Umhlahlandlela Wezingxoxo Zodokotela: Amathiphu Okuxoxa Ngokuguquka Kwe-PIK3CA noDokotela Wakho

-Delile

• Kuyini ukuguqulwa kwe-PIK3CA?
• Ukuthola kanjani lokhu kuguquka?
• Ngabe ukuguquka komzimba wami kukuthinta kanjani ukwelashwa kwami?
• Ukuguquka kwesimo sami emzimbeni kuwuthinta kanjani umbono wami?
• Ukudla okudlela endlini

Ukuhlolwa okuningana kungasiza udokotela wakho ukuthola umdlavuza webele we-metastatic, ukubikezela ukuthi uzosebenza kanjani, futhi akuthole ukwelashwa okuphumelela kakhulu. Ukuhlolwa kofuzo kubheka ukuguquka kwezakhi zofuzo, izingxenye ze-DNA ezingaphakathi kwamaseli akho ezilawula ukuthi umzimba wakho usebenza kanjani.

Enye yezinguquko zofuzo udokotela wakho angahlola ukuthi PIK3CA. Funda ukuze ufunde ukuthi lokhu kuguquka kwezakhi zofuzo kungakuthinta kanjani ukwelashwa nombono wakho.

Kuyini ukuguqulwa kwe-PIK3CA?

I- PIK3CA ufuzo luphethe imiyalo yokwenza iprotheni ebizwa nge-p110α. Le phrotheni ibalulekile emisebenzini eminingi yamaseli, kufaka phakathi ukutshela amangqamuzana akho ukuthi kufanele akhule nini futhi ahlukane nini.

Abantu abathile bangaba nokuguquka kwezakhi zofuzo kulesi sizakhi. PIK3CA Ukuguqulwa kwezakhi zofuzo kubangela ukuthi amaseli akhule ngokungalawuleki, okungaholela kumdlavuza.

PIK3CA Ukuguqulwa kwezakhi zofuzo kuhlotshaniswa nomdlavuza webele, kanye nomdlavuza we-ovary, iphaphu, isisu nobuchopho. Umdlavuza webele kungenzeka uvela enhlanganisweni yezinguquko kuye PIK3CA nezinye izakhi zofuzo.

PIK3CA ukuguqulwa kuthinta cishe wonke umdlavuza webele, namaphesenti angama-40 abantu abane-estrogen receptor (ER) -i-positive, i-human epidermal growth factor receptor 2 (HER2) - umdlavuza webele ongeyena.

I-ER-positive isho ukuthi umdlavuza wakho webele ukhula ngokuphendula i-hormone estrogen. I-HER2-negative isho ukuthi awunawo amaprotheni we-HER2 angajwayelekile ebusweni bamaseli akho omdlavuza webele.

Ukuthola kanjani lokhu kuguquka?

Uma une-ER-positive, umdlavuza webele we-HER2-negative, udokotela ophatha umdlavuza wakho angakuhlolela PIK3CA ukuguquka kwezakhi zofuzo. Ngo-2019, i-FDA ivume ukuhlolwa okubizwa nge-therascreen ukuthola ushintsho ku PIK3CA isakhi sofuzo.

Lokhu kuhlolwa kusebenzisa isampula yegazi lakho noma izicubu ezivela esifubeni sakho. Ukuhlolwa kwegazi kwenziwa njenganoma yikuphi okunye ukuhlolwa kwegazi. Umhlengikazi noma uchwepheshe uzodonsa igazi engalweni yakho ngenaliti.

Isampuli yegazi bese iya elabhoratri iyohlaziywa. Umdlavuza wamabele uchitha izingcezu ezincane ze-DNA yawo egazini. Ilebhu izovivinya i- PIK3CA zofuzo kusampula yegazi lakho.

Uma uthola umphumela ongemuhle ekuhlolweni kwegazi, kufanele ube ne-biopsy ukukuqinisekisa. Udokotela wakho uzosusa isampula lezicubu esifubeni sakho ngesikhathi senqubo encane yokuhlinzwa. Isampula lezicubu bese liya elabhoratri, lapho ochwepheshe bayihlolela khona PIK3CA ukuguquka kwezakhi zofuzo.

Ngabe ukuguquka komzimba wami kukuthinta kanjani ukwelashwa kwami?

Ukuba ne- PIK3CA ukuguquka komzimba kungavimbela umdlavuza wakho ekuphenduleni nasekwelashweni ngehomoni okusetshenziselwa ukwelapha umdlavuza webele we-metastatic. Kusho nokuthi uyilungu lomuthi omusha obizwa nge-alpelisib (Piqray).

IPiqray iyi-PI3K inhibitor. Yisidakamizwa sokuqala ngqa sohlobo lwaso. I-FDA ivume uPiqray ngoMeyi 2019 ukuthi aphathe abesifazane nabesilisa abangemva kokuya esikhathini nokuya esikhathini abanezicubu zesifuba PIK3CA kuguquka futhi kune-HR-positive ne-HER2-negative.

Ukugunyazwa bekususelwa kwimiphumela yocwaningo lwe-SOLAR-1. Icala lalibandakanya abesifazane nabesilisa abangama-572 abanomdlavuza webele we-HR-positive no-HER2-negative. Umdlavuza wabahlanganyeli uqhubeke nokukhula futhi usakazeka ngemuva kokuthi belashwe nge-aromatase inhibitor efana ne-anastrozole (Arimidex) noma i-letrozole (Femara).

Abaphenyi bathola ukuthi ukuthatha uPiqray kuthuthukise isikhathi abantu abaphila ngaphandle komdlavuza webele wabo uba mubi kakhulu. Kubantu abathathe lesi sidakamizwa, umdlavuza wabo awuzange uthuthuke izinyanga eziyi-11, uma kuqhathaniswa nesilinganiso sezinyanga ezingu-5.7 kubantu abangathathanga iPiqray.

I-Piqray ihlanganiswe ne-hormone therapy fulvestrant (Faslodex). Ukuthatha le mithi emibili ndawonye kuyabasiza ukuthi basebenze kangcono.

Ukuguquka kwesimo sami emzimbeni kuwuthinta kanjani umbono wami?

Uma une PIK3CA ukuguquka, ungahle ungaphenduli nezidakamizwa ezijwayele ukwelashwa umdlavuza webele we-metastatic. Kodwa-ke ukwethulwa kwePiqray kusho ukuthi manje kukhona umuthi obhekise ngqo ekuguqulweni kofuzo lwakho.

Abantu abathatha iPiqray kanye neFaslodex baphila isikhathi eside ngaphandle kokuthuthuka kwezifo zabo uma kuqhathaniswa nalabo abangawuthathi lo muthi.

Ukudla okudlela endlini

Ukwazi i- PIK3CA isimo sofuzo singasiza uma umdlavuza wakho ungakathuthuki noma ubuyile ngemuva kokwelashwa. Buza udokotela wakho ukuthi kufanele yini uhlolelwe lolu hlobo lofuzo. Uma uhlolwa unegciwane, ukwelashwa okusha kungasiza ekuthuthukiseni umbono wakho.