Somatostatinomas

-Delile

• Izimpawu ze-somatostatinoma
• Izimbangela nezici zobungozi be-somatostatinomas
• Zitholakala kanjani lezi zicubu?
• Baphathwa kanjani?
• Izimo ezihambisanayo nezinkinga
• Isilinganiso sokusinda kwe-somatostatinomas

Ukubuka konke

I-somatostatinoma uhlobo olungajwayelekile lwesimila se-neuroendocrine esikhula kumanyikwe kwesinye isikhathi amathumbu amancane. Isigaxa se-neuroendocrine yiso esakhiwa ngamaseli akhiqiza ama-hormone. Lawa maseli akhiqiza ama-hormone abizwa ngokuthi ama-islet cells.

I-somatostatinoma ikhula ngqo esitokisini se-delta islet, esibhekele ukukhiqiza i-hormone somatostatin. Isimila senza lawa maseli ukuthi akhiqize le hormone.

Lapho umzimba wakho ukhiqiza amanye ama-hormone e-somatostatin, uyeka ukukhiqiza amanye ama-hormone epancreatic. Lapho lawo amanye ama-hormone eba ayindlala, ekugcineni kuholela ekubonakaleni kwezimpawu.

Izimpawu ze-somatostatinoma

Izimpawu ze-somatostatinoma zivame ukuqala ngobumnene futhi zikhuphuke ebukhali kancane kancane. Lezi zimpawu ziyefana nalezo ezidalwa ezinye izimo zezokwelapha. Ngalesi sizathu, kubalulekile ukuthi wenze i-aphoyintimenti nodokotela wakho ukuthola ukuxilongwa okulungile. Lokhu kufanele kuqinisekise ukwelashwa okufanele nganoma yisiphi isimo sezokwelapha esinezimpawu zakho.

Izimpawu ezibangelwa i-somatostatinoma zingafaka okulandelayo:

• ubuhlungu esiswini (uphawu oluvame kakhulu)
• isifo sikashukela
• ukuncipha kwesisindo okungaqondakali
• amatshe enyongo
• i-steatorrhea, noma indle enamafutha
• ukuvinjelwa kwamathumbu
• isifo sohudo
• i-jaundice, noma isikhumba esiphuzi (esivame kakhulu lapho i-somatostatinoma isesiswini esincane)

Izimo zezokwelapha ngaphandle kwe-somatostatinoma zingadala eziningi zalezi zimpawu. Lokhu kuvame ukwenzeka, njengoba ama-somatostatinomas engandile. Kodwa-ke, udokotela wakho ukuphela komuntu ongahlola isimo ngqo ngemuva kwezimpawu zakho ezithile.

Izimbangela nezici zobungozi be-somatostatinomas

Yini ebangela i-somatostatinoma okwamanje ayaziwa. Kodwa-ke, kunezici ezithile zobungozi ezingadala i-somatostatinoma.

Lesi simo, esingathinta abesilisa nabesifazane, sivame ukuvela ngemuva kweminyaka yobudala engama-50. Lokhu okulandelayo kungezinye zezinto ezingaba yingozi yamathumba we-neuroendocrine:

• umlando womndeni wezinhlobo eziningi ze-endocrine neoplasia type 1 (MEN1), uhlobo olungavamile lwesifo somdlavuza oluyifa
• i-neurofibromatosis
• Isifo se-von Hippel-Lindau
• isifo sokuqina kwemithambo (tuberous sclerosis)

Zitholakala kanjani lezi zicubu?

Ukuxilongwa kufanele kwenziwe ngudokotela wezokwelapha. Udokotela wakho uvame ukuqala inqubo yokuxilongwa ngokuhlolwa kwegazi okusheshayo. Lokhu kuhlolwa kubheka izinga eliphakeme le-somatostatin. Ukuhlolwa kwegazi kuvame ukulandelwa ngeskena esisodwa noma eziningi zokuhlola okulandelayo noma ama-X-ray:

• i-endoscopic ultrasound
• Iskena se-CT
• i-octreoscan (okuyi-scan enemisebe)
• Ukuskena kwe-MRI

Lezi zivivinyo zivumela udokotela wakho ukuthi abone isimila, esingahle sibe nomdlavuza noma singabi nomdlavuza. Iningi lama-somatostatinomas linomdlavuza. Ukuphela kwendlela yokuthola ukuthi isimila sakho sinomdlavuza yini ngokuhlinzwa.

Baphathwa kanjani?

I-somatostatinoma ivame ukwelashwa ngokususa isimila ngokuhlinzwa. Uma isimila sinomdlavuza futhi umdlavuza usakazekile (isimo esibizwa ngokuthi i-metastasis), ukuhlinzeka kungenzeka kungabi inketho. Endabeni ye-metastasis, udokotela wakho uzokwelapha futhi aphathe noma yiziphi izimpawu i-somatostatinoma engase izibangele.

Izimo ezihambisanayo nezinkinga

Ezinye zezimo ezihlotshaniswa ne-somatostatinomas zingafaka okulandelayo:

• I-von Hippel-Lindau syndrome
• AMADODA1
• uhlobo lwe-neurofibromatosis 1
• isifo sikashukela

I-Somatostatinomas ivame ukutholakala ngokuhamba kwesikhathi, okungaba nzima ezinketho zokwelashwa. Esikhathini esedlule, izicubu ezinomdlavuza kungenzeka ukuthi sezivele zisetshenzisiwe. Ngemuva kwe-metastasis, ukwelashwa kunqunyelwe, ngoba ukuhlinzwa imvamisa akuyona inketho.

Isilinganiso sokusinda kwe-somatostatinomas

Ngaphandle kwesimo esingajwayelekile sama-somatostatinomas, umbono ulungile ezingeni lokusinda leminyaka emihlanu. Lapho i-somatostatinoma ingasuswa ngokuhlinzwa, kunamaphesenti acishe abe ngu-100 okusinda eminyakeni emihlanu ngemuva kokususwa. Isilinganiso seminyaka emihlanu sokusinda kwalabo abaphathwa ngemuva kwesifo somatostatinoma senziwe ngamaphesenti angama-60.

Isihluthulelo ukuthola ukuxilongwa ngokushesha ngangokunokwenzeka. Uma unezinye zezimpawu ze-somatostatinoma, kufanele wenze i-aphoyintimenti nodokotela wakho ngokushesha okukhulu. Ukuhlola okuxilongayo kuzokwazi ukuthola imbangela ethile yezimpawu zakho.

Uma udokotela wakho enquma ukuthi une-somatostatinoma, khona-ke lapho uqala ukwelashwa kusenesikhathi, kungcono ukubikezela kwakho kube ngcono.