Kuyini ukwelashwa kweRegenokine futhi kuyasebenza?

-Delile

• Yini iRegenokine?
• Ngabe inqubo yeRegenokine ifaka ini?
• Kuzodonswa igazi lakho
• Kuzocutshungulwa igazi lakho
• Igazi lakho lizobuyiselwa kujoyini elithintekile
• Asikho isikhathi sokuphumula sokutakula esidingekayo
• Isebenza kanjani iRegenokine?
• Ngabe iRegenokine iyasebenza?
• Kungani iRegenokine ingasebenzi kuwo wonke umuntu?
• Okushiwo yizifundo
• Bangaki abantu asebelashiwe?
• Kuthiwani ngokuvuselelwa kwe-cartilage?
• Uyini umehluko phakathi kokwelapha iRegenokine ne-PRP?
• I-Regenokine isebenzisa irejimeni yokucubungula ejwayelekile
• I-Regenokine isusa amangqamuzana egazi nezinye izithako ezinamandla okuvuvukala
• Ngabe iRegenokine iphephile?
• Kubiza malini iRegenokine?
• Akuhlanganisiwe ngumshuwalense e-United States
• Ukwelashwa kweRegenokine kuthatha isikhathi esingakanani?
• Ngingamtholaphi umhlinzeki ofanelekayo?
• Ukudla okudlela endlini

I-Regenokine iyindlela yokwelapha eqeda ukuvuvukala yezinhlungu ezihlangene nokuvuvukala. Inqubo ifaka amaprotheni awusizo aqoqwe egazini lakho emajoyintini akho athintekile.

Ukwelashwa kwenziwa nguDkt Peter Wehling, udokotela ohlinzayo ongumgogodla waseJalimane, futhi sekuvunyiwe ukuthi kusetshenziswe eJalimane. Abasubathi abaningi abavelele, okubalwa kubo u-Alex Rodriguez noKobe Bryant, baye eJalimane ukuyothola ukwelashwa kweRegenokine futhi babika ukuthi kuqeda izinhlungu.

Yize iRegenokine ingakavunyelwa i-Food and Drug Administration (FDA), isetshenziswa ngaphandle kwelebula ezindaweni ezintathu e-United States ezinelayisense yi-Wehling.

I-Regenokine iyefana nokwelashwa kwe-platelet-rich plasma (PRP), esebenzisa imikhiqizo yakho yegazi ukusiza ukuvuselela izicubu endaweni elimele.

Kulesi sihloko, sizobuyekeza ukuthi inqubo yeRegenokine injani, ihluke kanjani ku-PRP, nokuthi isebenza kangakanani ekunciphiseni ubuhlungu.

Yini iRegenokine?

Ekukhuleni kwakhe kwangaphambilini kweRegenokine, uWehling waphatha ngempumelelo amahhashi ase-Arabia ayeke walimala ngokuhlanganyela. Ngemuva kokuqhubeka nocwaningo lwakhe nabantu, ukwakheka kuka-Wehling kwavunyelwa ukusetshenziswa kwabantu ngo-2003 yi-FDA elingana ne-FDA.

Inqubo igxila emaprotheni egazini lakho alwa nokuvuvukala futhi akhuthaze ukuvuselelwa. I-serum esetshenzisiwe bese ijojelwa emuva ejoyintini elithintekile. I-serum ayinamaseli abomvu egazi noma amaseli amhlophe egazi angadala ukucasuka.

I-serum ingabizwa nangokuthi i-autologous conditioned serum, noma i-ACS.

Ngabe inqubo yeRegenokine ifaka ini?

Ngaphambi kwenqubo, uchwepheshe weRegenokine uzosebenzisana nomhlinzeki wakho wezokunakekelwa kwezempilo oyinhloko ukuze anqume ukuthi ngabe uyilungele yini lolu lwazi. Bazokwenza ukuzimisela kwabo ngokuhlola ukusebenza kwegazi okujwayelekile nezikena zokucabanga zokulimala kwakho.

Uma uthola ukuqhubeka, nakhu ongakulindela ngesikhathi senqubo:

Kuzodonswa igazi lakho

Udokotela uzodonsa cishe ama-ounces amabili egazi engalweni yakho. Lokhu kuthatha imizuzu embalwa kuphela.

