Yini i-Trimetazidine?

-Delile

• Isetshenziswa kanjani
• Yini indlela yokusebenza
• Ngubani ongafanele asebenzise
• Imiphumela emibi engaba khona

I-Trimetazidine yinto esebenzayo ekhonjisiwe ekwelapheni ukwehluleka kwenhliziyo ye-ischemic kanye nesifo senhliziyo esiyischemic, okuyisifo esidalwa ukuntuleka kwegazi emithanjeni yegazi.

I-Trimetazidine ingathengwa emakhemisi ngentengo engama-reais angama-45 kuye kwayi-107, lapho kwethulwa incwadi kadokotela.

Isetshenziswa kanjani

Umthamo onconyiwe yi-1 tablet ye-35 mg, kabili ngosuku, kanye ekuseni, ngesikhathi sasekuseni kanye nakanye kusihlwa, ngesikhathi sedina.

Yini indlela yokusebenza

I-Trimetazidine igcina amandla emetabolism yamaseli we-ischemic, evezwe ekuhlanzekeni komoya-mpilo omncane, evimbela ukwehla kwamazinga we-intracellular we-ATP (amandla), ngaleyo ndlela kuqinisekiswe ukusebenza kahle kwamaphampu e-ionic nokugeleza kwe-transmembrane kwe-sodium ne-potassium, ngenkathi kugcinwa iseli le-homeostasis.

Lokhu kulondolozwa kwe-metabolism yamandla kutholakala ngokuvimbela i-β-oxidation ye-fatty acids, eyenziwe yi-trimetazidine, eyandisa uketshezi kwe-glucose, okuyindlela yokuthola amandla adinga ukusetshenziswa komoya-mpilo omncane uma kuqhathaniswa nenqubo ye-β-oxidation. Ngakho-ke, amandla we-glucose oxidation alungiselela inqubo yamandla eselula, agcine amandla afanele we-metabolism ngesikhathi se-ischemia.

Ezigulini ezinesifo senhliziyo eschemic, i-trimetazidine isebenza njenge-ejenti ye-metabolic egcina amazinga we-intracellular we-myocardial high energy phosphates.

Ngubani ongafanele asebenzise

Lo muthi uphikisiwe ezigulini ezine-hypersensitivity to trimetazidine noma yiziphi izingxenye zefomula, abantu abanesifo sikaParkinson, izimpawu zeparkinsonism, ukundindizela, isifo semilenze esingenakuphumula nezinye izinguquko ezihlobene nokunyakaza kanye nokuhluleka okukhulu kwezinso nge-clear creatineine engaphansi kuka-30mL / iminithi.

Ngaphezu kwalokho, lo muthi akufanele futhi usetshenziswe izingane ezingaphansi kweminyaka eyi-18, abesifazane abakhulelwe noma abesifazane abancelisayo.

Imiphumela emibi engaba khona

Eminye yemiphumela emibi kakhulu engahle yenzeke ngenkathi welashwa nge-trimetazidine yisiyezi, ikhanda, ubuhlungu besisu, isifo sohudo, ukugaya ukudla okungafanele, isicanucanu, ukuhlanza, ukuqubuka, ukulunywa, isifuba nobuthakathaka.