Izinzuzo eziyi-10 zokukhishwa kwembewu yamagilebhisi, ngokususelwa kuSayensi

-Delile

• 1.Inganciphisa umfutho wegazi
• 2. Kungathuthukisa ukugeleza kwegazi
• 3. Kunganciphisa ukulimala okwenziwe nge-oxidative
• 4. Kungathuthukisa amazinga e-collagen namandla amathambo
• 5. Isekela ubuchopho bakho njengoba bukhula
• 6. Ingathuthukisa ukusebenza kwezinso
• 7. Ingavimbela ukukhula kokutheleleka
• 8. Kunganciphisa ingozi yomdlavuza
• 9. Kungavikela isibindi sakho
• 10. Ithuthukisa ukululama nokubukeka kwesilonda
• Imiphumela emibi engaba khona
• Okubalulekile

Ukukhishwa kwembewu yamagilebhisi (i-GSE) kuyisengezo sokudla esenziwe ngokususa, ukomisa, nokugaya imbewu yamagilebhisi ebabayo.

Imbewu yamagilebhisi icebile ngama-antioxidants, kufaka phakathi ama-phenolic acid, ama-anthocyanins, ama-flavonoids, nama-oligomeric proanthocyanidin complexes (OPCs).

Eqinisweni, i-GSE ingenye yemithombo eyaziwa kakhulu yama-proanthocyanidins (,).

Ngenxa yokuqukethwe kwayo okuphezulu kwe-antioxidant, i-GSE ingasiza ekuvikeleni izifo futhi ivikele ekucindezelekeni kwe-oxidative, ukulimala kwezicubu nokuvuvukala ().

Qaphela ukuthi ukukhishwa kwembewu yamagilebhisi kanye nokukhishwa kwembewu yamagilebhisi zombili kuthengiswa njengezithasiselo futhi kufushanisiwe yi-GSE. Lo mbhalo ukhuluma ngokukhishwa kwembewu yamagilebhisi.

Nazi izinzuzo eziyishumi zezempilo zokukhishwa kwembewu yamagilebhisi, konke kususelwa kwisayensi.

1.Inganciphisa umfutho wegazi

Ucwaningo oluningi lucwaninge imiphumela ye-GSE kumfutho wegazi ophakeme.

Ukubuyekezwa kwezifundo eziyi-16 kubantu abayi-810 abanengcindezi ephezulu yegazi noma ingozi ephezulu yalokho kuthole ukuthi ukuthatha u-100-2,000 mg we-GSE nsuku zonke kunciphise kakhulu umfutho wegazi we-systolic ne-diastolic (inombolo ephezulu nengezansi) ngesilinganiso esingu-6.08 mmHg no-2.8 mmHg, ngokulandelana.

Labo abangaphansi kweminyaka engama-50 abanokukhuluphala noma ukuphazamiseka emzimbeni bakhombise ukuthuthuka okukhulu kakhulu.

Imiphumela ethembise kakhulu iqhamuke emithamo ephansi ka-100-800 mg nsuku zonke emavikini ayi-8-16, kunokuba kube nomthamo owodwa ka-800 mg noma ngaphezulu ().

Olunye ucwaningo kubantu abadala abangama-29 abane-high blood pressure luthole ukuthi ukuthatha ama-300 mg we-GSE nsuku zonke kwehlisa umfutho wegazi we-systolic ngo-5.6% kanye ne-diastolic blood pressure ngo-4.7% ngemuva kwamaviki ayisithupha ().

Isifinyezo I-GSE ingasiza ekunciphiseni ukucindezelwa kwegazi, ikakhulukazi kubantu abasha kuya kubantu abaneminyaka ephakathi naphakathi nalabo abanesisindo esiningi.

2. Kungathuthukisa ukugeleza kwegazi

Ezinye izifundo ziphakamisa ukuthi i-GSE ingathuthukisa ukugeleza kwegazi.

Esifundweni samasonto ayisishiyagalombili kwabesifazane abangu-17 abanempilo ngemuva kokuya esikhathini, ukuthatha ama-400 mg we-GSE kube nemiphumela yokuncipha kwegazi, okungahle kunciphise ubungozi bamahlule egazi ().

