Yini okusha ngezindlela zokwelashwa ze-PPMS? Umhlahlandlela Wezinsiza

-Delile

• Ucwaningo lwezidakamizwa oluvela ku-NINDS
• Izidakamizwa zokwelapha
• Ukuguqulwa kwe-Gene
• Izincomo zokuvuselela
• Ukwelashwa ngokomzimba kanye nocwaningo ekuzivocavoca umzimba
• Ukuqamba ekwelashweni komsebenzi
• Izilingo zomtholampilo ze-PPMS
• Ikusasa lokwelashwa kwe-PPMS

Ukuqanjwa okusha ku-Multiple Sclerosis Treatment

I-primary progressive multiple sclerosis (PPMS) ayinayo ikhambi, kepha kunezindlela eziningi ezikhona zokuphatha lesi simo. Ukwelashwa kugxile ekwehliseni izimpawu ngenkathi kwehliswa amathuba okukhubazeka unomphela.

Udokotela wakho kufanele abe ngumthombo wakho wokuqala wokwelapha i-PPMS. Bangakunikeza izeluleko zokuphatha njengoba bebheka ukuqhubeka kwesifo.

Noma kunjalo, usengaba nentshisekelo ekuhloleni izinsiza ezengeziwe zokwelashwa kwe-PPMS. Funda ngamathuba lapha.

Ucwaningo lwezidakamizwa oluvela ku-NINDS

INational Institute of Neurological Disorders and Stroke (NINDS) yenza ucwaningo oluqhubekayo kuzo zonke izinhlobo ze-multiple sclerosis (MS).

I-NINDS igatsha leNational Institutes of Health (NIH), futhi isekelwa uxhaso lukahulumeni. I-NINDS okwamanje iphenya izidakamizwa ezingaguqula i-myelin nezakhi zofuzo ezingavimba ukuqala kwe-PPMS.

Izidakamizwa zokwelapha

Ku-2017, i-ocrelizumab (i-Ocrevus) yamukelwa yi-Food and Drug Administration (FDA) ekwelapheni i-PPMS kanye ne-MS ebuyisela kabusha (RRMS). Lesi sidakamizwa esijojwayo yisidakamizwa sokuqala futhi kuphela se-PPMS emakethe.

Ngokusho kwe-NINDS, ezinye izidakamizwa ezithuthukiswayo nazo zikhombisa isithembiso. Le mithi yokwelapha izosebenza ngokuvimbela amaseli e-myelin ukuthi angavuvukali aphenduke izilonda. Angavikela amaseli we-myelin noma asize ukuwalungisa ngemuva kokuhlaselwa okuvuthayo.

Isidakamizwa somlomo i-cladribine (Mavenclad) ngesinye sezibonelo ezinjalo.

Eminye imishanguzo ephenywayo ingahle ikhuthaze ukuthuthukiswa kwama-oligodendrocyte. Ama-oligodendrocyte amangqamuzana obuchopho athile azosiza ekwakheni amaseli amasha e-myelin.

Ukuguqulwa kwe-Gene

Isizathu esiqondile se-PPMS - ne-MS jikelele - asaziwa. Ingxenye yezakhi zofuzo kucatshangwa ukuthi inikela ekuthuthukiseni izifo. Abaphenyi bayaqhubeka nokutadisha indima yezakhi zofuzo ku-PPMS.

I-NINDS ibhekisa kwizakhi zofuzo ezingakhuphula ubungozi be-MS "njengezakhi zofuzo ezithintekayo." Inhlangano ibheka izidakamizwa ezingashintsha lezi zakhi zofuzo ngaphambi kokuba i-MS ikhule.

Izincomo zokuvuselela

INational Multiple Sclerosis Society ingenye inhlangano enikezela ngezibuyekezo emisha ekwelashweni.

Ngokungafani nabakwa-NINDS, iNhlangano iyinhlangano engenzi nzuzo. Umsebenzi wabo ukusabalalisa ukuqwashisa nge-MS ngenkathi bekhulisa nemali yokuxhasa ucwaningo lwezokwelapha.

Njengengxenye yomsebenzi wayo wokuxhasa ukwethenjelwa kweziguli, iNhlangano ivame ukuvuselela izinsizakusebenza kuwebhusayithi yayo. Ngoba izinketho zezidakamizwa zikhawulelwe, ungathola izinsiza zomphakathi ekuvuseleleni zilusizo. Lapha bachaza:

• ukwelashwa ngokomzimba
• ukwelashwa emsebenzini
• ukuvuselelwa kwengqondo
• ukwelashwa okufundela umsebenzi (kwemisebenzi)
• izifo zolimi lokukhuluma

Ukwelashwa ngokomzimba nangokomsebenzi yizinhlobo ezivame kakhulu zokuvuselelwa ku-PPMS. Okulandelayo ngezinye zezinto ezintsha ezibandakanya lezi zindlela zokwelapha ezimbili.

