Ukwelashwa Kwenhlanganisela Yesigaba Esibanzi Somdlavuza Wamaphaphu Omzimba

-Delile

• Ukubuka konke
• Inhlanganisela chemotherapy
• I-Chemotherapy kanye ne-immunotherapy
• Isebenza kahle kangakanani inhlanganisela yokwelashwa?
• Imiphumela emibi yokwelashwa okuhlanganisiwe
• Izinto okufanele uzicabangele
• Ukudla okudlela endlini

Ukubuka konke

Ukwelashwa komdlavuza wamangqamuzana amancane wamangqamuzana amancane (SCLC) ngokuvamile kubandakanya ukwelashwa okuhlanganisiwe. Kungaba yinhlanganisela yezidakamizwa ze-chemotherapy noma i-chemotherapy kanye ne-immunotherapy.

Ake sibhekisise ukwelashwa okuhlanganisiwe kwe-SCLC ebanzi, ukuthi isebenza kanjani, nezinto okufanele uzicabangele ngaphambi kokukhetha ukwelashwa.

Inhlanganisela chemotherapy

Ngenkathi ukuhlinzwa nemisebe esifubeni kusetshenziselwa isigaba esilinganiselwe se-SCLC, akujwayele ukusetshenziselwa isigaba esibanzi. Ukwelashwa komugqa wokuqala kwesigaba esibanzi se-SCLC yinhlanganisela yamakhemikhali.

Kunezinhloso eziningana zokwelashwa ngamakhemikhali. Inganciphisa izicubu, inciphise izimpawu, kanye nokuqhubekela phambili kwezifo okuhamba kancane. Lokhu kubalulekile ekwelapheni i-SCLC ngoba umdlavuza okhula ngokushesha kakhulu. Le mithi enamandla ingavimba amangqamuzana omdlavuza ukuthi akhule futhi azalane.

Izidakamizwa ze-Chemotherapy azibhekisi isimila esithile noma ingxenye ethile yomzimba. Kuyinto yokwelashwa okuhlelekile. Lokho kusho ukuthi ifuna amaseli omdlavuza noma ngabe ukuphi.

Inhlanganisela yamakhemikhali ingafaka:

• i-etoposide kanye ne-cisplatin
• i-etoposide kanye ne-carboplatin
• irinotecan kanye ne-cisplatin
• irinotecan kanye ne-carboplatin

I-Chemotherapy ivame ukunikezwa ngokumnika esimisweni esethiwe. Ngaphambi kokuba uqale, udokotela wakho uzohlola impilo yakho yonke ukuze aqiniseke ukuthi uyakwazi ukumelana nemiphumela emibi yokwelashwa.

I-Chemotherapy kanye ne-immunotherapy

Amaseli womdlavuza ayizingcweti zokuzifihla. Bangakhohlisa amasosha akho omzimba ukuthi angababoni beyingozi.

I-Immunotherapy, eyaziwa nangokuthi yi-biologic therapy, inika amandla amasosha omzimba. Kuyisiza ukuthi ibone futhi ihlasele amangqamuzana omdlavuza. Ngokungafani ne-chemotherapy, ayibangeli ingozi kumaseli aphilile.

Umuthi we-immunotherapy atezolizumab (Tecentriq) unganikezwa kanye ne-chemotherapy ehlanganisiwe. Uma usuqedile ngamakhemikhali, ungahlala ku-atezolizumab njengokwelashwa kwesondlo.

Ezinye izidakamizwa ze-immunotherapy ezingasetshenziselwa i-SCLC yilezi:

• ipilimumab (Yervoy)
• i-nivolumab (Opdivo)
• i-pembrolizumab (Keytruda)

I-Immunotherapy ivame ukunikezwa nge-infravenous (IV) ukumnika esimisweni esijwayelekile.

Isebenza kahle kangakanani inhlanganisela yokwelashwa?

Inhlanganisela yokwelashwa ngamakhemikhali esiteji esikhulu se-SCLC inganciphisa ukukhula kwesifo futhi inikeze ukukhululeka ezimpawu. Inezinga lokuphendula lokuqala lamaphesenti angama-60 kuye kwangama-80. Kwezinye izimo, impendulo inkulu kakhulu kangangokuba ukuhlolwa kwe-imaging akusakwazi ukuthola umdlavuza.

Lokhu kuvame ukuba kwesikhashana, noma kunjalo. Isiteji esikhulu se-SCLC sicishe sibuyele njalo, kwesinye isikhathi kungakapheli izinyanga. Ngemuva kokuphindeka, umdlavuza ungamelana nokwelashwa ngamakhemikhali.

Ngalesi sizathu, udokotela wakho angancoma ukuqhubeka ne-immunotherapy ngemuva kokuqeda i-chemotherapy. Udokotela wakho futhi angaphakamisa ukwelashwa ngemisebe ebuchosheni. Lokhu kungasiza ukuvimbela umdlavuza ukuthi usabalale uye ebuchosheni bakho.

