Amakhambi we-psoriasis: amafutha namaphilisi

-Delile

• Izindlela zokwelapha (okhilimu namafutha)
• 1. AmaCorticoids
• 2. ICalcipotriol
• 3. Amafutha kanye nama-emollients
• Amakhambi esenzo asetshenziswayo (amaphilisi)
• 1. I-Acitretin
• 2. IMethotrexate
• 3. ICyclosporine
• 4. Ama-biological agents

I-Psoriasis yisifo esingelapheki futhi esingelapheki, kodwa-ke, kungenzeka ukukhulula izimpawu nokwelula ukuthethelelwa kwalesi sifo isikhathi eside ngokwelashwa okufanele.

Ukwelashwa kwe-psoriasis kuya ngohlobo, indawo kanye nobukhulu bezilonda, futhi kungenziwa ngamafutha noma amafutha ngama-corticosteroids nama-retinoids noma imithi yomlomo, njenge-cyclosporine, i-methotrexate noma i-acitretin, ngokwesibonelo, enconyweni kadokotela.

Ngaphezu kokwelashwa kwemithi, kubalulekile futhi ukuthambisa isikhumba nsuku zonke, ikakhulukazi izifunda ezithintekile, kanye nokugwema imikhiqizo eqeda kakhulu ebangela ukucasuka kwesikhumba nokoma ngokweqile.

Eminye yemithi evame ukubekwa ngudokotela ekwelapheni i-psoriasis yile:

Izindlela zokwelapha (okhilimu namafutha)

1. AmaCorticoids

Ama-topical corticosteroids ayasebenza ekwelapheni izimpawu, ikakhulukazi uma lesi sifo silinganiselwe esifundeni esincane, futhi singahlotshaniswa ne-calcipotriol kanye nezidakamizwa zesistimu.

Ezinye izibonelo zama-corticosteroids aphezulu asetshenziswa ekwelashweni kwe-psoriasis yi-clobetasol cream noma i-0.05% capillary solution kanye ne-dexamethasone cream 0.1%, ngokwesibonelo.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity to the components, abanezilonda zesikhumba ezibangelwa amagciwane, isikhunta noma amabhaktheriya, abantu abane-rosacea noma i-perioral dermatitis engalawulwa.

Imiphumela emibi engaba khona: ukulunywa, ubuhlungu nokusha esikhunjeni.

2. ICalcipotriol

I-Calcipotriol iyi-analogue ka-vitamin D, okukhonjiswa ekwelapheni i-psoriasis lapho kugcinwa khona u-0.005%, ngoba inegalelo ekwehliseni ukwakheka kwamapuleti e-psoriatic. Ezimweni eziningi, i-calcipotriol isetshenziswa ngokuhlangana ne-corticosteroid.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity kuzinto kanye ne-hyperkalaemia.

Imiphumela emibi engaba khona: ukucasuka kwesikhumba, ukuqubuka, ukuqaqamba, i-keratosis, ukulunywa, i-erythema kanye ne-dermatitis yokuxhumana.

3. Amafutha kanye nama-emollients

Amafutha namafutha okugcoba kufanele kusetshenziswe nsuku zonke, ikakhulukazi njengokwelashwa kwesondlo ngemuva kokusebenzisa i-corticosteroids, esiza ukuvimbela ukuphindaphinda kubantu abane-psoriasis emnene.

Lawa makhilimu kanye namafutha okugcoba kufanele aqukethe i-urea kokugxila okungahluka phakathi kuka-5% kuya ku-20% kanye / noma i-salicylic acid ekugxileni phakathi kuka-3% no-6%, ngokuya ngohlobo lwesikhumba nenani lezikali.

