tysabri)
  • i-alemtuzumab (Lemtrada)
  • umagazine

I-Aubagio vs. Tecfidera

Ungazibuza ukuthi i-Aubagio iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi i-Aubagio neTecfidera zifana kanjani futhi zehlukile.

Izithako

I-Aubagio iqukethe isithako esisebenzayo se-teriflunomide. Kungokwesigaba sezidakamizwa se-pyrimidine synthesis inhibitor.

I-Tecfidera iqukethe isithako esisebenzayo esehlukile, i-dimethyl fumarate. Kungokwesigaba semithi yokwelapha esiguqula izifo.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume i-Aubagio neTecfidera ukwelapha amafomu abuyayo e-multiple sclerosis (MS).

Amafomu wezidakamizwa nokuphathwa

I-Aubagio iza njengethebhulethi. Uyithatha ngomlomo (uyayigwinya) kanye ngosuku.

I-Tecfidera iza njenge-capsule. Uyithatha ngomlomo (uyayigwinya) kabili ngosuku.

Imiphumela emibi kanye nezingozi

I-Aubagio neTecfidera zisebenza ngezindlela ezihlukile kepha zinemiphumela emibi efanayo. Izibonelo zemiphumela emibi ejwayelekile futhi emibi yomuthi ngamunye zibhalwe ngezansi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Aubagio, ne-Tecfidera, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Aubagio:
    • i-alopecia (ukuncipha kwezinwele noma ukulahleka kwezinwele)
    • amazinga akhuphukile ama-enzyme wesibindi (kungaba uphawu lokulimala kwesibindi)
    • ikhanda
    • kwehle amazinga e-phosphate
    • ukuba ndikindiki noma ukuncinza ezandleni noma ezinyaweni
    • ubuhlungu obuhlangene
  • Kungenzeka ngeTecfidera:
    • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)
    • ukuqubuka kwesikhumba
    • ubuhlungu esiswini sakho
  • Kungenzeka nge-Aubagio neTecfidera:
    • isicanucanu
    • isifo sohudo

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aubagio, ne-Tecfidera, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Aubagio:
    • okunye ukusabela okungathi sína kwesikhumba, njengeStevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emphinjeni, emehlweni noma ezithweni zangasese)
    • ukwanda komfutho wegazi
  • Kungenzeka ngeTecfidera:
    • i-leukoencephalopathy eqhubekayo ye-multifocal (PML), isifo segciwane lesistimu yezinzwa emaphakathi
  • Kungenzeka nge-Aubagio neTecfidera:
    • ukulimala kwesibindi
    • ukwehluleka kwesibindi
    • amazinga aphansi amangqamuzana amhlophe egazi
    • ukusabela okweqile komzimba

Ukusebenza ngempumelelo

I-Multiple sclerosis (MS) ukuphela kwesimo lapho i-Aubagio neTecfidera zisetshenziselwa ukwelapha.

Ucwaningo lomtholampilo luqhathanise ngqo ukuthi i-Aubagio neTecfidera zisebenza kanjani ekwelapheni i-MS. Abaphenyi babheka ukuskena kwamagnetic resonance imaging (MRI) kwabantu abasebenzisa noma imuphi umuthi. Kubantu abathathe i-Aubagio, ama-30% ayenezilonda ezintsha noma ezinkulu (izicubu ezibomvu). Lokhu kwaqhathaniswa nabantu abangama-40% abathatha iTecfidera.

Le mithi emibili yayisebenza ngokufanayo. Kodwa-ke, lapho kubhekwa ukuthi izidakamizwa zithinte kanjani ubuchopho ngokuphelele, i-Aubagio ibe nemiphumela engcono kuneTecfidera.

Lokho kusho, ngoba bekukhona abantu abangama-50 kuphela ocwaningweni, kudingeka olunye ucwaningo ukwenza ukuqhathanisa okucacile phakathi kwale mithi emibili.

