I-infliximab, Isixazululo Somjovo

-Delile

• Izexwayiso ezibalulekile
• Isexwayiso se-FDA:
  
• Ezinye izexwayiso
• Kuyini infliximab?
• Kungani kusetshenziswa
• Isebenza kanjani
• Imiphumela emibi ye-infliximab
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• I-infliximab ingaxhumana neminye imithi
• Izexwayiso ze-infliximab
• Isexwayiso somzimba
• Izexwayiso zabantu abanezimo ezithile zempilo
• Izexwayiso kwamanye amaqembu
• Ungayithatha kanjani i-infliximab
• Thatha njengoba kuqondisiwe
• Ukucatshangelwa okubalulekile kokuthatha i-infliximab
• Ukuvakasha
• Ukuhlolwa komtholampilo nokuqapha
• Ngaphambi kokugunyazwa

Okuvelele kwe-infliximab

1. Isixazululo somjovo we-infliximab siyatholakala njengezidakamizwa ezinegama lomkhiqizo. Akutholakali kunguqulo ejwayelekile. Amagama omkhiqizo: Remicade, Inflectra, Renflexis.
2. I-infliximab iza nesisombululo somjovo sokusetshenziswa njenge-infusion emthanjeni.
3. Isixazululo somjovo we-infliximab sisetshenziselwa ukwelapha isifo sikaCrohn, i-ulcerative colitis, i-rheumatoid arthritis, i-ankylosing spondylitis, i-psoriatic arthritis, ne-plaque psoriasis.

Izexwayiso ezibalulekile

Isexwayiso se-FDA:

• Lo muthi unezixwayiso zebhokisi elimnyama. Lezi izexwayiso ezibucayi kakhulu ezivela ku-Food and Drug Administration (FDA). Isexwayiso sebhokisi elimnyama sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.
• Ingozi yesixwayiso esibucayi sokutheleleka: I-infliximab inganciphisa amandla omzimba wakho wokulwa nezifo. Abanye abantu baba nezifo ezimbi ngenkathi bethatha lo muthi. Lokhu kungafaka isifo sofuba (i-TB) noma ezinye izifo ezibangelwa amagciwane, amagciwane noma isikhunta. Ungathathi i-infliximab uma unanoma yiluphi uhlobo lokutheleleka ngaphandle kokukhuluma nodokotela wakho kuqala. Udokotela wakho angakuhlolela izimpawu zokutheleleka ngaphambi, ngesikhathi nangemva kokwelashwa kwakho nge-infliximab. Udokotela wakho futhi angakuhlolela i-TB ngaphambi kokuqala i-infliximab.
• Ingozi yesixwayiso somdlavuza: Le mithi inyusa ubungozi be-lymphoma, umdlavuza womlomo wesibeletho, nezinye izinhlobo zomdlavuza. Abantu abangaphansi kweminyaka eyi-18, abantu abadala besilisa abasebasha, nalabo abanesifo sikaCrohn's or ulcerative colitis bangaba namathuba amaningi okuthola umdlavuza. Khuluma nodokotela wakho uma ngabe unanoma yiluphi uhlobo lomdlavuza. Udokotela wakho angadinga ukulungisa imithi yakho.

Ezinye izexwayiso

• Isexwayiso sokulimala kwesibindi: I-infliximab ingalimaza isibindi sakho. Tshela udokotela wakho uma unezimpawu zokulimala kwesibindi, njenge:
  • ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho
  • umchamo onombala omnyama
  • ubuhlungu ohlangothini lokunene lwesisu sakho
  • imfiva
  • ukukhathala ngokweqile
• Ingozi yesifo esifana nelupus: I-Lupus yisifo esithinta amasosha akho omzimba. Izimpawu zingafaka ubuhlungu besifuba obungapheli, ukuphefumula okuncane, ubuhlungu bamalunga, kanye nokuqubuka ezihlathini noma ezingalweni eziya ziba zimbi elangeni. Wena dokotela unganquma ukumisa i-infliximab uma uthuthukisa lezi zimpawu.
• Isexwayiso sokugoma: Ungawutholi umuthi wokugoma obukhoma ngenkathi uthatha i-infliximab. Linda okungenani izinyanga ezintathu ngemuva kokumisa i-infliximab ukuthola umuthi wokugoma obukhoma. Izibonelo zemithi yokugoma ebukhoma ifaka umuthi wokugomela umkhuhlane wamakhala, isimungumungwane, umumbu, nomuthi wokugomela i-rubella, kanye nomuthi wokugomela inkukhu noma wesingles. Umuthi wokugoma obukhoma kungenzeka ungakuvikele ngokuphelele kulesi sifo ngenkathi uthatha lo muthi. Uma ungaphansi kweminyaka engu-18, qiniseka ukuthi yonke imigomo isesikhathini ngaphambi kokuqala i-infliximab.
• Ukusabela okubucayi ngemuva kwesixwayiso sokumnika. Ukuphendula okubucayi okuthinta inhliziyo yakho, isigqi senhliziyo, nemithambo yegazi kungenzeka kungakapheli amahora angama-24 ukuqala kokufakwa ngakunye kwalomuthi. Lokhu kusabela kungabandakanya ukuhlaselwa yinhliziyo, okungabulala. Uma unezimpawu ezifana nesiyezi, ubuhlungu besifuba, noma ukushaya kwenhliziyo kungakapheli amahora angama-24 wokumnika kwakho, shayela udokotela wakho ngokushesha.

