I-Inositol: Izinzuzo, Imiphumela emibi kanye Nesilinganiso

-Delile

• Kuyini i-Inositol?
• Kungaba Nezinzuzo Zempilo Yengqondo
• Ukuphazamiseka Kwetwetwe
• Ukucindezeleka
• Ukuphazamiseka KweBipolar
• Kwangathi Kungathuthukiswa Izimpawu zePolycystic Ovary Syndrome
• Kwangathi Kungasiza Ukulawula Izingozi Zengozi Ye-Metabolic Syndrome
• Kwangathi Kungavimbela Isifo Sikashukela Ngesikhathi Sokukhulelwa
• Ezinye Izinzuzo Ezingaba khona
• Imiphumela emibi nokusebenzisana
• Izilinganiso ezinconyiwe
• Okusemqoka

I-Inositol, kwesinye isikhathi ebizwa ngokuthi yi-vitamin B8, ivela ngokwemvelo ekudleni okufana nezithelo, ubhontshisi, okusanhlamvu namantongomane ().

Umzimba wakho nawo ungakhiqiza i-inositol kusuka kuma-carbohydrate owadlayo.

Kodwa-ke, ucwaningo luphakamisa ukuthi i-inositol eyengeziwe ngesimo sezithasiselo ingaba nezinzuzo eziningi zezempilo.

Lo mbhalo ubheka ngokuningiliziwe izinzuzo, imithamo enconyiwe nemiphumela emibi engaba khona yezithako ze-inositol.

Kuyini i-Inositol?

Yize kuvame ukubizwa ngokuthi uvithamini B8, i-inositol ayilona ivithamini nakancane kepha iluhlobo lukashukela olunemisebenzi eminingana ebalulekile.

I-Inositol idlala indima yokwakha emzimbeni wakho njengengxenye enkulu yolwelwesi lweseli ().

Iphinde ibe nomthelela esenzweni se-insulin, i-hormone ebalulekile ekulawuleni ushukela wegazi. Ngaphezu kwalokho, kuthinta izithunywa zamakhemikhali ebuchosheni bakho, njenge-serotonin ne-dopamine (,).

Kulinganiselwa ukuthi ukudla okujwayelekile e-US kuqukethe cishe i-1 gram ye-inositol ngosuku. Imithombo ecebile ifaka okusanhlamvu, ubhontshisi, amantongomane nezithelo nemifino ().

Kodwa-ke, imithamo eyengeziwe ye-inositol ivame ukuphakama. Abaphenyi bafunde izinzuzo zemithamo efinyelela kuma-gramu ayi-18 ngosuku - ngemiphumela ethembisayo kanye nemiphumela engemihle embalwa.

I-Inositol uhlobo lukashukela olusiza ukuhlinzeka ukwakheka kumaseli akho. Iphinde ithinte i-hormone insulin nomsebenzi wezithunywa zamakhemikhali ebuchosheni bakho.

Kungaba Nezinzuzo Zempilo Yengqondo

I-Inositol ingasiza ukulinganisela amakhemikhali abalulekile ebuchosheni bakho, kufaka phakathi lawo okukholakala ukuthi athinta imizwa yakho, njenge-serotonin ne-dopamine ().

Kuyathakazelisa ukuthi abacwaningi bathole ukuthi abanye abantu abanokudangala, ukukhathazeka kanye nokuphazamiseka okucindezelayo banamazinga aphansi e-inositol ebuchosheni babo (,).

Yize kudingeka olunye ucwaningo, ucwaningo oluningi lukhombisa ukuthi i-inositol inamandla okuba enye indlela yokwelapha izimo zempilo yengqondo. Kubukeka sengathi kunemiphumela emibi embalwa kunemithi yendabuko ().

Ukuphazamiseka Kwetwetwe

Ngenkathi ucwaningo lusalinganiselwe, izithako ze-inositol zingasiza ekwelapheni i-panic disorder, uhlobo olunzima lokukhathazeka.

Labo abanenkinga yokwethuka babhekana nokuhlaselwa uvalo njalo, okuyimizwa engazelelwe yokwesaba okukhulu. Izimpawu zifaka ukushaya kwenhliziyo okusheshayo, ukuphefumula okuncane, isiyezi, ukujuluka kanye nokuhayiza noma ukuzwa okundindizele ezandleni (7).

