Kuyini i-mosaicism nemiphumela yako esemqoka

-Delile

• Izici eziyinhloko
• Imiphumela yobuciko

I-Mosaicicism yigama elinikezwe uhlobo lokwehluleka kofuzo ngesikhathi sokukhula kombungu ngaphakathi kwesibeletho sikamama, lapho umuntu eqala khona ukuba nezinto zokwakha zofuzo ezi-2, eyodwa eyakhiwa ukuhlangana kweqanda nesidoda sabazali , futhi okunye okuvela ngenxa yokuguquka kweseli ngenkathi kukhula umbungu.

Ngakho-ke, umuntu uzokwakha inhlanganisela yamaseli, nephesenti lamaseli ajwayelekile kanye namanye amaphesenti amaseli anokuguquka, njengoba kukhonjisiwe kumfanekiso olandelayo:

Izici eziyinhloko

I-Mosaicicism yenzeka lapho uguquko lwenzeka esitokisini sombungu, imvamisa ukulahleka noma ukuphindwa kwe-chromosome, okwenza umuntu athuthukise umzimba wakhe ngezinhlobo ezimbili zamaseli, nezinhlobo ezi-2 zezinto zofuzo. Lokhu kuguquka kungaba ngezinhlobo ezimbili:

• Ukuhluma noma uGonadal: kuthinta isidoda noma amaqanda, ngezinguquko ezingadluliselwa ezinganeni. Ezinye izibonelo zezifo ezibangelwa izinguquko kumaseli amagciwane yi-Turner's syndrome, i-osteogenesis engaphelele ne-Duchenne muscular dystrophy;
• AmaSomatics: lapho amangqamuzana avela kunoma iyiphi enye ingxenye yomzimba ethwala lokhu kuguqulwa, noma ngabe umuntu angathuthukisa izinguquko zomzimba ezibangelwa yiyo. Ngakho-ke, ukubonakaliswa komzimba kokuguquka kwesimo kuncike ekutheni mangaki futhi mangaki amangqamuzana emzimbeni athintekile. I-Somatic mosaicism ingadluliselwa isuka kubazali iye ezinganeni, kanti ezinye izibonelo zezifo ezibangelwe yi-Down's syndrome ne-neurofibromatosis.

I-mosaic exubekile, ngakolunye uhlangothi, yenzeka lapho umuntu enezinhlobo zombili ze-mosaicism, zombili zokuhluma kanye ne-somatic.

I-Mosaicic yehlukile kwe-chimerism ngoba, kulesi simo, izinto zofuzo zombungu ziphindwa ngokuhlanganiswa kwemibungu ehlukene emi-2, eba munye. Funda kabanzi ngalesi simo ku-chimerism.

Imiphumela yobuciko

Yize izimo eziningi zobuciko bezandla zingadali zimpawu noma yimuphi umphumela empilweni yomuntu, lesi simo singadala ukuvela kwezinkinga eziningana nezifo kulowo ophethe, kanti ezinye izibonelo yilezi:

• Ukwandulela umdlavuza;
• Izinguquko ekukhuleni;
• Ukuhlelwa kwangaphambili kokukhipha izisu okuzenzakalelayo;
• Izinguquko kuphethini lesikhumba lesikhumba;
• I-heterochromia ye-Ocular, lapho umuntu angaba neso elilodwa lombala ngamunye;
• I-Down's syndrome;
• I-Turner syndrome;
• I-Osteogenesis imperfecta;
• IDuchenne muscular dystrophy;
• Ama-syndromes kaMcCune-Albright;
• Isifo sePallister-Killian;
• I-Proteus syndrome.

Ngaphezu kwalokho, kuye kwaqashelwa ukuthi ubuciko bemvelo buthuthukisa ukuthambekela kwezifo zemizwa eziwohlokayo, ngokwesibonelo, i-Alzheimer's noma iParkinson.