Izindleko

I-Aubagio neTecfidera zombili izidakamizwa zomuthi. Azinawo amafomu ejwayelekile. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iTecfidera ngokuvamile ibiza ngaphezu kwe-Aubagio. Izindleko zangempela ozikhokhela noma yisiphi isidakamizwa zizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Aubagio vs. Gilenya

Ngaphezu kweTecfidera (ngenhla), iGilenya isetshenziselwa ukwelapha i-multiple sclerosis. Lapha sibheka ukuthi i-Aubagio ne-Gilenya zifana kanjani futhi zehlukile.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume i-Aubagio ne-Gilenya ukwelapha abantu abadala abanezinhlobo eziphindayo ze-multiple sclerosis (MS). Kepha uGilenya uvunyelwe futhi ukwelapha i-MS ezinganeni ezineminyaka yobudala eyi-10.

I-Aubagio iqukethe isithako esisebenzayo se-teriflunomide. IGilenya iqukethe isithako esisebenzayo esihlukile, i-fingolimod hydrochloride. Le mithi emibili ayikho esigabeni esisodwa semithi, ngakho-ke isebenza ngezindlela ezehlukene zokwelapha i-MS.

Amafomu wezidakamizwa nokuphathwa

I-Aubagio iza njengethebhulethi oyigwinyayo. Uphuza lesi sidakamizwa kanye ngosuku. IGilenya iza njengephilisi oliginyayo. Uphuza lesi sidakamizwa kanye ngosuku.

Imiphumela emibi kanye nezingozi

I-Aubagio neGilenya zisebenza ngezindlela ezahlukahlukene kepha zinemiphumela efanayo efanayo. Izibonelo zemiphumela emibi ejwayelekile futhi emibi yomuthi ngamunye zibhalwe ngezansi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Aubagio, ne-Gilenya, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Aubagio:
    • i-alopecia (ukuncipha kwezinwele noma ukulahleka kwezinwele)
    • isicanucanu
    • ukuba ndikindiki noma ukuncinza ezandleni noma ezinyaweni
    • ubuhlungu obuhlangene
    • kwehle amazinga e-phosphate
  • Kungenzeka nge-Gilenya:
    • ubuhlungu esiswini sakho
    • umkhuhlane
    • iqolo
    • ukukhwehlela
  • Kungenzeka nge-Aubagio ne-Gilenya:
    • isifo sohudo
    • amazinga akhuphukile ama-enzyme wesibindi (okungaba uphawu lokulimala kwesibindi)
    • ikhanda

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aubagio, ne-Gilenya, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Aubagio:
    • ukusabela okungathi sína kwesikhumba, njengeStevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emphinjeni, emehlweni noma ezithweni zangasese)
    • ukukhubazeka kokuzalwa
    • amazinga aphansi amangqamuzana amhlophe egazi
    • ukusabela okweqile
  • Kungenzeka nge-Gilenya:
    • umdlavuza wesikhumba
    • izinkinga zokubona
    • ukudideka okungazelelwe
  • Kungenzeka nge-Aubagio ne-Gilenya:
    • ukwanda komfutho wegazi
    • izinkinga zokuphefumula
    • ukulimala kwesibindi
    • ukwehluleka kwesibindi

Ukusebenza ngempumelelo

Esifundweni somtholampilo, i-Aubagio yaqhathaniswa ngqo neGilenya kubantu abane-multiple sclerosis (MS). Abantu abathathe iGilenya babephindela emuva ngo-0.18 MS unyaka nonyaka, kanti abantu abathatha i-Aubagio babephindaphinda i-0.24 MS unyaka nonyaka. Kodwa lezi zidakamizwa ezimbili zazisebenza ngokufanayo ekunciphiseni ukuqhubeka kokukhubazeka. Lokhu kusho ukuthi ukukhubazeka kwabantu ngokomzimba akuzange kubhebhetheke ngokushesha okukhulu.

Izindleko

I-Aubagio ne-Gilenya zombili izidakamizwa ezidumile. Azinawo amafomu ejwayelekile. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iGilenya ngokuvamile ibiza ngaphezu kwe-Aubagio. Izindleko zangempela ozikhokhela noma yisiphi isidakamizwa zizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Ungayithatha kanjani i-Aubagio

Kufanele uthathe i-Aubagio njengoba udokotela noma umhlinzeki wakho wezempilo ekutshela.