Kuyini infliximab?

I-Infliximab iyisidakamizwa esivela kudokotela. Itholakala njengesisombululo somjovo.

I-Infliximab iyatholakala njengemithi egama lingu-Remicade, Inflectra, ne-Renflexis. (I-Inflectra ne-Renflexis zingama-biosimilars. *) I-Infliximab ayitholakali kunguqulo ejwayelekile.

I-infliximab ingahlanganiswa ne-methotrexate lapho isetshenziselwa ukwelapha i-rheumatoid arthritis.

* I-biosimilar uhlobo lwesidakamizwa se-biologic. I-biologics yenziwa ngomthombo wezinto eziphilayo, njengamaseli aphilayo. I-biosimilar iyefana nomuthi wegama lomkhiqizo we-biologic, kodwa akuyona ikhophi eqondile. (Umuthi ojwayelekile, ngakolunye uhlangothi, uyikhophi ngqo yomuthi owenziwe ngamakhemikhali. Izidakamizwa eziningi zenziwa ngamakhemikhali.)

I-biosimilar ingahle ichazwe ukuthi yelaphe ezinye noma zonke izimo umuthi ophatha igama lomkhiqizo, futhi kulindeleke ukuthi ibe nemiphumela efanayo esigulini. Kulokhu, i-Inflectra ne-Renflexis yizinhlobo ze-biosimilar ze-Remicade.

Kungani kusetshenziswa

I-infliximab isetshenziselwa ukwelapha:

• Isifo sikaCrohn (lapho ungaphendulanga kwezinye izidakamizwa)
• i-ulcerative colitis (uma ungaphendulanga kwezinye izidakamizwa)
• i-rheumatoid arthritis (esetshenziswa ne-methotrexate)
• i-ankylosing spondylitis
• isifo samathambo psoriatic
• i-plaque psoriasis yesikhathi eside futhi enzima (esetshenziswa lapho udinga ukwelapha umzimba wakho wonke noma uma ezinye izindlela zokwelashwa zingakulungele)

Isebenza kanjani

Lo muthi usebenza ngokuvimba isenzo sephrotheni emzimbeni wakho esibizwa nge-tumor necrosis factor-alpha (TNF-alpha) emzimbeni wakho. I-TNF-alpha yenziwa amasosha omzimba wakho. Abantu abanezimo ezithile bane-TNF-alpha eningi kakhulu. Lokhu kungadala ukuthi amasosha omzimba ahlasele izingxenye zomzimba ezinempilo. I-infliximab ingavimba umonakalo odalwe yi-TNF-alpha eningi kakhulu.

Imiphumela emibi ye-infliximab

Isixazululo somjovo we-infliximab asibangeli ukozela, kepha singadala eminye imiphumela emibi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile engenzeka nge-infliximab ifaka:

• izifo zokuphefumula, njengezifo zesinus nomphimbo obuhlungu
• ikhanda
• ukukhwehlela
• ubuhlungu besisu

Imiphumela emibi emincane ingahle iphele ezinsukwini ezimbalwa noma emasontweni ambalwa. Khuluma nodokotela wakho noma usokhemisi uma benamandla kakhulu noma bengahambi ngendlela.

