Isifo sePaget sethambo

Isifo sePaget yisifo esibandakanya ukubhujiswa kwamathambo okungavamile nokubuyela esimeni. Lokhu kubangela ukukhubazeka kwamathambo athintekile.

Ayaziwa imbangela yesifo sePaget. Kungahle kube ngenxa yezici zofuzo, kepha futhi kungabangelwa ukutheleleka ngegciwane ekuqaleni kwempilo.

Lesi sifo sivela emhlabeni wonke, kepha sivame kakhulu eYurophu, e-Australia naseNew Zealand. Lesi sifo sesiye saba ngaphansi kakhulu kule minyaka engama-50 edlule.

Kubantu abanesifo sePaget, kunokuwohloka okungajwayelekile kwezicubu zethambo ezindaweni ezithile. Lokhu kulandelwa ukwakheka kwamathambo okungavamile. Indawo entsha yethambo inkulu, kepha ibuthakathaka. Ithambo elisha ligcwele nemithambo yegazi emisha.

Ithambo elithintekile lingaba sendaweni eyodwa noma ezimbili kuphela zamathambo, noma emathanjeni amaningi ahlukene emzimbeni. Imvamisa kufaka amathambo ezingalo, amakhola, imilenze, ukhalo, umgogodla nogebhezi.

Iningi labantu abanesimo abanazo izimpawu. Isifo se-Paget sivame ukutholakala lapho kwenziwa i-x-ray ngesinye isizathu. Kungatholwa futhi lapho uzama ukuthola imbangela yamazinga aphezulu egazi le-calcium.

Uma kwenzeka, izimpawu zingabandakanya:

• Ubuhlungu bamathambo, ubuhlungu bamalunga noma ukuqina, nobuhlungu bentamo (ubuhlungu bungaba bukhulu futhi bube khona isikhathi esiningi)
• Ukukhothama kwemilenze nokunye ukukhubazeka okubonakalayo
• Kukhuliswe ukukhubazeka kwekhanda nekhanda
• Ukwephuka
• Ubuhlungu bekhanda
• Ukulahlekelwa ukuzwa
• Ukuphakama okuncishisiwe
• Isikhumba esifudumele phezu kwethambo elithintekile

Izivivinyo ezingakhombisa ukuthi isifo se-Paget zifaka:

• Ukuskena kwamathambo
• I-X-ray yethambo
• Omaki abaphakeme bokuwohloka kwamathambo (ngokwesibonelo, i-N-telopeptide)

Lesi sifo singathinta nemiphumela yokuhlolwa okulandelayo:

• I-alkaline phosphatase (ALP), isoenzyme ethize ethize
• I-calcium yeserum

Akubona bonke abantu abanesifo sePaget abadinga ukwelashwa. Abantu okungenzeka bangadingi ukwelashwa kubandakanya labo:

• Yiba nokuhlolwa kwegazi okungajwayelekile kahle
• Awunazo izimpawu futhi awunabufakazi besifo esisebenzayo

Isifo sePaget sivame ukwelashwa lapho:

• Amathambo athile, njengamathambo athwala isisindo, ayabandakanyeka futhi ingozi yokuphuka iphezulu.
• Izinguquko zamathambo ziba zimbi ngokushesha (ukwelashwa kunganciphisa ubungozi bokuqhekeka).
• Ukukhubazeka kwamathambo kukhona.
• Umuntu unezinhlungu noma ezinye izimpawu.
• Ukhakhayi luthintekile. (Lokhu ukuvimbela ukulahleka kokuzwa.)
• Amazinga e-calcium aphakeme futhi abangela izimpawu.

Ukwelashwa kwezidakamizwa kusiza ukuvimbela ukuqhubeka kwamathambo nokwakheka. Njengamanje, kunezigaba eziningana zezidakamizwa ezisetshenziselwa ukwelapha isifo sePaget. Lokhu kufaka phakathi:

• Ama-bisphosphonates: Le mithi iyindlela yokwelashwa yokuqala, futhi iyasiza ekwehliseni ukulungiswa kwamathambo. Imithi ivame ukuphuzwa ngomlomo, kodwa futhi inganikezwa ngomthambo (ngemithambo).
• I-Calcitonin: Le hormone ibandakanyeka ekuguqulweni kwamathambo. Inganikezwa njengesifutho samakhala (i-Miacalcin), noma njengomjovo ngaphansi kwesikhumba (iCalcimar noma iMithracin).

I-Acetaminophen (Tylenol) noma izidakamizwa ezingezona ukuvuvukala (ama-NSAID) nazo zinganikezwa ngobuhlungu. Ezimweni ezinzima, kungadingeka ukuhlinzeka ngamathambo ukulungisa ukukhubazeka noma ukuphuka.

Abantu abanalesi simo bangazuza ngokubamba iqhaza emaqenjini okusekela abantu abanokuhlangenwe nakho okufanayo.

Isikhathi esiningi, isimo singalawulwa ngemithi. Inani elincane labantu lingaba nomdlavuza wethambo elibizwa nge-osteosarcoma. Abanye abantu bazodinga ukuhlinzekwa kokujoyina okuhlanganyelwe.

Izinkinga zingafaka:

• Ukuqhekeka kwamathambo
• Izithulu
• Ukukhubazeka
• Ukwehluleka kwenhliziyo
• I-Hypercalcemia
• I-Paraplegia
• I-spinal stenosis

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma uthuthukisa izimpawu zesifo sePaget.

Ama-deformans e-Osteitis

• I-X-ray

URalston SH. Isifo sePaget samathambo. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 233.

Umculi uFR. Isifo samathambo sikaPaget. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 72.