Ingabe I-Ketamine Ingasiza Ukwelapha Ukucindezeleka?

-Delile

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Ukucindezeleka kuvame kakhulu kunalokho ongase ucabange. Kuthinta abantu baseMelika abangaphezu kwezigidi ezingu-15, futhi i-World Health Organization ilinganisela ukuthi lelo nani likhula lifinyelele ezigidini ezingu-300 uma unwebeka emhlabeni jikelele. Kunokushaywa kwezinketho zokwelashwa ezahlukahlukene ezitholakalayo ukusiza ukunciphisa izimpawu zayo-ukucabanga ukukhathazeka, ukuqwasha, ukukhathala, nokulahleka kwesifiso phakathi kwabanye-ukwelashwa okuvame kakhulu ukuba yi-serotonin reuptake inhibitors (noma ama-SSRIs). Kodwa kusukela cishe ngo-2000, odokotela nabacwaningi bebelokhu behlola i-ketamine-ekuqaleni imithi yokulawula ubuhlungu, manje esetshenziswa kabi njengesidakamizwa sasemgwaqweni ngenxa yemiphumela yaso ye-hallucinogenic-njengenye indlela engaba khona yokwelapha lesi simo, ngokusho kukaRuben Abagyan, Ph.D. , uprofesa wezemithi e-University of California San Diego (UCSD).

Cishe uyacabanga, "Ima! Ini?" Uma uke wezwa nge-ketamine, eyaziwa nangokuthi i-Special K, uyazi ukuthi akuwona umdlalo noma umuthi we-OTC ojwayelekile. Eqinisweni, kwaziwa ngokuthi yi-dissociative anesthetic (okusho umuthi ophazamisa ukuqonda kokubona nomsindo, ngenkathi kukhiqizwa imizwa yangempela yokuxhunyaniswa nobuntu kanye nemvelo). Isetshenziswa ngokuyinhloko odokotela bezilwane ekwelapheni ubuhlungu ezilwaneni, kodwa futhi ingabhalwa kubantu abalawulwa ubuhlungu obukhulu, ikakhulukazi labo abanezinkinga ze-neuropathic, uhlobo lobuhlungu obungapheli bezinzwa, ngokusho kocwaningo luka-2014 olushicilelwe ku I-British Journal of Pharmacology.

"Kuyaziwa ukuthi ubuhlungu nokucindezeleka kuhlobene," kusho u-Isaac Cohen, umfundi wezokwelapha owasebenza kulolu cwaningo. Uthi: "Abantu abacindezelekile bavame ukuhlala ebuhlungu futhi abantu abanobuhlungu obungapheli banamathuba amaningi okucindezeleka ngenxa yokunciphisa ukuhamba, ukuncipha kwekhono lokuzivocavoca, nezinye izici. ukudangala ngasikhathi sinye, okuholele emiphumeleni engcono yazo zombili lezi zimo. "Futhi manje ososayensi bathi akunabufakazi nje obuyimbangi, kodwa futhi nemininingwane yezibalo ekhombisa ukuthi i-ketamine ingasiza ekunciphiseni izimpawu zokudangala.

Ekuhlaziyweni kokuqala kohlobo lwayo, okushicilelwe ku Imvelo, abacwaningi bathole ukuthi iziguli ezithola i-ketamine zibike izimo eziphansi kakhulu zokucindezeleka. Lolu cwaningo, olwenziwa iSikole Sekhemisi Nesayensi Yezemithi e-UCSD, luqinisa idatha ye-anecdotal kanye nezifundo ezincane zabantu eziphinde zaphakamisa imiphumela ye-ketamine yokunciphisa ukucindezeleka.

Yini ebeka i-ketamine ngaphandle kwezinye izindlela zokwelashwa, ikakhulukazi, ukuthi isebenza ngokushesha kangakanani. "Ukwelashwa kwamanje okugunyazwe yi-FDA kokucindezeleka kwehluleka ezigidini ngoba akusebenzi ngokushesha okukhulu," kusho u-Abaygan. I-Ketamine isebenza emahoreni ambalwa. Lokho kuncane kakhulu kunama-SSRI, isibonelo, angathatha amasonto ayisithupha kuya kwayishumi ukufinyelela umthamo wawo ogcwele. Futhi lowo mehluko esikhathini kungase kube indaba yokuphila noma ukufa, ikakhulukazi kulabo abacabanga ukuzibulala.

Ngocwaningo lwabo, u-Abaygan nethimba lakhe babuyekeze imininingwane evela ku-FDA's Adverse Event Report System, i-ejensi eqoqa imininingwane ngemiphumela emibi (noma imiphumela engahlosiwe yanoma yiluphi uhlobo) yanoma imuphi umuthi ovunyelwe obikwe osokhemisi nodokotela. Ngokuqondile, bathola iziguli ze-40,000 ezanikezwa imithi yobuhlungu futhi zabahlukanisa ngamaqembu amabili-labo abathatha i-ketamine nalabo abaphathwa ngemithi yobuhlungu ehlukile (ngaphandle kwama-NSAID).

Imiphumela ibonise "ibhonasi" ebaluleke kakhulu, nakuba ingahlosiwe, umphumela. Ingxenye yabantu abaphatha izinhlungu zabo nge-ketamine babike ukuthi babecindezelekile kancane kunalabo ababephuze ezinye izinhlobo zemithi yokwehlisa izinhlungu. Nakuba singazi ukuthi noma yisiphi salezi ziguli, ikakhulukazi lezo eziku-ketamine, zazinezimpawu zokucindezeleka ngaphambi kokuthatha noma yimiphi imithi, umphumela omuhle emoyeni, ohambisana nesixhumanisi esivamile phakathi kobuhlungu nokucindezeleka, kungase kugunyaze ingxoxo eyengeziwe mayelana nokusetshenziswa kwe-ketamine phatha ukucindezeleka ngqo.

Ngokusho kwabaphenyi, i-ketamine ayibizi kakhulu futhi uma uke wazama okungenani eminye imishanguzo emithathu yokulwa nokudangala ungaphumeleli, imbozwa yizinhlelo eziningi zomshuwalense wezempilo. Ukhomba ukuthi? Ungasheshi ukubhala i-ketamine njenge-hallucinogen. Kungahle kube okukhethekile empeleni. (Futhi uma kungenjalo, bafana, hlola lezi zindlela zokuphatha ukucindezeleka noma imizwa yokudangala nganoma yisiphi isikhathi.)

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