Isikhathi

Thatha i-Aubagio kanye ngosuku cishe ngesikhathi esifanayo usuku ngalunye.

Ukuthatha i-Aubagio ngokudla

Ungathatha i-Aubagio ngokudla noma ngaphandle kokudla. Ukuthatha lo muthi ngokudla ngeke kuthinte ukuthi umuthi usebenza kanjani emzimbeni wakho.

Ngabe i-Aubagio ingachotshozwa, ihlafunwe, noma yehlukaniswe?

Akunconyelwa ukuthi i-Aubagio ichotshozwe, ihlukaniswe, noma ihlafunwe. Akuzange kube khona ucwaningo olwenziwe ukuthola ukuthi ukwenza lezi zinto kungashintsha ukuthi u-Aubagio usebenza kanjani emzimbeni.

Umuthi osebenzayo e-Aubagio, teriflunomide, uyaziwa ukuthi uphethe ukunambitheka okumunyu, ngakho-ke kunconywa kakhulu ukuthi uthathe i-Aubagio iphelele.

Yikuphi ukuhlolwa engizokudinga ngaphambi kokuqala ukwelashwa?

Ngaphambi kokuthatha i-Aubagio, udokotela wakho uzokwenza izivivinyo ukuze aqiniseke ukuthi umuthi uphephile kuwe. Lokhu kufaka phakathi:

  • Ukuhlolwa kwegazi ukubona ukuthi isibindi sakho siphilile ngokwanele yini.
  • Ukuhlolwa kwesikhumba sofuba (i-TB) noma ukuhlolwa kwegazi ukuhlola i-TB.
  • Ukubalwa okuphelele kwegazi ukuhlola izifo, kufaka phakathi i-leukoencephalopathy eqhubekayo ye-multifocal (PML). (Bheka isigaba “semininingwane eseceleni” ngenhla ukuze ufunde kabanzi nge-PML.)
  • Ukuhlolwa kokukhulelwa. Akufanele uthathe i-Aubagio uma ukhulelwe.
  • Ukuhlolwa kwengcindezi yegazi. Ukuthatha i-Aubagio kungakhuphula umfutho wegazi lakho, ngakho-ke udokotela wakho uzobona ukuthi usuvele unawo yini umfutho wegazi ophezulu.
  • I-Magnetic resonance imaging (MRI) ngaphambi nangesikhathi uthatha i-Aubagio. Udokotela wakho uzohlola ubuchopho bakho ukuthola noma yiziphi izinguquko ezilondeni (izicubu ezibomvu).

Ngenkathi uthatha i-Aubagio, udokotela wakho uzokunika ukuhlolwa kwegazi nyangazonke ukuze uhlole isibindi sakho. Bazogcina futhi nomkhondo wegazi lakho.

Isebenza kanjani i-Aubagio

I-Multiple sclerosis (MS) isifo esingelapheki (sesikhathi eside). Kubangela ukuthi amasosha omzimba wakho ahlasele i-myelin (ungqimba lwangaphandle) emithanjeni esemehlweni akho, ebuchosheni nasemgogodleni. Lokhu kudala izicubu ezibomvu, okwenza kube nzima ebuchosheni bakho ukuthumela amasiginali kulezi zingxenye zomzimba wakho.

I-Aubagio isebenza ngokwehlukile kweminye imithi ye-MS. Yiyona kuphela i-pyrimidine synthesis inhibitor yokwelapha i-MS.

Ukuthi i-Aubagio isebenza kanjani ngqo akuqondakali ngokuphelele. Kucatshangwa ukuthi i-teriflunomide, umuthi osebenzayo e-Aubagio, uvimba i-enzyme ethile. Amaseli omzimba adinga le enzyme ukuze yande ngokushesha. Lapho i-enzyme ivinjiwe, amaseli omzimba awakwazi ukusabalala futhi ahlasele i-myelin.

Kuthatha isikhathi esingakanani ukusebenza?

I-Aubagio iqala ukusebenza ngokushesha ngemuva kokuyithatha. Kodwa-ke, ungahle ungaboni umehluko ezimpawu zakho noma ngabe isidakamizwa sesiqale ukusebenza. Lokho kungenxa yokuthi kusebenza ukusiza ukuvimbela ukubuyela emuva kanye nezilonda ezintsha, okuyizenzo ezingase zingabonakali ngqo.