Kuzocutshungulwa igazi lakho

Izinga lokushisa kwesampula segazi lakho lizophakanyiswa kancane kuze kufike emahoreni angama-28 endaweni oyinyumba. Ngemuva kwalokho izobekwa ku-centrifuge ukuze:

• hlukanisa imikhiqizo yegazi
• gxila kuma-protein alwa nokuvuvukala
• yakha i-serum engenaselula

Ngokuya ngesimo sakho, amanye amaprotheni angafakwa ku-serum.

Ngokusho kukaDkt. Jana Wehling, ongudokotela wamathambo nowokuhlukumezeka osebenza noyise emtholampilo waseRegenokine eDusseldorf, eJalimane, “Okwengeziwe kule seramu kufaka phakathi amaprotheni ahlanganisa izinto ezifana ne-IL-1 Ra, i-anesthetics yendawo, noma i-cortisone enomthamo omncane.”

Isampuli elashwa bese iqandisiwe bese ifakwa emijoweni yomjovo.

Igazi lakho lizobuyiselwa kujoyini elithintekile

Inqubo yokufaka kabusha ithatha imizuzu embalwa. UPeter Wehling usanda kwethula inqubo yomjovo owodwa (iRegenokine® One Shot), esikhundleni somjovo owodwa usuku ngalunye izinsuku ezi-4 noma ezi-5.

Udokotela angasebenzisa i-ultrasound njengosizo lokucabanga ukubeka indawo yomjovo ngokunembile.

Uma i-serum isele, ingabanda ukuze isetshenziswe ngokuzayo.

Asikho isikhathi sokuphumula sokutakula esidingekayo

Asikho isikhathi sokuphumula esilandela inqubo. Uzokwazi ukuqalisa kabusha imisebenzi yakho ngokushesha ngemuva kokufaka kabusha.

Isikhathi okusithathayo ukuthi uzwe ukukhululeka ebuhlungwini nasekuvuvukeni kuyehlukahluka kumuntu ngamunye.

Isebenza kanjani iRegenokine?

Ngokusho kukaPeter Wehling, i-serum ephethwe i-Regenokine serum inezikhathi eziphindwe ka-10,000 ukuphakama okujwayelekile kwamaphrotheni aphikisayo. Le protein, eyaziwa ngokuthi i-interleukin-1 receptor antagonist (IL-1 Ra), ivimba uzakwabo odala ukuvuvukala, i-interleukin 1.

UDkt. Christopher Evans, umqondisi weRehabilitation Medicine Research Center eMayo Clinic, wakuchaza ngale ndlela: “I-‘dle interleukin,’ i-interleukin 1, ihlangana ne-receptor ethize ebusweni beseli ephendula kuyo. Ima lapho. Ngemuva kwalokho, kwenzeka zonke izinhlobo zezinto ezimbi. ”

“I-interleukin enhle,” kuqhubeka u-Evans, “iyinto ephikisana ne-interleukin-1 receptor antagonist. Lokhu kuvimba i-receptor (yeseli). … Iseli aliyiboni i-interleukin-1, ngoba ivinjiwe, ngakho-ke, izinto ezimbi azenzeki. "

Kucatshangwa ukuthi i-IL-1 Ra nayo ingaphikisana nezinto eziholela kuqwanga kanye nokuwohloka kwezicubu kanye ne-osteoarthritis.

Ngabe iRegenokine iyasebenza?

Ucwaningo lweRegenokine lukhombisa ukuthi luyasebenza kubantu abaningi, kodwa hhayi bonke.

Impahla yomtholampilo we-Wehling ithi bacabanga ukuthi ukwelashwa kweRegenokine kuyimpumelelo lapho ubuhlungu besiguli noma ukusebenza kuthuthuka ngamaphesenti angama-50. Basebenzisa imibuzo ejwayelekile yabantu abanokwelashwa ukukala umphumela wayo.

Umtholampilo ulinganisela ukuthi cishe amaphesenti angama-75 abantu abane-osteoarthritis yamadolo aphakathi nendawo kanye nobuhlungu bazophumelela ngokwelashwa.

Odokotela baseMelika abanelayisense lokusebenzisa iRegenokine banenani elifanayo lempumelelo. Kukhonjisiwe ukuhlehlisa isidingo sokufakwa ngokuhlanganyela, noma ukugwema isidingo sokufakwa ngokuhlanganyela kwabanye abantu.

Kungani iRegenokine ingasebenzi kuwo wonke umuntu?

