Lokho Wonke Umuntu one-Psoriasis Edinga Ukwazi Ngama-PDE4 Inhibitors

-Delile

• Ukubuka konke
• Yini ama-PDE4 inhibitors?
• Basebenzela kanjani i-psoriasis?
• Ukwelashwa kwe-PDE4 inhibitor kuqhathaniswa nokunye ukwelashwa kwe-psoriasis
• Izinzuzo ezingaba khona
• Imiphumela emibi nezixwayiso
• Ukuthatha

Ukubuka konke

I-plaque psoriasis yisimo esingapheli sokuzivikela komzimba. Lokho wukuthi, amasosha omzimba ahlasela umzimba ngephutha. Kubanga amabala abomvu, anezikhala ukuvela esikhunjeni. Lezi zigcawu kwesinye isikhathi zingazizwa ziluma kakhulu noma zibuhlungu.

Izinketho zokwelashwa zihlose ukunciphisa lezi zimpawu. Ngoba ukuvuvukala kungumsuka we-plaque psoriasis, inhloso yemithi eminingi ukunciphisa le mpendulo yamasosha omzimba nokwenza ibhalansi ejwayelekile.

Uma uhlala ne-plaque psoriasis elinganiselayo kuya kwelinzima, i-PDE4 inhibitor ingaba ithuluzi eliphumelelayo ekulawuleni izimpawu.

Kodwa-ke, umuthi akuwona owabo bonke abantu. Kufanele uxoxe ngezinketho zakho zokwelashwa nodokotela wakho.

Yini ama-PDE4 inhibitors?

Ama-PDE4 inhibitors ayindlela yokwelashwa esanda kuqhathaniswa. Basebenza ukucindezela amasosha omzimba, anciphisa ukuvuvukala. Basebenza ezingeni lamaselula ukumisa ukukhiqizwa kwe-enzyme eyeqile ebizwa nge-PDE4.

Abaphenyi bayazi ukuthi i-phosphodiesterases (PDEs) ilulaza i-cyclic adenosine monophosphate (cAMP). i-cAMP inikela kakhulu ekusayineni izindlela eziphakathi kwamaseli.

Ngokumisa ama-PDE4, ikamu liyakhuphuka.

Ngokuya ngocwaningo lwango-2016, leli zinga eliphakeme lekamu lingaba nemiphumela yokulwa nokuvuvukala, ikakhulukazi kubantu abaphila ne-psoriasis ne-atopic dermatitis.

Basebenzela kanjani i-psoriasis?

Ama-PDE4 inhibitors, njenge-apremilast (Otezla), asebenza ngaphakathi komzimba ukuvimbela ukuvuvukala.

Njengesilinganiso sokuvimbela, kungasiza abantu abane-psoriasis ukuphatha ukuvuvukala. Ukunciphisa ukuvuvukala kungadala ukuthi ukuqubuka kungabi njalo futhi kube nzima kakhulu.

Kungase futhi kuvimbe noma kuvimbele ukuqhubekela phambili kwezifo ukuholela ku-psoriatic arthritis (PsA).

Kulabo abaphila nanoma yiluphi uhlobo lwe-psoriasis, cishe amaphesenti angama-30 ekugcineni aba ne-PsA, edala ubuhlungu obuhlangene obumaphakathi nobunzima. I-PsA inganciphisa ikhwalithi yempilo yakho.

Ukwelashwa kwe-PDE4 inhibitor kuqhathaniswa nokunye ukwelashwa kwe-psoriasis

I-Apremilast, i-PDE4 inhibitor, ithathwa ngomlomo. Ibuye isebenze endleleni ebalulekile ngokuphazamisa impendulo yokuvuvukala enomthelela ezimpawu ze-plaque psoriasis.

Imithi yokwelapha efana ne-adalimumab (Humira), i-etanercept (i-Enbrel), ne-infliximab (i-Remicade) ijojowe emzimbeni.

Ezinye izindlela zokwelapha ezijojwayo zifaka:

• I-Ustekinumab (IL-12/23 inhibitor)
• secukinumab (IL-17A inhibitor)
• ixekizumab (IL-17A inhibitor)
• i-guselkumab (IL-23 inhibitor)
• i-risankizumab (IL-23 inhibitor)

I-Tofacitinib iyi-Janus kinase (JAK) inhibitor evunyelwe njengokwelashwa ngomlomo.

I-Abatacept iyi-T-cell activation inhibitor enikezwa njenge-infravenous (IV) infusion noma umjovo.

Izinzuzo ezingaba khona

Kunconywa i-Apremilast kubantu abaphila ne-plaque psoriasis elinganiselayo kuya kwelinzima nabo abangabakhokhelwa ukwelashwa kwesistimu noma i-phototherapy.

Ku, inani elikhulu labantu abathatha i-apremilast lithole kahle kuzo zombili i-Physician's Global Assessment (sPGA) ne-Psoriasis Area and Severity Index (PASI) uma kuqhathaniswa nalabo abathatha i-placebo.

Imiphumela emibi nezixwayiso

Yize ama-PDE4 inhibitors akhombisa ukuthembisa okukhulu, akuwona wonke umuntu. I-Apremilast ayizange ihlolwe kwabesifazane abakhulelwe noma abancelisayo. Njengamanje, kuvunyelwe kuphela abantu abadala.

Kubalulekile futhi ukukala ubungozi kanye nezinzuzo ezingaba khona ze-PDE4 inhibitors.

I-Apremilast iza nezingozi ezithile ezaziwayo.

Abantu abathatha i-apremilast bangathola ukusabela okufana nalokhu:

• isicanucanu
• isifo sohudo
• ukutheleleka okuphezulu okuphefumulayo
• ikhanda

Abanye abantu babhekana nokulahleka kwesisindo okuphawulekayo.

I-Apremilast nayo ingakhuphula imizwa yokudangala nemicabango yokuzibulala.

Kubantu abanomlando wokudangala noma wokuzibulala, kunconywa ukuthi bakhulume nodokotela wabo ukuze abasize ngokucophelela ukukala izinzuzo zomuthi ngokuhambisana nezingozi.

Uma uhlangabezana nemiphumela engemihle, udokotela wakho angancoma ukumisa umuthi.

Ukuthatha

I-Psoriasis yisifo esingelapheki - kepha esilawulekayo. Indima edlalwa ukuvuvukala ukugxila ekwelashweni nasekucwaningeni.

Uma udokotela wakho enquma ukuthi i-plaque psoriasis yakho imnene noma iphethwe kahle, bangancoma izidakamizwa ezingezona ukuvuvukala (ama-NSAID). Bangancoma nokwelashwa ngezihloko ezithile.

Cishe bazozama zombili lezi zincomo ngaphambi kokucabangela ukusetshenziswa kwe-PDE4 inhibitor noma abanye abasebenza ngama-immune modulators.

Abaphenyi bathole okuningi mayelana nezinqubo ezisemzimbeni ezibangela ukuvuvukala. Lolu lwazi lusizile ekwakhiweni kwemithi emisha engahlinzeka ukukhululeka kulabo abaphila ne-psoriasis.

Ama-PDE4 inhibitors amasha amasha, kepha eza nezingozi. Wena nodokotela wakho kufanele nizibheke ngokucophelela lezi zinto ngaphambi kokuqala uhlobo olusha lokwelashwa.