I-Aubagio nokukhulelwa

Ukuthatha i-Aubagio lapho ukhulelwe kungadala ukukhubazeka okukhulu kokuzalwa. Ungathathi lo muthi uma ukhulelwe. Uma ungakhulelwa futhi ungasebenzisi ukulawulwa kokuzalwa okuthembekile, akufanele uthathe i-Aubagio.

Uma ukhulelwa ngenkathi usebenzisa i-Aubagio, yeka ukuthatha lesi sidakamizwa bese utshela udokotela wakho khona manjalo. Tshela nodokotela wakho uma ufuna ukukhulelwa kungakapheli iminyaka emibili. Kulokhu, bangakuqala ekwelashweni ukuze ususe i-Aubagio ngokushesha kusistimu yakho (bheka "imibuzo ejwayelekile nge-Aubagio" ngezansi).

I-Aubagio ingahlala egazini lakho isikhathi eside, mhlawumbe kuze kube seminyakeni emibili ngemuva kokuyeka ukwelashwa. Ukuphela kwendlela yokwazi ukuthi ngabe i-Aubagio isekhona ohlelweni lwakho ukwenza ukuhlolwa kwegazi. Sebenza nodokotela wakho ukuze kuhlolwe amazinga akho ukuqinisekisa ukuthi ukukhulelwa kuphephile. Kuze kube yilapho wazi ukuthi i-Aubagio iphumile ohlelweni lwakho, kubalulekile ukuqhubeka nokulawula inzalo.

Ungabhalisela nokubhaliswa okusiza ukuqoqa imininingwane emayelana nesipiliyoni sakho. Ukubhaliswa kokuvezwa kokukhulelwa kusiza odokotela ukuthi bafunde kabanzi ngokuthi izidakamizwa ezithile zibathinta kanjani abesifazane nokukhulelwa kwabo. Ukuze ubhalise, shayela ku-800-745-4447 bese ucindezela inketho 2.

Uma ukhathazekile ngokukhulelwa ngenkathi uthatha i-Aubagio, khuluma nodokotela wakho. Bangaphakamisa izindlela ezisebenzayo zokulawula ukubeletha.

Kwabesilisa: Abesilisa abathatha i-Aubagio kufanele futhi basebenzise izindlela zokuvimbela inzalo ezisebenzayo. Kufanele futhi bazise udokotela wabo uma umlingani wabo ehlela ukukhulelwa.

I-Aubagio nokuncelisa

Akwaziwa ukuthi i-Aubagio idlulela ebisini lwebele.

Ngaphambi kokuthatha i-Aubagio, tshela udokotela wakho uma uncelisa ingane yakho ibele noma uhlela ukumncelisa. Bangakhuluma nawe ngezingozi nezinzuzo zokuthatha lo muthi ngenkathi uncelisa.

Imibuzo ejwayelekile nge-Aubagio

Nazi izimpendulo zemibuzo ebuzwa njalo nge-Aubagio.

Ingabe i-Aubagio i-immunosuppressant?

I-Aubagio ayihlukaniswa njenge-immunosuppressant, kepha isenganciphisa amasosha akho omzimba. Uma amasosha omzimba wakho engaqinile ngokwanele ukulwa namagciwane, maningi amathuba okuthi uthole ukutheleleka.

Uma ukhathazekile ngezifo ezingenzeka ngenkathi uthatha i-Aubagio, khuluma nodokotela wakho.

Ngikwenza kanjani “ukugeza” kwe-Aubagio?

Uma uthatha i-Aubagio futhi ukhulelwe noma ufuna ukukhulelwa, tshela udokotela wakho khona manjalo. Bangasebenza ukususa ngokushesha i-Aubagio emzimbeni wakho.

I-Aubagio ingahlala ohlelweni lwakho kuze kube yiminyaka emibili ngemuva kokuyeka ukuyithatha.Ukuthola ukuthi usenayo yini i-Aubagio ohlelweni lwakho, kuzodingeka ukuthi uhlolwe igazi.

