Ama-Prokinetic Agents

-Delile

• Izinhlobo zeProkinetics
• IBethanechol
• I-Cisapride
• I-Metoclopramide

Esimeni somuntu esinempilo, ukugwinya kukhuthaza i-peristalsis eyinhloko. Lezi yiziphazamiso ezihambisa ukudla kwakho phansi kwesisu nangaso sonke isimiso sakho sokugaya ukudla. Ngokulandelayo, i-reflux ye-gastroesophageal ivusa umvuthwandaba wesibili wokucindezela kwemisipha okususa i-esophagus, kududule ukudla kuye phansi nge-esophageal sphincter (LES) nokungena esiswini.

Kodwa-ke, kwabanye abantu, i-LES ingahle ikhululeke noma ivuleke ngokuzenzekelayo, ivumela okuqukethwe yisisu, kufaka phakathi ama-acid, ukuthi kungene kabusha i-esophagus. Lokhu kubizwa nge-acid reflux futhi kungaholela ezimpawu ezifana nesilungulela.

Ama-Prokinetic agents, noma ama-prokinetics, yimithi esiza ukulawula i-acid reflux. Ama-Prokinetics asiza ukuqinisa i-esophageal sphincter (LES) ephansi futhi abangele okuqukethwe yisisu ukukhipha ngokushesha. Lokhu kuvumela isikhathi esincane se-acid reflux ukuthi yenzeke.

Namuhla, ama-prokinetics asetshenziswa kakhulu nezinye izifo ze-gastroesophageal reflux (GERD) noma imithi yesilungulela, njenge-proton pump inhibitors (PPIs) noma i-H2 receptor blockers. Ngokungafani neminye le mithi ye-acid reflux, evame ukuphepha, ama-prokinetics angaba nemiphumela emibi kakhulu, noma eyingozi. Zivame ukusetshenziswa kuphela ezimweni ezibucayi kakhulu ze-GERD.

Isibonelo, ama-prokinetics angasetshenziselwa ukwelapha abantu abanesifo sikashukela esincike ku-insulin, noma izinsana nezingane ezinokukhubazeka okukhulu kwamathumbu noma ukuqunjelwa okunzima okungaphenduli kwezinye izindlela zokwelapha.

Izinhlobo zeProkinetics

IBethanechol

IBethanechol (Urecholine) umuthi ovuselela isinye futhi okusiza ukudlulisa umchamo uma unenkinga yokukhipha isinye. Kuyasiza ukuqinisa i-LES, futhi kwenze isisu singabi nalutho ngokushesha. Kuyasiza futhi ukuvimbela isicanucanu nokuhlanza. Itholakala ngendlela yethebhulethi.

Kodwa-ke, usizo lwayo lungadlulwa yimiphumela emibi ejwayelekile. Imiphumela yaso emibi ingafaka:

• ukukhathazeka
• ukudana
• ukozela
• ukukhathala
• izinkinga zomzimba njengokuhamba okungazibandakanyi nokuqaqamba kwemisipha

I-Cisapride

I-Cisapride (Propulsid) isebenza kuma-serotonin receptors esiswini. Yayisetshenziselwa ikakhulukazi ukuthuthukisa ithoni yemisipha ku-LES. Kodwa-ke, ngenxa yemiphumela yaso emibi, njengokushaya kwenhliziyo okungajwayelekile, isusiwe emakethe emazweni amaningana, kubandakanya nase-United States. Kwake kwathathwa njengokusebenza ngempumelelo ekwelapheni i-GERD njengama-H2 receptor blocker afana ne-famotidine (Pepcid). I-Cisapride isasetshenziswa kaningi emithini yezilwane.

I-Metoclopramide

I-Metoclopramide (i-Reglan) i-agent ye-prokinetic esetshenziselwe ukwelapha i-GERD ngokwenza ngcono isenzo semisipha emgodini wamathumbu. Kutholakala kuzo zombili izinhlobo zama-tablet nezoketshezi. Njengamanye ama-prokinetics, ukusebenza kwe-metoclopramide kuvinjelwe imiphumela emibi kakhulu.

Imiphumela emibi ingafaka ingozi eyandayo yezimo zezinzwa ezinjenge-tardive dyskinesia, ebangela ukunyakaza okuphindayo okungazibandakanyi. Le miphumela emibi yaziwa ukuthi yenzeke kubantu abahlala kulo muthi isikhathi esingaphezu kwezinyanga ezintathu. Abantu abathatha i-metoclopramide kufanele baqaphele kakhulu ngenkathi beshayela noma besebenzisa imishini esindayo noma imishini.

Sebenza nodokotela wakho ukuthola ukuthi yiluphi uhlelo lwezokwelapha olulungele wena. Qiniseka ukuthi ulandela izinkomba udokotela wakho akunikeza zona. Shayela udokotela wakho uma uzizwa sengathi imithi yakho idale imiphumela emibi.