I-EGCG (Epigallocatechin Gallate): Izinzuzo, Isilinganiso, Nokuphepha

-Delile

• Yini i-EGCG?
• Kutholakala ngokwemvelo ekudleni okuhlukahlukene
• Kwangathi ungahlinzeka ngezinzuzo ezinamandla zezempilo
• Imiphumela ye-antioxidant ne-anti-inflammatory
• Impilo yenhliziyo
• Ukwehla kwesisindo
• Impilo yobuchopho
• Isikali kanye nemiphumela engemihle engaba khona
• Imiphumela emibi engaba khona
• Okubalulekile

I-Epigallocatechin gallate (EGCG) iyinhlanganisela yezitshalo eyingqayizivele ethola ukunakwa okuningi ngomthelela wayo omuhle empilweni.

Kucatshangwa ukuthi kunciphise ukuvuvukala, kusize ekunciphiseni isisindo, futhi kusize ekuvikeleni isifo senhliziyo nobuchopho.

Lo mbhalo ubuyekeza i-EGCG, kufaka phakathi izinzuzo zayo zezempilo kanye nemiphumela emibi engaba khona.

Yini i-EGCG?

Eyaziwa ngokusemthethweni ngokuthi i-epigallocatechin gallate, i-EGCG uhlobo lwenhlanganisela esuselwa ezitshalweni ebizwa nge-catechin. AmaCatechin angahle ahlukaniswe abe iqembu elikhudlwana lamakhemikhali ezitshalo abizwa ngama-polyphenols ().

I-EGCG namanye ama-catechins ahlobene asebenza njengama-antioxidants anamandla angavikela ekulimaleni kwamangqamuzana okubangelwa ama-radicals amahhala ().

Ama-radicals wamahhala izinhlayiya ezisebenza kakhulu ezakhiwe emzimbeni wakho ezingalimaza amaseli akho lapho izinombolo zawo ziphakama kakhulu. Ukudla ukudla okunama-antioxidants amaningi njengamakhatheni kungasiza ekunciphiseni ukulimala okukhulu kwamahhala.

Ngokwengeziwe, ucwaningo luphakamisa ukuthi ama-catechins afana ne-EGCG anganciphisa ukuvuvukala futhi avimbele izimo ezithile ezingalapheki, kufaka phakathi isifo senhliziyo, isifo sikashukela, neminye imidlavuza (,).

I-EGCG ikhona ngokwemvelo ekudleni okuningana okususelwa ezitshalweni kepha iyatholakala njengesengezo sokudla esivame ukuthengiswa ngendlela yokukhipha.

I-EGCG wuhlobo lwesakhi sezitshalo okuthiwa i-catechin. Ucwaningo lukhombisa ukuthi amakatekini afana ne-EGCG angadlala indima enkulu ekuvikeleni amaseli akho ekulimaleni nasekuvikeleni izifo.

Kutholakala ngokwemvelo ekudleni okuhlukahlukene

I-EGCG mhlawumbe yaziwa kakhulu ngendima yayo njengenhlanganisela enkulu esebenzayo kutiye oluhlaza.

Eqinisweni, izinzuzo eziningi zezempilo ezihlobene nokuphuza itiye eliluhlaza ngokuvamile zifakwa kokuqukethwe kwe-EGCG ().

Yize i-EGCG itholakala kakhulu etiyeni eliluhlaza, ibuye ibe ngamanani amancane kokunye ukudla, okufana (3):

• Itiye: oluhlaza, omhlophe, oolong, netiye ezimnyama
• Izithelo: ama-cranberries, ama-strawberry, amajikijolo, ama-kiwis, ama-cherries, amapheya, amapentshisi, ama-apula nama-avocado
• Amantongomane: ama-pecans, ama-pistachio, namantongomane

Ngenkathi i-EGCG iyi-catechin ecwaningwe kakhulu futhi enamandla, ezinye izinhlobo ezinjenge-epicatechin, epigallocatechin, ne-epicatechin 3-gallate zinganikeza izinzuzo ezifanayo. Futhi, eziningi zazo zitholakala kakhulu ekunikezelweni kokudla (3,).

Iwayini elibomvu, ushokoledi omnyama, imidumba, nezithelo eziningi kuyizibonelo ezimbalwa zokudla okunikela ngomthamo omkhulu wamakhathekini akhuthaza impilo ().

I-EGCG ivame kakhulu etiyeni eluhlaza kepha futhi itholakala ngamanani amancane kwezinye izinhlobo zetiye, izithelo namanye amantongomane. Amanye amakatekini akhuthaza impilo maningi ewayinini elibomvu, kushokoledi omnyama, emidumba, nasezithelweni eziningi.

Kwangathi ungahlinzeka ngezinzuzo ezinamandla zezempilo

I-test-tube, isilwane, kanye nezifundo ezimbalwa zabantu zikhomba ukuthi i-EGCG inikela ngezinzuzo eziningi zezempilo, kufaka phakathi ukuvuvukala okunciphisiwe, ukuncipha, kanye nempilo yenhliziyo nengqondo ethuthukisiwe.