Ucwaningo olwengeziwe kwabesifazane abasebasha abayisishiyagalombili abaphilile lwahlola imiphumela yomthamo owodwa we-400-mg we-proanthocyanidin ovela ku-GSE ngokushesha owalandelwa amahora angu-6 ehleli. Kuboniswe ukunciphisa ukuvuvukala kwemilenze ne-edema ngama-70%, uma kuqhathaniswa nokungathathi i-GSE.

Ocwaningweni olufanayo, abanye besifazane abasebasha abayi-8 abathathe umuthi wansuku zonke we-133-mg wama-proanthocyanidins kusuka ku-GSE izinsuku eziyi-14 bathola ukuvuvukala okungaphansi komlenze okungama-40% ngemuva kwamahora angu-6 behleli ().

Isifinyezo I-GSE ikhonjisiwe ukuthi ithuthukisa ukugeleza kwegazi futhi inciphise ubungozi bokuqina kwegazi, okungasiza labo abanezinkinga zokujikeleza kwegazi.

3. Kunganciphisa ukulimala okwenziwe nge-oxidative

Izinga eliphakeme legazi le-LDL (elibi) le-cholesterol liyingozi eyaziwayo yesifo senhliziyo.

I-oxidation ye-LDL cholesterol iyayandisa kakhulu le ngozi futhi idlala indima enkulu ekuthini isifo sokuqina kwemithambo yegazi, noma ukwakheka kocwecwe olunamafutha emithanjeni yakho ().

Izithasiselo ze-GSE zitholakele ukunciphisa i-LDL oxidation ebangelwa ukudla okunamafutha aphezulu ezifundweni eziningana zezilwane (,,).

Olunye ucwaningo kubantu lubonisa imiphumela efanayo (,).

Lapho abantu abayisishiyagalombili abaphilile bedla ukudla okunamafutha amaningi, ukuthatha ama-300 mg we-GSE kuvimbele uketshezi kwamafutha egazini, uma kuqhathaniswa nokukhuphuka okungu-150% okubonwe kulabo abangathathanga i-GSE ().

Kwesinye isifundo, abantu abadala abangama-61 abaphilile babone ukwehla okungu-13.9% kwe-LDL ene-oxidized ngemuva kokuthatha ama-400 mg we-GSE. Kodwa-ke, ucwaningo olufanayo alukwazanga ukuphindaphinda le miphumela (,).

Ngokwengeziwe, ucwaningo kubantu abangama-87 abahlinzwa inhliziyo lwathola ukuthi ukuthatha ama-400 mg we-GSE ngosuku lwangaphambi kokuhlinzwa kunciphise kakhulu ukucindezeleka okwenziwe nge-oxidative. Ngakho-ke, i-GSE kungenzeka ivikelekile ekulimaleni okuqhubekayo kwenhliziyo ().

Isifinyezo I-GSE ingasiza ekunciphiseni ubungozi besifo senhliziyo ngokuvimbela uketshezi kwe-cholesterol ye-LDL (embi) nokunciphisa i-oxidation ezicutshini zenhliziyo ngezikhathi zokuxineka.

4. Kungathuthukisa amazinga e-collagen namandla amathambo

Ukwandisa ukusetshenziswa kwe-flavonoid kungathuthukisa ukuhlanganiswa kwe-collagen nokwakheka kwamathambo.

Njengomthombo ocebile wama-flavonoids, i-GSE ngaleyo ndlela ingasiza ukukhulisa ukuqina kwamathambo akho namandla.

Eqinisweni, izifundo zezilwane zithole ukuthi ukufaka i-GSE kokudla okune-calcium ephansi, ejwayelekile, noma ephezulu ye-calcium kungakhuphula ukuqina kwamathambo, okuqukethwe kwamaminerali, kanye namandla amathambo (,).

I-rheumatoid arthritis yisimo sokuzimela esiholela ekuvukeleni okukhulu nokubhujiswa kwamathambo namalunga.

Ucwaningo lwezilwane lukhombisile ukuthi i-GSE ingahle icindezele ukubhujiswa kwethambo ku-arthritis yokuvuvukala okuzenzakalelayo (,,).

