Ingabe iMethotrexate Iyasebenza Nge-Rheumatoid Arthritis?

-Delile

• Ukwelapha i-RA nge-methotrexate
• Ukusebenza ngempumelelo
• Ngokuhlanganiswa nezinye izidakamizwa
• Imiphumela emibi ye-methotrexate
• Khuluma nodokotela wakho

I-rheumatoid arthritis (RA) yisifo esingapheliyo se-autoimmune. Uma unale nkinga, ujwayelene nokuvuvukala namalunga okubuhlungu akudalayo. Lezi zinhlungu azidalwa ukuguga kwemvelo okwenzeka ngokuguga. Esikhundleni salokho, amasosha akho omzimba enza amaphutha emalungeni akho abahlaseli bangaphandle bese ehlasela umzimba wakho. Akekho owaziyo ngokuqinisekile ukuthi kungani lokhu kwenzeka noma ukuthi kungani abanye abantu benalesi sifo.

Okwamanje alikho ikhambi le-RA, kodwa kunezindlela zokwelapha. Udokotela wakho angakunika imishanguzo eyehlisa ijubane ukuqhubeka kwesifo noma icindezele amasosha akho omzimba. Bangakunika nemithi eyehlisa ukuvuvukala nobuhlungu emajoyintini akho.

Isincomo samanje sokwelashwa kokuqala kwe-RA sinezidakamizwa zokuguqula izifo (i-DMARDs) eziguqula izifo. Enye yale mithi i-methotrexate. Bheka ukuthi lo muthi usebenza kanjani, kufaka phakathi ukuthi usebenza kangakanani ekwelapheni i-RA.

Ukwelapha i-RA nge-methotrexate

I-Methotrexate uhlobo lwe-DMARD. Ama-DMARD yisigaba semithi esivame ukusetshenziswa ezigabeni zokuqala ze-RA. Izidakamizwa ezimbalwa ekilasini le-DMARD zenzelwe ukwelapha i-RA, kepha i-methotrexate yathuthukiswa ngesizathu esihlukile. Ekuqaleni kwakwenzelwe ukwelapha umdlavuza, kodwa kutholakele ukuthi kusetshenzelwa neRA. Kuthengiswa ngaphansi kwegama lomkhiqizo iRheumatrex neTrexall. Kuza njengethebhulethi yomlomo nesisombululo somjovo.

I-Methotrexate namanye ama-DMARD asebenzela ukunciphisa ukuvuvukala. Benza lokhu ngokucindezela amasosha akho omzimba. Kunezingozi ezihlobene nokugcina amasosha akho omzimba ehlolwe ngale ndlela, noma kunjalo, kufaka phakathi ingozi eyengeziwe yokutheleleka.

Ngenkathi i-methotrexate iza nethuba lemiphumela emibi, ibuye inikeze nezinzuzo ezinkulu kubantu abane-RA. Ama-DMARD angavimbela ukulimala okuhlangene uma uwasebenzisa kusenesikhathi ngokwanele ngemuva kokuthi izimpawu zakho ze-RA ziqale ukuvela. Banganciphisa futhi ukulimala okuhlangene ngokunye futhi banciphise izimpawu zeRA. Odokotela abaningi nabantu abane-RA bacabanga ukuthi izinzuzo zalo muthi zibaluleke kakhulu ezingozini.

IMethotrexate yisidakamizwa sesikhathi eside uma sisetshenziselwa iRA. Iningi labantu liyalithatha lize lingabe lisabasebenzela noma lize lingabe lisakwazi ukubekezelela imiphumela yalo kumasosha omzimba.

Ukusebenza ngempumelelo

IMethotrexate iyisidakamizwa sodokotela abaningi abelapha i-RA. Lokhu kungenxa yokuthi isebenza kahle kangakanani. NgokukaJohns Hopkins, iningi labantu lithatha i-methotrexate isikhathi eside uma iqhathaniswa namanye ama-DMARDs-kuze kube yiminyaka emihlanu. Lokhu kukhombisa ukuthi sisebenza kanjani ekwelapheni lesi simo nokuthi abantu abaningi basibekezelela kanjani.

Izinombolo zikhombisa ukuthi i-methotrexate isiza abantu abaningi abane-RA. Ngokusho kweNational Rheumatoid Arthritis Society, ngaphezu kwengxenye yabantu abayithathayo babona ukuthuthuka okungamaphesenti angama-50 ngokuqhubeka kwesifo sabo. Futhi ngaphezu kwengxenye eyodwa kwezintathu zabantu babona ukuthuthuka okungamaphesenti angama-70. Akuwona wonke umuntu ozothola ukukhululeka nge-methotrexate, kepha isebenza kangcono kubantu abaningi kunamanye ama-DMARD.

Uma ukwelashwa kwe-methotrexate kungasebenzelanga i-RA yakho okokuqala, lisekhona ithemba. A

Ngokuhlanganiswa nezinye izidakamizwa

I-Methotrexate ivame ukusetshenziswa namanye ama-DMARD noma eminye imithi yezinhlungu nokuvuvukala. Kukhombisile ukuba ngumlingani omuhle. Inhlanganisela ethile yama-DMARD amabili noma ngaphezulu-njalo ene-methotrexate njengengxenye eyodwa-isebenza kangcono kune-methotrexate yodwa. Gcina lokhu engqondweni uma ungaphenduli i-methotrexate ngokwayo. Ungakhuluma nodokotela wakho mayelana nokwelashwa okuhlanganisiwe.

Imiphumela emibi ye-methotrexate

Ngaphandle kweqiniso lokuthi isebenza kubantu abaningi, odokotela bathanda ukusebenzisa i-methotrexate ngoba imiphumela emibi kakhulu ayijwayelekile. Kepha njengayo yonke imithi, i-methotrexate ingadala imiphumela emibi. Imiphumela emibi ejwayelekile ingafaka:

• isisu esibuhlungu
• ukukhathala
• ukuncipha kwezinwele

Ungakwazi ukwehlisa ubungozi bale miphumela emibi uma uthatha isengezo se-folic acid. Buza udokotela wakho ukuthi ngabe lesi sengezo sikufanele yini.

Khuluma nodokotela wakho

Uma une-RA, khuluma nodokotela wakho mayelana ne-methotrexate. Lesi sidakamizwa sikhonjiswe ukuthi sisebenza kahle ngaphandle kokubanga imiphumela emibi eminingi kubantu abane-RA. Uma i-methotrexate ingasebenzi ukwelapha izimpawu zakho ze-RA, udokotela wakho angakunika isilinganiso esiphezulu noma esinye isidakamizwa ongasisebenzisa ne-methotrexate.