ISimvastatin vs. Atorvastatin: Okufanele Ukwazi

-Delile

• Okuqhamuka uma udla imishanguzo
• Ubuhlungu bemisipha
• Ukukhathala
• Ukucasula isisu nohudo
• Isibindi nesifo sezinso
• Unhlangothi
• Ushukela wegazi ophakeme nesifo sikashukela
• Ukusebenzisana
• Ukutholakala nezindleko
• Ukuthatha

Mayelana nezitatimende

I-Simvastatin (i-Zocor) ne-atorvastatin (i-Lipitor) yizinhlobo ezimbili zezitatimende udokotela wakho angakunika zona. Izitatimende zivame ukunikezwa ukusiza ukwehlisa i-cholesterol yakho. Ngokuya nge-American College of Cardiology, ama-statins angasiza uma:

• une-cholesterol eningi emithanjeni yakho yegazi
• une-LDL, eyaziwa nangokuthi i-cholesterol embi, ileveli engaphezu kwama-milligram ayi-190 nge-deciliter ngayinye (mg / dL)
• unesifo sikashukela, uphakathi kweminyaka engama-40 nengama-75 ubudala, futhi unezinga le-LDL eliphakathi kuka-70 no-189 mg / dL, ngisho nangaphandle kwe-cholesterol emithanjeni yakho yegazi
• une-LDL phakathi kuka-70 mg / dL no-189 mg / dL, uphakathi kweminyaka engama-40 neminyaka engama-75 ubudala, futhi okungenani unengozi engamaphesenti ayi-7.5 yokuthi i-cholesterol ingakha emithanjeni yakho yegazi

Le mithi iyafana, inomehluko omncane. Bona ukuthi bahlangana kanjani.

Okuqhamuka uma udla imishanguzo

Kokubili i-simvastatin ne-atorvastatin kungadala imiphumela emibi eyahlukahlukene. Eminye imiphumela emibi kungenzeka yenzeke nge-simvastatin, kanti eminye kungenzeka nge-atorvastatin.

Ubuhlungu bemisipha

Zonke izitatimende zingadala ubuhlungu bemisipha, kepha lo mphumela kungenzeka ngokusetshenziswa kwe-simvastatin. Ubuhlungu bemisipha bungakhula kancane kancane. Kungazizwa njengesicubu esidonswayo noma ukukhathala okuvivinya umzimba. Shayela udokotela wakho nganoma yibuphi ubuhlungu obusha onabo lapho uqala ukuthatha i-statin, ikakhulukazi i-simvastatin. Ubuhlungu bemisipha bungaba uphawu lokuthuthukisa izinkinga zezinso noma ukulimala.

Ukukhathala

Umphumela oseceleni ongavela nganoma yisiphi isidakamizwa ukukhathala. Ucwaningo oluxhaswe yi (NIH) luqhathanisa ukukhathala ezigulini ezithathe imithamo emincane ye-simvastatin nomunye umuthi obizwa ngepravastatin. Abesifazane, ikakhulukazi, banengozi enkulu yokukhathala okuvela kuma-statins, yize kunjalo kakhulu kusuka ku-simvastatin.

Ukucasula isisu nohudo

Zombili lezi zidakamizwa zingadala isisu nesifo sohudo. Le miphumela emibi ivame ukuxazululwa phakathi kwamasonto ambalwa.

Isibindi nesifo sezinso

Uma unesifo sezinso, i-atorvastatin kungaba yisinqumo esihle kuwe ngoba asikho isidingo sokushintsha umthamo. Ngakolunye uhlangothi, i-simvastatin ingathinta izinso zakho lapho zinikezwa kumthamo omkhulu kakhulu (80 mg ngosuku). Kunganciphisa izinso zakho. ISimvastatin nayo iyakha ohlelweni lwakho ngokuhamba kwesikhathi. Lokhu kusho ukuthi uma uyithatha isikhathi eside, inani lomuthi ohlelweni lwakho lingangeza ngempela. Udokotela wakho kungadingeka ukuthi alungise isilinganiso sakho.

Kodwa-ke, ngokuya ngemiphumela evela ocwaningweni luka-2014 olwenziwe ngu-the, cishe akunabungozi obengeziwe bokulimala kwezinso phakathi komthamo omkhulu we-simvastatin ne-dose ephezulu i-atorvastatin. Ngaphezu kwalokho, imithamo ye-simvastatin efinyelela kuma-80 mg ngosuku ayisajwayelekile kakhulu.