Sibuze u-Evans, obesebenza noPeter Wehling ekuqaleni kocwaningo lwakhe, ukuthi kungani uRegenokine esebenzela abantu abaningi kodwa hhayi wonke umuntu. Nakhu akusho:

“I-osteoarthritis akusona isifo esisodwa esilinganayo. Iza ngokuhlukahluka okuningi futhi kungenzeka ukuthi kukhona ama-subtypes ahlukahlukene, amanye awo azophendula, kanti amanye ngeke. UDkt Wehling wenza i-algorithm yalokhu esebenzisa izingxenye ezahlukahlukene ze-DNA yesiguli. Abantu abanokulandelana okuthile kwe-DNA kwakubikezelwe ukuthi bazophendula kangcono. ”

UDkt Thomas Buchheit, MD, CIPS, umqondisi we-Regenerative Pain Therapies eDuke University - enye yezindawo ezintathu e-United States ezinelayisense lokusebenzisa i-serum eyenziwe yi-Wehling - uphinde wathi, “Sibona imiphumela emihle kakhulu kubantu nginesifo samathambo esiphakathi nendawo kuya kwesilinganisweni, hhayi ithambo emathanjeni. ”

Okushiwo yizifundo

Izifundo ezincane zibheke ukwelashwa kweRegenokine, okubizwa nangokuthi yi-autologous conditioned serum (ACS), yezinhlungu ezihlangene. Abanye bakuqhathanisa nezinye izindlela zokwelapha. Ezinye izifundo zibheka amalunga athile.

Nazi izifundo ezimbalwa zakamuva:

• Ucwaningo lwango-2020 lwabantu abangu-123 abane-osteoarthritis luqhathanisa i-ACS nokwelashwa kwe-PRP. Ucwaningo luthole ukuthi ukwelashwa kwe-ACS kuyasebenza futhi "kuphakeme ngokwempilo kune-PRP." Abantu abathole i-ACS babenokuncishiswa kobuhlungu okungcono kakhulu nokusebenza kangcono kunalabo ababene-PRP.
• Abantu abangu-28 abane-osteoarthritis yamadolo noma ye-hip bathola ukuthi ukwelashwa kwe-ACS kuveze "ukwehla okusheshayo kobuhlungu" kanye nokwanda kokunyakaza okuhlukahlukene.
• Umuthi wezinhlungu ozivuselelayo uqhathanisa i-Regenokine nezinye izindlela zokwelapha ezivuselela. Ibika ukuthi i-ACS “inciphisa ubuhlungu nomonakalo ohlangene wesifo samathambo.”
• Abantu abangu-47 abanezilonda ze-meniscus baphathwa bathola ukuthi i-ACS ikhiqize ukuthuthuka okuphawulekayo kwesakhiwo ngemuva kwezinyanga eziyisithupha. Ngenxa yalokho, ukuhlinzwa kwagwenywa kumaphesenti angama-83 amacala.
• A ngamadolo ayi-118 aphathwe nge-ACS athola ukuthuthuka okusheshayo ebuhlungwini obusimiselwe iminyaka emi-2 yocwaningo. Munye kuphela umuntu othole ukushintshwa kwedolo ngesikhathi kufundwa.

Bangaki abantu asebelashiwe?

Ngokusho kukaJana Wehling, "Uhlelo lweRegenokine selusetshenziswe cishe iminyaka eyishumi kanti iziguli ezilinganiselwa ku-20 000 selashwe emhlabeni wonke."

Isizukulwane sokuqala seRegenokine, i-Orthokine, sasetshenziswa ukwelapha iziguli ezingaphezu kuka-100 000, kusho yena.

Kuthiwani ngokuvuselelwa kwe-cartilage?

Njengoba u-Evans ebeka, ukuvuselelwa kwe-cartilage yi-grail engcwele kubantu abasebenza nge-osteoarthritis. Ngabe i-Regenokine ingavuselela uqwanga? Kungumbuzo ocwaningwa nguPeter Wehling nelabhu yakhe.

Lapho ebuzwa ngokuvuselelwa kabusha koqwanga, uJana Wehling waphendula: “Ngempela, sinobufakazi obucacile besayensi bokuvuselelwa kwezicubu nemisipha ngaphansi kwe-ACS. Kunezimpawu zokuvikelwa koqwanga kanye nokuvuselelwa ekuhlolweni kwezilwane kanye nasekusebenziseni imitholampilo yabantu, ”kusho yena.