Imiphumela emibi kakhulu

Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha. Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

• Ukwehluleka kwenhliziyo. Izimpawu zingafaka:
  • inkinga yokuphefumula
  • ukuvuvukala kwamaqakala noma izinyawo zakho
  • ukuzuza ngokushesha kwesisindo
• Izinkinga zegazi. Izimpawu zingafaka:
  • ukulimaza noma ukopha kalula
  • umkhuhlane ongapheli
  • kubukeka kuphaphathekile impela
• Izinkinga zesistimu yezinzwa. Izimpawu zingafaka:
  • umbono uyashintsha
  • ubuthakathaka bezingalo noma imilenze yakho
  • ukuba ndikindiki noma ukuncinza komzimba wakho
  • isithuthwane
• Ukusabela okwe-allergen / ukumnika. Kungenzeka kwenzeke kuze kube ngamahora amabili ngemuva kokufakwa kwe-infliximab. Izimpawu zingafaka:
  • ukuqubuka kwesikhumba
  • ukulunywa
  • isifuba
  • ukuvuvukala kobuso bakho, izindebe, noma ulimi
  • umkhuhlane noma amakhaza
  • izinkinga zokuphefumula
  • ubuhlungu besifuba
  • umfutho wegazi ophakeme noma ophansi (udizizi noma uzizwe uphelelwa amandla)
• Ukuphuza ukusabela okweqile. Izimpawu zingafaka:
  • ubuhlungu bemisipha noma bamalunga
  • imfiva
  • ukuqubuka
  • ikhanda
  • Umphimbo obuhlungu
  • ukuvuvukala kobuso noma izandla
  • ubunzima bokugwinya
• I-Psoriasis. Izimpawu zingafaka:
  • okubomvu, ama-scaly patches noma amaqhubu aphakanyisiwe esikhunjeni
• Ukutheleleka. Izimpawu zingafaka:
  • umkhuhlane noma amakhaza
  • ukukhwehlela
  • Umphimbo obuhlungu
  • ubuhlungu noma inkinga yokudlulisa umchamo
  • ngizizwe ngikhathele ngokweqile
  • isikhumba esifudumele, esibomvu, noma esibuhlungu

Ukuzikhulula: Inhloso yethu ukukunikeza imininingwane efanelekile futhi yamanje. Kodwa-ke, ngoba izidakamizwa zithinta umuntu ngamunye ngokuhlukile, asikwazi ukuqinisekisa ukuthi lolu lwazi lubandakanya yonke imiphumela emibi engaba khona. Lolu lwazi aluyithathi indawo yeseluleko sezokwelapha. Hlala uxoxa ngemiphumela emibi engaba khona nomhlinzeki wezokunakekelwa kwempilo owazi umlando wakho wezokwelapha.

I-infliximab ingaxhumana neminye imithi

Isixazululo somjovo we-infliximab singahlangana neminye imithi, amakhambi, noma amavithamini ongahle uwathathe. Umhlinzeki wakho wezokunakekelwa kwempilo uzobheka ukuxhumana nemithi yakho yamanje. Njalo qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi, amakhambi, noma amavithamini owathathayo.

Ukuzikhulula: Inhloso yethu ukukunikeza imininingwane efanelekile futhi yamanje. Kodwa-ke, ngoba izidakamizwa zisebenzisana ngokwehlukile kumuntu ngamunye, asikwazi ukuqinisekisa ukuthi lolu lwazi lubandakanya konke ukuxhumana okungenzeka. Lolu lwazi aluyithathi indawo yeseluleko sezokwelapha. Hlala ukhuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nokuhlangana okungenzeka ngayo yonke imishanguzo kadokotela, amavithamini, amakhambi kanye nezithasiselo, kanye nemithi oyithenga uphuza yona.

Izexwayiso ze-infliximab

Lesi sidakamizwa siza nezixwayiso eziningana.

Isexwayiso somzimba

I-infliximab ingadala ukusabela okweqile komzimba. Lokhu kusabela kungenzeka ngenkathi uthola ukwelashwa noma kufika emahoreni amabili ngemuva kwalokho. Izimpawu zingafaka:

• isifuba (obomvu, ophakanyisiwe, amabala wesikhumba)
• inkinga yokuphefumula
• ubuhlungu besifuba
• umfutho wegazi ophakeme noma ophansi. Izimpawu zomfutho wegazi ophansi zifaka:
  • isiyezi
  • ngizizwe ngiphela amandla
  • inkinga yokuphefumula
  • umkhuhlane namakhaza

Kwesinye isikhathi i-infliximab ingadala ukubambezeleka komzimba. Ukusabela kungavela ezinsukwini ezi-3 kuye kwezi-12 ngemuva kokuthola umjovo wakho. Tshela udokotela wakho ngaso leso sikhathi uma unanoma iyiphi yalezi zimpawu zokuphuza ukungezwani komzimba:

• imfiva
• ukuqubuka
• ikhanda
• Umphimbo obuhlungu
• ubuhlungu bemisipha noma bamalunga
• ukuvuvukala kobuso nezandla zakho
• inkinga yokugwinya

Izexwayiso zabantu abanezimo ezithile zempilo

Kubantu abanezifo: Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka, noma ngabe lincane, njengokusika okuvulekile noma isilonda esibukeka sinegciwane. Umzimba wakho ungaba nesikhathi esinzima ukulwa nokutheleleka ngenkathi uthatha i-infliximab.

