Ngingathola I-Grapefruit Ngenkathi Ngithatha iMetformin?

-Delile

• Yini i-metformin?
• Ukusebenzisana kwezidakamizwa nokusebenza kwamagilebhisi kusebenza kanjani
• Yimiphi imishanguzo ehlangana ne-grapefruit?
• Ngabe i-grapefruit iyithinta kanjani i-metformin?
• Ezinye izinto okufanele uzigweme ngenkathi uku-metformin
• I-grapefruit ingabasiza kanjani abantu abanesifo sikashukela
• Ukudla okudlela endlini

NgoMeyi 2020, okunconywayo ukuthi abanye abenzi be-metformin enwetshiwe bakhiphe amanye amaphilisi abo emakethe yase-U.S. Lokhu kungenxa yokuthi izinga elingamukeleki le-carcinogen (i-agent ebangela umdlavuza) itholakale kwamanye amaphilisi e-metformin akhululwa isikhathi eside. Uma okwamanje uthatha lo muthi, shayela umhlinzeki wakho wezokunakekelwa kwempilo. Bazokweluleka ngokuthi ngabe kufanele uqhubeke nokudla imishanguzo yakho noma uma udinga incwadi kadokotela entsha.

Imithi eminingi, njengama-statins namanye ama-antihistamine, anokuxhumana okungalungile ne-grapefruit. I-Metformin isetshenziswa ekwelapheni isifo sikashukela sohlobo lwe-2.

Ngabe ukuthola ubhamubhamu ngenkathi uthatha i-metformin kuholela emiphumeleni emibi? Kukhona ucwaningo olunomkhawulo, kepha nakhu okumele ukwazi.

Yini i-metformin?

I-Metformin isidakamizwa esinqunyelwe ukwelapha uhlobo lwesifo sikashukela sohlobo 2. Abantu abanesifo sikashukela sohlobo lwe-2 abakwazi ukusebenzisa i-insulin ngokujwayelekile. Lokhu kusho ukuthi abakwazi ukulawula inani likashukela egazini labo. I-Metformin isiza abantu abanesifo sikashukela sohlobo lwe-2 ukulawula izinga likashukela egazini labo ngezindlela eziningana, kufaka phakathi:

• ukunciphisa inani likashukela emzimbeni wakho olimunca ekudleni
• ukunciphisa inani likashukela elikhiqizwa isibindi sakho
• ukwandisa impendulo yomzimba wakho ku-insulin eyenzayo ngokwemvelo

I-Metformin ayikwazi ukubangela isimo esibi kakhulu nesongela impilo esibizwa nge-lactic acidosis. Abantu abanezinkinga zesibindi, izinso, noma inhliziyo kufanele bagweme ukuthatha i-metformin.

Ukusebenzisana kwezidakamizwa nokusebenza kwamagilebhisi kusebenza kanjani

Kukhona okungaphezu kwalokho okwaziwayo ukuthi kusebenzisana ne-grapefruit. Kulezi zidakamizwa, kungaholela emiphumeleni emibi kakhulu. Zonke izinhlobo zamagilebhisi - kufaka phakathi ijusi esanda kufinywa, ukugxila kweqhwa, nezithelo zonke - kungaholela ekuxhumaneni kwezidakamizwa.

Amanye amakhemikhali atholakala ku-grapefruit angabopha futhi angasebenzi i-enzyme emzimbeni wakho etholakala emathunjini akho nasesibindi. Le enzyme isiza ukwehlisa imithi oyiphuzayo.

Imvamisa lapho uphuza umuthi ngomlomo, wephulwa kancane ngama-enzyme ngaphambi kokuba ufinyelele egazini lakho. Lokhu kusho ukuthi uthola okuncane okuncane komuthi egazini lakho kunenani obulidla ekuqaleni.

