Ama-immune System Suppressors weSifo sikaCrohn

-Delile

• I-Azathioprine
• I-Mercaptopurine
• IMethotrexate
• Izinto okufanele uzigcine engqondweni

Ukubuka konke

Alikho ikhambi lesifo sikaCrohn, ngakho ukukhululeka kwezimpawu kuza ngesimo sokuxolelwa. Kunezinhlobonhlobo zokwelashwa ezingasiza ekunciphiseni izimpawu zakho. Ama-immunomodulators yimithi eguqula amasosha omzimba.

Kumuntu oneCrohn's, lokhu kungasiza ukunciphisa ukuvuvukala okubangela izimpawu eziningi.

Ama-immunomodulators afaka izidakamizwa ezingama-immunosuppressants kanye nama-immunostimulants. Ama-immuneosuppressants avimbela ukuzivikela komzimba, kepha ukucindezelwa kokuzivikela komzimba kungabeka nomzimba engcupheni ephezulu yezinye izifo.

Ama-immuneostimulants akhulisa noma "avusa" amasosha omzimba, akhuthaza umzimba ukuthi uqale ukulwa nokugula.

Kunezinhlobo ezahlukahlukene zama-immunomodulators, ngalinye lithengiswa ngaphansi kwegama lalo lomkhiqizo. I-Azathioprine, i-mercaptopurine, ne-methotrexate yizinhlobo ezintathu eziyinhloko.

I-Azathioprine

I-Azathioprine ivame ukusetshenziswa kubantu abathola ukufakelwa isitho ukuvimbela umzimba ukuthi wenqabe isitho esisha ngokucindezela amasosha omzimba. Ibuye isetshenziselwe ukwelapha i-rheumatoid arthritis, okuyisimo lapho umzimba womuntu uhlasela khona amalunga omzimba.

Yize i-azathioprine ingakhonjiswanga ukuthi iyasebenza ekwehliseni izimpawu zesikhashana zikaCrohn noma ukufezekisa ukuxolelwa, kunganciphisa isidingo sokwelashwa kwe-steroid. Ucwaningo luyakhombisa ukuthi i-azathioprine isiza ukugcina abantu bethethelelwe uma izimpawu zikaCrohn sezilawuliwe.

Ngalesi sizathu, i-American College of Gastroenterology isekela ukusebenzisa i-azathioprine yabantu abathethelelayo noma abasenezimpawu zabo yize besebenzisa i-steroids.

Kukhona neminye imiphumela emibi, kodwa emibi, ye-azathioprine. Lesi sidakamizwa senza ukuthi umzimba wakho ukhiqize amangqamuzana amhlophe egazi ambalwa. Lokhu kungadala izinkinga ngoba amaseli amhlophe egazi alwa nokutheleleka.

Abantu abathatha i-azathioprine bangase babhekane nokuvuvukala kwamanyikwe noma ingozi enkulu yokuba ne-lymphoma.

Ngenxa yale miphumela engemihle, i-azathioprine ivame ukunikezwa kuphela amacala alinganiselayo nakakhulu weCrohn's. Kufanele ucabangele zonke izingozi ngaphambi kokuthatha i-azathioprine. Ungahlolwa nokushoda kwe-TPMT, okungathinta amasosha akho omzimba.

I-Mercaptopurine

IMercaptopurine, ebizwa nangokuthi yi-6-MP, yaziwa ngokuvimba amangqamuzana omdlavuza ukuthi angakhuli. Lesi sidakamizwa sivame ukusetshenziselwa ukwelapha i-leukemia. Kubantu abane-Crohn's, i-mercaptopurine ingasiza ukugcina ukuxolelwa.

IMercaptopurine inganciphisa ukukhiqizwa kwamangqamuzana amhlophe abomvu. Udokotela wakho kungenzeka afune ukwenza ukuhlolwa kwegazi njalo ukuqinisekisa ukuthi akukho monakalo kumnkantsha wakho wethambo. Ungahlolwa nokushoda kwe-TPMT, okungathinta amasosha akho omzimba.

Eminye imiphumela emibi ye-mercaptopurine ingafaka:

• izilonda zomlomo
• imfiva
• Umphimbo obuhlungu
• igazi emchameni noma esitulweni

Kufanele ucabangele yonke imiphumela emibi engaba khona ngaphambi kokuba uqale ukwelashwa.

IMethotrexate

I-Methotrexate ivimba i-cell metabolism, ebangela ukuthi amaseli afe. Lokhu kuholele ekusetshenzisweni kwayo kwesifo sikaCrohn, umdlavuza, kanye ne-psoriasis.

I-American College of Gastroenterology isekela ukusebenzisa i-methotrexate ukwelapha izimpawu zesifo sikaCrohn kubantu abathembele kuma-steroids. IMethotrexate ibuye isize ukugcina abantu abane-Crohn’s bethethelelwa.

Kodwa-ke, i-methotrexate inemiphumela engemihle efaka phakathi ubuthi obungahle bube khona esibindini noma emnkantsheni futhi, ezimweni ezingavamile, ubuthi bamaphaphu. Abesilisa noma abesifazane abazama ukukhulelwa akufanele basebenzise lesi sidakamizwa. Imiphumela emibi kakhulu ihlanganisa:

• ikhanda
• ukozela
• ukuqubuka kwesikhumba
• isicanucanu nokuhlanza
• ukulahleka kwezinwele

Izinto okufanele uzigcine engqondweni

Ama-immunomodulator angasiza ekulweni nezimpawu ezihlobene nesifo sikaCrohn, kepha aphazamisa amandla omzimba wakho wokulwa nokutheleleka. Ngenkathi uthatha ama-immunomodulators, naka noma yiziphi izimpawu zokutheleleka, ezinjengomkhuhlane noma ukubanda.

Uma uthuthukisa lezi zimpawu, xhumana nodokotela wakho ngokushesha.

Noma nini lapho uthatha ama-immunomodulators, qiniseka ukuthi udokotela wakho uhlola igazi lakho njalo ukuthola izimpawu zokulimala kwamathambo akho kanye nezitho zangaphakathi.

Amanye ama-immunomodulators angahle awathathe ngesikhathi sokukhulelwa, kepha kuzodingeka uxoxe ngobuhle nobubi bokuthi uqale umuthi omusha nodokotela wakho kuqala. Kufanele ukhulume nodokotela wakho uma ukhulelwe noma, noma ngabe ungowesilisa noma owesifazane, kungenzeka ukuthi ukhulelwe.