I-GSE iphinde yehlise kakhulu ubuhlungu, i-bony spurs, kanye nomonakalo ohlangene kumagundane e-osteoarthritic, ukwenza ngcono amazinga e-collagen nokunciphisa ukulahleka kwe-cartilage ().

Naphezu kwemiphumela ethembisayo evela ocwaningweni lwezilwane, izifundo zabantu ziyashoda.

Isifinyezo Izifundo zezilwane zibonisa imiphumela ethembisayo mayelana nekhono le-GSE lokusiza ukwelapha izimo ze-arthritic nokukhuthaza impilo ye-collagen. Kodwa-ke, ucwaningo olwenziwe ngabantu luyashoda.

5. Isekela ubuchopho bakho njengoba bukhula

Inhlanganisela kaFlavonoids yezakhi ze-antioxidant kanye ne-anti-inflammatory kucatshangwa ukuthi kubambezela noma ukunciphisa ukuqala kwezifo ze-neurodegenerative njengesifo se-Alzheimer's ().

Enye yezinto ze-GSE yi-gallic acid, okuboniswe yizilwane kanye namalebhu kungavimbela ukwakheka kwama-fibrils ngama-beta-amyloid peptides ().

Amaqoqo amaprotheni we-beta-amyloid ebuchosheni ayimpawu yesifo i-Alzheimer's ().

Izifundo zezilwane zithole ukuthi i-GSE ingavimbela ukulahleka kwememori, ithuthukise isimo sokuqonda kanye namazinga obuchopho e-antioxidant, futhi inciphise izilonda zobuchopho namaqoqo e-amyloid (,,,).

Isifundo esisodwa samasonto angu-12 kubantu abadala asebekhulile abangu-111 bathole ukuthi ukuthatha ama-150 mg we-GSE nsuku zonke kuthuthukisa ukunakekelwa, ulimi, kanye nememori esheshayo nephuzile ().

Kodwa-ke, izifundo zabantu ekusetshenzisweni kwe-GSE kubantu abadala abanememori ekhona noma ukusilela kokuqonda ziyashoda.

Isifinyezo I-GSE ikhombisa amandla okuvimbela izici eziningi eziwohlokayo zobuchopho nokwehla kwengqondo. Kodwa-ke, kudingeka izifundo eziningi zabantu.

6. Ingathuthukisa ukusebenza kwezinso

Izinso zakho zithinteka kakhulu ekulimaleni okwenziwe nge-oxidative, okuvame ukubuyiselwa emuva.

Ucwaningo lwezilwane lukhombisile ukuthi i-GSE inganciphisa ukulimala kwezinso futhi ithuthukise ukusebenza ngokunciphisa ukucindezeleka kwe-oxidative nomonakalo wokuvuvukala (,,).

Kokunye ukuhlola, abantu abangama-23 abatholakale benokuhluleka kwezinso okungamahlalakhona banikezwa amagremu ama-2 we-GSE nsuku zonke izinyanga eziyisithupha bese beqhathaniswa neqembu le-placebo. Amaprotheni e-Urinary ehle ngo-3% kanti ukuhlunga izinso kuthuthukiswe ngo-9%.

Lokhu kusho ukuthi izinso zalabo abaseqenjini lokuhlola bezikwazi kangcono ukuhlunga umchamo kunezinso zalabo abaseqenjini le-placebo ().

Isifinyezo I-GSE ingahlinzeka ngokuvikelwa ekulimaleni okuvela ekucindezelekeni kwe-oxidative nokuvuvukala, ngaleyo ndlela kuthuthukiswe impilo yezinso.

7. Ingavimbela ukukhula kokutheleleka

I-GSE ikhombisa izakhiwo ezethembisayo zokulwa namagciwane kanye ne-antifungal.

Ucwaningo lukhombisile ukuthi i-GSE ivimbela ukukhula kwamagciwane ajwayelekile okudla, kufaka phakathi I-Campylobacter futhi E. coli, zombili lezi ezivame ukubhekana nokudla okunobuthi obunzima nokuxakeka esiswini (33, 34).