"Kodwa ukuvuselelwa kwe-cartilage kunzima kakhulu ukufakazela ezifundweni zokwelashwa."

Uyini umehluko phakathi kokwelapha iRegenokine ne-PRP?

Ukwelashwa kwe-PRP kudonsa igazi lakho, kulicubungule ukukhulisa ukugcwala kwamaplatelets, bese kulifaka endaweni ethintekile.

Igazi lakho ligijinywa nge-centrifuge ukuze ligxilise ama-platelet, kodwa alihlungiwe. Kucatshangwa ukuthi ukuhlangana okuphezulu kwama-platelet kusiza ukuphulukiswa kwendawo ngokukhipha izinto ezidingekayo zokukhula.

I-PRP ayikavunywa yi-FDA, futhi imvamisa ayimboziwe ngumshuwalense. Izindleko zokwelashwa kwe-PRP ziyahluka kusuka ku- $ 500 kuye ku- $ 2,000 ngomjovo ngamunye. Kodwa-ke, isetshenziswa kahle kaningi ekwelapheni izimo zemisipha.

. I-Arthritis Foundation iphawula ukuthi i-PRP ingahlala izinyanga ezi-3 kuya kwezi-6. "Yayiphumelela futhi kwesinye isikhathi idlula i-hyaluronic acid noma imijovo ye-corticosteroid," kusho isisekelo.

Udokotela ohlinzayo wamathambo uDkt Laura Timmerman ukubeka ngale ndlela: I-PRP “kuyinto elungile ukuzama kuqala… kodwa uRegenokine unethuba elingcono lokuthola isiguli sibe ngcono.”

I-Regenokine isebenzisa irejimeni yokucubungula ejwayelekile

NjengoRegenokine, i-PRP iyindlela yokwelapha ye-biologic. Kepha iRegenokine inezinqubo ezihleliwe zokucubungula, ngaphandle kokungafani ekwakhiweni, kusho uJana Wehling.

Ngokuphikisana, i-PRP ilungiselelwe ngawodwa nge. Lokhu kwenza kube nzima ukuqhathanisa ukwelashwa ezifundweni zesayensi ngoba ukwakheka kwe-PRP kuyehluka.

I-Regenokine isusa amangqamuzana egazi nezinye izithako ezinamandla okuvuvukala

Ngokungafani neRegenokine, i-PRP ayinayo iseli. Iqukethe amangqamuzana amhlophe egazi nezinye izingxenye zegazi ezingadala ukuvuvukala nobuhlungu lapho ujovwa, ngokusho kukaDkt Thomas Buchheit, eDuke University's Center for Translational Pain Medicine.

Ngokuphambene, iRegenokine iyahlanzwa.

Ngabe iRegenokine iphephile?

Ukuphepha kweRegenokine akubuzwa, ngokusho kochwepheshe abaningi. Njengoba uMev Clinic ka-Evans akubeka: “Into yokuqala ukwazi ukuthi iphephile. Lokho kungashiwo ngokweqile. ”

Ayikho imibiko yemiphumela emibi ezifundweni zeRegenokine.

Ukuvunyelwa kwe-FDA kuyadingeka ukuze kusetshenziswe iRegenokine e-United States ngoba ukuvuselelwa kwesampula segazi lakho elaphathwayo kuthathwa njengesidakamizwa.

Ukuvunywa kwe-FDA kudinga izifundo ezahlukahlukene nezigidi zamaRandi ukuxhasa ucwaningo.

Kubiza malini iRegenokine?

Ukwelashwa kabusha kwe-Regenokine kuyabiza, cishe u- $ 1,000 kuya ku- $ 3,000 ngomjovo ngamunye, ngokusho kukaJana Wehling.

Uchungechunge oluphelele ngokwesilinganiso lunemijovo emine kuya kwemihlanu. Intengo nayo iyahluka ngokuya ngesifunda somzimba esiphethwe nobunzima bayo. Isibonelo, uJana Wehling uthe, emgogodleni "sijova amalunga amaningi nezinzwa ezizungezile ngesikhathi esisodwa."

Akuhlanganisiwe ngumshuwalense e-United States

E-United States, i-Regenokine isetshenziswa ngaphandle kwelebula ngabanikazi abanamalayisense kaPeter Wehling. Amanani alandelayo alandela okwenziwa nguWehling eDusseldorf, eJalimane, kanti ukwelashwa akuhlanganiswa nomshuwalense.

