Ingabe I-Pancreatic Cancer Ifa? Funda Izimbangela Nezici Zengozi

-Delile

• Yini ebangela umdlavuza we-pancreatic, futhi ubani osengozini?
• Wande kangakanani umdlavuza wepancreatic?
• Izimpawu okufanele uzibheke
• Lapho uzobona udokotela wakho
• Yini ongayilindela ekuhlolweni
• Kwenzekani ngokulandelayo?

Ukubuka konke

Umdlavuza wepancreatic uqala lapho amaseli amanyikwe eqala ukuguquka kwezakhi zofuzo kwi-DNA yawo.

Lawa maseli angajwayelekile awafi, njengoba kwenza amangqamuzana ajwayelekile, kodwa aqhubeke nokuzala. Kukwakhiwa kwala maseli anomdlavuza okwenza isimila.

Lolu hlobo lomdlavuza luvame ukuqala kumaseli agudle imigudu yamanyikwe. Ingaqala futhi kumaseli we-neuroendocrine noma amanye amaseli akhiqiza ama-hormone.

Umdlavuza wepancreatic usebenza kweminye imindeni. Amaphesenti amancane ezinguquko zofuzo ezibandakanyeka kumdlavuza we-pancreatic azuzwe njengefa. Iningi liyatholakala.

Kunezinye izinto ezimbalwa ezingakhuphula ingozi yokuba nomdlavuza wepancreatic. Ezinye zalezi zingashintshwa, kepha ezinye azinakushintshwa. Qhubeka ufunde ukuze ufunde kabanzi.

Yini ebangela umdlavuza we-pancreatic, futhi ubani osengozini?

Imbangela eqondile yomdlavuza wepancreatic ayikwazi ukukhonjwa ngaso sonke isikhathi. Izinguquko ezithile zofuzo, zombili ezizuzwe njengefa futhi zitholakele, zihlotshaniswa nomdlavuza we-pancreatic. Kunezici ezimbalwa eziyingozi zomdlavuza we-pancreatic, noma ukuba nazo noma yiziphi zazo akusho ukuthi uzothola umdlavuza we-pancreatic. Khuluma nodokotela wakho ngezinga lakho lobungozi.

Ama-syndromes ezakhi zofuzo ahambisana nalesi sifo yilawa:

• ataxia telangiectasia, kubangelwe yizinguquko ezitholwe ngofuzo kuhlobo lwe-ATM
• i-pancreatitis yomndeni (noma eyifa), imvamisa ngenxa yokuguquka kwezakhi zofuzo ku-PRSS1 gene
• umndeni adenomatous polyposis, kubangelwa isakhi sofuzo se-APC esingalungile
• imindeni e-atypical multiple melanoma syndrome, ngenxa yokuguquka kwezakhi zofuzo ku-p16 / CDKN2A gene
• isifuba sofuzo nesifo somdlavuza we-ovari, kubangelwe ukuguqulwa kwezakhi zofuzo ze-BRCA1 ne-BRCA2
• Isifo se-Li-Fraumeni, umphumela wesici kuhlobo lwe-p53
• I-Lynch syndrome (i-nonpolyposis ye-cololorectal cancer), evame ukubangelwa izakhi zofuzo ze-MLH1 noma ze-MSH2
• ama-endocrine neoplasia amaningi, uhlobo 1, kubangelwa isakhi sofuzo esingalungile se-MEN1
• i-neurofibromatosis, uhlobo 1, ngenxa yezinguquko kuhlobo lweNF1
• I-Peutz-Jeghers syndrome, kubangelwa ukukhubazeka kuhlobo lwe-STK11
• Isifo seVon Hippel-Lindau, umphumela wokuguqulwa kwezakhi zofuzo kuhlobo lwe-VHL

"Umdlavuza we-pancreatic ojwayelekile" kusho ukuthi usebenza emndenini othize lapho:

• Okungenani izihlobo ezimbili zokuqala (umzali, ingane yakini, noma ingane) zibe nomdlavuza wepancreatic.
• Kunezihlobo ezintathu noma ngaphezulu ezinomdlavuza we-pancreatic ngasohlangothini olulodwa lomndeni.
• Kunesifo somdlavuza owaziwayo womndeni kanye nelungu okungenani elilodwa lomndeni elinomdlavuza we-pancreatic.

Ezinye izimo ezingakhuphula ubungozi bomdlavuza wepancreatic yilezi:

• i-pancreatitis engapheli
• ukuqina kwesibindi
• Ukutheleleka nge-Helicobacter pylori (H. pylori)
• thayipha 2 sikashukela

Ezinye izinto ezinobungozi zifaka:

• Ubudala. Amaphesenti angaphezu kwama-80 omdlavuza we-pancreatic akhula kubantu abaphakathi kweminyaka engama-60 nengama-80.
• Ubulili. Abesilisa banengozi engaphezulu kancane kwabesifazane.
• Ubuhlanga. Abantu base-Afrika baseMelika banengozi ephakeme kancane kunabaseCaucasus.