Kubantu abanofuba (TB): I-infliximab ithinta amasosha akho omzimba futhi ingenza kube lula kuwe ukuthola i-TB. Udokotela wakho angakuhlolela i-TB ngaphambi kokuqala umuthi.

Kubantu abane-hepatitis B: Uma uphethe igciwane le-hepatitis B, lingasebenza ngenkathi usebenzisa i-infliximab. Uma igciwane lisebenza futhi, kuzodingeka uyeke ukuthatha umuthi futhi welaphe ukutheleleka. Udokotela wakho angenza ukuhlolwa kwegazi ngaphambi kokuqala ukwelashwa, ngesikhathi sokwelashwa, nangezinyanga ezimbalwa kulandela ukwelashwa nge-infliximab.

Kubantu abanezinkinga zegazi: I-infliximab ingathinta amangqamuzana akho egazi. Tshela udokotela wakho nganoma yiziphi izinkinga onazo ngegazi lakho ngaphambi kokuba uqale ukuthatha i-infliximab.

Kubantu abanezinkinga zesistimu yezinzwa: I-infliximab ingenza izimpawu zezinkinga ezithile zesistimu yezinzwa zibe zimbi kakhulu. Yisebenzise ngokuqapha uma une-multiple sclerosis noma i-Guillain-Barre syndrome.

Kubantu abanokwehluleka kwenhliziyo: Lo muthi ungenza ukwehluleka kwenhliziyo kube kubi kakhulu. Shayela udokotela wakho ngokushesha uma uthola izimpawu zokwehluleka kwenhliziyo. Izimpawu zingafaka ukuphefumula okuncane, ukuvuvukala kwamaqakala noma izinyawo zakho, nokuzuza kwesisindo okungazelelwe. Kuzodingeka uyeke ukuthatha i-infliximab uma ukwehluleka kwenhliziyo yakho kuba kubi kakhulu.

Izexwayiso kwamanye amaqembu

Kwabesifazane abakhulelwe: I-infliximab iyisidakamizwa sesigaba B sokukhulelwa. Lokho kusho izinto ezimbili:

1. Izifundo zomuthi ezilwaneni ezikhulelwe azikhombisanga ubungozi enganeni.
2. Azikho izifundo ezanele ezenziwa kwabesifazane abakhulelwe ukukhombisa ukuthi umuthi uyingozi yini embungwini.

Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. I-infliximab kufanele isetshenziswe ngesikhathi sokukhulelwa kuphela uma inzuzo engaba khona ibeka ubungozi enganeni.

Shayela udokotela wakho uma ukhulelwa ngenkathi usebenzisa lo muthi.

Kwabesifazane abancelisayo: Akukaziwa ukuthi lo muthi udlulela yini ebisini lwebele. Uma i-infliximab idluliselwa enganeni yakho ngobisi lwakho lwebele, kungadala imiphumela emibi kakhulu.

Wena nodokotela wakho kungadingeka ukuthi ninqume ukuthi uzothatha i-infliximab noma uncelise.

Okwabadala: Ungaba sengozini enkulu yokutheleleka okunzima ngenkathi uthatha i-infliximab uma ungaphezu kweminyaka engama-65.

Okwezingane: I-infliximab ayikhonjiswanga iphephile futhi isebenza ngempumelelo ngesifo sikaCrohn noma i-ulcerative colitis kubantu abangaphansi kweminyaka engu-6.

Ukuphepha nokusebenza kwe-infliximab kwezinye izimo akuzange kusungulwe kubantu abangaphansi kweminyaka eyi-18.

Ungayithatha kanjani i-infliximab

Udokotela wakho uzonquma isilinganiso esifanele wena ngokuya ngesimo sakho nesisindo sakho. Impilo yakho ejwayelekile ingathinta umthamo wakho. Tshela udokotela wakho ngazo zonke izimo zempilo onazo ngaphambi kokuba udokotela noma umhlengikazi akunikeze umuthi. Uzonikezwa i-infliximab ngenaliti efakwe emthanjeni (IV noma ukumnika ngomjovo) engalweni yakho.

