Isifo seDubin-Johnson

I-Dubin-Johnson syndrome (i-DJS) yisifo esidluliselwa emindenini (esizuzwe njengefa). Kulesi simo, ungaba ne-jaundice emnene kukho konke ukuphila.

I-DJS yisifo esingavamile kakhulu sezakhi zofuzo. Ukuze uzuze lesi simo, ingane kufanele ithole ikhophi yesakhi esingalungile kubo bobabili abazali.

I-syndrome iphazamisa amandla omzimba okuhambisa i-bilirubin ngesibindi iye enyameni. Lapho isibindi nobende kuphuka amaseli abomvu egazi, kukhiqizwa i-bilirubin. I-Bilirubin ijwayele ukungena enyameni, ekhiqizwa isibindi. Bese igelezela emigodini ye-bile, idlule i-gallbladder, futhi ingene ohlelweni lokugaya ukudla.

Lapho i-bilirubin ingahanjiswanga kahle kwi-bile, iyakhiwa egazini. Lokhu kubangela ukuthi isikhumba nabamhlophe bamehlo baphenduke baphuzi. Lokhu kubizwa nge-jaundice. Amazinga aphezulu kakhulu e-bilirubin angalimaza ubuchopho nezinye izitho.

Abantu abane-DJS bane-jaundice ephila impilo yonke engenziwa yimbi nge:

• Utshwala
• Amaphilisi okuvimbela inzalo
• Izici zemvelo ezithinta isibindi
• Ukutheleleka
• Ukukhulelwa

I-jaundice emnene, engahle ingabonakali kuze kube sekuthombeni noma ekubeni mdala, imvamisa kuphela uphawu lwe-DJS.

Ukuhlolwa okulandelayo kungasiza ukuxilonga lesi sifo:

• I-biopsy yesibindi
• Amazinga e-enzyme yesibindi (ukuhlolwa kwegazi)
• I-serum bilirubin
• Amaleveli we-uroproporphyrin Urinary, kufaka phakathi ileveli ye-coproporphyrin

Akukho ukwelashwa okuthile okudingekayo.

Umbono muhle kakhulu. Ngokuvamile i-DJS ayinciphisi isikhathi sokuphila komuntu.

Izinkinga azijwayelekile, kepha zingafaka okulandelayo:

• Ubuhlungu besisu
• I-jaundice enamandla

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma kwenzeka okunye kwalokhu okulandelayo:

• I-jaundice inzima
• I-jaundice iba yimbi ngokuhamba kwesikhathi
• Unezinhlungu zesisu noma ezinye izimpawu (okungaba uphawu lokuthi esinye isifo sibangela i-jaundice)

Uma unomlando womndeni we-DJS, ukwelulekwa ngezakhi zofuzo kungasiza uma uhlela ukuba nezingane.

• Izitho zohlelo lokugaya ukudla

I-Korenblat KM, iBerk PD. Sondela esigulini nge-jaundice noma ngokuhlolwa kwesibindi okungavamile. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 138.

ILidofsky SD. I-jaundice. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. Sleisenger kanye neFordtran's Gastrointestinal and Liver Disease. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 21.

URoy-Chowdhury J, uRoy-Chowdhury N. Bilirubin metabolism kanye nokuphazamiseka kwawo. Ku: Sanyal AJ, Terrault N, abahleli. I-Hepatology kaZakim neBoyer: Incwadi Yesifo Sezifo Zesibindi. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 58.