Abantu abambalwa abathatha ama-statins baba nesifo sesibindi. Uma ngabe umnyama umchamo noma ubuhlungu ohlangothini lwakho ngenkathi usebenzisa noma imuphi umuthi, shayela udokotela wakho ngokushesha.

Unhlangothi

Umthamo ophakeme we-atorvastatin (80 mg ngosuku) uhlotshaniswa nengozi ephezulu yokushaywa yisifo esopha uma unesifo sohlangothi noma ukuhlaselwa yischemic okudlulayo (i-TIA, kwesinye isikhathi okubizwa ngokuthi yi-mini stroke), ezinyangeni eziyisithupha ezedlule.

Ushukela wegazi ophakeme nesifo sikashukela

Kokubili i-simvastatin ne-atorvastatin kungakhuphula ushukela wegazi kanye nengozi yokuba nesifo sikashukela. Zonke izitatimende zingakhuphula izinga lakho le-hemoglobin A1C, okuyisilinganiso samazinga kashukela wesikhathi eside egazini.

Ukusebenzisana

Yize i-grapefruit ingesona isidakamizwa, odokotela bancoma ukuthi ugweme ukudla inani elikhulu lamagilebhisi noma ijusi lamagilebhisi uma uthatha ama-statins. Lokho kungenxa yokuthi ikhemikhali eliku-grapefruit lingaphazamisa ukuwohloka kwama-statin athile emzimbeni wakho. Lokhu kungakhuphula izinga lama-statin egazini lakho futhi kwandise amathuba okuba nemiphumela emibi.

Kokubili i-simvastatin ne-atorvastatin kungasebenzisana nezinye izidakamizwa. Ungathola uhlu oluningiliziwe lokuxhumana kwabo kuzindatshana zeHealthline ku-simvastatin ne-atorvastatin. Ngokuphawulekayo, i-atorvastatin ingaxhumana namaphilisi wokulawula ukubeletha.

Ukutholakala nezindleko

Kokubili i-simvastatin ne-atorvastatin ngamaphilisi agcwele ifilimu owathathayo ngomlomo, imvamisa kanye ngosuku. ISimvastatin iba ngaphansi kwegama elithi Zocor, kanti iLipitor yigama lomkhiqizo le-atorvastatin. Ngayinye iyatholakala njengomkhiqizo ojwayelekile, futhi. Ungathenga noma imuphi umuthi emakhemisi amaningi ngemithi kadokotela wakho.

Izidakamizwa zitholakala ngamandla alandelayo:

• ISimvastatin: 5 mg, 10 mg, 20 mg, 40 mg, kanye no-80 mg
• I-Atorvastatin: 10 mg, 20 mg, 40 mg, kanye no-80 mg

Izindleko ze-generic simvastatin ne-atorvastatin zombili ziphansi impela, kanti i-generic simvastatin ibiza kancane. Ingena cishe ngama- $ 10-15 ngenyanga. I-Atorvastatin imvamisa ingama- $ 25-40 ngenyanga.

Imithi enegama lomkhiqizo ibiza kakhulu kunaleyo ejwayelekile. I-Zocor, uphawu lwe-simvastatin, icishe ibe ngama- $ 200-250 ngenyanga. ILipitor, uphawu lwe-atorvastatin, imvamisa iba ngama- $ 150-200 ngenyanga.

Ngakho-ke uma uthenga okujwayelekile, i-simvastatin ishibhile. Kepha uma kukhulunywa ngezinguqulo zamagama, i-atorvastatin ayibizi kakhulu.

Ukuthatha

Udokotela wakho uzobheka izinto eziningi lapho encoma ukwelashwa nge-statin efana ne-simvastatin ne-atorvastatin. Imvamisa, ukukhetha umuthi ofanele kuncane ngokuqhathanisa izidakamizwa komunye nomunye nokuningi ngokufanisa ukuxhumana okungenzeka kanye nemiphumela emibi yomuthi ngamunye nomlando wakho wezokwelapha kanye nezinye izidakamizwa ozithathayo.

Uma njengamanje uthatha i-simvastatin noma i-atorvastatin, buza udokotela wakho le mibuzo elandelayo:

• Kungani ngithatha lo muthi?
• Ngabe ungisebenza kahle kanjani lo muthi?

Uma unemiphumela emibi efana nobuhlungu bemisipha noma umchamo omnyama, khuluma nodokotela wakho khona manjalo. Kodwa-ke, ungayeki ukuthatha i-statin yakho ngaphandle kokukhuluma nodokotela wakho. Izitatimende zisebenza kuphela uma zithathwa nsuku zonke.