Uzothola umthamo wakho wesibili emasontweni amabili ngemuva komthamo wakho wokuqala. Ukweqiwa kungasakazeka nangaphezulu ngemuva kwalokho.

Ukuzikhulula: Inhloso yethu ukukunikeza imininingwane efanelekile futhi yamanje. Kodwa-ke, ngoba izidakamizwa zithinta umuntu ngamunye ngokuhlukile, asikwazi ukuqinisekisa ukuthi lolu hlu lubandakanya yonke imithamo engenzeka. Lolu lwazi aluyithathi indawo yeseluleko sezokwelapha. Hlala ukhuluma nodokotela wakho noma usokhemisi ngemithamo ekufanele.

Thatha njengoba kuqondisiwe

I-infliximab isetshenziselwa ukwelashwa kwesikhathi eside. Kuza nezingozi ezinkulu uma ungayithathi njengokuyalelwe.

Uma ungayithathi nhlobo: Uma ungathathi i-infliximab, isimo sakho kungenzeka singabi ngcono futhi singase sibe sibi kakhulu.

Uma uyeka ukuyithatha: Isimo sakho singase sibe sibi kakhulu uma uyeka ukuthatha i-infliximab.

Uma uthatha kakhulu: Umhlinzeki wezempilo kuphela okufanele alungiselele umuthi futhi akunikeze. Ukuthatha kakhulu isidakamizwa akunakwenzeka. Kodwa-ke, qiniseka ukuthi uxoxa ngomthamo wakho nodokotela wakho ekuvakasheni ngakunye.

Okufanele ukwenze uma uphuthelwa umthamo: Kubalulekile ukuthi ungaphuthelwa umthamo wakho. Shayela udokotela wakho uma ungakwazi ukugcina ukuqokwa kwakho.

Ungasho kanjani ukuthi umuthi uyasebenza: Izimpawu zakho kufanele zibe ngcono. Ngesifo sikaCrohn nesifo sezilonda emathunjini, ungaba nezimpawu ezimbalwa zokuqubuka. Ukuze uthole isifo samathambo, ungakwazi ukuhambahamba futhi wenze imisebenzi kalula.

Ukucatshangelwa okubalulekile kokuthatha i-infliximab

Gcina lokhu kucatshangelwa engqondweni uma udokotela wakho ekuchazela i-infliximab.

Ukuvakasha

Ukuhamba kungathinta uhlelo lwakho lokulinganisa. I-infliximab inikezwa ngumhlinzeki wezokunakekelwa kwempilo esibhedlela noma endaweni yomtholampilo. Uma uhlela ukuhamba, khuluma nodokotela wakho ngezinhlelo zakho zokuhamba futhi ubone ukuthi zizothinta yini uhlelo lwakho lokulinganisa.

Ukuhlolwa komtholampilo nokuqapha

Ngaphambi nokwelashwa kwakho ngalo muthi, udokotela wakho angenza izivivinyo ukuqapha impilo yakho. Lezi zivivinyo zingafaka:

• Ukuhlolwa kwesifo sofuba (TB): Udokotela wakho angakuhlolela i-TB ngaphambi kokuqala i-infliximab futhi akuhlolisise ukuze uthole izimpawu nezimpawu ngenkathi uyiphuza.
• Ukuhlolwa kokutheleleka ngegciwane le-Hepatitis B: Udokotela wakho angenza ukuhlolwa kwegazi ukukuhlolela igciwane le-hepatitis B ngaphambi kokuba uqale ukwelashwa futhi ngenkathi uthola i-infliximab. Uma unegciwane lesifo sokusha kwesibindi kohlobo B, udokotela wakho uzohlola igazi ngesikhathi eselashwa nangezinyanga ezimbalwa kulandela ukwelashwa.
• Olunye uvivinyo: Lezi zivivinyo zingafaka:
  • ukuhlolwa kwegazi ukuhlola izifo
  • ukuhlolwa kwesibindi

Ngaphambi kokugunyazwa

Izinkampani eziningi zomshuwalense zidinga ukugunyazwa kwangaphambili kwalomuthi. Lokhu kusho ukuthi udokotela wakho uzodinga ukuthola imvume enkampanini yakho yomshuwalense ngaphambi kokuba inkampani yakho yomshuwalense ikhokhele incwadi kadokotela.

Ukuzikhulula: I-Healthline yenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.