Ekugcineni, kudingeka olunye ucwaningo ukuqonda kangcono ukuthi i-EGCG ingasetshenziswa kanjani njengethuluzi lokuvimbela noma ukwelashwa kwezifo, yize imininingwane yamanje ithembisa.

Imiphumela ye-antioxidant ne-anti-inflammatory

Iningi lesimangalo se-EGCG lodumo sivela emandleni alo anamandla e-antioxidant namandla okunciphisa ukucindezeleka nokuvuvukala.

Ama-radicals amahhala ayizinhlayiya ezisebenza kakhulu ezingadala ukulimala kumaseli akho. Ukukhiqizwa okukhululekile kwamahhala okuholela ekucindezelekeni kwe-oxidative.

Njenge-antioxidant, i-EGCG ivikela amaseli akho ekulimaleni okuhambisana nengcindezi ye-oxidative futhi icindezela umsebenzi wamakhemikhali ahlasela ukuvuvukala akhiqizwa emzimbeni wakho, njenge-tumor necrosis factor-alpha (TNF-alpha) ().

Ingcindezi nokuvuvukala kuxhunyaniswa nezifo ezahlukahlukene ezingamahlalakhona, kufaka phakathi umdlavuza, isifo sikashukela kanye nesifo senhliziyo.

Ngakho-ke, imiphumela elwa nokuvuvukala ne-antioxidant ye-EGCG kucatshangwa ukuthi ingesinye sezizathu eziyinhloko zokusebenzisa kwayo okubanzi okuvimbela izifo ().

Impilo yenhliziyo

Ucwaningo lukhombisa ukuthi i-EGCG etiyi eluhlaza ingaxhasa impilo yenhliziyo ngokunciphisa umfutho wegazi, i-cholesterol, kanye nokuqongelela koqwembe emithanjeni yegazi - konke okuyizinto eziyingozi enkulu yesifo senhliziyo (,).

Esifundweni samasonto ayisishiyagalombili kubantu abangama-33, ukuthatha ama-250 mg we-EGCG aqukethe i-green tea extract nsuku zonke kuholele ekwehlisweni okuphawulekayo kwe-4.5% kwe-LDL (bad) cholesterol ().

Ucwaningo oluhlukile kubantu abangama-56 luthole ukwehla okuphawulekayo kwengcindezi yegazi, i-cholesterol, kanye nezimpawu zokuvuvukala kulabo abathatha umthamo wansuku zonke ka-379 mg weti eluhlaza etiye ngaphezu kwezinyanga ezintathu ().

Yize le miphumela ikhuthaza, ucwaningo olwengeziwe luyadingeka ukuqonda kangcono ukuthi i-EGCG ngeti eliluhlaza ingayinciphisa kanjani ingozi yesifo senhliziyo.

Ukwehla kwesisindo

I-EGCG nayo ingakhuthaza ukulahleka kwesisindo, ikakhulukazi uma ithathwa eceleni kwe-caffeine ngokwemvelo etholakala kutiye oluhlaza.

Yize imiphumela eminingi yocwaningo kumthelela wesisindo se-EGCG ingahambelani, olunye ucwaningo lwesikhathi eside lokuhlola luthi ukuphuza cishe izinkomishi ezi-2 (14.7 ounces noma 434 ml) wetiye oluhlaza ngosuku kuhlotshaniswa namafutha omzimba aphansi nesisindo ().

Izifundo zabantu ezingeziwe zithole ngokubambisana ukuthi ukuthatha u-100-460 mg we-EGCG kanye no-80-300 mg we-caffeine okungenani amasonto ayi-12 kuxhumene nokulahleka kwesisindo okuphawulekayo nokwehliswa kwamafutha omzimba ().

Noma kunjalo, ushintsho kusisindo noma ekwakhekeni komzimba alubonakali njalo lapho i-EGCG ithathwa ngaphandle kwe-caffeine.

Impilo yobuchopho

Ucwaningo lwakuqala luphakamisa ukuthi i-EGCG ngetiye eliluhlaza ingadlala indima ekuthuthukiseni ukusebenza kwamangqamuzana emizwa nokuvikela izifo zobuchopho eziwohlozayo.

Kwezinye izifundo, imijovo ye-EGCG ithuthukise kakhulu ukuvuvukala, kanye nokululama nokuvuselelwa kwamaseli we-neural kumagundane anokulimala komgogodla (,).

Ukwengeza, izifundo eziningi zokubuka kubantu zathola ukuxhumana phakathi kokudliwa okuphezulu kwetiye eliluhlaza kanye nokwehla kwengozi yokwehla kobuchopho obuhlobene nobudala, kanye nesifo i-Alzheimer's kanye nesifo sikaParkinson. Noma kunjalo, imininingwane etholakalayo ayihambelani ().

Ngaphezu kwalokho, kuhlala kungacaci ukuthi i-EGCG ikakhulukazi noma mhlawumbe ezinye izingxenye zamakhemikhali zetiye eliluhlaza zinayo yini le miphumela.

