I-Lactic Acidosis: Okudingeka Ukwazi

-Delile

• Ziyini izimpawu?
• Ziyini izimbangela?
• Isifo senhliziyo
• Ukutheleleka okukhulu (sepsis)
• I-HIV
• Umdlavuza
• Isifo samathumbu esifushane (amathumbu amafushane)
• Ukusetshenziswa kwe-Acetaminophen
• Ukuphuza ngokweqile
• Ukuzivocavoca okukhulu noma ukuvivinya umzimba
• I-Lactic acidosis nesifo sikashukela
• Kutholakala kanjani?
• Yiziphi izinketho zokwelashwa?
• Uyini umbono?
• Ukuvimbela i-lactic acidosis

Yini i-lactic acidosis?

I-Lactic acidosis yindlela ye-metabolic acidosis eqala lapho umuntu ekhiqiza ngokweqile noma esebenzisa i-lactic acid ngokweqile, futhi umzimba wabo awukwazi ukuzivumelanisa nalezi zinguquko.

Abantu abane-lactic acidosis (futhi kwesinye isikhathi izinso zabo) bayakwazi ukususa i-asidi eyeqile emzimbeni wabo. Uma i-lactic acid yakhela emzimbeni ngokushesha okungasuswa, amazinga e-asidi emanzini oketshezi lomzimba - njenge-spike yegazi.

Lokhu kwanda kwe-asidi kubangela ukungalingani ezingeni le-pH lomzimba, okufanele ngaso sonke isikhathi libe ne-alkaline kancane esikhundleni se-acidic. Kunezinhlobo ezimbalwa ezahlukahlukene ze-acidosis.

I-Lactic acid buildup yenzeka lapho ingekho i-oxygen eyanele emisipheni yokwephula i-glucose ne-glycogen. Lokhu kubizwa ngokuthi yi-anaerobic metabolism.

Kunezinhlobo ezimbili ze-lactic acid: L-lactate ne-D-lactate. Izinhlobo eziningi ze-lactic acidosis zidalwa yi-L-lactate eningi kakhulu.

Kunezinhlobo ezimbili ze-lactic acidosis, Uhlobo A nohlobo B:

• Thayipha i-lactic acidosis kubangelwa i-tishu hypoperfusion ngenxa ye-hypovolemia, ukwehluleka kwenhliziyo, i-sepsis, noma ukuboshwa kwe-cardiopulmonary.
• Uhlobo B lactic acidosis kubangelwa ukukhubazeka kokusebenza kwamangqamuzana nezindawo zasendaweni ze-tishu hypoperfusion.

I-Lactic acidosis inezimbangela eziningi futhi ingahle yelashwe. Kepha uma kushiywe kungalashwa, kungasongela impilo.

Ziyini izimpawu?

Izimpawu ze-lactic acidosis zivamile ezindabeni eziningi zezempilo. Uma uhlangabezana nenye yalezi zimpawu, kufanele uxhumane nodokotela wakho ngokushesha. Udokotela wakho angakusiza ukuthola imbangela.

Izimpawu eziningana ze-lactic acidosis zimelela isimo esiphuthumayo sezokwelapha:

• ukuphefumula okunuka okwezithelo (okungahle kube yisibonakaliso senkinga enkulu yesifo sikashukela, okuthiwa i-ketoacidosis)
• ukudideka
• i-jaundice (ukuphuzi kwesikhumba noma abamhlophe bamehlo)
• ukuphefumula kanzima noma ukuphefumula okungajulile, okusheshayo

Uma wazi noma usola ukuthi une-lactic acidosis futhi unalezi zimpawu, shayela ku-911 noma uye egumbini lezimo eziphuthumayo ngokushesha.

Ezinye izimpawu ze-lactic acidosis zifaka:

• ukukhathala noma ukukhathala ngokweqile
• amajaqamba noma ubuhlungu
• ubuthakathaka bomzimba
• imizwa yonke yokungakhululeki ngokomzimba
• ubuhlungu besisu noma ukungaphatheki kahle
• isifo sohudo
• ukuncipha kokudla
• ikhanda
• ukushaya kwenhliziyo okusheshayo

Ziyini izimbangela?

I-Lactic acidosis inezimbangela ezahlukahlukene, kufaka phakathi ubuthi be-carbon monoxide, ikholera, umalaleveva kanye nokuphefumula. Ezinye izimbangela ezivamile zifaka:

Isifo senhliziyo

Izimo ezinjengokuboshwa kwenhliziyo kanye nokuhluleka kwenhliziyo okucindezelayo kunganciphisa ukuhamba kwegazi ne-oxygen kuwo wonke umzimba. Lokhu kungakhuphula amazinga e-lactic acid.

Ukutheleleka okukhulu (sepsis)

Noma yiluphi uhlobo lokutheleleka okunzima ngegciwane noma kwamagciwane kungadala i-sepsis. Abantu abane-sepsis bangathola i-spike ku-lactic acid, ebangelwa ukuncipha kokugeleza komoya-mpilo.

I-HIV

Imithi ye-HIV, efana ne-nucleoside reverse transcriptase inhibitors, inganyusa amazinga e-lactic acid. Futhi kungadala ukulimala kwesibindi. Lokhu kwenza kube nzima emzimbeni ukucubungula i-lactate.

Umdlavuza

Amaseli womdlavuza enza i-lactic acid. Lokhu kwanda kwe-lactic acid kungashesha njengoba umuntu ancipha futhi isifo siqhubeka.