Ukuze “kuhlanzwe,” noma kususwe ngokushesha, kwe-Aubagio, udokotela wakho uzokunika i-cholestyramine noma i-powder yelahle esebenzayo.

Ingabe kufanele ngisebenzise ukulawulwa kokubeletha ngenkathi ngithatha i-Aubagio?

Yebo, kufanele usebenzise izinto zokuvimbela inzalo (ukuthatha inzalo) ngenkathi uthatha i-Aubagio.

Uma ungowesifazane ongakhulelwa, udokotela wakho uzokunikeza isivivinyo sokukhulelwa ngaphambi kokuqala ukwelashwa kwe-Aubagio. Kubalulekile ukuthi ungakhulelwa ngenkathi uthatha i-Aubagio ngoba umuthi ungadala ukukhubazeka kokuzalwa.

Abesilisa abathatha i-Aubagio kufanele futhi basebenzise inzalo esebenzayo. Kufanele futhi bazise udokotela wabo uma umlingani wabo ehlela ukukhulelwa.

Ngabe i-Aubagio ibangela ukuqhuma?

Cha. Ucwaningo lwe-Aubagio aluzange lubike ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho) njengomphumela oseceleni wokuthatha lesi sidakamizwa.

Kodwa-ke, ukuqhuma kungaba umphumela ohlangothini wezinye izidakamizwa ezelapha i-multiple sclerosis (MS), njengeTecfidera.

Ngabe ngizoba nemiphumela yokuhoxa uma ngiyeka ukuthatha i-Aubagio?

Imiphumela yokuhoxa ayibikwanga ezifundweni ze-Aubagio. Ngakho-ke akunakwenzeka ukuthi uzoba nezimpawu zokuhoxa lapho uyeka ukwelashwa kwe-Aubagio.

Kodwa-ke, izimpawu zakho ze-multiple sclerosis (MS) zingase zibe zimbi kakhulu lapho uyeka ukuthatha i-Aubagio. Lokho kungabonakala kuyimpendulo yokuhoxa, kodwa akuyona into efanayo.

Ungayeki ukuthatha i-Aubagio ngaphandle kokukhuluma nodokotela wakho kuqala. Bangakusiza ukuphatha noma yikuphi ukwanda kwezimpawu zakho ze-MS.

Ingabe i-Aubagio ingadala umdlavuza? Ngabe ihlotshaniswa nokufa okuthile?

Ezifundweni zokwelashwa ze-Aubagio, umdlavuza wawungeyona imiphumela emibi eyenzekile. Kodwa-ke, embikweni wecala, owesifazane one-multiple sclerosis waba ne-follicular lymphoma ngemuva kokuthatha i-Aubagio izinyanga eziyisishiyagalombili. Lo mbiko awuzange uthi i-Aubagio iyimbangela yomdlavuza, kodwa akuvumanga ukuthi lokho kungenzeka.

Ezifundweni zokwelashwa zase-Aubagio, abantu abane babulawa yizinkinga zenhliziyo. Lokhu bekungabantu ababalelwa ku-2 600 abathatha lo muthi. Kodwa akuboniswanga ukuthi ukuthatha i-Aubagio kudale lokhu kufa.

Izexwayiso ze-Aubagio

Lesi sidakamizwa siza nezixwayiso eziningana.

Izexwayiso ze-FDA

Lo muthi unezixwayiso zesibhakela. Isexwayiso esibhakeleni yisixwayiso esibi kakhulu esivela ku-Food and Drug Administration (FDA). Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

  • Ukulimala okukhulu kwesibindi. I-Aubagio ingadala izinkinga ezinzima zesibindi, kufaka phakathi ukwehluleka kwesibindi. Ukuthatha i-Aubagio nezinye izidakamizwa ezingathinta isibindi sakho kungakhuphula inani le-Aubagio emzimbeni wakho. Lokhu kungalimaza isibindi sakho. Omunye wale mithi yi-Arava (leflunomide), enqunyelwe ukwelapha isifo samathambo. Udokotela wakho uzokunika ukuhlolwa kwegazi ngaphambi nangesikhathi uthatha i-Aubagio ukuhlola isibindi sakho.
  • Ubungozi bokukhubazeka kokuzalwa. Uma ukhulelwe, akufanele uthathe i-Aubagio ngoba ingadala ukukhubazeka okukhulu kokuzalwa. Uma ungakhulelwa futhi ungasebenzisi ukulawulwa kokuzalwa okuthembekile, akufanele uthathe i-Aubagio. Uma ukhulelwa ngenkathi uthatha i-Aubagio, yeka ukuyithatha bese utshela udokotela wakho khona manjalo.