Ukwelashwa ngokomzimba kanye nocwaningo ekuzivocavoca umzimba

Ukwelashwa ngokomzimba (PT) kusetshenziswa njengendlela yokuvuselela ku-PPMS. Izinhloso ze-PT zingahluka ngokuya ngobukhulu bezimpawu zakho. Isetshenziselwa ikakhulukazi uku:

• siza abantu abane-PPMS benze imisebenzi yansuku zonke
• khuthaza ukuzimela
• thuthukisa ukuphepha - ngokwesibonelo, ukufundisa izindlela zokulinganisa ezinganciphisa ubungozi bokuwa
• ukunciphisa amathuba okukhubazeka
• nikeza ukusekelwa okungokomzwelo
• thola isidingo samadivayisi okusiza ekhaya
• thuthukisa ikhwalithi yempilo isiyonke

Udokotela wakho cishe uzoncoma ukwelashwa ngokomzimba ngemuva nje kokutholakala kokuqala. Ukuzikhandla ngale ndlela yokwelashwa kubalulekile - ungalindi kuze kube yilapho izimpawu zakho ziqhubeka.

Ukuzivocavoca umzimba kuyingxenye ebalulekile ye-PT. Kuyasiza ukuthuthukisa ukuhamba kwakho, amandla, nobubanzi bokunyakaza ukuze ukwazi ukugcina ukuzimela.

Abaphenyi baqhubeka nokubheka izinzuzo zokuzivocavoca nge-aerobic kuzo zonke izinhlobo ze-MS. Ngokusho kweNational Multiple Sclerosis Society, ukuzivocavoca umzimba akuzange kunconywe kabanzi kwaze kwaba maphakathi nawo-1990. Yilapho inkolelo yokuthi ukuzivocavoca kwakungeyona i-MS ekugcineni yaxoshwa.

Umelaphi wakho angancoma izivivinyo ze-aerobic ongazenza - ngokuphepha - phakathi kwama-aphoyintimenti wokuthuthukisa izimpawu zakho nokwakha amandla akho.

Ukuqamba ekwelashweni komsebenzi

Ukwelashwa emsebenzini kuya ngokuya kwamukelwa njengempahla ekwelashweni kwe-PPMS. Kungaba wusizo ekuzinakekeleni nasemsebenzini, futhi kungasiza futhi:

• ongakwenza kwezokuvakasha
• ezokungcebeleka
• ukuzijabulisa
• ngokuzithandela
• ukuphathwa kwekhaya

I-OT ivame ukubonwa njengefana ne-PT. Yize lezi zindlela zokwelashwa zincedisana, ngayinye inesibopho sezici ezahlukahlukene zokwelashwa kwe-PPMS.

I-PT ingakusekela amandla nokuhamba kwakho jikelele, kanti i-OT ingasiza ngezinto ezithinta ukuzimela kwakho, njengokugeza nokugqoka wedwa. Kunconywa ukuthi abantu abane-PPMS bafune kokubili ukuhlolwa kwe-PT ne-OT kanye nokwelashwa okulandelayo.

Izilingo zomtholampilo ze-PPMS

Ungafunda futhi mayelana nokwelashwa kwamanje nokuvelayo kwe-PPMS ku-ClinicalTrials.gov. Leli elinye igatsha le-NIH. Inhloso yabo ukuhlinzeka “ngemininingwane egciniwe eyenziwa ngasese nangomphakathi izifundo zomtholampilo ezenziwa emhlabeni jikelele.”

Faka i- "PPMS" enkambini ethi "Isimo noma isifo". Uzothola izifundo eziningi ezisebenzayo neziqediwe ezibandakanya imishanguzo nezinye izinto ezingathinta lesi sifo.

Ngokwengeziwe, ungazicabangela nokuzibandakanya esivivinyweni somtholampilo ngokwakho. Lokhu ukuzibophezela okukhulu. Ukuze uqinisekise ukuphepha kwakho, kufanele uxoxe nodokotela wakho ngokuhlolwa kwemitholampilo kuqala.

Ikusasa lokwelashwa kwe-PPMS

Alikho ikhambi le-PPMS, futhi izinketho zezidakamizwa zilinganiselwe. Kusenziwa ucwaningo ukuhlola izidakamizwa ngaphandle kwe-ocrelizumab ezingasiza ekulawuleni izimpawu eziqhubekayo.

Ngaphezu kokungena nodokotela wakho njalo, sebenzisa lezi zinsiza ukugcina unolwazi ngezibuyekezo zakamuva ngaphakathi kocwaningo lwe-PPMS. Mningi umsebenzi owenziwayo wokuqonda kangcono iPPMS nokuphatha abantu ngempumelelo enkulu.