Ezifundweni zebhu, i-GSE itholakale ukuthi ivimbela izinhlobo ezingama-43 zemithi elwa namagciwane I-Staphylococcus aureus amagciwane ().

ICandida yisikhunta esivamile esifana nemvubelo kwesinye isikhathi esingaholela ekukhuleni kwe-candida, noma i-thrush. I-GSE isetshenziswa kakhulu emithini yesintu njengekhambi le-candida.

Kwesinye isifundo, amagundane ane-candidiasis yangasese anikezwa isisombululo se-GSE sangaphakathi njalo ezinsukwini ezimbili izinsuku eziyi-8. Ukutheleleka kwavinjelwa ngemuva kwezinsuku ezinhlanu kwalandela okungu-8 ().

Ngeshwa, izifundo zabantu mayelana nekhono le-GSE lokusiza ukwelapha izifo zisashoda.

Isifinyezo I-GSE ingavimbela amagciwane ahlukahlukene futhi inikeze ukuvikeleka ezifweni zamagciwane ezingamelana namagciwane, izifo ezibangelwa amagciwane okudla, kanye nezifo zefungal njenge-candida.

8. Kunganciphisa ingozi yomdlavuza

Izimbangela zomdlavuza ziyinkimbinkimbi, kepha ukulimala kwe-DNA kuyisici esiyinhloko.

Ukudla okuphezulu kwama-antioxidants, njenge-flavonoids nama-proanthocyanidins, kuhlotshaniswa nengozi encishisiwe yomdlavuza ohlukahlukene ().

Umsebenzi we-antioxidant we-GSE ukhombise amandla okuvimbela isifuba somuntu, amaphaphu, isisu, iseli yomlomo e-squamous, isibindi, i-prostate, kanye nolayini be-pancreatic kumasethingi ebhu (,,,).

Ezifundweni zezilwane, i-GSE ikhonjisiwe ukuthi ithuthukise umphumela wezinhlobo ezahlukahlukene zamakhemikhali (,,).

I-GSE ibonakala ivikela ekucindezelekeni kwe-oxidative kanye nobuthi besibindi ngenkathi ibhekise isenzo se-chemotherapy kumaseli anomdlavuza (,,).

Ukubuyekezwa kwezifundo zezilwane ezingama-41 kutholakale ukuthi i-GSE noma i-proanthocyanidins inciphise ubuthi kanye nomonakalo obangelwa umdlavuza kuzo zonke izifundo ngaphandle kwesisodwa ().

Gcina ukhumbula ukuthi amandla we-GSE kanye ne-proanthocyanidins yayo angeke adluliselwe ngqo kubantu abanomdlavuza. Kudingeka izifundo eziningi kubantu.

Isifinyezo Ezifundweni zebhu, i-GSE ikhonjisiwe ukuthi ivimbela umdlavuza ezinhlotsheni ezahlukahlukene zamaseli womuntu. I-GSE futhi ibonakala inciphisa ubuthi obenziwe ngamakhemikhali ezifundweni zezilwane ngaphandle kokuthinta kabi ukwelashwa. Ucwaningo olwengeziwe olwenziwa ngabantu luyadingeka.

9. Kungavikela isibindi sakho

Isibindi sakho sidlala indima ebalulekile ekukhipheni ubuthi ezintweni eziyingozi ezifakwe emzimbeni wakho ngezidakamizwa, izifo ezibangelwa amagciwane, ukungcola, utshwala, nokuningi.

I-GSE ibonakala inomthelela wokuvikela esibindini sakho.

Ezifundweni ze-test-tube, i-GSE inciphise ukuvuvukala, ama-antioxidants asetshenzisiwe, futhi yavikelwa ekulimaleni okukhululekile ngesikhathi sokuvezwa kwe-toxin (,,).

I-enzyme yesibindi i-alanine aminotransferase (ALT) iyinkomba eyinhloko yobuthi besibindi, okusho ukuthi amazinga ayo akhuphuka lapho isibindi sesilimele ().

Kokunye ukuhlola, abantu abangu-15 abanezifo zesibindi ezinamafutha ezingezona utshwala kanye namazinga aphezulu e-ALT alandelayo anikezwa i-GSE izinyanga ezintathu. Ama-enzyme wesibindi ayegadwa njalo ngenyanga, futhi imiphumela yaqhathaniswa nokuthatha u-2 gram kavithamini C ngosuku.

