I-Proton Pump Inhibitors

-Delile

• Ngabe I-Proton Pump Inhibitors Isebenza Kanjani?
• Ingabe Zikhona Izinhlobo Ezihlukile ZamaProton Pump Inhibitors?
• Ziyini Izingozi Zokusebenzisa iProton Pump Inhibitors?
• Izinyathelo Ezilandelayo

Ukwelashwa kwesifo se-reflux se-gastroesophageal (GERD) imvamisa kunezigaba ezintathu. Izigaba ezimbili zokuqala zifaka phakathi ukuthatha imishanguzo nokwenza ushintsho endleleni odla ngayo nendlela ophila ngayo. Isigaba sesithathu ukuhlinzwa. Ukuhlinzwa kuvame ukusetshenziswa kuphela njengezinyathelo zokugcina ezimweni ezinzima kakhulu ze-GERD ezibandakanya izinkinga.

Iningi labantu lizozuza ekwelashweni kwesigaba sokuqala ngokulungisa ukuthi lidla kanjani, nini nokuthi lidlani. Kodwa-ke, ukulungiswa kokudla nezindlela zokuphila kukodwa kungenzeka kungasebenzi kwabanye. Ezimweni ze-theses, odokotela bangancoma ukusebenzisa imishanguzo eyehlisa noma imise ukukhiqizwa kwe-asidi esiswini.

Ama-Proton pump inhibitors (ama-PPIs) awuhlobo olulodwa lwemithi engasetshenziswa ukunciphisa isisu i-asidi nokunciphisa izimpawu ze-GERD. Eminye imishanguzo engaphatha i-acid esiswini ngokweqile ifaka i-H2 receptor blockers, efana ne-famotidine (Pepcid AC) ne-cimetidine (Tagamet). Kodwa-ke, ama-PPIs ngokuvamile asebenza kangcono kune-H2 receptor blockers futhi anganciphisa izimpawu kuningi labantu abane-GERD.

Ngabe I-Proton Pump Inhibitors Isebenza Kanjani?

Ama-PPIs asebenza ngokuvimba nokunciphisa ukukhiqizwa kwe-asidi esiswini. Lokhu kunikeza noma yisiphi isicubu somzimba esilimele isikhathi sokululama. Ama-PPIs nawo asiza ukuvimbela isilungulela, umuzwa ovuthayo ovame ukuhambisana ne-GERD. Ama-PPIs ngomunye wemithi enamandla kakhulu yokuqeda izimpawu ze-GERD ngoba noma inani elincane le-asidi lingadala izimpawu ezinkulu.

Ama-PPI asiza ukwehlisa i-asidi esiswini esikhathini esingamasonto amane kuya kwayi-12. Lesi sikhathi sesikhathi sivumela ukwelashwa okufanele kwezicubu zomzimba. Kungathatha isikhathi eside nge-PPI ukunciphisa izimpawu zakho kune-H2 receptor blocker, evame ukuqala ukwehlisa i-asidi esiswini kungakapheli ihora elilodwa. Kodwa-ke, ukukhululeka kwezimpawu kuma-PPIs kuzohlala isikhathi eside. Ngakho-ke imishanguzo ye-PPI ivame ukufaneleka kakhulu kulabo abane-GERD.

Ingabe Zikhona Izinhlobo Ezihlukile ZamaProton Pump Inhibitors?

Ama-PPI ayatholakala kuwo womabili amathenda nangomuthi kadokotela. Ama-PPI e-counter-the-counter afaka:

• I-lansoprazole (Prevacid 24 HR)
• i-omeprazole (Prilosec)
• i-esomeprazole (Nexium)

I-Lansoprazole ne-omeprazole nazo ziyatholakala ngemithi kadokotela, njengama-PPIs alandelayo:

• i-dexlansoprazole (i-Dexilant, i-Kapidex)
• i-pantoprazole sodium (Protonix)
• irabeprazole sodium (Aciphex)

Omunye umuthi kadokotela owaziwa nge-Vimovo nawo uyatholakala ukwelapha i-GERD. Iqukethe inhlanganisela ye-esomeprazole ne-naproxen.

Amandla kadokotela namandla e-counter-the-counter ama-PPI abonakala esebenza ngokulinganayo ekuvikeleni izimpawu ze-GERD.