Udokotela ohlinzayo wamathambo uTimmerman uthi ukhokhisa u- $ 10,000 ochungechungeni lomjovo wejoyinti lokuqala, kodwa uhhafu walelojoyinti lesibili noma elilandelayo. Uyaphawula futhi ukuthi ukudonsa kwegazi okukodwa kungakunika izitsha eziningana ze-serum ezingamiswa ukuze zisetshenziswe kamuva.

Uhlelo ngalunye lwezokwelapha "lwenzelwe ngokwezifiso" izidingo zomuntu ngamunye, ngokusho kukaJana Wehling. Ezinye izinto zingathinta izindleko, njengokuthi "uhlobo nobukhulu besifo, isimo sobuhlungu bomuntu ngamunye, izikhalazo zomtholampilo, kanye nama-comorbidities (izifo ebezivele zikhona)."

Ugcizelele ukuthi inhloso yabo ukwehlisa intengo.

Ukwelashwa kweRegenokine kuthatha isikhathi esingakanani?

Ukuthi i-Regenokine idinga ukuphindwa iyahlukahluka ngazinye nangobukhulu besimo sakho. UPeter Wehling ulinganisela ukuthi ukukhululeka kwamadolo nesinqe samathambo kungahlala phakathi konyaka owodwa kuya kwemihlanu.

Abantu abasabela kahle ekwelashweni bavame ukuyiphinda njalo eminyakeni emi-2 kuye kwengu-4, kusho uPeter Wehling.

Ngingamtholaphi umhlinzeki ofanelekayo?

Ihhovisi likaPeter Wehling eDusseldorf, eJalimane, linikeza amalayisense futhi lihlola njalo amalebhu odokotela abaphatha ukwelashwa kweRegenokine. Bafuna ukuqinisekisa ukuthi ukwelashwa kwenziwa ngendlela efanele nangendlela esezingeni.

Nayi imininingwane yokuxhumana nomtholampilo oseDusseldorf nezindawo ezintathu zase-U.S. Ezinelayisensi yokusebenzisa le mithi:

UDkt Wehling nozakwethu
UDusseldorf, eJalimane
UPeter Wehling, MD, PhD
I-imeyili: [email protected]
Iwebhusayithi: https://drwehlingandpartner.com/en/
Ucingo: 49-211-602550

Uhlelo lwe-Duke Regenerative Pain Therapies Program
URaleigh, eNyakatho Carolina
UThomas Buchheit, MD
I-imeyili: [email protected]
Iwebhusayithi: dukerptp.org
Ifoni: 919-576-8518

Imithi yeLifeSpan
ISanta Monica, eCalifornia
UChris Renna, INGABE
I-imeyili: [email protected]
Iwebhusayithi: https://www.lifespanmedicine.com
Ifoni: 310-453-2335

ULaura Timmerman, MD
I-Walnut Creek, eCalifornia
I-imeyili: [email protected]
Iwebhusayithi: http://lauratimmermanmd.com/-regenokinereg-program.html
Ucingo: 925- 952-4080

Ukudla okudlela endlini

I-Regenokine iyindlela yokwelapha ubuhlungu obuhlangene nokuvuvukala. Le nqubo icubungula igazi lakho ukugxilisa amaprotheni alusizo bese ijova igazi eliphathwayo endaweni ethintekile.

I-Regenokine ukwakheka okunamandla ukwedlula ukwelashwa kwe-platelet-rich plasma (PRP), futhi isebenza kangcono futhi isikhathi eside kune-PRP.

I-Regenokine ivunyelwe ukusetshenziswa eJalimane, lapho yathuthukiswa khona nguDkt. Peter Wehling, kepha ayinayo imvume ye-FDA e-United States. Isetshenziswa ngaphandle kwelebula ezindaweni ezintathu e-United States ezinelayisense yi-Wehling.

Kudingeka izifundo eziningi ukuqinisekisa ukusebenza kweRegenokine nokuthola imvume ye-FDA.

Ukwelashwa kuphephile futhi kuyasebenza, ngokusho kwezifundo zokwelashwa kanye nochwepheshe bezokwelapha. Okubi ukuthi iRegenokine iyindlela yokwelapha ebizayo okumele ikhokhwe iphuma ephaketheni eMelika.