Ngemuva kwezinyanga ezi-3, iqembu le-GSE lahlangabezana nokuncipha kwe-46% ku-ALT, ngenkathi iqembu likavithamini C likhombisa ushintsho oluncane ().

Isifinyezo I-GSE ibonakala ivikela isibindi sakho kubuthi obudalwa yizidakamizwa nomonakalo. Kodwa-ke, kudingeka izifundo eziningi zabantu.

10. Ithuthukisa ukululama nokubukeka kwesilonda

Izifundo eziningana zezilwane zithole ukuthi i-GSE ingasiza ukuphulukiswa kwesilonda (,, 52).

Izifundo zabantu zibonisa isithembiso futhi.

Kokunye ukufunda okunjalo, abantu abadala abangama-35 abaphilile abahlinzwe okuncane banikezwa ukhilimu we-GSE noma i-placebo engu-2%. Labo abasebenzisa ukhilimu we-GSE bathola ukwelashwa okuphelele kwesilonda ngemuva kwezinsuku eziyi-8, ngenkathi iqembu le-placebo lathatha izinsuku eziyi-14 ukuphola.

Le miphumela kungenzeka kakhulu ngenxa yamazinga aphezulu ama-proanthocyanidins ku-GSE abangela ukukhishwa kwezici zokukhula esikhunjeni ().

Kwesinye isifundo samasonto ayisishiyagalombili ezinsizweni eziyi-110 ezinempilo, i-2% GSE cream yathuthukisa ukubukeka kwesikhumba, ukuqina, nokuqukethwe kwe-sebum, okungasiza ukunciphisa izimpawu zokuguga ().

Isifinyezo Ukhilimu we-GSE ubonakala ukhulisa izici zokukhula esikhunjeni sakho. Njengoba kunje, zingasiza ukuphulukiswa kwesilonda futhi zisize ukunciphisa izimpawu zokuguga kwesikhumba.

Imiphumela emibi engaba khona

I-GSE ngokuvamile ibhekwa iphephile ngemiphumela emibi embalwa.

Imithamo ezungeze i-300-800 mg ngosuku ngamaviki ayi-8-16 itholakale iphephile futhi ibekezelelwe kahle kubantu ().

Labo abakhulelwe noma abancelisayo kufanele bakugweme, ngoba kunemininingwane enganele ngemiphumela yayo kulezi zindawo.

I-GSE inganciphisa umfutho wegazi, inciphise igazi lakho, futhi inyuse ukugeleza kwegazi, ngakho-ke ukwelulekwa kuyalulekwa kulabo abathatha imithi yokuncipha igazi noma yengcindezi yegazi (,,).

Ngaphezu kwalokho, kunganciphisa ukumuncwa kwensimbi, futhi kuthuthukise ukusebenza kwesibindi kanye nezidakamizwa zomzimba. Xhumana nomhlinzeki wakho wezempilo ngaphambi kokuthatha izithasiselo ze-GSE (,).

Isifinyezo I-GSE ibonakala ibekezeleleke kahle. Kodwa-ke, abesifazane abakhulelwe nabancelisayo kufanele bakugweme. Futhi, labo abathatha imithi ethile kufanele baxoxe ngokuthatha lesi sengezo nomhlinzeki wabo wezokunakekelwa kwempilo.

Okubalulekile

Ukukhishwa kwembewu yamagilebhisi (i-GSE) kuyisengezo sokudla esenziwe ngembewu yamagilebhisi.

Kungumthombo onamandla wama-antioxidants, ikakhulukazi ama-proanthocyanidins.

Ama-antioxidants ku-GSE angasiza ekunciphiseni ukucindezeleka kwe-oxidative, ukuvuvukala, kanye nokonakala kwezicubu okungenzeka kuhambisane nezifo ezingamahlalakhona.

Ngokunezela nge-GSE, uzovuna izinzuzo zenhliziyo engcono, ubuchopho, izinso, isibindi, nempilo yesikhumba.