Kepha uma i-enzyme ivinjelwe - njengoba injalo lapho ihlangana namakhemikhali asozitaphepheni - kunenani elikhulu kakhulu lomuthi ongena egazini lakho. Lokhu kuholela engcupheni enkulu yokweqisa ngokweqile. Bheka ngokujulile ukusebenzisana kwamagilebhisi nezidakamizwa.

Yimiphi imishanguzo ehlangana ne-grapefruit?

Ngokusho kwe-, izinhlobo ezilandelayo zemithi zingaba nokuxhumana okungekuhle ne-grapefruit:

• izitatimende, njenge-simvastatin (Zocor) ne-atorvastatin (Lipitor)
• izidakamizwa zomfutho wegazi ophezulu, njenge-nifedipine (Procardia)
• izidakamizwa zokuzivikela, njenge-cyclosporine (iSandimmune)
• i-corticosteroids esetshenziselwa ukwelapha isifo sikaCrohn noma i-ulcerative colitis, efana ne-budesonide (Entocort EC)
• izidakamizwa ezelapha isigqi senhliziyo esingajwayelekile, njenge-amiodarone (Pacerone)
• ama-antihistamine, njenge-fexofenadine (Allegra)
• ezinye izidakamizwa ezilwa nokukhathazeka, njenge-buspirone (BuSpar)

Ijusi lamagilebhisi alinawo umthelela kuwo wonke umuthi ezigabeni ezingenhla. Ukusebenzisana nejusi lamagilebhisi kuqondene nezidakamizwa, hhayi okuqondene nesigaba sezidakamizwa.

Lapho uqala umuthi omusha, kubaluleke kakhulu ukuthi ubuze udokotela noma usokhemisi wakho ukuthi uyakwazi yini ukudla ubhamubhamu noma imikhiqizo ehlobene novundululu.

Ngabe i-grapefruit iyithinta kanjani i-metformin?

Kubalulekile ukwazi ukuthi i-metformin ayidilizwa yi-enzyme efanayo nemithi ebalwe ngenhla. Ayenziwa ngumzimba wakho futhi ixoshwa emchameni wakho.

Kunolwazi olulinganiselwe olutholakalayo lokuthi ukuba no-grapefruit ngenkathi uthatha i-metformin kubathinta kanjani abantu abane-type 2 diabetes.

Kuxoxwe ngemiphumela yamagilebhisi ne-metformin kumagundane angenasifo sikashukela. Amanye amagundane atholwe ujusi wamagilebhisi kanye ne-metformin. Abanye bavezwa yi-metformin kuphela. Abaphenyi bathole ukuthi kube nokwanda kwenani lokukhiqizwa kwe-lactic acid kumagundane avezwe ujusi we-grapefruit ne-metformin.

Abaphenyi baqagela ukuthi ijusi yamagilebhisi ithuthukise ukuqoqwa kwe-metformin esibindi. Lokhu-ke kudale nokwanda komkhiqizo we-lactic acid. Ngenxa yalokhu, abacwaningi baphakamise ukuthi ukuphuza ujusi wamagilebhisi kungaholela engcupheni eyengeziwe ye-lactic acidosis kubantu abathatha i-metformin.

Kodwa-ke, le miphumela ibonwe kumagundane angenasifo sikashukela, hhayi kubantu abanesifo sikashukela sohlobo 2. Kuze kube manje, akukaze kube khona ucwaningo olwenziwe kubantu olukhombisa ukuthi ukuthatha i-metformin nejusi lamagilebhisi kuholela ku-lactic acidosis.

Ezinye izinto okufanele uzigweme ngenkathi uku-metformin

Ukuthatha imishanguzo ethile ngenkathi uthatha i-metformin kungakhuphula ubungozi bokuthola i-lactic acidosis. Kufanele wazise udokotela wakho uma ngabe uthatha noma iyiphi yale mithi elandelayo:

• isisu, njenge-acetazolamide
• ama-corticosteroids, njenge-prednisone
• imithi yomfutho wegazi, njenge-amlodipine (Norvasc)
• ama-anticonvulsants, njenge-topiramate (Topamax) ne-zonisamide (iZonegran)
• izinto zokuvimbela inzalo ngomlomo
• imishanguzo yokulwa nezengqondo, njenge-chlorpromazine

Gwema ukuphuza utshwala obuningi ngenkathi uku-metformin. Ukuphuza utshwala ngenkathi uthatha i-metformin kwandisa amathuba okuba noshukela ophansi wegazi noma i-lactic acidosis.