Amakhambi esenzo asetshenziswayo (amaphilisi)

1. I-Acitretin

I-Acitretin iyi-retinoid evamise ukukhonjiswa ukwelapha izinhlobo ezinzima ze-psoriasis lapho kunesidingo sokugwema ukucindezelwa komzimba futhi itholakala ngemithamo ye-10 mg noma i-25 mg.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity to the components, abesifazane abakhulelwe nabesifazane abafisa ukukhulelwa eminyakeni ezayo, abesifazane abancelisayo nabantu abanesibindi esibi noma ukwehluleka kwezinso

Imiphumela emibi engaba khona: ikhanda, ukoma nokuvuvukala kolwelwesi lwamafinyila, umlomo owomile, ukoma, i-thrush, ukuphazamiseka kwamathumbu, i-cheilitis, ukulunywa, ukulahleka kwezinwele, ukuqhuma emzimbeni wonke, ubuhlungu bemisipha, ukwanda kwe-cholesterol yegazi kanye ne-triglycerides kanye ne-edema ejwayelekile.

2. IMethotrexate

I-Methotrexate ikhonjisiwe ekwelapheni i-psoriasis enamandla, ngoba yehlisa ukwanda nokuvuvukala kwamaseli esikhumba. Leli khambi liyatholakala kumaphilisi ama-2.5 mg noma ama-ampoules angama-50 mg / 2mL.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity to the components, abesifazane abakhulelwe nabancelisayo, abantu abane-cirrhosis, isifo se-ethyl, isifo sokusha kwesibindi esisebenzayo, ukwehluleka kwesibindi, ukutheleleka okungathi sína, i-immunodeficiency syndromes, i-aplasia noma i-hypoplasia yomgogodla, i-thrombocytopenia noma i-anemia efanelekile kanye nesilonda esiswini esiswini.

Imiphumela emibi engaba khona: ubuhlungu obukhulu bekhanda, ukuqina kwentamo, ukuhlanza, umkhuhlane, isikhumba esibomvu, ukwanda kwe-uric acid, ukwehla kwesibalo sesidoda emadodeni, i-thrush, ukuvuvukala kolimi nezinsini, isifo sohudo, ukunciphisa isibalo segazi elimhlophe nokubala kweplatelet, ukwehluleka kwezinso ne-pharyngitis

3. ICyclosporine

ICyclosporine ngumuthi wokuvikela ukuzivikela okhonjiswe ukwelapha i-psoriasis ngokulingene kuya kokubi, futhi akufanele idlule iminyaka emibili yokwelashwa.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity to the components, umfutho wegazi ophakeme, abangazinzi futhi abangalawuleki ngezidakamizwa, izifo ezisebenzayo nomdlavuza.

Imiphumela emibi engaba khona: ukuphazamiseka kwezinso, umfutho wegazi ophakeme kanye namasosha omzimba abuthakathaka.

4. Ama-biological agents

Eminyakeni yamuva nje, intshisekelo yokuthuthukisa ama-biological agents anezakhiwo zokuzivikela ezifweni ezikhethwa kakhulu kune-cyclosporine ikhuphukile ukuze kuthuthukiswe iphrofayili yokuphepha yezidakamizwa ze-psoriasis.

Ezinye izibonelo zama-biological agents ezisanda kwenziwa zokwelashwa kwe-psoriasis yilezi:

• Adalimumab;
• Etanercept;
• I-infliximab;
• Ustecinumab;
• I-Secukinumab.

Lesi sigaba esisha semithi siqukethe amaprotheni noma ama-antibody monoclonal akhiqizwa yizinto eziphilayo, ngokusebenzisa i-recombinant biotechnology, ekhombise ukuthuthuka kwezilonda kanye nokwehliswa kokunwetshwa kwazo.

Ngubani okungafanele asebenzise: abantu abane-hypersensitivity ezingxenyeni, ngokuhluleka kwenhliziyo, ukudonswa kwesifo, umlando wakamuva we-neoplasia, ukutheleleka okusebenzayo, ukusetshenziswa kwemithi yokugomela bukhoma nokukhulelwe.

Imiphumela emibi engaba khona: ukusabela komjovo wesayithi, ukutheleleka, isifo sofuba, ukusabela kwesikhumba, izimila, izifo ezidambisa umzimba, ikhanda, isiyezi, uhudo, ukulunywa, ubuhlungu bemisipha nokukhathala.