Izici zendlela yokuphila zingakhuphula nengozi yomdlavuza wepancreatic. Ngokwesibonelo:

• Ukubhema osikilidi bayiphinda kabili ingozi yokuba nomdlavuza wepancreatic. Isigaxa, amapayipi, nemikhiqizo kagwayi engenantuthu nakho kukhulisa ingozi yakho.
• Ukukhuluphala ngokweqile kuphakamisa ingozi yomdlavuza we-pancreatic cishe ngamaphesenti angama-20.
• Ukuvezwa kanzima kwamakhemikhali esetshenziswa ezimbonini zensimbi nezokuhlanza ezomile kungakhuphula ubungozi bakho.

Wande kangakanani umdlavuza wepancreatic?

Uhlobo olungajwayelekile lomdlavuza. Cishe amaphesenti we-1.6 wabantu azokwakha umdlavuza we-pancreatic empilweni yabo.

Izimpawu okufanele uzibheke

Isikhathi esiningi, izimpawu azibonakali esigabeni sokuqala somdlavuza wepancreatic.

Njengoba umdlavuza uthuthuka, izimpawu nezimpawu zingafaka:

• ubuhlungu esiswini sakho esingenhla, mhlawumbe sikhipha emhlane wakho
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukukhathala
• ukuphuzi kwesikhumba namehlo (i-jaundice)
• ukuqala okusha kwesifo sikashukela
• ukudana

Lapho uzobona udokotela wakho

Akunakho ukuhlolwa okujwayelekile kokuhlolwa kwabantu abasengozini emaphakathi yomdlavuza we-pancreatic.

Ungahle ubhekwe njengengozi eyengeziwe uma unomlando womndeni womdlavuza we-pancreatic noma une-pancreatitis engapheli. Uma kunjalo, udokotela wakho angayalela ukuhlolwa kwegazi ukuze kuhlolwe ukuguqulwa kwezakhi zofuzo okuhambisana nomdlavuza we-pancreatic.

Lezi zivivinyo zingakutshela uma unezinguquko, kodwa hhayi uma unomdlavuza we-pancreatic. Futhi, ukushintshwa kwezakhi zofuzo akusho ukuthi uzothola umdlavuza we-pancreatic.

Noma ngabe usengozini ejwayelekile noma ephezulu, izimpawu ezinjengobuhlungu besisu kanye nokwehla kwesisindo akusho ukuthi unomdlavuza we-pancreatic. Lokhu kungaba yizimpawu zezimo ezahlukahlukene, kepha kubalulekile ukubona udokotela wakho ukuze ahlolwe. Uma unezimpawu ze-jaundice, bheka udokotela wakho ngokushesha okukhulu.

Yini ongayilindela ekuhlolweni

Udokotela wakho uzofuna ukuthatha umlando ophelele wezokwelapha.

Ngemuva kokuhlolwa komzimba, ukuhlolwa kokuxilongwa kungafaka:

• Ukuhlola ukuhlolwa. Ukuskena kwe-Ultrasound, CT, iMRI, nePET kungasetshenziselwa ukudala izithombe ezinemininingwane yokubheka ukungajwayelekile kwamanyikwe nezinye izitho zangaphakathi.
• I-endoscopic ultrasound. Kule nqubo, ishubhu elincane, eliguquguqukayo (i-endoscope) lidluliselwa phansi kwesisu sakho nasesiswini sakho ukuze ubuke amanyikwe akho.
• Isidumbu. Udokotela uzofaka inaliti ezacile esiswini sakho nasemanyikwe ukuze athole isampula lezicubu ezisolisayo. Isazi sezifo sizohlola isifanekiso ngaphansi kwesibonakhulu ukuthola ukuthi amaseli anomdlavuza yini.

Udokotela wakho angahlola igazi lakho ukuthola izimpawu zesimila ezihambisana nomdlavuza we-pancreatic. Kodwa lokhu kuhlolwa akulona ithuluzi lokuhlola elithembekile; kuvame ukusetshenziselwa ukuhlola ukuthi ukwelashwa kusebenza kahle kangakanani.

Kwenzekani ngokulandelayo?

Ngemuva kokuxilongwa, umdlavuza udinga ukuhlelwa ngokuya ngokuthi ususabalale kangakanani. Umdlavuza wepancreatic uhlelwe kusuka ku-0 kuye ku-4, kuthi i-4 ibe yiyona ethuthuke kakhulu. Lokhu kusiza ukunquma izinketho zakho zokwelashwa, ezingabandakanya ukuhlinzwa, ukwelashwa ngemisebe nokwelashwa ngamakhemikhali.

Ngezinhloso zokwelashwa, umdlavuza we-pancreatic nawo ungabekwa njenge:

• Kuyabukeka. Kubonakala sengathi isimila singasuswa ngokuhlinzwa ngokuphelele.
• I-Borderline resectable. Umdlavuza ufinyelele emithanjeni yegazi eseduze, kodwa kungenzeka ukuthi udokotela ohlinzayo angawususa ngokuphelele.
• Akuphindaphindwe. Ayikwazi ukususwa ngokuphelele ekuhlinzweni.

Udokotela wakho uzokubheka lokhu, kanye nephrofayili yakho ephelele yezokwelapha, ukusiza ukunquma ngezindlela zokwelashwa ezingcono kakhulu kuwe.