Kwesinye isifundo, abantu abangama-20 abanenkinga yokwethuka bathathe isengezo esingu-18-gram inositol noma umuthi ovamile wokukhathazeka nsuku zonke inyanga eyodwa. Labo abathatha i-inositol babe nokuhlaselwa okuncane kwesonto ngesonto, uma kuqhathaniswa nabantu abathatha umuthi wokukhathazeka ().

Ngokufanayo, ocwaningweni lwamaviki ama-4, abantu babhekana nokuhlaselwa uvalo okuncane nokuncane lapho bethatha amagremu ayi-12 e-inositol ngosuku ().

Ukucindezeleka

I-Inositol ingathuthukisa izimpawu zokucindezeleka, kepha ucwaningo lube nemiphumela exubekile.

Isibonelo, isifundo sokuqala sikhombise ukuthi ukuthatha i-12-gram inositol supplement nsuku zonke amaviki ama-4 kuthuthukise izimpawu kubantu abane-depression ().

Ngokuphambene nalokho, izifundo ezalandela azikwazanga ukukhombisa noma yiziphi izinzuzo ezibalulekile ().

Kukonke, abukho ubufakazi obenele bokusho ukuthi i-inositol inethonya langempela yini ekucindezelekeni.

Ukuphazamiseka KweBipolar

Njengakwezinye izimo zempilo yengqondo, ucwaningo ngemiphumela ye-inositol ne-bipolar disorder lilinganiselwe. Kodwa-ke, imiphumela yezifundo zokuqala ibonakala iyathembisa (,).

Isibonelo, ucwaningo oluncane ezinganeni ezine-bipolar spectrum disorders lubonise izimpawu ezinciphile ze-mania kanye nokudangala lapho inhlanganisela yama-gramu ama-3 ama-omega-3 fatty acids kuze kufike ku-2 gramu we-inositol athathwa nsuku zonke amasonto ayi-12 ().

Ngaphezu kwalokho, ucwaningo lukhombisa ukuthi u-3-6 amagremu we-inositol athathwa nsuku zonke angasiza ekwehliseni izimpawu ze-psoriasis ezibangelwa yi-lithium, umuthi ojwayelekile osetshenziselwa ukwelapha i-bipolar disorder (,).

Yize kudingeka olunye ucwaningo, i-inositol ikhombisa okungahle kube njengenye indlela yokwelashwa yezimo zezempilo yengqondo, kufaka phakathi i-panic disorder, i-depression kanye ne-bipolar disorder.

Kwangathi Kungathuthukiswa Izimpawu zePolycystic Ovary Syndrome

I-Polycystic ovary syndrome (i-PCOS) yisimo esidala ukungalingani kwama-hormone kwabesifazane, okungaholela ezikhathini ezingajwayelekile nokungabi nenzalo. Ukuzuza kwesisindo, ushukela ophakeme wegazi kanye namazinga we-cholesterol angathandeki namazinga e-triglyceride nakho kuyakhathazeka nge-PCOS (16).

Izithako ze-Inositol zingathuthukisa izimpawu ze-PCOS, ikakhulukazi uma zihlanganiswe ne-folic acid.

Isibonelo, izifundo zokwelashwa ziphakamisa ukuthi imithamo yansuku zonke ye-inositol ne-folic acid ingasiza ekwehliseni amazinga e-triglycerides egazini. Bangaphinda bathuthukise ukusebenza kwe-insulin kanye nomfutho wegazi ophansi kancane kulabo abane-PCOS (,,).

Ngaphezu kwalokho, ucwaningo lokuqala luthole ukuthi inhlanganisela ye-inositol ne-folic acid ingakhuthaza ukuvuthwa kwe-ovulation kwabesifazane abanezinkinga zokuzala ezivela ku-PCOS (, 21).

Kokunye ukuhlola, amagremu ama-4 we-inositol kanye no-400 mcg we-folic acid athathwe nsukuzonke izinyanga ezi-3 enza i-ovulation ku-62% wabesifazane abaphathwayo ().

I-Inositol ingasiza ekwehliseni amazinga egazi e-triglyceride, ithuthukise ukusebenza kwe-insulin, yehlise umfutho wegazi futhi ikhuthaze ukukhiqizwa kwe-ovulation kwabesifazane abane-polycystic ovary syndrome (PCOS).