Ngokusho kweYunivesithi yaseMichigan, kufanele ugweme ukudla ukudla okunefayibha ephezulu ngemuva kokuthatha i-metformin. Lokhu kungenxa yokuthi i-fiber ingabopha ezidakamizweni futhi yehlise ukugxila kwayo. Amazinga e-Metformin ancipha lapho ethathwa ngenqwaba yefayibha (engaphezu kwama-milligram angama-30 ngosuku).

Eminye imihlahlandlela yokudla ejwayelekile yabantu abanesifo sikashukela imi kanje:

• Faka phakathi ama-carbohydrate aqhamuka kwimifino, izithelo, nakuzinhlamvu ezigcwele. Qinisekisa ukuqapha ukudla kwakho kwe-carbohydrate, ngoba lokhu kuzothinta ngqo ushukela wegazi lakho.
• Gwema ukudla okunamafutha amaningi agcwele futhi adlulisiwe. Esikhundleni salokho, dla amafutha enhlanzi, amantongomane, namafutha omnqumo. Nazi izindlela eziyi-10 zokwengeza amafutha anempilo ekudleni kwakho.
• Ukudla ama-milligram angama-25 kuye kwangama-30 efayibha ngosuku kungasiza ekulawuleni amazinga eglucose egazini. Bona lolu hlu lokudla okungu-22 okuphezulu-fiber ukuze uqalise.
• Gwema i-sodium. Zama ukusebenzisa ama-milligram angaphansi kwama-2,300 ngosuku.

I-grapefruit ingabasiza kanjani abantu abanesifo sikashukela

Ukuphuza ijusi lamagilebhisi kungasiza kakhulu uma unesifo sikashukela.

Okhombisile ukuthi amalungiselelo okuphuza wejusi yamagilebhisi ecacisiwe anciphise kokubili i-glucose yokuzila nokuzuza kwesisindo. Imiphumela ebonwayo ibifana nemiphumela ye-metformin. Kwakungekho mphumela owenziwe ngcono lapho ujusi we-grapefruit ne-metformin behlolwa ndawonye.

Ngenkathi kuthembisa, kubalulekile ukuthi uqaphele ukuthi lokhu kubhekwa kwenziwa kwimodeli yegundane yesifo sikashukela.

Indima yendima yamagilebhisi ekudleni nasekusebenzisaneni kwezidakamizwa iphakamisa nokuthi ubhamubhamu uhlobene nokuncipha kwesisindo kanye nokwenza ngcono ukumelana ne-insulin. Ngaphezu kwalokho, ukubuyekezwa kubuye kubike inhlanganisela yejusi lamagilebhisi (i-naringin) itholakale ithuthukisa i-hyperglycemia kanye ne-cholesterol ephezulu kuhlobo lwesibili lwesilwane sesilwane. Funda kabanzi ngokuphila nesifo sikashukela kanye ne-cholesterol ephezulu.

Ukudla okudlela endlini

I-Grapefruit iholela ekuxhumaneni okungalungile neminye imithi. Kodwa-ke, azikho izifundo ezimayelana nokudla ijusi yamagilebhisi ngenkathi uthatha i-metformin kuholele emiphumeleni emibi kubantu.

Kunobunye ubufakazi obuthembisayo bokuhlola ukuthi ukufaka i-grapefruit ekudleni kwakho kungasiza ukukhuthaza ukwehla kwesisindo nokunciphisa amazinga e-glucose asheshayo.

Uma uthatha i-metformin futhi ukhathazekile ngokuhlangana kwezidakamizwa noma ukuhlangana kwezidakamizwa, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.