Ukuhlolwa kwemitholampilo kwe-immunotherapy ye-SCLC kube nemiphumela exubekile. Olunye uvivinyo lwakamuva lubheke i-atezolizumab nge-plotherapy-based chemotherapy.Uma kuqhathaniswa ne-chemotherapy kuphela, kube nokuthuthuka okukhulu ekusindeni okuphelele nasekuqhubekeni ngaphandle kwenqubekela phambili.

I-Immunotherapy yokwelashwa kwesiteji esibanzi se-SCLC iyathembisa kepha isha sha. Ukuhlolwa komtholampilo okufunda i-immunotherapy ngokuhlanganiswa kwamakhemikhali kuyaqhubeka.

Uma umdlavuza ungangeni ekuxolelweni noma uqhubeka nokusabalala, uzodinga ukwelashwa okuqhubekayo. Ukukhetha kwakho kuzoya ngokuthi kusabalale kuphi nokuthi iziphi izindlela zokwelapha osuke wazama.

Imiphumela emibi yokwelashwa okuhlanganisiwe

Umdlavuza uhilela ukuhlukanisa amaseli ngokushesha. Imithi yokwelashwa ngamakhemikhali ikhomba amaseli ahlukana ngokushesha. Lokho kusho ukuthi nawo athinta amanye amaseli anempilo. Yilokhu okwenza imiphumela emibi eminingi ehambisana nalokhu kwelashwa.

Imiphumela emibi yokwelashwa ngamakhemikhali iyahlukahluka ngokuya ngemithi ethile, isilinganiso, nokuthi uyithola kangaki. Wonke umuntu usabela ngendlela ehlukile. Uhlu lwemiphumela emibi engaba khona yinde, kodwa mhlawumbe ngeke uhlangabezane nayo yonke. Imiphumela emibi ingafaka:

• ukukhathala
• ubuthakathaka
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• isifo sohudo
• ukulahleka kwezinwele
• ukuncipha komzimba
• izipikili eziphukile
• izinsini ezophayo
• ingozi eyengeziwe yokutheleleka

I-immunotherapy ingadala:

• isicanucanu
• ukukhathala
• ubuhlungu obuhlangene
• uhudo noma ukuqunjelwa
• izimpawu ezinjengomkhuhlane
• izinguquko esisindweni
• ukulahlekelwa isifiso sokudla

Izimpawu zokuphendula ukumnika zingadala:

• umkhuhlane, ukubanda, noma ukugcwala ubuso
• ukuqubuka
• isikhumba esilumayo
• isiyezi
• isifuba
• inkinga yokuphefumula

Ukwelashwa ngemisebe kungaholela ku:

• ukukhathala
• ukulahlekelwa isifiso sokudla
• ukucasuka kwesikhumba okufana nokushiswa yilanga
• ukucasuka kwesikhumba
• ukulahleka kwezinwele

Imiphumela emibi eminingi ingalawulwa nezinye izindlela zokwelashwa noma ukuguqulwa kwendlela yokuphila. Qiniseka ukuthi utshela iqembu lakho lokunakekelwa kwezempilo uma unemiphumela engemihle.

Izinto okufanele uzicabangele

Ngaphambi kokukhetha ukwelashwa, udokotela wakho uzohlola impilo yakho yonke. Kwezinye izimo, imiphumela emibi yokwelashwa okujwayelekile ingaba nzima kakhulu. Ngokubambisana, ninganquma ukuthi ngabe kufanele nibe nemithamo ephansi yokwelashwa ngamakhemikhali, i-immunotherapy, noma ukunakekelwa kokudambisa umzimba kukodwa. Ungase futhi ukhulume nodokotela wakho mayelana nokubhalisa esivivinyweni somtholampilo.

Ukunakekelwa kwe-Palliative kwaziwa nangokuthi ukunakekelwa kokusekela. Ngeke ilaphe umdlavuza wakho, kepha ingasiza ukuphatha izimpawu zomuntu ngamunye futhi ibuyisele ikhwalithi yempilo yakho isikhathi eside ngangokunokwenzeka. Ungathola ukunakekelwa okunciphisayo kanye nokwelashwa okuhlanganisiwe.

Noma ngabe ngaphambi, ngesikhathi, noma ngemuva kokwelapha, nakanjani uzoba nemibuzo nokukhathazeka. Ithimba lakho lezempilo likhona ukusiza. Bafuna ukuthi ukwelashwa kwakho kuhambe ngokushelela ngangokunokwenzeka futhi bakwazi ukuboleka lapho kudingeka khona. Lapho kudingeka, bangakudlulisela kwabanye abangase babe usizo.

Ukudla okudlela endlini

Ukwelashwa komugqa wokuqala kwesigaba esibanzi se-SCLC ukwelashwa okuhlanganisiwe. Lokhu kungasho ukuhlanganiswa kwezidakamizwa ze-chemo zodwa noma zihlangene ne-immunotherapy. Kodwa ukwelashwa kufanele kuhambisane nezidingo zakho ezithile.

Ukuxhumana okuvulekile nodokotela wakho kuyindlela engcono yokuqinisekisa ukuthi usekhasini elilodwa. Ngokubambisana, ningenza izinqumo ezikulungele kakhulu.