Isifo samathumbu esifushane (amathumbu amafushane)

Ngenkathi, abantu abanesisu esifushane bangahlangabezana nokwanda kwe-D-lactic acid, okubangelwa ukwanda kwamagciwane emathunjini amancane. Abantu abake bahlinzwa esiswini bangathola ne-D-lactic acidosis.

Ukusetshenziswa kwe-Acetaminophen

Ukusetshenziswa njalo kwe-acetaminophen (iTylenol) kungadala i-lactic acidosis, noma ngabe ithathwa kumthamo ofanele. Lokhu kungenxa yokuthi kungadala ukuqoqwa kwe-pyroglutamic acid egazini.

Ukuphuza ngokweqile

Ukuphuza utshwala ngokweqile isikhathi eside kungaholela ku-lactic acidosis kanye ne-ketoacidosis yotshwala. I-ketoacidosis yotshwala yisimo esingahle sibulale uma singelashwa, kepha singalwa ne-intravenous (IV) hydration kanye ne-glucose.

Utshwala bukhuphula amazinga e-phosphate, anomthelela omubi ezinso. Lokhu kwenza i-pH yomzimba ibe ne-asidi kakhulu. Uma unenkinga yokwehlisa ukuphuza kwakho utshwala, amaqembu okusekela angasiza.

Ukuzivocavoca okukhulu noma ukuvivinya umzimba

Ukwakheka kwesikhashana kwe-lactic acid kungadalwa wukuzivocavoca okunamandla uma umzimba wakho ungenayo i-oxygen eyanele yokwehlisa i-glucose egazini. Lokhu kungadala umuzwa ovuthayo emaqenjini emisipha owasebenzisayo. Kungadala futhi isicanucanu nobuthakathaka.

I-Lactic acidosis nesifo sikashukela

Isigaba esithile semithi yesifo sikashukela ngomlomo, esibizwa ngama-biguanides, singadala ukwanda kwamazinga e-lactic acid.

IMetformin (Glucophage) ingenye yalezi zidakamizwa. Isetshenziselwa ukwelapha isifo sikashukela futhi ingahle inqunyelwe nezinye izimo, njengokungasebenzi kahle kwezinso. I-Metformin isetshenziswa futhi ngaphandle kwelebuli ukwelapha i-polycystic ovarian syndrome.

Kubantu abanesifo sikashukela, i-lactic acidosis ingakhathaza kakhulu uma isifo sezinso sikhona. Uma unesifo sikashukela futhi uhlangabezana nezimpawu ze-lactic acidosis, shayela u-911 noma uye egumbini lezimo eziphuthumayo ngokushesha.

Kutholakala kanjani?

I-Lactic acidosis itholakala ngokuhlolwa kwegazi okusheshayo. Udokotela wakho angakuyala ukuthi ungadli noma uphuze noma yini amahora ayisishiyagalombili kuya kwayishumi ngaphambi kokuhlolwa. Ungase futhi uyalelwe ukunciphisa izinga lomsebenzi wakho emahoreni aholela esivivinyweni.

Ngesikhathi sokuhlolwa, udokotela wakho angakutshela ukuthi ungabophi isibhakela sakho, ngoba lokhu kungahle kube ngamazinga we-acid okwenziwe ngobuciko. Ukubopha ibhande lokunwebeka engalweni nakho kungaba nalo mphumela.

Ngalezi zizathu, ukuhlolwa kwegazi kwe-lactic acidosis kwesinye isikhathi kwenziwa ngokuthola umthambo ngemuva kwesandla esikhundleni sengalo.

Yiziphi izinketho zokwelashwa?

Indlela engcono kakhulu yokwelapha i-lactic acidosis ukwelapha imbangela yayo. Ngaleso sizathu, izindlela zokwelashwa ziyahlukahluka.

I-Lactic acidosis kwesinye isikhathi imelela isimo esiphuthumayo sezokwelapha. Lokhu kudinga ukwelashwa kwezimpawu, kungakhathalekile ukuthi iyini imbangela yazo. Ukwandisa i-oksijini ezicutshini nokunikeza uketshezi lwe-IV kuvame ukusetshenziselwa ukunciphisa amazinga e-lactic acid.

I-Lactic acidosis ebangelwa ukuzivocavoca ingelashwa ekhaya. Ukumisa okwenzayo ukunisela amanzi nokuphumula, kuvame ukusiza. Iziphuzo zezemidlalo zokufaka esikhundleni se-Electrolyte, njengeGatorade, zisiza nge-hydration, kepha amanzi ajwayelekile kakhulu.

Uyini umbono?

Ngokuya ngembangela, ukwelashwa kwe-lactic acidosis kuvame ukuletha ukululama okugcwele, ikakhulukazi uma ukwelashwa kushesha. Kwesinye isikhathi, ukwehluleka kwezinso noma ukwehluleka ukuphefumula kungahle kuvele. Uma ishiywe ingalashwa, i-lactic acidosis ingaba yingozi.

Ukuvimbela i-lactic acidosis

Ukuvinjelwa kwe-Lactic acidosis nakho kunqunywa imbangela yayo. Uma unesifo sikashukela, i-HIV, noma umdlavuza, xoxa ngesimo sakho nemithi oyidingayo nodokotela wakho.

I-Lactic acidosis evela ekuzivocavoca umzimba ingavinjelwa ngokuhlala unamanzi futhi uzinikeze nezikhathi zokuphumula ezinde phakathi kwezikhathi zokuzivocavoca.

Kubaluleke kakhulu ukugwema ukusebenzisa kabi utshwala. Xoxa ngokuvuselelwa nezinyathelo zezinyathelo eziyi-12 nodokotela wakho noma umeluleki.