Ukwelashwa Kwemisebenzi Yangaphambi Kokusebenza: I-Calcium Channel Blockers (CCBs)

-Delile

• Izimpawu zomsebenzi wokuqala
• Izimbangela nezici zobungozi
• Ukuvivinywa kokuhlonza ukusebenza ngaphambi kwesikhathi
• Ngabe asebenza kanjani ama-calcium channel blocker?
• Isebenza kanjani i-nifedipine?
• Yimiphi imiphumela emibi engaba khona ye-nifedipine?
• Ingabe bakhona abesifazane okungafanele bathathe i-nifedipine?
• Umbono

Ama-block block weziteshi zangaphambi komsebenzi kanye ne-calcium

Ukukhulelwa okujwayelekile kuhlala cishe amasonto angama-40. Lapho owesifazane ebeletha emasontweni angama-37 noma ngaphambili, kubizwa ngokuthi i-preterm labor futhi ingane kuthiwa ingaphambi kwesikhathi. Ezinye izingane ezizalwe ngaphambi kwesikhathi zidinga ukunakekelwa okukhethekile lapho zizalwa, kanti ezinye zinokukhubazeka isikhathi eside ngokomzimba nangokwengqondo ngoba azinaso isikhathi esanele sokukhula ngokugcwele

AmaCalcium channel blockers (CCBs), asetshenziswa kakhulu ukunciphisa umfutho wegazi, nawo angasetshenziswa ukukhulula izingqinamba zesibeletho nokuhlehlisa ukuzalwa kwangaphambi kokubeletha. I-CCB ejwayelekile yalesi sizathu yi-nifedipine (Procardia).

Izimpawu zomsebenzi wokuqala

Izimpawu zomsebenzi wokuqala zingabonakala noma zicashile. Ezinye izimpawu zifaka:

• ukucindezela okuvamile noma okuvamile
• ingcindezi okhalo
• ukucindezela kwesisu okuphansi
• amajaqamba
• ukubonwa kwesitho sangasese sowesifazane
• ukopha esithweni sangasese
• ukuphuka kwamanzi
• ukukhishwa kwesitho sangasese sowesifazane
• isifo sohudo

Bheka udokotela wakho uma uhlangabezana nanoma iyiphi yalezi zimpawu noma uzizwe ukuthi kungenzeka ukuthi uya emsebenzini ngaphambi kwesikhathi.

Izimbangela nezici zobungozi

Izimbangela zokuya emsebenzini ngaphambi kwesikhathi kunzima ukuzithola.

Ngokusho koMtholampilo iMayo, noma imuphi umuntu wesifazane angaya emsebenzini kusenesikhathi. Izici zobungozi ezixhunyaniswe nomsebenzi wokuqala ngaphambi kwesikhathi yilezi:

• ukuzalwa ngaphambi kwesikhathi ngaphambi kwesikhathi
• ukhulelwe amawele, noma ezinye iziphindaphindo
• unenkinga ngesibeletho sakho, umlomo wesibeletho, noma i-placenta
• ukuba nomfutho wegazi ophezulu
• ukuba nesifo sikashukela
• ukuba ne-anemia
• ukubhema
• ukusebenzisa izidakamizwa
• ukuba nezifo ezithinta izitho zangasese
• ukukhuluphala noma ukukhuluphala ngaphambi kokukhulelwa
• ukuba ne-amniotic fluid eningi kakhulu, ebizwa nge-polyhydramnios
• ukopha esithweni sangasese ngesikhathi sokukhulelwa
• ukuba nengane engakazalwa enenkinga yokuzalwa
• ukuba nesikhathi esingaphansi kwezinyanga eziyisithupha kusukela ekukhulelweni kokugcina
• ukunakekelwa okuncane noma cha
• ukuhlangabezana nezehlakalo zokuphila ezicindezelayo, njengokushona kothandekayo

Ukuvivinywa kokuhlonza ukusebenza ngaphambi kwesikhathi

Udokotela wakho angenza esisodwa noma eziningi zalezi zivivinyo ukuze ahlolisise ukuqala komsebenzi:

• ukuhlolwa kwezitho zangasese ukuthola ukuthi umlomo wakho wesibeletho usuqale ukuvuleka nokuthi kunqunywe ubumnene besibeletho sakho nengane
• i-ultrasound yokukala ubude besibeletho sakho bese unquma usayizi wengane yakho nokuma kwayo esibelethweni sakho
• ukuqapha kwesibeletho, ukukala ubude nobude bezinciphiso zakho
• ukuvuthwa i-amniocentesis, ukuhlola i-amniotic fluid yakho ukuthola ukukhula kwengane yengane yakho
• i-swab yesitho sangasese sangasese yokuhlolela izifo

Ngabe asebenza kanjani ama-calcium channel blocker?