Kwangathi Kungasiza Ukulawula Izingozi Zengozi Ye-Metabolic Syndrome

Ucwaningo lwezokwelapha lubonisa ukuthi izithako ze-inositol zingasiza labo abane-metabolic syndrome (,).

I-Metabolic syndrome yiqembu lezimo eziphakamisa ubungozi besifo esingelapheki, kufaka phakathi isifo senhliziyo nohlobo lwesifo sikashukela esingu-2.

Ngokuqondile, izimo ezinhlanu zihlotshaniswa ne-metabolic syndrome ():

• Amafutha amaningi ngokweqile esiswini
• Amazinga aphezulu we-triglycerides egazini
• Amazinga we-cholesterol we-HDL “amahle” aphansi
• Umfutho wegazi ophezulu
• Ushukela ophakeme wegazi

Ocwaningweni lomtholampilo lonyaka wonke kwabesifazane abangama-80 abane-metabolic syndrome, amagremu ama-2 we-inositol athathwe kabili ngosuku anciphisa amazinga e-triglyceride egazi ngama-34% aphakathi nendawo ne-cholesterol ephelele ngama-22%. Kuthuthukiswe nomfutho wegazi kanye noshukela wegazi ().

Ngokumangazayo, u-20% wabesifazane abathatha izithasiselo ze-inositol abasazifezekisanga izindlela zesifo se-metabolic ekupheleni kocwaningo ().

I-Inositol ingasiza ekulawuleni izinto ezinobungozi emzimbeni ngokusiza amazinga aphansi egazi e-triglyceride, umfutho wegazi noshukela wegazi. Kungabuye kuthuthukise amazinga e-cholesterol.

Kwangathi Kungavimbela Isifo Sikashukela Ngesikhathi Sokukhulelwa

Abanye besifazane bathola ushukela ophakeme wegazi ngesikhathi sokukhulelwa. Lesi simo sibizwa ngokuthi yisifo sikashukela sokukhulelwa (GDM) futhi sihlanganisa kuze kufike ku-10% wokukhulelwa e-US minyaka yonke (25,).

Ezifundweni zezilwane, i-inositol ibilokhu ihlobene ngqo nomsebenzi we-insulin, i-hormone elawula amazinga kashukela egazini (,).

Kunezinombolo ezimbalwa kuphela zezifundo ezitholakalayo kokungezelelwe ne-GDM kubantu. Kodwa-ke, abanye basikisela ukuthi inhlanganisela yama-4 amagremu we-myo-inositol kanye ne-400 mcg ye-folic acid ingasiza ekuvimbeleni i-GDM lapho ithathwa nsuku zonke phakathi nokukhulelwa (,,).

Kodwa-ke, kudingeka olunye ucwaningo, njengoba ezinye izifundo zingakhombisanga imiphumela efanayo ().

I-Inositol ingasiza ekuvikeleni amazinga aphezulu kashukela ngesikhathi sokukhulelwa lapho ithathwa ihlanganiswe ne-folic acid, kepha kudingeka izifundo eziningi ukuqinisekisa lo mphumela.

Ezinye Izinzuzo Ezingaba khona

I-Inositol ifundwe njengenketho yokwelashwa engaba khona yezimo eziningi.

Ngaphandle kwalezo esezishiwo, ucwaningo lukhombisa ukuthi i-inositol ingasiza ezimweni ezilandelayo:

• Isifo sokucindezeleka sokuphefumula: Ezinganeni ezizalwe ngaphambi kwesikhathi, i-inositol ibonakala ilusizo ekwelapheni izinkinga zokuphefumula emaphashini angathuthuki kahle ().
• Thayipha 2 sikashukela: Ucwaningo lokuqala lubonisa ukuthi i-inositol ne-folic acid ethathwa nsuku zonke izinyanga eziyisithupha kungasiza ekulawuleni ushukela egazini kubantu abanesifo sikashukela sohlobo 2 ().
• Isifo se-Obsessive-compulsive (OCD): Ucwaningo oluncane lukhombisa ukuthi i-18 gram ye-inositol ethathwa nsuku zonke amasonto ayisithupha inganciphisa izimpawu ze-OCD ().

I-Inositol iyindlela yokwelashwa engaba khona yezinsana ezizalwe ngaphambi kwesikhathi ezinesifo sokuphefumula. Kungasiza nokulawulwa kukashukela wegazi kubantu abane-type 2 yesifo sikashukela futhi kunganciphisa izimpawu zokuphazamiseka okuphoqelela ngokweqile.

