I-lupus erythematosus eyenziwe yizidakamizwa

I-lupus erythematosus eyenziwe yizidakamizwa i-autoimmune disorder ebangelwa ukusabela komuthi.

I-lupus erythematosus eyenziwe yizidakamizwa iyafana kodwa ayifani ne-systemic lupus erythematosus (SLE). Kuyisifo sokuzimela komzimba. Lokhu kusho ukuthi umzimba wakho uhlasela izicubu ezinempilo ngephutha. Kubangelwa ukusabela kumuthi othile. Izimo ezihambisanayo yi-lupus eyenziwe nge-cutaneous ne-ANCA vasculitis eyenziwe yizidakamizwa.

Imithi ejwayelekile kakhulu eyaziwa ukudala i-lupus erythematosus eyenziwe yizidakamizwa yile:

• Isoniazid
• I-Hydralazine
• I-Procainamide
• I-Tumor-necrosis factor (TNF) alpha inhibitors (njenge-etanercept, infliximab ne-adalimumab)
• I-Minocycline
• I-Quinidine

Ezinye izidakamizwa ezingajwayelekile zingadala lesi simo. Lokhu kungafaka:

• Imithi elwa nokuquleka
• I-Capoten
• I-chlorpromazine
• IMethyldopa
• I-Sulfasalazine
• I-Levamisole, imvamisa ingukungcola kwe-cocaine

Imithi ye-Cancer immunotherapy efana ne-pembrolizumab nayo ingadala ukusabela okwehlukile okuzenzakalelayo okubandakanya i-lupus eyenziwe yizidakamizwa.

Izimpawu ze-lupus ezibangelwa izidakamizwa zivame ukuvela ngemuva kokuthatha umuthi okungenani izinyanga ezi-3 kuye kwezi-6.

Izimpawu zingafaka:

• Imfiva
• Ukuzizwa okujwayelekile (malaise)
• Ubuhlungu obuhlangene
• Ukuvuvukala okuhlangene
• Ukuphelelwa isifiso sokudla
• Ubuhlungu besifuba sePleuritic
• Ukuqhuma kwesikhumba ezindaweni ezikhanyiswe yilanga

Umhlinzeki wezempilo uzokwenza ukuhlolwa ngokomzimba futhi alalele isifuba sakho nge-stethoscope. Umhlinzeki angase ezwe umsindo obizwa ngokuthi i-rub friction yenhliziyo noma i-pleural friction rub.

Ukuhlolwa kwesikhumba kukhombisa ukuqubuka.

Amalunga angavuvukala futhi abe nethenda.

Ukuhlolwa okungenziwa kufaka phakathi:

• I-antihistone antibody
• Iphaneli ye-Antinuclear antibody (ANA)
• Iphaneli le-Antineutrophil cytoplasmic antibody (ANCA)
  
• Qedela ukubalwa kwegazi (CBC) ngokuhluka
• Iphaneli ephelele yamakhemikhali
• Ukuhlolwa komchamo

I-x-ray yesifuba ingakhombisa izimpawu ze-pleuritis noma i-pericarditis (ukuvuvukala okuzungeze ulwelwesi lwephaphu noma kwenhliziyo). I-ECG ingakhombisa ukuthi inhliziyo iyathinteka.

Isikhathi esiningi, izimpawu ziyaphela zingakapheli izinsuku ezimbalwa kuya emavikini ngemuva kokumisa umuthi obangele isimo.

Ukwelashwa kungafaka:

• Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) okwelapha i-arthritis ne-pleurisy
• Amafutha e-Corticosteroid aphatha ukuqubuka kwesikhumba
• Imithi elwa namagciwane (i-hydroxychloroquine) yokwelapha izimpawu zesikhumba ne-arthritis

Uma lesi simo sithinta inhliziyo yakho, izinso, noma uhlelo lwezinzwa, ungahle unikezwe imithamo ephezulu ye-corticosteroids (i-prednisone, i-methylprednisolone) kanye ne-immune system suppressants (azathioprine noma i-cyclophosphamide). Lokhu akuvamile.

Uma lesi sifo sisebenza, kufanele ugqoke izingubo zokuzivikela nezibuko zelanga ukuze uvikele ilanga eliningi.

Isikhathi esiningi, i-lupus erythematosus eyenziwe yizidakamizwa ayinzima njenge-SLE. Izimpawu zivame ukuphela ezinsukwini ezimbalwa kuya emavikini ngemuva kokumisa umuthi obewuphuza. Imvamisa, ukuvuvukala kwezinso (nephritis) kungakhula nge-lupus eyenziwe yizidakamizwa ebangelwa yi-TNF inhibitors noma nge-ANCA vasculitis ngenxa ye-hydralazine noma i-levamisole. I-Nephritis ingadinga ukwelashwa ngemithi ye-prednisone kanye ne-immunosuppressive.

Gwema ukuthatha umuthi odale ukusabela ngokuzayo. Izimpawu kungenzeka zibuye uma wenza kanjalo.

Izinkinga zingafaka:

• Ukutheleleka
• I-Thrombocytopenia purpura - ukuphuma kwegazi eduze kwesikhumba, okuvela kwinani eliphansi lama-platelet egazini
• I-hemolytic anemia
• I-myocarditis
• I-Pericarditis
• I-Nephritis

Shayela umhlinzeki wakho uma:

• Uba nezimpawu ezintsha lapho uthatha noma yimiphi imithi ebalwe ngenhla.
• Izimpawu zakho azibi ngcono ngemuva kokuyeka ukuthatha umuthi obangele isimo.

Bheka izimpawu zokuphendula uma uthatha noma imuphi umuthi ongadala le nkinga.

I-Lupus - isidakamizwa esenziwe

• I-Lupus, discoid - umbono wezilonda esifubeni
• Amasosha omzimba

UBenfaremo D, uManfredi L, uLuchetti MM, uGabrielli A. Izifo zemisculoskeletal kanye ne-rheumatic ezibangelwa ama-immune checkpoint inhibitors: ukubuyekezwa kwezincwadi. ICurr Drug Saf. 2018; 13 (3): 150-164. I-PMID: 29745339 www.ncbi.nlm.nih.gov/pubmed/29745339.

UDooley MA. I-lupus ebangelwa izidakamizwa. Ku: Tsokos GC, ed. Uhlelo Lupus Erythematosus. ICambridge, MA: I-Elsevier Academic Press; 2016: isahluko 54.

URadhakrishnan J, uPerazella MA. Isifo se-glomerular esibangelwa izidakamizwa: ukunakwa kuyadingeka! Umtholampilo J Am Soc Nephrol. 2015; 10 (7): 1287-1290. I-PMID: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

URichardson BC. I-lupus ebangelwa izidakamizwa. Ku: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, abahleli. I-Rheumatology. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2019: isahluko 141.

URubin RL. I-lupus ebangelwa izidakamizwa. Isazi Opin Drug Saf. 2015; 14 (3): 361-378. I-PMID: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

IVaglio A, i-Grayson PC, i-Fenaroli P, et al. I-lupus eyenziwe yizidakamizwa: imiqondo yendabuko kanye nemisha. Gwema ngokuzenzakalela uMfu. I-2018; 17 (9): 912-918. I-PMID: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.