Ezinye izexwayiso

Ngaphambi kokuthatha i-Aubagio, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Aubagio kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lokhu kufaka phakathi:

  • Isifo sesibindi. I-Aubagio ingadala ukulimala kwesibindi okukhulu. Uma unesifo sesibindi, i-Aubagio ingasenza sibi kakhulu.
  • Ukusabela okweqile okwedlule. Gwema ukuthatha i-Aubagio uma ngabe uphendulile ku:
    • umabhebhana
    • leflunomide
    • noma iziphi ezinye izithako e-Aubagio

Ukudlula ngokweqile kwe-Aubagio

Kunolwazi olunqunyelwe mayelana nokusebenzisa okungaphezu kwesilinganiso esinconyiwe se-Aubagio.

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe i-Aubagio eningi kakhulu, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kodwa uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukuphelelwa yisikhathi kwe-Aubagio, ukugcina nokulahla

Lapho uthola i-Aubagio ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame ukuba unyaka owodwa kusukela ngosuku abanikeze ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Gcina amaphilisi e-Aubagio ekamelweni lokushisa eliphakathi kuka-68 ° F no-77 ° F (20 ° C no-25 ° C).

Ukulahlwa

Uma ungasadingi ukuthatha i-Aubagio futhi unemithi esele, kubalulekile ukuyilahla ngokuphepha. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi. Kuyasiza futhi ukugcina umuthi ungalimazi imvelo.

Iwebhusayithi ye-FDA inikeza amathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho imininingwane yokuthi ungayilahla kanjani imithi yakho.

Imininingwane yobungcweti ye-Aubagio

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Inkomba

I-Aubagio ikhonjiswa ukwelapha abantu abanezinhlobo ezibuyela emuva ze-multiple sclerosis (MS).

Indlela yokusebenza

I-Aubagio iqukethe isithako esisebenzayo se-teriflunomide. I-Teriflunomide ivimbela i-enzyme ye-mitochondrial ebizwa nge-dihydroorotate dehydrogenase, ebandakanyeka ku-de novo pyrimidine synthesis. I-Aubagio nayo ingasebenza ngokunciphisa inani lama-lymphocyte asebenze ohlelweni lwemizwa oluphakathi.

I-Pharmacokinetics ne-metabolism

Ngemuva kokuphathwa ngomlomo, ukugxila okuphezulu kwenzeka ngaphakathi kwamahora amane. I-Aubagio ngokuyinhloko ithola i-hydrolysis futhi ihlanganiswa namametabolite amancane. Izindlela zesibili ze-metabolism zifaka ukuhlanganiswa, i-oxidation, ne-N-acetylation.

I-Aubagio iyi-inducer ye-CYP1A2 futhi ivimbela i-CYP2C8, i-efflux transporter protein umdlavuza webele (BCRP), OATP1B1, ne-OAT3.

I-Aubagio ine-half-life yezinsuku eziyi-18 kuya kwezingu-19 futhi ikhishwa ngokuyinhloko ngendle (cishe ama-38%) nomchamo (cishe ama-23%).

Izimo

I-Aubagio iphikisana neziguli ezine:

  • ukukhubazeka okukhulu kwe-hepatic
  • umlando we-hypersensitivity to teriflunomide, leflunomide, noma ezinye izinto zomuthi
  • Ukusetshenziswa okuhambisanayo ne-leflunomide
  • amandla okukhulelwa ngaphandle kokusebenzisa izinto zokuvimbela inzalo noma ukhulelwe

Isitoreji

I-Aubagio kufanele igcinwe ekamelweni lokushisa eliphakathi kuka-68 ° F no-77 ° F (20 ° C no-25 ° C).

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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