Multiple system atrophy - i-cerebellar subtype

I-Multiple system atrophy - cerebellar subtype (MSA-C) isifo esingajwayelekile esidala izindawo ezijulile ebuchosheni, ngenhla nje komgogodla, ukuncipha (i-atrophy). I-MSA-C beyaziwa njenge-olivopontocerebellar atrophy (OPCA).

I-MSA-C ingadluliselwa emindenini (ifomu elizuzwe njengefa). Kungathinta nabantu abangenawo umlando womndeni owaziwayo (ifomu elivela kancane).

Abaphenyi bathole izakhi zofuzo ezithile ezihilelekile kufomu elifunyenwe ngalesi simo.

Isizathu se-MSA-C kubantu abanefomu elivela kancane asaziwa. Lesi sifo siya ngokuya siba sibi (siyaqhubeka).

I-MSA-C ivame kakhulu emadodeni kunabesifazane. Isilinganiso seminyaka yokuqala sineminyaka engama-54 ubudala.

Izimpawu ze-MSA-C zivame ukuqala zisencane kubantu abanefomu elizuzwe njengefa. Uphawu oluyinhloko ukuxakaniseka (ataxia) okuya ngokuya kuba kubi kakhulu. Kungase kube nezinkinga ngokulinganisela, ukukhuluma kancane, nobunzima bokuhamba.

Ezinye izimpawu zingafaka:

• Ukunyakaza kwamehlo okungajwayelekile
• Ukunyakaza okungavamile
• Izinkinga zamathumbu noma zesinye
• Kunzima ukugwinya
• Izandla nezinyawo ezibandayo
• Ubumhlophe lapho umile
• Ubuhlungu bekhanda ngenkathi umile obuthululwayo ngokulala phansi
  
• Ukuqina kwemisipha noma ukuqina, ama-spasms, ukuthuthumela
• Ukulimala kwemizwa (i-neuropathy)
• Izinkinga ekukhulumeni nasekulaleni ngenxa yokuqaqamba kwezintambo zezwi
• Izinkinga zomsebenzi wezocansi
• Ukujuluka okungavamile

Kudingeka ukuhlolwa okuphelele kohlelo lwezokwelapha nolwezinzwa, kanye nokubuyekezwa kwezimpawu nomlando womndeni ukwenza ukuxilongwa.

Kukhona ukuhlolwa kofuzo ukubheka izimbangela zezinye izinhlobo zokuphazamiseka. Kepha, alukho uvivinyo oluthile olutholakalayo ezimweni eziningi. I-MRI yobuchopho ingakhombisa ushintsho ngosayizi wezakhi zobuchopho ezithintekile, ikakhulukazi njengoba lesi sifo siba sibi kakhulu. Kepha kungenzeka ukuba nalesi sifo futhi ube ne-MRI ejwayelekile.

Ezinye izivivinyo ezifana ne-positron emission tomography (PET) zingenziwa ukukhipha ezinye izimo. Lokhu kungabandakanya ukugwinya izifundo ukubona ukuthi umuntu angakugwinya yini ukudla noketshezi ngokuphepha.

Akukho ukwelashwa noma ikhambi elithile le-MSA-C. Inhloso yokwelapha izimpawu nokuvikela izinkinga. Lokhu kungafaka:

• Imithi yokwethuka, njengaleyo yesifo i-Parkinson
• Inkulumo, ukwelashwa emsebenzini nangokomzimba
• Izindlela zokuvimbela ukuminyana
• Izinsiza zokuhamba ukusiza ngokulinganisela nokuvikela ukuwa

Amaqembu alandelayo anganikeza ngezinsizakusebenza nokusekelwa kwabantu abane-MSA-C:

• Nqoba i-MSA Alliance - conqumsa.org/patient-programs/
• I-MSA Coalition - www.multiplesystematrophy.org/msa-resource/

I-MSA-C iya ngokuya iba yimbi, futhi alikho ikhambi. Isimo ngokuvamile asibi. Kepha, kungathatha iminyaka ngaphambi kokuthi umuntu akhubazeke kakhulu.

Izinkinga ze-MSA-C zifaka:

• Ukuchofoza
• Ukutheleleka okuhogela ukudla kumaphaphu (i-aspiration pneumonia)
• Ukulimala okuwa
• Izinkinga zokudla okunomsoco ngenxa yobunzima bokugwinya

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma unezimpawu ze-MSA-C. Uzodinga ukubonwa ngudokotela wezinzwa. Lona ngudokotela olapha izinkinga zesistimu yezinzwa.

I-MSA-C; I-Cerebellar multiple system atrophy; I-Olivopontocerebellar atrophy; I-OPCA; Ukwehla kwe-Olivopontocerebellar

• Isistimu yezinzwa emaphakathi nesistimu yezinzwa ezungezayo

UCiolli L, uKrismer F, uNicoletti F, uWenning GK. Isibuyekezo ku-subtype ye-cerebellar ye-multiple system atrophy. I-Cerebellum Ataxias. 2014; 1-14. I-PMID: 26331038 pubmed.ncbi.nlm.nih.gov/26331038/.

UGilman S, Wenning GK, Low PA, et al. Isitatimende sesibili sokuvumelana ngokuxilongwa kwe-multiple system atrophy. Neurology. 2008; 71 (9): 670-676. I-PMID: 18725592 pubmed.ncbi.nlm.nih.gov/18725592/.

Isifo sikaJancovic J. Parkinson nezinye izinkinga zokuhamba. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ama-eds. I-Neurology kaBradley ekwenziweni kwemitholampilo. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2016: isahluko 96.

Ma MJ. I-biopsy pathology yezifo ze-neurodegenerative kubantu abadala. Ku: Perry A, Brat DJ, ama-eds. I-Neuropathology Yokuhlinzwa Esebenzayo: Indlela Yokuxilonga. Okwesibili. IPhiladelphia, PA: Elsevier, 2018: isahluko 27.

UWalsh RR, uKrismer F, uGalpern WR, et al. Izincomo zomhlangano womhlaba wonke wocwaningo lwe-atrophy research roadmap. Neurology. 2018; 90 (2): 74-82. I-PMID: 29237794 pubmed.ncbi.nlm.nih.gov/29237794/.