Ucwaningo oluningi luyadingeka ukuqonda kangcono ukuthi ngabe i-EGCG ingavimbela ngempumelelo noma yelaphe izifo zobuchopho eziwohlozayo kubantu.

I-EGCG ngetiye eliluhlaza inganikela ngezinzuzo ezahlukahlukene zezempilo, njengokuncipha kokuvuvukala, ukwehla kwesisindo, nokuvikela izifo zenhliziyo nobuchopho. Noma kunjalo, kudingeka olunye ucwaningo ngokusebenza kwalo.

Isikali kanye nemiphumela engemihle engaba khona

Yize i-EGCG ifundwe amashumi eminyaka, imiphumela yayo yomzimba ihluke kakhulu.

Abanye ochwepheshe bakholelwa ukuthi lokhu kungenxa yokuthi i-EGCG ilulaza kalula lapho kukhona umoya-mpilo, futhi abantu abaningi abawungenisi kahle emgudwini wokugaya ukudla ().

Isizathu salokhu asiqondakali ngokuphelele, kepha kungahle kuhlobene neqiniso lokuthi i-EGCG eningi idlula amathumbu amancane ngokushesha okukhulu futhi igcina sehliswa amagciwane esiswini esikhulu ().

Lokhu kuye kwenza ukuthuthuka kwezincomo ezithile zomthamo kube nzima.

Inkomishi eyodwa (ama-ounces ayisishiyagalombili noma ama-250 ml) wetiye elihlaza eliphekiwe ngokuvamile liqukethe cishe u-50-100 mg we-EGCG. Imithamo esetshenziswe ezifundweni zesayensi imvamisa iphakeme kakhulu, kepha inani eliqondile belingahambelani (,).

Ukufakwa kwansuku zonke okulingana noma ngaphezulu kwe-800 mg ye-EGCG ngosuku kukhulisa amazinga egazi ama-transaminases, inkomba yokulimala kwesibindi (17).

Iqembu elilodwa labaphenyi liphakamise izinga lokudla eliphephile lama-338 mg we-EGCG ngosuku lapho lingeniswa ngendlela eqinile yokwengeza (18).

Imiphumela emibi engaba khona

Kubalulekile ukuqaphela ukuthi i-EGCG ayiphephile i-100% noma ayinangozi. Eqinisweni, izengezo ze-EGCG zihlotshaniswe nemiphumela emibi kakhulu, efana ():

• ukwehluleka kwesibindi nezinso
• isiyezi
• ushukela wegazi ophansi
• i-anemia

Abanye ochwepheshe bathi le miphumela emibi ingahle ihlobene nokungcola okunobuthi kwezithako hhayi i-EGCG uqobo, kepha noma ngabe kunjalo, kufanele uqaphele kakhulu uma ucabanga ukuthatha lesi sithasiselo.

Ukuthatha imithamo eyengeziwe ye-EGCG akunconywa uma ukhulelwe, ngoba kungaphazamisa imetabolism ye-folate - uvithamini B obalulekile ekukhuleni kwengane nokukhula - okwandisa ubungozi bokukhubazeka kokuzalwa njenge-spina bifida ().

Kuhlala kungacaci ukuthi izithasiselo ze-EGCG ziphephile yini kwabesifazane abancancisayo, ngakho-ke kungcono kakhulu ukukugwema kuze kutholakale ucwaningo olwengeziwe ().

I-EGCG nayo ingaphazamisa ukumuncwa kwemithi ethile kadokotela, kufaka phakathi izinhlobo ezithile zemithi yokwehlisa i-cholesterol kanye nemithi yokulwa nezengqondo ().

Ukuqinisekisa ukuphepha, hlala uthintana nomhlinzeki wakho wezokunakekelwa kwempilo ngaphambi kokuqala isengezo esisha sokudla.

Okwamanje asikho isincomo somthamo esicacile se-EGCG, yize i-800 mg nsuku zonke kuze kube amasonto ama-4 isetshenziswe ngokuphepha ezifundweni. Izengezo ze-EGCG zixhunyaniswe nemiphumela emibi kakhulu futhi zingaphazamisa ukumuncwa kwemithi.

Okubalulekile

I-EGCG iyinhlanganisela enamandla engahlomulisa impilo ngokunciphisa ukuvuvukala, ukusiza ukwehla kwesisindo, nokuvikela izifo ezithile ezingamahlalakhona.

Igcwele kakhulu itiye eliluhlaza kepha itholakale nakokunye ukudla kwezitshalo.

Lapho ithathwa njengesengezo, i-EGCG kwesinye isikhathi ihlotshaniswa nemiphumela emibi kakhulu. Indlela ephephe kunazo zonke ukubonisana nomhlinzeki wakho wezokunakekelwa kwempilo ngaphambi kokungeza i-EGCG enkambisweni yakho ukuqinisekisa ukuthi lesi sengezo sikufanele.