Imiphumela emibi nokusebenzisana

Izithako ze-Inositol zibukeka zibekezeleleka kahle ngabantu abaningi.

Kodwa-ke, imiphumela emibi emincane ibikiwe ngemithamo yamagremu ayi-12 ngosuku noma ngaphezulu. Lokhu kufaka phakathi isicanucanu, igesi, ubunzima bokulala, ikhanda elibuhlungu, isiyezi nokukhathala ().

Kuze kufike ku-4 amagremu we-inositol nsuku zonke athathwe ngabesifazane abakhulelwe ezifundweni ngaphandle kwemiphumela emibi, yize ucwaningo oluningi luyadingeka kulesi sibalo (,).

Futhi azikho izifundo ezanele zokuthola ukuphepha kwezithasiselo ngenkathi uncelisa. Kodwa-ke, ubisi lwebele lubonakala lucebe ngokwemvelo ku-inositol ().

Ngaphezu kwalokho, akucaci ukuthi izithasiselo ze-inositol ziphephile yini ekusetshenzisweni kwesikhathi eside. Ezifundweni eziningi, izithasiselo ze-inositol zithathwe kuphela unyaka noma ngaphansi.

Njenganoma yikuphi ukwengeza, khuluma nodokotela wakho ngaphambi kokuthatha i-inositol.

Izithako ze-Inositol zihlotshaniswa nemiphumela emibi kakhulu futhi imnene kuphela. Ucwaningo oluningi luyadingeka ukuthola ukuphepha kwalo kwabesifazane abakhulelwe nabancelisayo kanye nasekusebenziseni isikhathi eside.

Izilinganiso ezinconyiwe

Kunezinhlobo ezimbili eziyinhloko ze-inositol ezisetshenziswa kuma-supplements, okuyi-myo-inositol (MYO) ne-D-chiro-inositol (DCI).

Yize kungekho ukuvumelana okusemthethweni ngohlobo olusebenzayo kakhulu nomthamo, okulandelayo kubonakale kusebenza ngempumelelo ezifundweni zocwaningo:

• Ngezimo zempilo yengqondo: 12-18 amagremu we-MYO kanye nsuku zonke amasonto ama-4-6 (,,,).
• Nge-polycystic ovary syndrome: 1.2 amagremu weDCI kanye nsuku zonke, noma amagremu ama-2 we-MYO kanye nama-200 mcg we-folic acid kabili nsuku zonke izinyanga eziyisithupha (,).
• Nge-metabolic syndrome: 2 amagremu we-MYO kabili nsuku zonke unyaka owodwa ().
• Ukulawulwa kweshukela egazini kwisifo sikashukela sokukhulelwa: 2 amagremu we-MYO no-400 mcg we-folic acid kabili nsuku zonke ngesikhathi sokukhulelwa (,,).
• Ukulawulwa kukashukela egazini kuhlobo 2 sikashukela: I-1 gram ye-DCI ne-400 mcg folic acid kanye ngosuku izinyanga eziyisithupha ().

Ngenkathi le migomo ye-inositol ibonakala ilusizo ezimweni ezithile esikhathini esifushane, kudingeka olunye ucwaningo ukunquma ukuthi ngabe luphephile futhi lusebenza isikhathi eside.

Akukho ukuvumelana okusemthethweni ngamanani anconyiwe we-inositol. Isilinganiso nohlobo lwe-inositol supplement luyahlukahluka kuye ngesimo.

Okusemqoka

Ucwaningo lukhombisa ukuthi i-inositol ingasiza abantu abanempilo yezengqondo nezimo ze-metabolic, njenge-panic disorder, ukudangala, i-bipolar disorder, i-polycystic ovary syndrome, i-metabolic syndrome nesifo sikashukela.

Kubonakala kuphephe kubantu abaningi futhi kubangela ubumnene kuphela uma kukhona imiphumela emibi ngemithamo yansuku zonke efinyelela kuma-gramu ayi-18.

Ngenkathi indlela odla ngayo kungenzeka iqukethe inani elincane le-inositol, ukuthatha isengezo kungahle kuzuzise abanye.

Ngaso sonke isikhathi xoxa ngokusetshenziswa kwezithako nomhlinzeki wakho wezokunakekelwa kwempilo kuqala.