Khuluma nodokotela wakho uma izimpawu ze-GERD zingathuthuki nge-counter-counter noma i-prescription PPIs phakathi kwamasonto ambalwa. Ungahle ube ne- I-Helicobacter pylori (H. pylori) ukutheleleka kwamagciwane. Lolu hlobo lokutheleleka ludinga ukwelashwa okuyinkimbinkimbi. Kodwa-ke, ukutheleleka akubanga njalo izimpawu. Lapho izimpawu zikhula, zifana kakhulu nezimpawu ze-GERD. Lokhu kwenza kube nzima ukuhlukanisa phakathi kwale mibandela emibili. Izimpawu ze- H. pylori ukutheleleka kungafaka:

• isicanucanu
• ukubhoboza njalo
• ukulahlekelwa isifiso sokudla
• ukuqunjelwa

Uma udokotela wakho esola ukuthi une H. pylori ukutheleleka, bazokwenza izivivinyo ezahlukahlukene ukuqinisekisa ukuxilongwa. Ngemuva kwalokho bazonquma uhlelo lokwelashwa olusebenzayo.

Ziyini Izingozi Zokusebenzisa iProton Pump Inhibitors?

Ama-PPI ngokwesiko abhekwe njengemithi ephephile futhi ebekezelela kahle. Kodwa-ke, ucwaningo manje luphakamisa ukuthi izingozi ezithile zingabandakanyeka ekusetshenzisweni kwesikhathi eside kwale mithi.

Ucwaningo lwakamuva luthole ukuthi abantu abasebenzisa ama-PPIs isikhathi eside banokuhluka okuncane emathunjini abo emathumbu.Lokhu kushoda kokuhlukahluka kubabeka engcupheni eyengeziwe yokungenwa yizifo, ukuqhekeka kwamathambo, nokushoda kwamavithamini namaminerali. Amathumbu akho aqukethe izigidigidi zamagciwane. Ngenkathi amanye ala mabhaktheriya “emabi,” iningi lawo alinabungozi futhi lisiza kukho konke kusuka ekugayeni nasekuqiniseni imizwa. Ama-PPI angaphazamisa ukulingana kwamagciwane ngokuhamba kwesikhathi, kubangele ukuthi amabhaktheriya "amabi" athole amagciwane "amahle". Lokhu kungaholela ekuguleni.

Ngaphezu kwalokho, i-US Food and Drug Administration (i-FDA) yakhipha ngo-2011 ukuthi ukusetshenziswa kwesikhathi eside kwama-PPI kadokotela kungahle kuhlotshaniswe namazinga aphansi we-magnesium. Lokhu kungaholela ezinkingeni ezinkulu zempilo, kufaka phakathi ukuqina kwemisipha, ukushaya kwenhliziyo okungafanele, nokudlikiza. Cishe ngamaphesenti angama-25 wamacala ahlolwe yi-FDA, i-magnesium supplementation iyodwa ayizange ithuthukise amazinga aphansi e-serum magnesium. Ngenxa yalokhu, ama-PPIs kwadingeka ukuthi ayekiswe.

Yize kunjalo i-FDA igcizelela ukuthi kunengozi encane yokuthuthukisa amazinga aphansi we-magnesium lapho usebenzisa ama-PPI e-counter-counter njengoba kuqondisiwe. Ngokungafani ne-PPIs kadokotela, izinhlobo ezithengiswa ezithengiswayo zithengiswa ngamanani aphansi. Futhi zihloselwe ukwelashwa amasonto amabili okungekho kathathu ngonyaka.

Naphezu kwemiphumela emibi engaba khona, ama-PPI imvamisa ayindlela yokwelapha ephumelela kakhulu ye-GERD. Wena nodokotela wakho ningaxoxa ngezingozi ezingaba khona futhi nibone ukuthi ama-PPI ayindlela engcono yini kuwe.

Izinyathelo Ezilandelayo

Uma uyeka ukuthatha ama-PPIs, ungathola ukwanda kokukhiqizwa kwe-asidi. Lokhu kwanda kungahlala izinyanga ezimbalwa. Udokotela wakho angakususa kancane kancane kule mithi ukusiza ukuvimbela lokhu ukuthi kungenzeki. Bangancoma futhi ukuthatha lezi zinyathelo ezilandelayo ukunciphisa ukungakhululeki kwakho kunoma yiziphi izimpawu ze-GERD:

• ukudla izingxenye ezincane
• kudla amafutha amancane
• ukugwema ukubeka phansi okungenani amahora amabili ngemuva kokudla
• ukugwema ukudla okulula ngaphambi kokulala
• egqoke izingubo ezixegayo
• ukuphakamisa ikhanda lombhede cishe ngamayintshi ayisithupha
• ukugwema utshwala, ugwayi, kanye nokudla okudala izimpawu

Qiniseka ukuthi uthintana nodokotela wakho ngaphambi kokuba uyeke ukuthatha noma imiphi imithi oyibekelwe.