Odokotela bavame ukunquma ama-CCB ukuthi ahlehlise ukusebenza ngaphambi kwesikhathi. Isibeletho isicubu esikhulu esakhiwa izinkulungwane zamaseli emisipha. Lapho i-calcium ingena kulawa maseli, izicubu zomzimba ziyaqina futhi ziyaqina. Lapho i-calcium ibuyela emuva isuka esitokisini, imisipha iyakhululeka. Ama-CCB asebenza ngokuvimbela i-calcium ekuthutheleleni kumaseli emisipha yesibeletho, okwenza ingakwazi ukungena.

Ama-CCB ayiqoqo lezidakamizwa ezibizwa ngokuthi i-tocolytics. Omunye ukhombisa ukuthi i-nifedipine iyi-CCB ephumelela kunazo zonke yokuhlehlisa ukusebenza kwangaphambi kwesikhathi nokuthi iphumelela kakhulu kunamanye ama-tocolytics.

Isebenza kanjani i-nifedipine?

INifedipine inganciphisa inani nobuningi bokuphambana, kepha umphumela wayo nokuthi ihlala isikhathi eside kangakanani kuyehluka kuye ngokuya kowesifazane. Njengayo yonke imishanguzo ye-tocolytic, ama-CCB awavimbeli noma abambezele ukulethwa kwangaphambi kwesikhathi isikhathi esibalulekile.

Ngokusho kwesinye, ama-CCB angabambezela ukulethwa izinsuku ezimbalwa, kuya ngokuthi umlomo wesibeletho sowesifazane uvuleka kangakanani lapho eqala umuthi. Lokhu kungahle kungabonakali njengesikhathi esiningi, kepha kungenza umehluko omkhulu ekukhuleni kwengane yakho uma unikezwa ama-steroids kanye nama-CCB. Ngemuva kwamahora angama-48, ama-steroids angathuthukisa ukusebenza kwamaphaphu engane yakho futhi anciphise ubungozi bawo bokufa.

Yimiphi imiphumela emibi engaba khona ye-nifedipine?

Ngokusho kukaMashi kaDimes, i-nifedipine iyasebenza futhi iphephe kakhulu, yingakho odokotela beyisebenzisa kakhulu. INifedipine ayinayo imiphumela emibi enganeni yakho. Imiphumela emibi ongayifaka ingafaka:

• ukuqunjelwa
• isifo sohudo
• isicanucanu
• ngizwe nginesiyezi
• ngizizwe ngiphela amandla
• ikhanda elibuhlungu
• umfutho wegazi ophansi
• ukubomvu kwesikhumba
• ukushaya kwenhliziyo
• ukuqubuka kwesikhumba

Uma umfutho wakho wegazi wehla isikhathi eside, ungathinta ukugeleza kwegazi kuye enganeni yakho.

Ingabe bakhona abesifazane okungafanele bathathe i-nifedipine?

Abesifazane abanezimo zezokwelapha ezingenziwa zimbi ngemiphumela emibi echazwe ngenhla akufanele bathathe ama-CCB. Lokhu kufaka phakathi abesifazane abanengcindezi yegazi ephansi, ukwehluleka kwenhliziyo, noma ukuphazamiseka okuthinta amandla emisipha.

Umbono

Ukuya emsebenzini wokuqala kungathinta ukukhula kwengane yakho. AmaCCB ayindlela ephephile nephumelelayo yokuhlehlisa ukusebenza ngaphambi kwesikhathi. AmaCCB ahlehlisa ukusebenza kuze kube ngamahora angama-48. Uma usebenzisa i-CCB kanye ne-corticosteroids, le mithi emibili ingasiza ekukhuleni kwengane yakho ngaphambi kokuzalwa futhi isize ekuqinisekiseni ukuthi unokubeletha okuphephile nengane enempilo.