Ukuhlolwa kwe-ACTH

-Delile

• Kwenziwa kanjani ukuhlolwa kwe-ACTH
• Kungani kwenziwa ukuhlolwa kwe-ACTH
• Ungasho ukuthini imiphumela yokuhlolwa kwe-ACTH
• Izingozi zokuhlolwa kwe-ACTH
• Yini ongayilindela ngemuva kokuhlolwa kwe-ACTH

Kuyini ukuhlolwa kwe-ACTH?

I-Adrenocorticotropic hormone (ACTH) iyi-hormone ekhiqizwa engxenyeni yangaphakathi, noma ngaphambili, yendlala yobuchopho ebuchosheni. Umsebenzi we-ACTH ukulawula amazinga we-steroid hormone cortisol, ekhishwe ku-adrenal gland.

I-ACTH yaziwa nangokuthi:

• i-hormone ye-adrenocorticotropic
• i-serum adrenocorticotropic hormone
• i-ACTH ezwela kakhulu
• i-corticotropin
• cosyntropin, okuyindlela yezidakamizwa ye-ACTH

Ukuhlolwa kwe-ACTH kukala amazinga we-ACTH kanye ne-cortisol egazini futhi kusiza udokotela wakho ukuthola izifo ezihlotshaniswa ne-cortisol eningi kakhulu noma encane kakhulu emzimbeni. Izimbangela ezingaba khona zalezi zifo zihlanganisa:

• ukungasebenzi kahle kwepituitary noma i-adrenal
• isimila sesifuba
• isimila esiyindlala
• isimila samaphaphu

Kwenziwa kanjani ukuhlolwa kwe-ACTH

Udokotela wakho angakweluleka ukuthi ungathathi noma imuphi umuthi we-steroid ngaphambi kokuhlolwa kwakho. Lokhu kungathinta ukunemba kwemiphumela.

Ukuhlolwa kuvame ukwenziwa okokuqala ekuseni. Amazinga e-ACTH aphakeme kakhulu uma usanda kuvuka. Udokotela wakho kungenzeka ahlele ukuhlolwa kwakho ekuseni kakhulu.

Amazinga e-ACTH ahlolwa kusetshenziswa isampula yegazi. Isampula yegazi lithathwa ngokudonsa igazi emthanjeni, imvamisa lisuka ngaphakathi kwendololwane. Ukunikeza isampula yegazi kufaka lezi zinyathelo ezilandelayo:

1. Umhlinzeki wezokunakekelwa kwezempilo uqale ahlanze isiza ngesibulali magciwane ukubulala amagciwane.
2. Ngemuva kwalokho, bazosonga ibhande lokunwebeka engalweni yakho. Lokhu kwenza umthambo uvuvukele igazi.
3. Bazofaka kahle umjovo wenaliti emthanjeni wakho bese beqoqa igazi lakho kushubhu lesirinji.
4. Lapho ishubhu ligcwele, inaliti iyasuswa. Ibhande le-elastic liyasuswa, bese kuthi indawo yokubhoboza imbozwe nge-gauze oyinyumba ukumisa ukopha.

Kungani kwenziwa ukuhlolwa kwe-ACTH

Udokotela wakho anga-oda ukuhlolwa kwegazi le-ACTH uma unezimpawu ze-cortisol eningi kakhulu noma encane kakhulu. Lezi zimpawu zingahluka kakhulu kuye ngomuntu futhi zivame ukuba uphawu lwezinkinga ezengeziwe zezempilo.

Uma uneleveli ephezulu ye-cortisol, ungahle ube:

• ukukhuluphala ngokweqile
• ubuso obuyindilinga
• isikhumba esibuthakathaka, esizacile
• olayini onsomi esiswini
• imisipha ebuthakathaka
• induna
• inani elikhulile lezinwele zomzimba
• umfutho wegazi ophakeme
• amazinga aphansi e-potassium
• izinga eliphezulu le-bicarbonate
• amazinga aphezulu eglucose
• isifo sikashukela

Izimpawu ze-cortisol ephansi zifaka:

• imisipha ebuthakathaka
• ukukhathala
• ukuncipha komzimba
• ukwanda kombala wesikhumba ezindaweni ezingatholakali elangeni
• ukungathandi ukudla
• umfutho wegazi ophansi
• amazinga eglucose egazi aphansi
• amazinga aphansi e-sodium
• amazinga aphezulu e-potassium
• amazinga aphezulu e-calcium

Ungasho ukuthini imiphumela yokuhlolwa kwe-ACTH

Amanani ajwayelekile we-ACTH angama-picograms ayi-9 kuye kwangama-52 ngemililitha ngayinye. Amanani wamanani ajwayelekile angahluka kancane ngokuya nge-laboratory. Udokotela wakho uzokuchazela imiphumela yakho yokuhlolwa.

Izinga eliphakeme le-ACTH kungaba uphawu lwe:

• Isifo i-Addison
• i-adrenal hyperplasia
• Isifo sikaCushing
• isimila se-ectopic esikhiqiza i-ACTH
• adrenoleukodystrophy, okuyinto engavamile kakhulu
• Nelson’s syndrome, okungajwayelekile kakhulu

Izinga eliphansi le-ACTH kungaba uphawu lwe:

• isimila adrenal
• i-exogenous Cushing's syndrome
• hypopituitarism

Ukuthatha imishanguzo ye-steroid kungadala amazinga aphansi e-ACTH, ngakho-ke qiniseka ukuthi utshela udokotela wakho uma uku-steroids.

Izingozi zokuhlolwa kwe-ACTH

Ukuhlolwa kwegazi kuvame ukubekezelelwa kahle. Abanye abantu banemithambo emincane noma emikhulu, engenza ukuthatha isampula yegazi kube nzima kakhulu. Kodwa-ke, izingozi ezihambisana nokuhlolwa kwegazi njengokuhlolwa kwamahomoni e-ACTH azivamile.

Izingozi ezingajwayelekile zokudonswa igazi zifaka:

• ukopha ngokweqile
• ubuhlanya noma ukuquleka
• i-hematoma, noma ukuhlangana kwegazi ngaphansi kwesikhumba
• ukutheleleka kusayithi

Yini ongayilindela ngemuva kokuhlolwa kwe-ACTH

Ukuthola izifo ze-ACTH kungaba yinkimbinkimbi kakhulu. Udokotela wakho angadinga uku-oda ezinye izivivinyo zaselabhoratri futhi enze ukuhlolwa komzimba ngaphambi kokuthola ukuxilongwa.

Ngezicubu zokufihla i-ACTH, kuvame ukukhonjiswa ukuhlinzwa. Kwesinye isikhathi, izidakamizwa ezinjenge-cabergoline zingasetshenziswa ukwenza amazinga we-cortisol ajwayelekile. I-Hypercortisolism ngenxa yamathumba adrenal ngokuvamile idinga ukuhlinzwa futhi.